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World Journal of Clinical Cases 2021年第16期9卷 3814-3825页

作者： Liliana Baroiu Caterina Dumitru Alina iancu Ana-Cristina Leșe Miruna Drăgănescu Nicușor Baroiu lucreția anghel Clinical Medical Department Faculty of Medicine and Pharmacy“Dunarea de Jos”University of GalatiGalati 800008Romania Pharmaceutical Sciences Department Faculty of Medicine and Pharmacy“Dunarea de Jos”University of GalatiGalati 800008Romania Department of Morphological and Functional Sciences Faculty of Medicine and Pharmacy“Dunarea de Jos”University of GalatiGalati 800008Romania Design Department Faculty of Visual Arts and Design“George Enescu”National University of ArtsIasi 700451Romania Department of Manufacturing Engineering Faculty of Engineering“Dunarea de Jos”University of GalatiGalati 800008Romania

The coronavirus disease 2019(COVID-19)pandemic imposed arestructuring of global health systems by rethinking spaces used for the care of these patients and the additions of intensive care,infectious diseases and pneumology *** paper provides evidence on the presence of severe acute respiratory syndrome coronavirus 2 in hepatocytes and its direct cytopathic activity,as well as the degree of liver damage due to drug toxicity,inflammation and hypoxia in COVID-19.A review of clinical trials has quantified liver damage through both pathology and biochemistry ***,we briefly present the results of a study conducted in our clinic on 849 patients admitted for COVID-19 treatment,of which 31 patients had pre-existing chronic liver disease and 388 patients had values above the normal limit for alanine aminotransferase,aspartate aminotransferase,and total *** was observed that patients with abnormal liver tests were significantly statistically older,had more comorbidities and had a higher percentage of unfavourable evolution(death or transfer to intensive care).The conclusion of this paper is that the main causes of liver damage are direct viral aggression,coagulation dysfunction and endothelial damage,and patients with impaired liver function develop more severe forms of COVID-19 which requires special care by a multidisciplinary team that includes a hepatologist.

关键词： COVID-19 Liver injury Cytopathic effect Hyper-inflammatory reaction Drug toxicity Biochemical changes

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Deactivation of Streptococcus mutans Biofilms on a Tooth Surface Using He Dielectric Barrier Discharge at Atmospheric Pressure

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Plasma Science and Technology 2013年第6期15卷 535-541页

作者： Imola MOLNAR Judit PAPP Alpar SIMON Sorin Dan anghel Babes-Bolyai University Faculty of Biology and GeologyCluj-Napoca 400015Romania Babes-Bolyai University Faculty of PhysicsCluj-Napoca 400084Romania

This paper presents a study of the effect of the low temperature atmospheric helium dielectric barrier discharge（DBD） on the Streptococcus mutans biofilms formed on tooth surface. Pig jaws were also treated by plasma to detect if there is any harmful effect on the *** plasma was characterized by using optical emission *** data indicated that the discharge is very effective in deactivating Streptococcus mutans *** can destroy them with an average decimal reduction time（D-time） of 19 s and about 98%of thein were killed after a treatment time of 30 *** to the survival curve kinetic an overall 32 s treatment time would be necessary to perform a complete *** experimental results presented in this study indicated that the helium dielectric barrier discharge,in plan-parallel electrode configuration,could be a very effective tool for deactivation of oral bacteria and might be a promising technique in various dental clinical applications.

关键词： Streptococcus mutans dielectric barrier discharge plasma treatment biofilm deactivation sterilization

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Fat poetry: a kingdom for PPARγ

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Cell Research 2007年第6期17卷 486-511页

作者： Silvia I anghel Walter Wahli Center for Integrative Genomics National Research Center Frontiers in GeneticsUniversity of LausanneLausanne CH-1015Switzerland

Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cel-lular components with highly specialized and complex functions. In addition to managing the most important energyreserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively,deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated responseto various signals received from many organs, which depends heavily on the integrity and physiological status of theadipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferator-activated receptor γ （PPARγ）, which is a fatty acid- and eicosanoid-dependent nuclear receptor that plays key roles inthe development and maintenance of the adipose tissue. Furthermore, synthetic PPARγagonists are therapeutic agentsused in the treatment of type 2 diabetes. This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles ofPPARγin this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits oftargeting this nuclear receptor with still-to-be-identified highly selective PPARγmodulators.

