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An in vitro demonstration of a passive,acoustic metamaterial as a temperature sensor with mK resolution for implantable applications

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Microsystems & Nanoengineering 2024年第1期10卷 41-54页

作者： lucrezia Maini Vicente Genovés Roman Furrer Nikola Cesarovic Christofer Hierold Cosmin Roman Micro-and Nanosystems Department of Mechanical and Process EngineeringETH ZurichTannenstrasse 38092 ZurichSwitzerland. Translational Cardiovascular Technology Department of Health Science and TechnologyETH ZurichLeopold-Ruzicka-Weg 48093 ZurichSwitzerland. Transport at Nanoscale Interfaces Swiss Federal Laboratories for Materials Science and TechnologyEMPAÜberlandstrasse 1298600 DübendorfSwitzerland Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charite(DHZC)13353 BerlinGermany

Wireless medical sensors typically utilize electromagnetic coupling or ultrasound for energy transfer and sensor *** transfer and management is a complex aspect that often limits the applicability of implantable sensor *** this work,we report a new passive temperature sensing scheme based on an acoustic metamaterial made of silicon embedded in a polydimethylsiloxane *** to other approaches,this concept is implemented without additional electrical components in situ or the need for a customized receiving unit.A standard ultrasonic transducer is used for this demonstration to directly excite and collect the reflected *** metamaterial resonates at a frequency close to a typical medical value(5 MHz)and exhibits a high-quality *** the design features of the metamaterial with the high-temperature sensitivity of the polydimethylsiloxane matrix,we achieve a temperature resolution of 30 *** value is below the current standard resolution required in infrared thermometry for monitoring postoperative complications(0.1 K).We fabricated,simulated,in vitro tested,and compared three acoustic sensor designs in the 29-43℃(~302-316 K)temperature *** this concept,we demonstrate how our passive metamaterial sensor can open the way toward new zero-power smart medical implant concepts based on acoustic interrogation.

关键词： passive resolution utilize

Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis

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International Journal of Oral Science 2022年第2期14卷 212-219页

作者： lucrezia Togni Antonio Zizzi Roberta Mazzucchelli Andrea Santarelli Corrado Rubini Marco Mascitti Department of Clinical Specialistic and Dental Sciences Marche Polytechnic Universityvia Tronto 10AnconaItaly Department of Biomedical Sciences and Public Health Marche Polytechnic Universityvia Tronto 10AnconaItaly Dentistry Clinic National Institute of Health and Science of AgingIRCCS INRCAvia Tronto 10AnconaItaly

Odontogenic tumors are rare lesions with unknown *** of them are benign,but local aggressiveness,infiltrative potential,and high recurrence rate characterize some *** MAP-kinase pathway activation can represent a primary critical event in odontogenic ***,the BRAF V600E mutation has been involved in 80%–90%of ameloblastic lesions,offering a biological rationale for developing new targeted *** study aims to evaluate the BRAF V600E mutation in odontogenic lesions,comparing three different detection methods and focusing on the Sequenom MassARRAY System.81 surgical samples of odontogenic lesions were subjected to immunohistochemical analysis,Sanger Sequencing,and Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry(Sequenom).The BRAF V600E mutation was revealed only in ameloblastoma ***,the presence of BRAF V600E was significantly associated with the mandibular site(ρ=0.627;P value<0.001)and the unicystic histotype(ρ=0.299,P value<0.001).However,any significant difference of 10-years disease-free survival time was not ***,Sequenom showed to be a 100%sensitive and 98.1%specific,suggesting its high-performance diagnostic *** results suggest the MAP-kinase pathway could contribute to ameloblastic ***,they could indicate the anatomical specificity of the driving mutations of mandibular ameloblastomas,providing a biological rational for developing new targeted ***,the high diagnostic accuracy of Sequenom was confirmed.

