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Progress in neurorehabilitation research and the support by the National Natural Science Foundation of China from 2010 to 2022

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Neural Regeneration Research 2024年第1期19卷 226-232页

作者： Qian Tao Honglu chao Dong fang Dou Dou School of Medicine Jinan UniversityGuangzhouGuangdong ProvinceChina School of Health and Life Science University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Department of Health Sciences National Natural Science Foundation of ChinaBeijingChina Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

The National Natural Science Foundation of China is one of the major funding agencies for neuro rehabilitation research in *** study reviews the frontier directions and achievements in the field of neurorehabilitation in China and wo *** used data from the Web of Science Core Collection(WoSCC) database to analyze the publications and data provided by the National Natural Science Foundation of China to analyze funding *** addition,the prospects for neurorehabilitation research in China are *** 2010 to 2022,a total of 74,220 publications in neurorehabilitation were identified,with there being an overall upward *** this period,the National Natural Science Foundation of China has funded 476 research projects with a total funding of 192.38 million RMB to support neuro rehabilitation research in *** the support of the National Natural Science Foundation of China,China has made some achievements in neurorehabilitation *** related to neurorehabilitation is believed to be making steady and significant progress in China.

关键词： brain computer interface invasive neuromodulation National Natural Science Foundation of China(NSFC) neuroreha bilitation non-invasive brain stimulation publication rehabilitation robotics virtual reality

Mechanisms underlying key agronomic traits and implications for molecular breeding in soybean

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Journal of Genetics and Genomics 2024年第4期51卷 379-393页

作者： chao fang Haiping Du Lingshuang Wang Baohui Liu Fanjiang Kong Guangdong Key Laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhouGuangdong 510006China

Soybean(Glycine max[L.]Merr.)is an important crop that provides protein and vegetable oil for human *** soybean is a photoperiod-sensitive crop,its cultivation and yield are limited by the photoperiodic conditions in the *** contrast to other major crops,soybean has a special plant architecture and a special symbiotic nitrogen fixation system,representing two unique breeding ***,flowering time,plant architecture,and symbiotic nitrogen fixation are three critical or unique yielddetermining *** review summarizes the progress made in our understanding of these three critical yield-determining factors in ***,we propose potential research directions to increase soybean production,discuss the application of genomics and genomic-assisted breeding,and explore research directions to address future challenges,particularly those posed by global climate changes.

关键词： Soybean Grain yield Flowering time Plant architecture Nodulation Symbiotic nitrogen fixation Genome study

Enrichment and reconfiguration of titanium-bearing phase in vortex smelting reduction process of vanadium-titanium magnetite

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Journal of iron and Steel Research(international) 2024年第7期31卷 1582-1589页

作者： Yong-chao Han Zhi-he Dou Rui Zhang Ting-an Zhang Shuai fang Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Shenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

To comprehensively utilize the low-iron high-vanadium-titanium magnetite,a new method of vortex smelting reduction of vanadium-titanium magnetite was proposed,and the enrichment and reconstitution regularity of Ti-bearing phases in the slag was investigated through X-ray fluorescence spectrometry,X-ray photoelectron spectroscopy,X-ray diffraction analysis,and optical *** phase diagram revealed that the preferential crystallization of MgTi_(2)O_(5) can be achieved by adjusting the CaO,MgO,and TiO_(2) contents of *** predominant Ti-bearing phases in the slag obtained from the reduction process are MgxTi_(3_x)O_(5)(0≤x≤1)and CaTiO_(3).FeTiO_(3) is present at carbon-iron ratio(CR)=1.3,while MgTi_(2)O4 and TiC are formed at CR=*** enrichment of TiO_(2) in the slag increases first and then decreases as the CR increases,and at CR=1.1,the enrichment of TiO_(2) in the slag reaches 51.3 wt.%.Additionally,the concentrations of MgxTi_(3_x)O_(5)(0≤x≤1)and CaTiO_(3) in the slag,along with the grain width of MgxTi_(3_x)O_(5)(0≤x≤1),decrease with the increase in CR.

