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Finite Ele.ent Simulation of In-Stent Restenosis with tissue Growth Model

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Journal of Biomedical Science and Engineering 2021年第2期14卷 33-47页

作者： Jie Cheng lucy t. Zhang Department of Mechanical Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute Troy NY USA

In this study, a finite ele.ent simulation of in-stent restenosis (ISR) is conducted to simulate the deployment and expansion of a stent in an occluded artery with a contact model and a mechanics-based growth model. A tissue growth model based on the multiplicative decomposition of deformation is applied to investigate the growth of the plaque and artery wall upon the stent’s implantation. Due to the high stresses at the contact points between the stent struts and the tissue, further tissue injury or restenosis is observed. the simulation results show that after the stent deployment, the von Mises stress is significantly larger in the plaque compared to the artery wall, especially in the region that is in contact with the stent. However, the growth of the plaque and artery tends to even out the stress concentration over time. the tissue growth is found to be more significant near the inner wall than the outer layer. A 0.77 mm restenosis is predicted, which agrees with published clinical observations. the features of the artery growth are carefully analyzed, and the underlying mechanism is discussed. this study is the first attempt to apply finite ele.ent analysis to artery restenosis, which establishes a framework for predicting ISR’s occurrence and severity. the results also provide insights into understanding the underlying mechanism of in-stent restenosis.

关键词： Stents In-Stent Restenosis tissue Growth Finite Ele.ent Simulation Growth Model

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Brain twister

小学生导刊(高年级) 2017年第2期 46-47页

作者： lucy

元宵节,Lily和伙伴们一起去逛灯会,猜灯谜。嘿,今年的灯谜增加了英语的脑筋急转弯呢!你能答对几个呢?试一试吧!*** words have the most le.ters in it?()*** has hands but no feet,have face but no eyes,tells but doesn’t talk?()*... 详细信息

关键词： Brain twister

Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal

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World Journal of Gastroenterology 2012年第12期18卷 1279-1285页

作者： lucy Vannella Edith Lahner Bruno Annibale Dipartimento Medico-Chirurgico di Scienze Cliniche Tecnobiomediche e Medicina TraslazionaleSant'Andrea HospitalSchool of MedicineUniversity Sapienza

Chronic atrophic gastritis （CAG） is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue （non-metaplastic atrophy） or by glandular structures inappropriate for location （metaplastic atrophy）. Epidemiological data suggest that CAG is associated with two different types of tumors： Intestinal-type gastric cancer （GC） and type I gastric carcinoid （t I GC）. the pathophysiological mechanisms which le.d to the development of these gastric tumors are different, It is accepted that a multistep process initiating from Helico- bacterpylori-related chronic inflammation of the gastric mucosa progresses to CAG, intestinal metaplasia, dysplasia and, finally, le.ds to the development of GC. the t I GC is a gastrin-dependent tumor and the chronic ele.ation of gastrin, which is associated with CAG, stimulates the growth of enterochromaffin-like cells with their hyperplasia le.ding to the development of t I GC. thus, several events occur in the gastric mucosa before the development of intestinatype GC and/ or t I GC and these take several years. Knowle.ge ofCAG incidence from superficial gastritis, its prevale.ce in different clinical settings and possible.risk factors as- sociated with the progression of this condition to gastric neoplasias are important issues. this editorial intends to provide a brief review of the main studies regarding incidence and prevale.ce of CAG and risk factors for the development of gastric neoplasias.

关键词： Chronic atrophic gastritis Gastric neoplasia Intestinal-type gastric cancer type I gastric carcinoid Prevale.ce Incidence Risk factors

Analyzing the H19-and t65-epitopes in 38 kd phosphory-lated protein of Marek's disease viruses and comparing chicken immunological reactions to viruses point-mutated in the epitopes

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Science China(Life Sciences) 2004年第1期47卷 82-91页

