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Effects of cancer on patients with COVID-19:a systematic review and meta-analysis of 63,019 participants

Cancer Biology & Medicine 2021年第1期18卷 298-307页

作者： ludi yang Peiwei Chai Jie Yu Xianqun Fan Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyNinth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:Patients with underlying diseases are more vulnerable to coronavirus disease 2019(COVID-19).The purpose of this study was to investigate cancer incidence in patients with COVID-19 and to determine whether cancer was associated with mortality among patients with ***:Electronic searches of Pub Med,Embase,Cochrane,Web of Science,and med Rxiv were conducted to collect studies that provided data regarding the incidence and mortality of cancer patients with ***-analyses were used to estimate pooled incidences,risk ratios(RRs),and 95%confidence intervals(CIs)using a random-effects *** among studies was detected using I2 ***:A total of 19 retrospective studies involving 63,019 patients(2,682 patients with cancer)were ***-analysis showed that the pooled incidence of cancer in COVID-19 patients was 6%(95%CI:3%–9%).The mortality rate of COVID-19 patients with cancer was higher than that of those without cancer[risk ratio(RR):1.8,95%CI:1.38–2.35,P<0.01].Studies on specific types of cancer showed that among COVID-19 patients,the mortality rate of lung cancer patients was higher than that of patients without lung cancer(RR:1.8,95%CI:0.85–3.80,P=0.02).Conclusions:Patients with cancer were more susceptible to *** a risk factor,cancer increased mortality among COVID-19 *** COVID-19 patients with cancer,those who had lung cancer had a higher mortality than those without lung *** findings suggested that clinicians should pay more attention to cancer patients diagnosed with COVID-19 and provide useful information for their clinical management.

关键词： COVID-19 cancer incidence mortality meta-analysi

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Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4069-4089页

作者： ludi yang Ruobing Jia Tongxin Ge Shengfang Ge Ai Zhuang Peiwei Chai Xianqun Fan Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai20025P.R.China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai20025P.R.China

Extrachromosomal circular DNA(eccDNA),ranging in size from tens to millions of base pairs,is independent of conventional ***,eccDNAs have been considered an unanticipated major source of somatic rearrangements,contributing to genomic remodeling through chimeric circularization and reintegration of circular DNA into the linear *** addition,the origin of eccDNA is considered to be associated with essential chromatin-related events,including the formation of super-enhancers and DNA repair ***,our understanding of the properties and functions of eccDNA has continuously and greatly *** investigations demonstrate that eccDNAs serve as multifunctional molecules in various organisms during diversified biological processes,such as epigenetic remodeling,telomere trimming,and the regulation of canonical signaling ***,its special distribution potentiates eccDNA as a measurable biomarker in many diseases,especially *** loss of eccDNA homeostasis facilitates tumor initiation,malignant progression,and heterogeneous evolution in many *** in-depth understanding of eccDNA provides novel insights for precision cancer *** this review,we summarized the discovery history of eccDNA,discussed the biogenesis,characteristics,and functions of ***,we emphasized the role of eccDNA during tumor pathogenesis and malignant ***,we summarized potential clinical applications that target aberrant eccDNA in multiple diseases.

关键词： chromosomal diseases circular

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Epigenetic drug library screening reveals targeting DOT1L abrogates NAD^(+)synthesis by reprogramming H3K79 methylation in uveal melanoma

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Journal of Pharmaceutical Analysis 2023年第1期13卷 24-38页

作者： Xiang Gu Yu Hua Jie Yu ludi yang Shengfang Ge Renbing Jia Peiwei Chai Ai Zhuang Xianqun Fan Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