关键词： V600E BRAF specificity

Sustainability of steel structures:towards an integrated approach to life-time engineering design

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Frontiers of Structural and Civil Engineering 2011年第3期5卷 304-314页

作者： Raffaele LANDOLFO lucrezia CASCINI Francesco PORTIOLI Department of Constructions Mathematical Methods in Architecture University of Naples Federico IINaples 40-80138Italy

Nowadays,the construction sector is more and more oriented toward the promotion of sustainability in all its *** goal to achieve is the optimization of performances,over the whole life-cycle,with respect to environmental,economic and social *** to the latest advances,the concept of sustainability applied to constructions covers a number of branches such as life-cycle costing,ecology,durability and even structural *** procedures and design tools have been implemented in the framework of international *** the current trend in civil engineering research is moving towards life-time engineering,with the aim to implement integrated methodologies to consider as a whole all the sustainability requirements according to time-dependent multi-performance-based design *** a general introduction of the concept of sustainability applied to constructions,this paper presents an overview of life-time engineering methodologies according to the current *** particular the methods currently received by International Standards are discussed.A special focus is devoted to the durability design of metal structures with respect to the degradation phenomena able to impair the structural capacity over *** a proposal towards an integrated approach to life-time engineering design of steel structures and needs for further advances are presented.

关键词： sustainability life-time engineering performance based design durability metal structures

Design and Analysis of Energy Absorbent Bioinspired Lattice Structures

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Journal of Bionic Engineering 2023年第4期20卷 1670-1686页

作者： lucrezia Greco Federica Buccino Zhuo Xu Laura Vergani Filippo Berto Mario Guagliano Seyyed Moahmmad Javad Razavi Sara Bagherifard Department of Mechanical Engineering Politecnico di MilanoMilanItaly Department of Mechanical and Industrial Engineering Norwegian University of Science and TechnologyTrondheimNorway Chemical Engineering and Materials Environment Department Sapienza University of RomeRomeItaly

The increasing demand for energy absorbent structures,paired with the need for more efficient use of materials in a wide range of engineering fields,has led to an extensive range of designs in the porous forms of sandwiches,honeycomb,and *** achieve an even better performance,an ingenious solution is to learn how biological structures adjust their configurations to absorb energy without catastrophic *** this study,we have attempted to blend the shape freedom,offered by additive manufacturing techniques,with the biomimetic approach,to propose new lattice structures for energy absorbent *** this aim we have combined multiple bio-inspirational sources for the design of optimized configurations under compressive *** lattice structures are fabricated based on the designed unit cell geometries and studied using experimental and computational *** individual effect of each bio-inspired feature has been evaluated on the energy absorbance performance of the designed *** on the design parameters of the lattices,a tuning between the strength and energy absorption could be obtained,paving the way for transition within a wide range of real-life applicative scenarios.

关键词： Energy absorbance Lattice structures Bio-inspiration Fused deposition modeling Lightweight design

Effect of extraction treatments on the functional properties of free and bound phenols in apple seeds

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FOOD BIOSCIENCE 2023年第3期53卷 1098-1106页

作者： Ding, Yubin Morozova, Ksenia Angeli, lucrezia Gasparini, Alessandra Ferrentino, Giovanna Scampicchio, Matteo Free Univ Bozen Bolzano Fac Agr Environm & Food Sci Piazza Univ 1 I-39100 Bolzano Italy Free Univ Bozen Bolzano Fac Agr Environm & Food Sci Piazza Univ 5 I-39100 Bozen Bolzano Italy