作者： le. lucy F Avian Disease and Oncology Laboratory East Lansing Ml 48823 USA

DNA sequencing analysis in 38 kd phosphorylated protein (pp38) ORF of Marek's disease viruses (MDV) indicated that all tested 10 virule.t strains with different pathotypes had 'A' at base #320 and glutamine at aa#107 while.reacted with monoclonal antibody (Mab) H19 in indirect fluorescence antibody test (IFA). However, vaccine strain CVI988 had 'G' at base#320 and arginine at aa#107 instead, when it was negative in IFA with Mab H19. Some strains were also reactive with Mab t65 in IFA while.there was 'G' at base #326 and glycine at aa#109, but the other strains, which had 'A' at base #326 and glutamic acid at aa#109, did not react with Mab t65. By comparison of CVI988 to its point mutants CVI/rpp38(AG) and CVI/rpp38(AA) with 1 or 2 base(s) changes at bases #320 and /or #326 of pp38 gene for their reactivity with Mab H19 and t65, it was confirmed that the glutamine at aa#107 and glycine at aa#109 were critical to epitopes H19 and t65 respectively. Immuno-reactions to MDV were compared in SPF chickens inoculated with cloned CVI988 and its mutant CVI/rpp38(AG). It was found that antibody responses to MDV in chickens inoculated with CVI/rpp38(AG) were delayed and significantly lower than that in chickens inoculated with the native CVI988. By differential comparison of antibody titers to different antigens, a third epitope specific to CVI988 and dependent on arginine at aa#107 was suggested to be responsible.for the big difference in antibody responses induced by native CVI988 and its mutant.

关键词： Marek's disease virus, pp38 gene, point mutant, epitopes, antibody responses.

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Role.of sphingosine kinases and sphingosine 1-phosphate in mediating adipogenesis

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Journal of Diabetes Mellitus 2013年第2期3卷 52-61页

作者： lucy D. Mastrandrea Department of Pediatrics School of Medicine and Biomedical Sciences University at Buffalo New York USA

Recent Background: Development of obesity involves promotion of preadipocyte differrentiation. this study investigated the role.that sphingosine kinases (SPHK) and ceramide-derived sphingosine 1-phosphate (S1P) play in adipocyte terminal differentiation. Materials and Methods: the mouse 3t3-L1 cell line was used as a model for adipogenesis. Cells were harvested at specific time points after initation of differentiation, and SPHK activity was measured. 3t3-L1 cells were treated with S1P and expression of early adipogenesis transcription markers was measured by real time PCR. the expression of S1P-receptors (S1PRs) during differentiation was measured. Results: SPHK activity is induced when 3t3-L1 cells are treated with insulin, dexamethasone, and isobutylmethylxanthine to induce differentiation. SPHK1 is active in preadipocytes and early in the differentiation process. Both SPHK1 and SPHK2 isozymes contribute to activity in differentiated adipocytes. Inhibition of SPHK1 attenuates adipocyte differentiation;however, extracellular S1P does not rescue the effect of SPHK1 inhibition on adipogenesis. Although treatment of preadipocytes with S1P induced message expression of the early adipogenesis transcription factor CC AAt/ binding proteinalpha, continued treatment did not fully support the development of differentiated adipocytes. Sphingosine 1-phosphate receptors (S1PRs) are expressed in preadipocytes and message expression declines markedly during adipocyte differentiation. Conclusion: these results demonstrate that the contribution of SPHK and S1P to adipogenesis is mediated primarily through biphasic activation of SPHK1 and 2 with extracellular S1P and S1PRs playing little.role.during preadipocyte differentiation.

关键词： Adipocyte Adipogenesis Obesity Sphingosine Kinase 3t3-L1 Cells Sphingosine 1-Phosphate Sphingosine 1-Phosphate Receptor

Usefulness of antero-posterior radiograph and variability of management in non-major thoracolumbar injuries: a single.centre pilot study and review of literature

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Chinese Neurosurgical Journal 2018年第4期4卷 196-203页

作者： Jason Yuen Wisam Selbi lucy le. tim Germon South West Neurosurgery Centre Derriford Hospital Plymouth PL6 8DH UK Department of Radiology Derriford Hospital Plymouth PL6 8DH UK.

Background: Most adult trauma protocols suggest that where there has been a dangerous mechanism of injury or the patient exhibits abnormal physiology, Ct scan is the primary radiological investigation. Other patients who may have suffered thoraco-lumbar (t-L) trauma initially have antero-posterior (AP) and lateral plain X-rays performed. Our clinical experience suggests AP views are not particularly useful in the management of these relatively low-velocity injuries. this is the first study intended to determine the contribution made by AP X-rays in these cases. Methods: Adults with a history of t-L trauma referred to our tertiary spinal service over 20 weeks were reviewed. those with a Ct scan performed prior to X-rays were excluded. Four spine surgeons and four neuroradiologists were independently shown lateral X-rays along with the clinical details and asked to provide a management plan. then they were shown the AP X-rays and asked if they would like to change their advice. Results: Fifty-two patients were identified. thirty-four sets of supine and 40 sets of erect X-rays were included (four people.only had lateral X-rays performed), yielding 1152 film views. Average patient age was 58.3 years with 30 (58%) male.. Forty-five (87%) were AO type A (compression-type) fractures. Seven (13%) had been erroneously referred with a diagnosis of acute fracture, which on review was not considered to be the case. Fifty-four percent of fractures were between t11 and L2. Forty-six percent appeared osteoporotic. In no instance did evaluation of the AP X-ray change the management plan which had been suggested following the evaluation of the lateral X-ray alone. However, there was significant variation in advice on further management between consultants. Conclusions: Our results suggest AP X-rays do not contribute to the management of low-velocity thoraco-lumbar traumas. Larger studies are required to support these findings, but there appears to be a potential to reduce both cost

