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Effect of alcohol consumption on liver stiffness measured by transient elastography

World Journal of Gastroenterology 2013年第4期19卷 516-522页

作者： Edouard Bardou-Jacquet ludivine legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand Hepatology and Addictology Department University Hospital PontchaillouF35000 RennesFrance Institut National de la Santé et de la Recherche Médicale U991 Institut Fédératif de Recherche 140University of Rennes 1F35000 RennesFrance

AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or ***:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver *** was performed at least one week apart by senior *** examinations with less than ten successful measures or with an interquartile range above 30% were *** retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was *** biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were *** fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis *** and final putative fibrosis score were compared according to alcohol consumption during ***:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two ***-seven patients met our criteria with a median follow-up of 32.5 *** the end of the study,13(35%) were abstinent,and 24(65%) *** patients had liver biopsy during *** decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off *** relapsers TE increased in 45% and decreased in 54% of *** was no statistical difference between initial and final TE in *** the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final ***

关键词： Alcohol Transient elastography Cirrhosis Fibrosis Liver biopsy Liver stiffness

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Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

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World Journal of Gastroenterology 2016年第20期22卷 4926-4935页

作者： Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff Morcet Sophie Michalak Antonia Le Gruyer ludivine legros Edouard Bardou-Jacquet Yves Gandon Romain Moirand Department of Abdominal Imaging Rennes University Hospital Clinical Inverstigation Center CIC INSERM 1414 Rennes University Hospital Department of Hepatology Rennes University Hospital Department of Pathology Rennes University Hospital Rennes Department of Pathology Angers University Hospital Department of Addictology Rennes University Hospital Department of Research INSERM UMR 991 Rennes 1 Medicine University

AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to ***: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each ***: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/***: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

关键词： Alcoholic liver disease Elastography Noninvasive Acoustic radiation force impulse Fibrosis

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Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation

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World Journal of Gastroenterology 2020年第16期26卷 1938-1949页

作者： Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel ludivine legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet Service des Maladies du Foie CHU RennesUniversity RennesRennes 35033France Service de Chirurgie Hepatobilaire CHU RennesUniversity RennesRennes 35033France Service de Réanimation médicale CHU RennesUniversity RennesRennes 35033France Laboratoire de biochimie CHU RennesUniversity RennesRennes 35033France

BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant *** identifying factors associated with mortality could help improve patient *** impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this *** studies suggest that increased serum ferritin is associated with higher *** iron deficiency which is a well described risk factor in critically ill patients has not been *** To assess the impact of pre-transplant iron metabolism parameters on posttransplant *** From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were *** were prospectively recorded at the time of evaluation and at the time of LT regarding donor and *** ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical *** regression analysis was used to determine mortality risks ***-up data were obtained from the local and national database regarding causes of *** At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of *** multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron m

关键词： Iron deficiency Overload Cirrhosis Infection Death Ferritin Transferrin saturation

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