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Journal of Genetics and Genomics 2024年第11期51卷 1300-1309页

作者： ludong yang Xinxin Zhang Fan Wang Li Zhang Jing Li Jia-Xing Yue State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Medical Oncology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical UniversityHuaianJiangsu 223200China

Nanopore direct RNA sequencing(DRS)provides the direct access to native RNA strands with full-length information,shedding light on rich qualitative and quantitative properties of gene expression *** with NanoTrans,we present an integrated computational framework that comprehensively covers all major DRS-based application scopes,including isoform clustering and quantification,poly(A)tail length estimation,RNA modification profiling,and fusion gene *** addition to its merit in providing such a streamlined one-stop solution,NanoTrans also shines in its workflow-orientated modular design,batch processing capability,all-in-one tabular and graphic report output,as well as automatic installation and configuration ***,by applying NanoTrans to real DRS datasets of yeast,Arabidopsis,as well as human embryonic kidney and cancer cell lines,we further demonstrate its utility,effectiveness,and efficacy across a wide range of DRS-based application settings.

关键词： Direct RNA sequencing Nanopore Transcriptome Long reads DRS

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芯片焊盘加固提升Au-Al键合可靠性研究

电子与封装 2024年第11期24卷 41-47页

作者：王亚飞杨鲁东吴雷李宏北京七星华创微电子有限责任公司北京101200

在芯片铝焊盘的表面制备Cu/Ni/Au凸块来对芯片进行焊盘加固,通过焊盘结构的优化解决常规芯片铝焊盘在金丝键合时存在的工艺窗口小和金铝键合长期可靠性的问题。进行焊盘加固后的芯片强度大幅度提升,有效避免了键合时击穿焊盘下介质层导... 详细信息

在芯片铝焊盘的表面制备Cu/Ni/Au凸块来对芯片进行焊盘加固,通过焊盘结构的优化解决常规芯片铝焊盘在金丝键合时存在的工艺窗口小和金铝键合长期可靠性的问题。进行焊盘加固后的芯片强度大幅度提升,有效避免了键合时击穿焊盘下介质层导致的短路问题。Ni层的存在有效避免了高温贮存时金属间化合物的生长导致的柯肯达尔空洞问题。通过试验证实了焊盘加固能大幅提高引线键合的工艺窗口,在300℃、24 h的高温贮存试验中焊盘加固后的界面组织保持高度稳定。

关键词：引线键合金属间化合物焊盘加固凸块可靠性封装技术

INTERACTION OF VISCOUS WAKES WITH A FREE SURFACE

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Applied Mathematics and Mechanics(English Edition) 2004年第6期25卷 647-655页

作者： ludong-qiang ShanghaiInstituteofAppliedMathematicsandMechanics ShanghaiUniversityShanghai200072P.R.China

The interaction of laminar wakes with free-surface waves generated by a moving body beneath the surface of an incompressible viscous fluid of infinite depth was investigated *** analysis was based on the steady Oseen equations for disturbed *** kinematic and dynamic boundary conditions were linearized for the small-amplitude free-surface *** effect of the moving body was mathematically modeled as an *** disturbed flow was regarded as the sum of an unbounded singular Oseen flow which represents the effect of the viscous wake and a bounded regular Oseen flow which represents the influence of the free *** exact solution for the free-surface waves was obtained by the method of integral *** asymptotic representation with additive corrections for the free-surface waves was derived by means of Lighthill's two-stage *** symmetric solution obtained shows that the amplitudes of the free-surface waves are exponentially damped by the presences of viscosity and submergence depth.

关键词： Asymptotic solution Free-surface wave Lighthill's two-stage scheme Oseenlet Submergence depth Viscosity Viscous wake

High-performance rigid and flexible ultraviolet photo- detectors with single-crystalline ZnGa2O4 nanowires

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Nano Research 2015年第7期8卷 2162-2169页

作者： Zheng Lou ludong Li Guozhen Shen State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing100083 China These authors contribute equally to this work.