关键词： adipose tissue energy homeostasis obesity peroxisome proliferator-activated receptor

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Primary Small Bowel Melanoma or Small Bowel Metastasis with Vanishing Primary Cutaneous Lesion

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Case Reports in Clinical Medicine 2022年第3期11卷 63-71页

作者： Dana Criṣan Andreea Ardelean Mihaela Coman Laurenţiu Stoicescu Ioana Rusu Nadim Al Hajjar Tudor Pop Sorin Criṣ an Constantin Bodolea lucreţ ia Avram Faculty of Medicine Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca Romania Clinical Municipal Hospital Cluj-Napoca Romania 3rd Medical Clinic “Octavian Fodor” Regional Institute of Gastroenterology and Hepatology Cluj Cluj-Napoca Romania

The small bowel represents one of the main sites for cutaneous melanoma metastasis;however, numerous cases of primary intestinal melanoma have recently been described. In view of this, we present the case of a 39-year-old woman admitted for nausea, heartburn, abdominal pain, change in bowel habits and weight loss. Contrast-enhanced CT revealed a small bowel mass. Surgical resection of a 6 cm ileal tumour with regional mesenteric lymphadenectomy and end-to-end anastomosis was performed. Histopathological findings indicated the presence of an ileal melanoma metastasis. Subsequent dermatological examination identified a cutaneous lesion on the right forearm, however no malignant cells were found at the histopathological exam. Whole body PET CT with FDG identified multiple frontal and parietal lesions. Genetic testing was positive for BRAF gene V600 E mutation. The patient underwent multiple neurosurgical procedures for the resection of cerebral metastases. Palliative external radiation and chemotherapy was also attempted. After approximately 2 years after the diagnosis, the patient died following multiple episodes of intracranial hypertension.

关键词： Melanoma Small Bowel Cerebral Metastasis

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Diagnostic accuracy of a new point-of-care screening assay for celiac disease

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World Journal of Gastroenterology 2013年第31期19卷 5111-5117页

作者： Faiza Benkebil Christophe Combescure Silvia I anghel Cécile Besson Duvanel Michela G Schppi Vidymed 1007 Lausanne Switzerland CRC and Division of Clinical Epi-demiology Department of Health and Community MedicineUniversity of Geneva and University Hospitals of Geneva 1007 Geneva Switzerland R and D Department Augurix BioArk 1870 Monthey Switzerland Scientific Officer Augurix BioArk1870 Monthey Switzerland Pediatric Gastroenterology Unit Pediatrics Department Geneva University Hospitals 1211 GenevaSwitzerland

AIM: To determine the diagnostic accuracy of a new point-of-care assay detecting anti-deamidated gliadin peptides in celiac disease(CD) ***: One-hundred-and-twelve patients(age range: 1.8-79.2 years old) with clinical symptoms suggestive of CD and/or first-degree relatives(FDR) of CD patients(n = 66),and confirmed CD on a gluten-free diet(GFD)(n = 46),were prospectively enrolled in the study at Gastroenterology outpatient clinics for adult patients and from the Gastroenterology Consultation Ward at the Pediatric Department of the University Hospital of *** informed consent was obtained from all subjects *** study received approval from the local ethics *** original CD diagnosis had been based on serum-positive IgA anti-tissue transglutaminase enzyme-linked immunosorbent assay(ELISA)(QuantaLite,Inova Diagnostics,San Diego,CA,United States) and on biopsy *** samples from all study participants were tested by the new CD lateral flow immunochromatographic assay(CD-LFia) device,Simtomax Blood Drop(Augurix SA,BioArk,Monthey,Switzerland) to detect immunoglobulin(Ig)A and IgG antibodies against deamidated gliadin *** diagnostic performance was evaluated using receiver operating characteristic curves with 95%CIs.A cut-off of 2 on the Rann colorimetric scale was used to calculate the device's sensitivity and ***: CD-LFia was highly accurate in detecting untreated celiac *** the group of patients with CD symptoms and/or FDR,eight new cases of CD were detected by ELISA and *** of these new cases were also correctly identified by *** test yielded four false positive and four false negative *** false positive results were all within the groups with clinical symptoms suggestive of CD and/or FDR,whereas the false negative results were all within the GFD *** test yeld a sensitivity of 78.9%(95%CI: 54.4-93.9) and specificity of 95.7%(95%CI: 89.4-98.8),and the area under