Apple seeds are one of the main by-products of the food industry. This research aims to characterize free and bound phenols from apple seeds first defatted with three methods: (1) supercritical CO2, (2) ultrasound assisted and (3) Soxhlet extraction. Next, defatted seeds were extracted with hydroalcoholic maceration to give free phenols fraction and a solid residue. The latter was further extracted by alkaline hydrolysis to give bound phenols fraction. The time, temperature, concentration of NaOH and solid-to-liquid ratio were optimized for maximum extraction of bound phenols. Results showed that, regardless to the defatting method used, the highest phenol content was found mainly in the bound fraction (up to 31 mg g-1 GAE), which was eight times higher than the free fraction. Also, the antioxidant capacity (DPPH and ORAC) of the bound fraction was twice that of the free fraction. Such differences were next linked to the polyphenol profile (HPLC-DAD), and to the electron transfer properties (HPLC-coulometric detector). Results showed that the highest electron transfer properties of bound phenols were explained with higher content and lower half-wave potential of redox species like protocatechuic acid, salvianic acid A, and caffeic acid (identified by HPLC HR-MS/MS). Instead, the redox properties of free phenol extracts were attributed mainly to phlorizin. Overall, bound phenols in defatted apple seeds are a rich source of antioxidants that can be easily extracted by alkaline hydrolysis.

关键词： Apple seeds Non -extractable polyphenol HPLC Coulometric array detector Food by-products

Precision medicine in gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 804-829页

作者： Patrizia Bonelli Antonella Borrelli Franca Maria Tuccillo lucrezia Silvestro Raffaele Palaia Franco Maria Buonaguro Molecular Biology and Viral Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Abdominal Medical Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Gastro-pancreatic Surgery Division Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy

Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic *** represents the second leading cause of cancer-related deaths *** onset is subtle,and the majority of patients are diagnosed once the cancer is already *** recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular *** to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic *** the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this *** phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic ***,the heterogeneity of this neoplasia makes the practical application of such approaches ***,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in *** continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate *** several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially ***,surgical resection with adjuvant or neoadjuvant radiotherapy and ch

关键词： Gastric cancer Molecular characterization Biomarkers Precision medicine Targeted therapy

Guild composition and habitat use of voles in 2 forest landscapes in south-eastern Norway

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Integrative Zoology 2011年第4期6卷 299-310页

作者： lucrezia GORINI John D.C.LINNELL Luigi BOITANI Ulrike HAUPTMANN Morten ODDEN Per WEGGE Erlend B.NILSEN Department of Animal and Human Biology Sapienza University of RomeRomeItaly Faculty of Applied Ecology and Agricultural Sciences Hedmark University CollegeCampus EvenstadKoppangNorway Norwegian Institute for Nature Research TrondheimNorway Department of Ecology and Natural Resource Management Norwegian University of Life SciencesÅsNorway

It is widely believed that intensive forestry has influenced small mammal population dynamics,and thereby the entire mammalian community in Fennoscandian boreal *** nature of these impacts on the different species is subject to *** live-trapped voles between 2006 and 2009 in 2 commercially harvested forests in south-eastern *** investigated the variation in vole abundance among habitat types(*** forest and clear-cut)and the hypothesis that graminivorous species such as field voles(Microtus agrestis L.)benefit from clear-cuts at the expense of forest dwellers(*** bank vole,Myodes glareolus Schreb.),using fine-scale descriptors of the ground *** could not find support for the hypothesis that field voles show a preference for clear-cuts,and their overall abundance was low,while bank voles were the dominant species in all habitat types,including clear-cuts in the peak and pre-peak *** found a positive association between bank vole abundance and bilberry(Vaccinium myrtillus L.)availability rather than a specific habitat *** field vole density in clear-cuts might be due to variation in local productivity and ground vegetation as well as to large variation in the species temporal *** latter is particularly associated with the widespread decline of field voles in *** has the potential to negatively affect bank vole population dynamics because of the negative effect on bilberry development.

关键词： bank vole bilberry clear-cut field vole forestry

Surgical complications after pancreatic transplantation:A computed tomography imaging pictorial review

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World Journal of Gastroenterology 2023年第46期29卷 6049-6059页

作者： Carlo D'Alessandro Matteo Todisco Caterina Di Bella Filippo Crimì lucrezia Furian Emilio Quaia Federica Vernuccio Department of Radiology University of PadovaPadova 35128Italy Department of Radiology 2 University Hospital of PadovaPadova 35128Italy Department of Surgical Kidney and Pancreas Transplantation UnitPadova 35128Italy Kidney and Pancreas Transplantation Unit University of PaduaPadova 35128Italy Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Department of Radiology University Hospital of PadovaPadova 35128Italy