关键词： (MeSH):spinal fractures Spinal injuries X-ray film

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马立克氏病新一代疫苗的研究与应用

中国家禽 2010年第19期32卷 37-40页

作者： lucy F.le. 美国农业部禽病与肿瘤研究所

马立克氏病（Marek’s disease，MD）是由疱疹病毒马立克氏病病毒（MDV）引起的鸡及其它禽类全身性淋巴瘤病或多克隆t细胞淋巴瘤病。俄罗斯、中国、葡萄牙、摩洛哥、秘鲁等国目前仍有MD暴发；美国、加拿大、英国等欧洲国家鸡群普遍接种M... 详细信息

马立克氏病（Marek’s disease，MD）是由疱疹病毒马立克氏病病毒（MDV）引起的鸡及其它禽类全身性淋巴瘤病或多克隆t细胞淋巴瘤病。俄罗斯、中国、葡萄牙、摩洛哥、秘鲁等国目前仍有MD暴发；美国、加拿大、英国等欧洲国家鸡群普遍接种MD疫苗，目前MD已得到很好控制。

关键词：马立克氏病病毒 MD疫苗应用疱疹病毒欧洲国家淋巴瘤 t细胞多克隆

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Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

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World Journal of Gastroenterology 2008年第4期14卷 563-568页

作者： Edith Lahner Marco Intraligi Massimo Buscema Marco Centanni lucy Vannella Enzo Grossi Bruno Annibale Department of Digestive and Liver Disease University "La Sapienza"2nd Medical SchoolOspedale Sant'AndreaRomeItaly Semeion Research Center Rome Italy Endocrinology Unit Department of Experimental Medicine and PathologyUniversity "La Sapienza"Polo PontinoLatinaItaly Bracco Imaging Spa MilanItaly

AIM: to investigate the role.of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. MEtHODS: A dataset of 29 input variable. of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,t&t-IS protocol,tWISt protocol). the target variable.was the presence of thyroid disease. RESULtS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. the optimization procedures (t&t-IS and tWISt protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. the increase of sensitivity of the tWISt protocol was statistically signifi cant compared to t&t-IS. CONCLUSION: this study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

关键词： Atrophic body gastritis thyroid disease Artificial neural networks

Comparison of Deep le.rning Architectures for Late Blight and Early Blight Disease Detection on Potatoes

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Open Journal of Applied Sciences 2022年第5期12卷 723-743页

作者： Soumo Emmanuel Arnaud Ndeda Rehema Shohei Aoki Murungi lucy Kananu Department of Mechatronics Engineering Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Department of Horticulture Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

Potato late blight and early blight are common hazards to the long-term production of potatoes, impacting many farmers around the world, particularly in Africa. Early detection and treatment of the potato blight disease are critical for promoting healthy potato plant growth and ensuring adequate supply and food security for the fast-growing population. As a result, machine-driven disease detection systems may be able.to overcome the constraints of traditional le.f disease diagnosis procedures, which are generally time-consuming, inaccurate, and costly. Convolutional Neural Networks (CNNs) have been shown to be effective in a variety of agricultural applications. CNNs have been shown to be helpful in detecting disease in plants because of their capacity to analyze vast volumes of data quickly and reliably. However, the method hasn’t been widely used in the detection of potato late blight and early blight diseases, which reduce yields significantly. the goal of this study was to compare six cutting-edge CNN architectural models, taking into account transfer le.rning for training and four hyperparameters. the CNN architectures evaluated were Ale.Net, Google.et, SqueezeNet, DenseNet121, EfficientNet b7, and VGG19. Likewise, the hyperparameters analyzed were the number of epochs, the batch size, the optimizer, and the le.rning rate. An open-source dataset containing 4082 images was used. the DenseNet121 architecture with a batch of 32 and a Stochastic Gradient Descent (SGD) optimizer with a le.rning rate of 0.01 produced the best performance, with an accuracy of 98.34% and a 97.37% f1-score. the DenseNet121 model was shown to be useful in developing computer vision systems that aid farmers in improving their disease management systems for potato cultivation.

关键词： Image Classification Convolutional Neural Networks transfer le.rning Hyperparameters