关键词： Celiac disease Deamidated gliadin Total immunoglobulin A Screening Point-of-care assay

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ENVIRONMENTAL TENDENCIES IN MODULAR GREEN INSTALLATIONS

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Journal of Green Building 2019年第4期14卷 197-221页

作者： Anamaria Andreea anghel Irina Mohora Alma-Dia Preda(Hapenciuc) Diana Giurea Flaviu Mihai Frigura-Iliasa Architecture Department Faculty of Architecture and Urban PlanningPOLITEHNICA University of TimisoaraRomania Power Systems Department Faculty of Electrical and Power EngineeringPOLITEHNICA University of TimisoaraRomania

There are two main approaches when discussing living green walls:an ecological one and an artistic *** thinking mainly considers environmental aspects,comfort enhancement and energy consumption and oversees human interaction and actual proximity to *** opposition,art or architecture installations that involve vegetation,lack technical and ecological aspects,aiming to raise awareness on environmental issues using human interaction either physically(direct)or emotionally(indirect).The present paper aims to analyze methods of combining the two directions,in a functional,ecological,yet aesthetically pleasing *** order to further develop previous experiences gathered by the team members,authors of this article,a green installation concept made out of interactive modular systems unites all the knowledge into a new,living,moving,dynamic,interactive structure whose inspiration is taken from nature while using biomimicry as main principle for its *** new concept responds and is influenced by both external,natural stimuli and by the human *** is a key element in developing this project,involving architecture,art,interior and landscape design,botany,geometry,mechanical and electrical engineering,leading towards new research directions and innovative approaches in greenery-interior environment connections.

关键词： living green walls ecological vegetation architecture installation interactive modular systems

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Fine-scale analysis reveals a potential influence of forest management on the spatial genetic structure of Eremanthus erythropappus

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Journal of Forestry Research 2021年第4期32卷 1567-1578页

作者： Lucas Fernandes Rocha Natália Ribeiro de Paula Dulcinéia De Carvalho Department of Forest Science Federal University of Lavras(UFLA)Av.Doutor Sylvio Menicucci1001 Aquental SolLavrasMinas Gerais State 37200-000Brazil Department of Forest Science College of Agricultural Sciences(FCA/UNESP)São Paulo State UniversityAv.Universitária3780Altos do ParaísoBotucatuSão Paulo State 18610-034Brazil

Forest management may have significant effects on forest connectivity and natural population *** old-growth single trees may also change natural patterns of genetic variation and spatial genetic *** study evaluated the impacts of forest management using a silvicultural system of seed trees on the genetic diversity and spatial genetic structure of Eremanthus erythropappus(DC.)MacLeish.A complete survey of 275 trees on four plots was undertaken out to compare the genetic variation of a managed stand with an unmanaged *** genotyped all adult and juvenile individuals 60 months after the management and compared the genetic diversity and the spatial genetic structure *** diversity was considered high because of an efficient gene flow between *** were no genetic differences between stands and no evidence of *** clustering identified a single population(K=1),indicating no genetic differentiation between managed and unmanaged *** and juvenile individuals of the unmanaged stand were more geographically structured than individuals from the managed *** was a tendency of coancestry among juveniles at the first class of distance of the managed stand,suggesting a drift of genetic structure possibly caused by *** early responses to management on genetic diversity and stand structure is a first step to ensuring the effectiveness of conservation practices of tree *** sustainability of forest management of *** on genetic diversity,and more accurately,on spatial genetic structure needs evaluation over time to promote effective conservation of the population size and genetic variability.