Pancreatic transplantation is considered by the American Diabetes Association and the European Association for the Study of Diabetes an acceptable surgical procedure in patients with type 1 diabetes also undergoing kidney transplantation in pre-final or end-stage renal disease if no contraindications are *** transplantation,however,is a complex surgical procedure and may lead to a range of postoperative complications that can significantly impact graft function and patient *** computed tomography(CT)is often adopted to evaluate perfusion of the transplanted pancreas,identify complications and as a guide for interventional radiology *** assessment after pancreatic transplantation should start with the evaluation of the arterial Y-graft,the venous anastomosis and the *** regard to complications,CT allows for the identification of vascular complications,such as thrombosis or stenosis of blood vessels supplying the graft,the detection of pancreatic fluid collections,including pseudocysts,abscesses,or leaks,the assessment of bowel complications(anastomotic leaks,ileus or obstruction),and the identification of *** aim of this pictorial review is to illustrate CT findings of surgical-related complications after pancreatic *** knowledge of surgical techniques is of key importance to understand postoperative anatomic changes and imaging ***,we first provide a short summary of the main techniques of pancreatic ***,we provide a practical imaging approach to pancreatic transplantation and its complications providing tips and tricks for the prompt imaging diagnosis on CT.

关键词： Diabetes mellitus Type 1 Pancreas transplantation Complications Computed tomography Diagnostic imaging

Special features of SARS-CoV-2 in daily practice

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World Journal of Clinical Cases 2020年第18期8卷 3920-3933页

作者： Ioannis A Charitos Andrea Ballini lucrezia Bottalico Stefania Cantore Pier Carmine Passarelli Francesco Inchingolo Antonio D'Addona Luigi Santacroce Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia 71122Italy Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity Campus"E.Quagliariello"University of Bari“Aldo Moro”Bari 70125Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Interdepartmental Research Center for Pre-Latin Latin and Oriental Rights and Culture Studies(CEDICLO)University of BariBari 70121Italy Department of Interdisciplinary Medicine University of Bari“Aldo Moro”Bari 70124Italy Sorriso&Benessere-Ricerca e Clinica S.R.L Bari 70129Italy Department of Head Neck and Sense OrgansDivision of Oral Surgery and ImplantologyFondazione Policlinico Universitario A.Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Interdisciplinary Medicine Section of Dental MedicineUniversity of Bari“Aldo Moro”Bari 70124Italy Department of Head and Neck and Sensory Organs Division of Oral Surgery and ImplantologyFondazione Policlinico Universitario A.Gemelli IRCCS—UniversitàCattolica del Sacro CuoreRoma 00168Italy Ionian Department Microbiology and Virology LaboratoryPoliclinico University HospitalUniversity of Bari“Aldo Moro”Bari 70124Italy

The severe acute respiratory syndrome-coronavirus-2(commonly known as SARS-CoV-2)is a novel coronavirus(designated as 2019-nCoV),which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan,China in December *** management of the Coronavirus Disease-2019 disease is evolving quickly and treatment guidelines,based on scientific evidence and experts’opinions with clinical experience,are constantly being *** January 30,2020,the World Health Organization declared the SARS-CoV-2 outbreak as a"Public Health Emergency of International Concern".The total lack of immune protection brought about a severe spread of the contagion all over the *** this reason,diagnostic tools,patient management and therapeutic approaches have been tested along the way,in the desperate race to break free from the widespread infection and its fatal respiratory *** medical knowledge and research on severe and critical patients’management and experimental treatments are still evolving,but several protocols on minimizing risk of infection among the general population,patients and healthcare workers have been approved and diffused by International Health Authorities.

关键词： Pandemics Viruses SARS-CoV-2/COVID-19 Sepsis Acute respiratory distress syndrome Acute respiratory distress syndrome Translational medicine Clinical microbiology Clinical biochemistry Antivirals Emergency and critical care medicine