Uveal melanoma(UM)is the most frequent and life-threatening ocular malignancy in *** histone methylation contributes to the abnormal transcriptome during ***,a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains ***,using a systematic epi-drug screening and a high-throughput transcriptome profiling of histone methylation modifiers,we observed that disruptor of telomeric silencing-1-like(DOT1L),a methyltransferase of histone H3 lysine 79(H3K79),was activated in UM,especially in the high-risk ***,a systematic epi-drug library screening revealed that DOT1L inhibitors exhibited salient tumor-selective inhibitory effects on UM cells,both in vitro and in *** Cleavage Under Targets and Tagmentation(CUT&Tag),RNA sequencing(RNA-seq),and bioinformatics analysis,we identified that DOT1L facilitated H3K79 methylation of nicotinate phosphoribosyltransferase(NAPRT)and epigenetically activated its ***,NAPRT served as an oncogenic accelerator by enhancing nicotinamide adenine dinucleotide(NAD^(+))***,DOT1L inhibition epigenetically silenced NAPRT expression through the diminishment of dimethylation of H3K79(H3K79me2)in the NAPRT promoter,thereby inhibiting the malignant behaviors of ***,our findings delineated an integrated picture of the histone methylation landscape in UM and unveiled a novel DOT1L/NAPRT oncogenic mechanism that bridges transcriptional addiction and metabolic reprogramming.

关键词： Histone methylation Metabolic reprogramming Uveal melanoma Transcriptional addiction

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顾及城市空间结构信息的元胞自动机模型构建及其应用

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地理科学 2019年第8期39卷 1276-1283页

作者：焦利民杨璐迪刘稼丰张博恩许刚武汉大学资源与环境科学学院/武汉大学地理信息系统教育部重点实验室

利用衡量新增斑块空间邻接关系的多阶景观扩张指数定量识别城市组团的空间特征,结合城市组团所表现出的城市空间结构信息,构建基于MLEI的元胞自动机城市扩展(MLEI-CA)模型。针对武汉市1990、2000、2013年3期遥感影像数据,运用MLEI-CA对... 详细信息

利用衡量新增斑块空间邻接关系的多阶景观扩张指数定量识别城市组团的空间特征,结合城市组团所表现出的城市空间结构信息,构建基于MLEI的元胞自动机城市扩展(MLEI-CA)模型。针对武汉市1990、2000、2013年3期遥感影像数据,运用MLEI-CA对武汉市城市扩展进行模拟,通过与Logistic-CA模型对比验证该模型的适用性。研究结果表明,MLEI-CA模型更加准确地揭示城市扩展的空间演变过程,MLEI-CA模型精度优于Logistic-CA模型,Kappa系数、城市用地的精度分别提高6%和4%。

关键词：城市扩展模拟城市空间结构城市组团多阶景观扩张指数元胞自动机模型

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一种新的城市景观扩张过程测度方法:多阶邻接度指数

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地理科学 2018年第11期38卷 1741-1749页

作者：刘稼丰焦利民董婷许刚张博恩杨璐迪武汉大学资源与环境科学学院

提出多阶邻接度指数(Multi-order Adjacency Index, MAI),应用多阶缓冲区完善对新旧斑块间空间关系的识别,从而更为详细地揭示城市扩张过程特征。MAI的延伸公式可供自下而上从宏观分析城市整体的扩张程度及空间变化过程。选取武汉市作... 详细信息

提出多阶邻接度指数(Multi-order Adjacency Index, MAI),应用多阶缓冲区完善对新旧斑块间空间关系的识别,从而更为详细地揭示城市扩张过程特征。MAI的延伸公式可供自下而上从宏观分析城市整体的扩张程度及空间变化过程。选取武汉市作为研究区,基于4期遥感影像(1995、2000、2005和2010年)划分3个时段应用MAI分析武汉市城市景观格局的演变特征。结果表明,MAI能够详细地反映出新增城市斑块在空间上有更加离散的分布趋势,新增斑块的扩张程度逐渐加深,建成区的边界不断向外延展。比较MAI与LEI(Landscape Expansion Index,LEI)的特征差异,指出MAI能够更加详尽地反映新旧斑块间的空间位置关系。

关键词：多阶邻接度指数景观扩张指数城市扩张多阶缓冲区.