关键词： Genetic diversity Microsatellite markers Gene flow Silvicultural management Brazilian Cerrado

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The Relationship between the Systemic Stress Produced by the Neuropsychic Strain and the Sensorial Integrity in Young People

The Relationship between the Systemic Stress Produced by the...

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The 6th Pan-Pacific Conference on Occupational Ergonomics

作者： Ion anghel Mihaela anghel Gabriela anghel Ioana Tatar Mircea Chiriac Department of Physiology Faculty of Medicine University "L.Blaga" SibiuROMANIA

The stress, "disease of the 20th century", concernes today all the fields of human life. In spite of the efforts made to fight against it, the phenomenon presents a worrying tendency to expand. The neurosensorial strain is likely to have an increasing importance in the future, that is the reason why we decided to study in our paper the impact of some nervous activities upon the functional entity of the organism through the induced systemic distress. Our investigation has been performed on a group of Medicine students (15), a group of Conservatory students (string instruments 15) and a group of blind pupils(12). They were all examined both in conditions of relative

关键词： Stress Occupational overstrain Ergonomy

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Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism

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Journal of Molecular Cell Biology 2023年第9期15卷 53-68页

作者： Quanxin Jiang Ning Wang Sĳia Lu Jie Xiong Yanmei Yuan Junli Liu Suzhen Chen Shanghai Diabetes Institute Department of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

Nonalcoholic steatohepatitis(NASH)is a condition that progresses from nonalcoholic fatty liver disease(NAFLD)and is characterized by hepatic fat accumulation,inflammation,and *** has the potential to develop into cirrhosis and liver cancer,and currently no effective pharmacological treatment is *** this study,we investigate the therapeutic potential of targeting ceruloplasmin(Cp),a copper-containing protein predominantly secreted by hepatocytes,for treating *** result show that hepatic Cp is remarkedly upregulated in individuals with NASH and the mouse NASH ***-specific Cp ablation effectively attenuates the onset of dietary-induced NASH by decreasing lipid accumulation,curbing inflammation,mitigating fibrosis,and ameliorating liver *** employing transcriptomics and metabolomics approaches,we have discovered that hepatic deletion of Cp brings about remarkable restoration of bile acid(BA)metabolism during *** deletion of Cp effectively remodels BA metabolism by upregulating Cyp7a1 and Cyp8b1,which subsequently leads to enhanced BA synthesis and notable alterations in BA *** conclusion,our studies elucidate the crucial involvement of Cp in NASH,highlighting its significance as a promising therapeutic target for the treatment of this disease.

关键词： ceruloplasmin nonalcoholic steatohepatitis bile acid inflammation fibrosis

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Ground motion prediction equations based on shallow crustal earthquakes in Georgia and the surrounding Caucasus

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Earthquake Science 2022年第6期35卷 497-509页

作者： Jorjiashvili Nato Shengelia ia Godoladze Tea Gunia Irakli Akubardia Dimitri Institute of Earth Sciences and National Seismic Monitoring Center Ilia State UniversityTbilisi 0177Georgia

Strong ground motions caused by earthquakes with magnitudes ranging from 3.5 to 6.9 and hypocentral distances of up to 300km were recorded by local broadband stations and three-component accelerograms within Georgia’s enhanced digital seismic *** data mixing is particularly effective in areas where strong ground motion data are *** data were used to produce models based on ground-motion prediction equations(GMPEs),one benefit of which is that they take into consideration information from waveforms across a wide range of *** this study,models were developed to predict ground motions for peak ground acceleration and 5%-damped pseudo-absolute-acceleration spectra for periods between 0.01 and 10 ***-period ground motions decayed faster than long-period motions,though decay was still in the order of approximately 1/*** mechanisms and local soil conditions greatly influence *** spectral acceleration(SA)of thrust faults was higher than that for either strike-slip or normal faults but the influence of strike-slip faulting on SA was slightly greater than that for normal *** soils also caused significantly more amplification than rocky sites.

关键词： strong ground motion peak ground acceleration spectral acceleration shallow earthquake

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