关键词： Vanadium-titanium magnetite Vortex smelting reduction Phase reconfiguration TiO_(2)enrichment

Experimental Study on the Molten Salt at Micron Scale during the Melting Process

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Journal of Thermal Science 2024年第1期33卷 70-85页

作者： TiAN Ziqian LiAO Zhirong XU chao fang Yongzhe JiANG Kaijun YUAN Mengdi Key Laboratory of Power Station Energy Transfer Conversion and System Ministry of Education of ChinaSchool of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China

The investigation of the melting behaviors of the molten salt at micron scale during the melting process is critical for explaining the solid-liquid phase transition *** this paper,a novel experimental system and analysis method were proposed to study the melting process with three heating rates in the range of1-10℃/min of the solar salt at micron *** solid-liquid boundary morphology and phase transition kinetics of molten salt particles were focused ***,the correlations between liquid fraction,temperature and time under different heating rates were *** solid-liquid boundary morphology was depicted by the visualized experimental set-up,and the instantaneous liquid volume fraction during the non-isothermal phase transition was ***,the correlation between temperature and liquid volume fraction was proposed to reveal the evolution of the solid-liquid boundary with temperature at different heating ***,the non-isothermal phase transition kinetic equation was established by introducing a constant parameter(V_(a,b)),and more kinetic parameters such as 1g V_(a,b) and-lg V_(a,b)/b were *** results showed that the exponent b is not sensitive to the heating rate with a range of 3-5 for solar salt ***,the heating rate influences the value of V_(a,b) and presents a positive ***,the non-isothermal phase transition kinetic equations at different heating rates in the range of 1-10℃/min can be quickly predicted by the proposed improved experimental test *** study could fill the research insufficiency and provide significant guidance for future research on the solid-liquid transition mechanism of molten salts at micron scale.

关键词： molten salt non-isothermal phase transition solid-liquid boundary morphology liquid volume fraction micron scale melting process

miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4

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BiOCELL 2024年第7期48卷 1071-1079页

作者： XULONG SUN WENTAO DiNG chao JiANG ZHiAN fang Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai200030China Department of Radiology Zhongda HospitalSoutheast University School of MedicineNanjing210009China

introduction:Hepatocellular carcinoma(HCC),a prevalent malignancy,poses signiﬁcant challenges with high tumor heterogeneity and poor ***(miRNAs)play a pivotal role in *** abnormalities in microRNA-557(miR-557)expression have been implicated in various cancer types,its role in HCC remains ***,there is a need to explore the function of microRNA-557 in ***:Candidate miRNAs were identiﬁed through screening in GSE108724 and ***-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and *** viability and migration assays were applied to assess the impact of miR-557 on HCC cell ***,the miR-557 target was predicted through three algorithms(Targetscan,miRWalk,and miRanda),and this was conﬁrmed through luciferase assay and Western ***:in this study,miR-557 was identiﬁed in two datasets and expressed at a low level in both hepatoma cell lines and ***,high expression of miR-557 in HCC cells inhibited ***,low expression of miR-557 enhanced tumor proliferation and *** chromobox 4(CBX4)was identiﬁed as a direct target of *** CBX4 inﬂuenced the functional impact of miR-557 on HCC cell ***:Taken together,our study contributed to elucidating the hepatoma molecular heterogeneity and provided novel insights into miR-557 role and its target CBX4 in HCC,suggesting its potential as a future effectively druggable target for HCC intervention.

关键词： Hepatocellular carcinoma miR-557 Chromobox 4 Hepatocarcinogenesis

Re-delocalization of localized d-electrons in VO_(2)(R)-VS_(4)hetero-structure enables high performance of rechargeable Mg-ion batteries

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Journal of Magnesium and Alloys 2024年第5期12卷 1830-1840页

作者： Lijiao Zhou chao Shen Xueyang Hou Zhao fang Ting Jin Keyu Xie School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