ZnGa2O4 nanowires （NWs） as a ternary oxide semiconductor were successfully synthesized by a simple vapor transport method for application as high- performance ultraviolet （UV） photodetectors. A single-nanowire UV photodetector fabricated on a rigid silicon substrate exhibited excellent spectral responsivity （3,174 A/W） and high external quantum efficiency （1.1 - 106%） at 350 nm UV light illumination. A flexible single-nanowire photodetector on a polyethylene terephthalate （PET） substrate was also fabricated and showed similar properties. The as-fabricated flexible photodetector exhibited stable electrical properties and mechanical flexibility under different bending curvatures over many cycles, indicating its potential application in future flexible photoelectronic devices.

关键词： nanowires,temary oxide, ZnGa2O4,UV photodetectors,flexible electronics

Studies of Composition and Structure of CO_2 Corrosion Film of X56 Steel in the Medium of CO_2 and Salt Water

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材料热处理学报 2004年第05B期25卷 1237-1241页

作者： LIChun-fu DAIJia-lin WANGBing ZHANGYing ZHANGXian-ju ludong-li LUOPing-ya StatekeyLaboratoryofOilandGasReservoirGeologyandE.rpfoitation SouthwestPetroleumInstituteChengduChina MaterialScienceandEngineeringCollege SouthwestPetroleumInstituteChengduChina

The X56 steel samples was corroded in the medium of salt water solution at the conditions of CO2 partial pressure POM 0.5 to 2.0 MPa, temperature 80 °C and flow rate 1.4m/s. Corrosion weigh loss, composition and structure, morphology and phase of corrosion films of the samples were investigate by SEM, EDS, XRD and XPS. The results indicated that the corrosion degree was accelerated with increasing POM ? The intense localised corrosion occurred on the surface of samples. The corrosion films mainly comprised of FeCO3 and complex phase products (Fe, Ca....)COj. There exists serious pitting on the metal substrates under the corrosion film. The theoretic and experimental analyses indicate this is caused by existed micropores or micro holes in films, which have the function of mass transportation.

关键词： X56钢 CO2腐蚀盐水组成结构

Fabrication of flexible reduced graphene oxide/Fe2O3 hollow nanospheres based on-chip micro-supercapacitors for integrated photodetecting applications

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Nano Research 2016年第2期9卷 424-434页

作者： Shaosong Gu Zheng Lou ludong Li Zhaojun Chen Xiangdong Ma Guozhen Shen Department of Material Science and Engineering China University of Mining & Technology (Beijing) Beijing 100083 China State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing 100083China College of Chemical Science and Engineering Qingdao University Qingdao 266071 China

Micro-supercapacitors （MSCs） as important on-chip micropower sources have attracted considerable attention because of their unique and advantageous design for optimized maximum functionality within a minimized sized chip and excellent mechanical flexibility/stability in miniaturized portable electronic device applications. In this work, we report a novel, high-performance flexible integrated on-chip MSC based on hybrid nanostructures of reduced graphene oxide/Fe2O3 hollow nanospheres using a microelectronic photo-lithography technology combined with plasma etching technique. The unique structural design for on-chip MSCs enables high-performance enhancements compared with graphene-only devices, exhibiting high specific capacitances of 11.57 F·cm^-3 at a scan rate of 200 mV·s^-1 and excellent rate capability and robust cycling stability with capacitance retention of 92.08% after 32,000 charge/discharge cycles. Moreover, the on-chip MSCs exhibit superior flexibility and outstanding stability even after repetition of charge/discharge cycles under different bending states. As-fabricated highly flexible on-chip MSCs can be easily integrated with CdS nanowire-based photodetectors to form a highly compacted photodetecting system, exhibiting comparable performance to devices driven by conventional external energy storage units.