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A flexible artificial solid-electrolyte interlayer supported by compactness-tailored carbon nanotube network for dendrite-free lithium metal anode

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Journal of Energy Chemistry 2022年第6期31卷 421-427,I0012页

作者： Haowen Liu Jifang Zhang yang Liu yang Wei Shuaiyang Ren ludi Pan Yi Su Jianhua Xiao Haiyan Fan Yitao Lin Yipeng Su Yuegang Zhang State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China

A dendrite-free lithium metal anode requires a stable interface designed for efficient and reversible lithium plating and stripping. In this work, we have devised a mechanically flexible artificial Li_(3)N solid-electrolyte interlayer supported by a dual-layer compactness-tailored carbon nanotube fiber network. The more compact side of the network ensures a full coverage of Li_(3)N, which prevents the reaction between electrolyte and lithium. The other side, with sparsely distributed nanotube fibers, provides mechanical flexibility for the film, and induces three-dimensional lithium deposition along its structure without any dendrite formation. The resulting full cell with NCM811 cathode has a high capacity retention of 95.1% for 160 cycles compared with less than 80% for the control.

关键词： Lithium metal anode Artificial SEI CNT network 3D deposition

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Tailoring Mg^(2+)Solvation Structure in a Facile All-Inorganic[Mg_(x)Li_(y)Cl2_(x+y)·nTHF]Complex Electrolyte for High Rate and Long Cycle-Life Mg Battery

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Energy & Environmental Materials 2023年第2期6卷 152-158页

作者： Haiyan Fan Xinxin Zhang Yuxing Zhao Jianhua Xiao Hua Yuan Guang Wang Yitao Lin Jifang Zhang ludi Pan Ting Pan yang Liu Yuegang Zhang State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China

A high-performance all-inorganic magnesium-lithium chloride complex(MLCC)electrolyte is synthesized by a simple room-temperature reaction of LiCl with MgCl_(2) in tetrahydrofuran(THF)*** dynamics simulation,density functional theory calculation,Raman spectroscopy,and nuclear magnetic resonance spectroscopy reveal that the formation of[Mg_(x)Li_(y)Cl_(2x+y)·nTHF]complex solvation structure significantly lowers the coordination number of THF in the first solvation sheath of Mg^(2+),which significantly enhances its de-solvation *** MLCC electrolyte presents a stable electrochemical window up to 3.1 V(vs Mg/Mg^(2+))and enables reversible cycling of Mg metal deposition/stripping with an outstanding Coulombic efficiency up to 99%at current densities as high as 10 mA cm^(-2).Utilizing the MLCC electrolyte,a Mg/Mo_(6)S_(8) full cell can be cycled for over 10000 cycles with a superior capacity retention of 85 mA h g^(-1) under an ultrahigh rate of 50 C(1 C=128.8 mA g^(-1)).The facile synthesis of highperformance MLCC electrolyte provides a promising solution for future practical magnesium batteries.

关键词： cycle life electrolyte Mg battery solvation structure

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Split-order consolidation optimization for online supermarkets:Process analysis and optimization models

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Frontiers of Engineering Management 2023年第3期10卷 499-516页

作者： Minfang HUANG Yuanyuan HAO Yanxin WANG Xiangpei HU ludi LI School of Economics and Management North China Electric Power UniversityBeijing 102206China Business College Beijing Union UniversityBeijing 100025China Institute of Systems Engineering Dalian University of TechnologyDalian 116024China

The large-scale online supermarket is a newly emerging online retailing mode which brings great convenience to *** supermarkets are characterized by having large amounts of daily orders with potentially multiple items,diverse delivery times,and a high order-split *** shipments for one order caused by order splitting result in high cost and disturbance and a large number of discarded consumable packages at online retailers and customers,causing severe damage to the ***,research on split-order consolidation fulfilment is critical for the advancement of the practice and theory in the context of highly complex online *** paper first analyzes the characteristics and the challenges associated with the split-order consolidation problem that online supermarket is confronting and summarizes the new operational process of split-order consolidation ***,a time–space network optimization model is built,and its corresponding solution algorithm is presented to solve the questions of where and when to consolidate the split ***,the computation results of the numerical experiments are provided to verify the effectiveness of the algorithm,and a sensitivity analysis of the relevant parameters is *** work highlights the effect of order consolidation processes and fulfilment methods on the order fulfilment decision-making for online *** purpose of this article is to help pave the way for more effective online supermarket management and order implementation.