Rechargeable Mg-ion batteries(MiBs)have attracted much more attentions by virtue of the high capacity from the two electrons ***,the reversible Mg^(2+)diffusion in cathode materials is restricted by the strong interactions between the high-polarized bivalent Mg^(2+)ions and anionic ***,we design and propose a hetero-structural VO_(2)(R)-VS_(4)cathode,in which the re-delocalized d-electrons can effectively shield the polarity of Mg^(2+)***,the electrons should spontaneously transfer from VS_(4)to VO_(2)(R)through the interfaces of hetero-structure due to the lower work function value of VS_(4).Furthermore,the internal electrons transfer lead to the electronic injection into VO_(2)(R)from VS_(4)and the partially broken V-V dimers,indicating the presence of lone pair electrons and charge *** from the shield effect of re-delocalized electrons,and the weakened attraction between cations and O/S anions enables more S^(2-)-S_(2)^(2-)redox groups to participate the electrochemical reactions and compensate the double charge of Mg^(2+)***,VO_(2)(R)-VS_(4)hetero-structure exhibits a high specific capacity of 554 mA h g^(-1)at 50 mA g^(-1).it is believed that the charge re-delocalization of cathode extremely boost the Mg^(2+)ions migration for the high-capacity of MiBs.

关键词： Mg-ion batteries Cathode Charge delocalization Electronic structure Heterostructure

Characteristics,origins,and significance of pyrites in deep-water shales

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Science China Earth Sciences 2024年第2期67卷 313-342页

作者： chao LiANG Shichao Ji Yingchang CAO Keyu LiU Jing WU fang HAO National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580China School of Geosciences China University of PetroleumQingdao266000China Laboratory for Marine Mineral Resource Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao266590China

As important metal sulfides in the geochemical cycle of sulfur,the characteristics and formation processes of pyrites can provide useful clues regarding their *** on previous findings,shale pyrites were divided into three major classes(euhedral pyrites,framboidal pyrites(framboids)and metasomatic pyrites)and six sub-classes in this *** the microscopic scale,each type of pyrite is associated with a different formation *** are formed by burst nucleation in environments with a homogeneous distribution of nutrients while euhedral pyrites are usually formed on pre-existing sites(such as=FeS on the minerals surface)in the heterogeneous *** pyrites formed by the replacement of other ions in accountable material by iron ions and hydrogen sulfide ions in hydrothermal *** morphology and isotope value of pyrite provide information to track the origins of their nutrient and characteristics of sulfur and iron *** addition,the trace element content of pyrite can serve as a proxy for paleo-ocean trace element abundance,indicating changes in atmospheric oxygen ***,pyrite can also serves as an indicator of shale gas reservoirs.

关键词： Shale Pyrite Sulfate reduction reaction isotope fractionation Pyrite element

Molecular recognition of cyclophanes in water

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Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： fang-Yuan Chen Wen-chao Geng Kang Cai Dong-Sheng Guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

Construction of MTX-CS-TMP-NPs Nano-drug Delivery System and its Observation on Telomerase Activity of Cervical Cancer Hela Cells

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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 27-32,39页

作者： YAN Xiao-shuai LUO chao YANG fang The Fifth Hospital of Xianmen Xiamen Fujian 361101China

Objective:To construct methotrexate(MTX)-chitosan(CS)-chuanxiongmuizine(TMP)nano-delivery system MTX-CS-TMP-NPs,and to investigate its effect on the telomerase activity of cervical cancer Hela ***:MTX-CS and MTX-CS-TMP-NPs were prepared by amide reaction and ionic gel method,and the encapsulation rate and drug loading rate were *** method and TRAP method were used to detect Hela cells and telomerase activity,and to compare the difference of telomerase activity of MTX,MTX-CS,and MTX-CS-TMP-NPs on cervical cancer Hela ***:in this study,the total amount of TMP was 150μg,of which the amount of free TMP was(26.46±1.72)μg,the encapsulation rate of TMP was(82.36±0.01)%,and the drug loading was(17.62±0.23)*** activity of Hela cells increased with the extension of time,and the OD value of Hela cell activity(1.24±0.05)was lower than that of the other three groups at 72 h of treatment,and the difference was statistically significant(Pivity of He La cells in the MTX-CS-TMP-NPs solution treatment group was(0.23±0.12)%lower than that of the other three groups,with statistically significant difference(Pion:MTX-CS-TMP-NPs may effectively reduce the activity and telomerase activity of cervical cancer Hela cells,showing its potential anti-cervical cancer effect.

关键词： cervical cancer(CC) Docetaxel MTX telomerase nano-drug delivery system cell cycle