关键词： Fe2O3 microsupercapacitor photodetector flexible

A NOTE ON THE COMPLEX DISPERSION RELATION FOR STEADY VISCOUS SHIP WAVES

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Journal of Hydrodynamics 2005年第1期17卷 22-26页

作者： ludong-qiang ShanghaiInstituteofAppliedMathematicsandMechanics ShanghaiUniversityShanghai200072China／／DepartmentofMechanicalEngineeringTheUniversityofHongKongHongKongChina

Based on the double Fourier integral representation for steady viscous ship waves, which involves a generic amplitude function and a complex dispersion relation, the phase function for three dimensional ship waves in the far field was asymptotically derived by means of the Lighthill two stage scheme combining the Cauchy residue theorem and the method of steepest descents, and the effect of viscosity on wavelengths was numerically investigated with the Newton iteration method. It is found that the transverse and diverging waves are elongated due to the presence of viscosity and the latter is more heavily affected and that the phase differences between the viscous transverse and diverging waves are larger than those of the corresponding inviscid waves.

关键词： free-surface wave Oseen flow viscosity complex dispersion relation

Propagation of a Pearcey beam in uniaxial crystals

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Chinese Physics B 2019年第2期28卷 210-214页

作者： Chuangjie Xu ludong Lin Zhengzhong Huang Donglong He Dongmei Deng Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices South China Normal University

An analytical propagation expression of a Pearcey beam in uniaxial crystals orthogonal to the optical axis is *** propagations of the Pearcey beam in the tourmaline and the quartz are investigated. The phase distribution and the angular momentum of the Pearcey beam in the tourmaline are also performed. The result shows that the positions of the auto-focusing and the inversion simply relate to the extraordinary refractive index of the crystals. In other words, we can choose the suitable crystals to adjust the positions of auto-focusing and inversion of the Pearcey beam to meet the actual needs.

关键词： crystal optics diffraction theory propagation

Delay-induced coherence bi-resonance-like behavior in stochastic Hodgkin-Huxley neuron networks

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Science China Chemistry 2010年第8期53卷 1762-1766页

作者： HAO YingHang,GONG YuBing,LIN Xiu & MA XiaoGuang School of Physics,ludong University,Yantai 264025,China School of Physics Ludong University Yantai China

In this paper,we study how information transmission delays affect the spiking behavior of electrically coupled stochastic Hodgkin-Huxley (HH) neurons on Newman-Watts *** is found that the spiking behavior becomes the most regular at an optimal time delay,indicating the occurrence of delay-induced coherence resonance-like (CR-like) ***,there are different CR-like types,depending on the membrane patch size of the *** a smaller patch size,only single CR-like behavior occurs;while for a larger patch size,coherence bi-resonance-like (CBR) behavior *** findings show that the delay-induced CR-like behavior is closely related to the channel noise strength,and the coupled neurons may exhibit different spiking behaviors under the interplay of the channel noise and time ***,the channel noise should be taken into account in the study of time delay-related spiking activity in stochastic HH *** work provides new insight into the role of channel noise and information transmission delays in realistic neural systems.

关键词： stochastic HH neuron delay through electric synapse coherence resonance and bi-resonance Newman-Watts network

Protein trans-splicing based dual-vector delivery of the coagulation factor Ⅷ gene

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Science China(Life Sciences) 2010年第6期53卷 683-689页

作者： ZHU FuXiang,LIU ZeLong,CHI XiaoYan & QU HuiGe Life Science College of ludong University,Yantai 264025,China Life Science College of ludong University Yantai China

A dual-vector system was explored for the delivery of the coagulation factor VIII gene,using intein-mediated protein trans-splicing as a means to produce intact functional factor VIII post-translationally.A pair of eukaryotic expression vectors,expressing Ssp DnaB intein-fused heavy and light chain genes of B-domain deleted factor VIII (BDD-FVIII),was *** transient co-transfection of the two vectors into 293 and COS-7 cells,the culture supernatants contained (137±23) and (109±22) ng mL–1 spliced BDD-FVIII antigen with an activity of (1.05±0.16) and (0.79±0.23) IU mL–1 for 293 and COS-7 cells,*** spliced BDD-FVIII was also detected in supernatants from a mixture of cells transfected with inteinfused heavy and light chain *** spliced BDD-FVIII protein bands from cell lysates were visualized by Western *** data demonstrated that intein could be used to transfer the split factor VIII gene and provided valuable information on factor VIII gene delivery by dual-adeno-associated virus in hemophilia A gene therapy.

关键词： intein protein trans-splicing coagulation factor VIII dual-vector gene delivery