关键词： online supermarkets split-order consolidation time–space network genetic algorithm

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Unraveling Shuttle Effect and Suppression Strategy in Lithium/Sulfur Cells by In Situ/Operando X-ray Absorption Spectroscopic Characterization

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Energy & Environmental Materials 2021年第2期4卷 222-228页

作者： Lujie Jia Jian Wang Shuaiyang Ren Guoxi Ren Xiang Jin Licheng Kao Xuefei Feng Feipeng yang Qi Wang ludi Pan Qingtian Li Yi-sheng Liu yang Wu Gao Liu Jun Feng Shoushan Fan Yifan Ye Jinghua Guo Yuegang Zhang State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Advanced Light Source and Energy Storage and Distributed Resources DivisionLawrence Berkeley National LaboratoryBerkeley CA 94720USA i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China CAS Center for Excellence in Superconducting Electronics State Key Laboratory of Functional Materials for InformaticsShanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China 不详

The polysulfides shuttle effect represents a great challenge in achieving high capacity and long lifespan of lithium/sulfur(Li/S)cells.A comprehensive understanding of the shuttle-related sulfur speciation and diffusion process is vital for addressing this ***,we employed in situ/operando X-ray absorption spectroscopy(XAS)to trace the migration of polysulfides across the Li/S cells by precisely monitoring the sulfur chemical speciation at the cathodic electrolyte-separator and electrolyte-anode interfaces,respectively,in a real-time *** we adopted a shuttle-suppressing strategy by introducing an electrocatalytic layer of twinborn bismuth sulfide/bismuth oxide nanoclusters in a carbon matrix(BSOC),we found the Li/S cell showed greatly improved sulfur utilization and longer life *** operando S Kedge XAS results revealed that the BSOC modification was bi-functional:trapping polysulfides and catalyzing conversion of sulfur species *** elucidated that the polysulfide trapping-and-catalyzing effect of the BSOC electrocatalytic layer resulted in an effective lithium anode *** results could offer potential stratagem for designing more advanced Li/S cells.

关键词： in situ/operando lithium/sulfur cell shuttle effect sulfur speciation X-ray absorption spectroscopy

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腹腔镜脾切除联合贲门周围血管离断术治疗肝硬化门静脉高压症的近期临床结果

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外科理论与实践 2021年第3期26卷 221-225页

作者：崔然叶伦河王旭菁王永坤张琪祺王恺京王明戴陈新杨鹿笛董春秀陈波同济大学附属东方医院肝胆胰外科上海200123

目的:探讨腹腔镜脾切除联合贲门周围血管离断术治疗门静脉高压症的近期结果和安全性。方法:回顾性分析2018年9月至2020年12月间我院行腹腔镜脾切除联合贲门周围血管离断术治疗的23例临床资料。选择同时、同科室临床病理基线相当的开腹... 详细信息

目的:探讨腹腔镜脾切除联合贲门周围血管离断术治疗门静脉高压症的近期结果和安全性。方法:回顾性分析2018年9月至2020年12月间我院行腹腔镜脾切除联合贲门周围血管离断术治疗的23例临床资料。选择同时、同科室临床病理基线相当的开腹脾切除联合贲门周围血管离断术13例临床资料作对比。结果:腹腔镜手术组较传统开腹镜组病人出血量相对较少、手术时间较长、肛门排气较早、恢复进食较早。两组术后住院时间、术后并发症(出血、胸腔积液、深静脉血栓、胃瘫、切口感染)差异均无统计学意义(P>0.05)。结论:腹腔镜脾切除联合贲门周围血管离断术有效治疗肝硬化门静脉高压症具有术中出血量少、术后恢复进食时间较早和安全的优势,近期结果与开腹手术相似。

关键词：腹腔镜脾切除门静脉高压症近期结果

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