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An Andean tectonic cycle:From crustal thickening to extension in a thin crust(34°-37°SL)

Geoscience Frontiers 2014年第3期5卷 351-367页

作者： Victor A.Ramos Vanesa d.Litvak andrés Folguera Mauro Spagnuolo Laboratorio de Tectonica Andina del Instituto de Estudios Andinos Don Pablo GroeberCONICET-Universidad de Buenos AiresArgentina

Several orogenic cycles of mountain building and subsequent collapse associated with periods of shal- lowing and steepening of subduction zones have been recognized in recent years in the Andes. Most of them are characterized by widespread crustal delamination expressed by large calderas and rhyolitic flare-up produced by the injection of hot asthenosphere in the subduction wedge. These processes are related to the increase of the subduction angle during trench roll-back. The Payenia paleoflat-slab, in the southern Central Andes of Argentina and Chile （34° -37°S） recorded a complete cycle from crustal thickening and mountain uplift to extensional collapse and normal faulting, which are related to changes in the subduction geometry. The early stages are associated with magmatic expansion and migration, subsequent deformation and broken foreland. New ages and geochemical data show the middle to late Miocene expansion and migration of arc volcanism towards the foreland region was associated with important deformation in the Andean foothills. However, the main difference of this orogenic cycle with the previously described cycles is that the steepening of the oceanic subducted slab is linked to basaltic flooding of large areas in the retroarc under an extensional setting. Crustal delamination is concentrated only in a narrow central belt along the cordilleran axis. The striking differences between the two types of cycles are interpreted to be related to the crustal thickness when steepening the subducting slab, The crustal thickness of the Altiplano is over 60-80 km, whereas Payenia is less than 42 km in the axial part, and near 30 km in the retroarc foothills. The final extensional regime associated with the slab steepening favors the basaltic flooding of more than 8400 km3 in an area larger than 40,000 km2, through 800 central vents and large fissures. These characteristics are unique in the entire present-day Andes.

关键词： Andes Retroarc magmatism Basaltic floods Crustal delamination Flat-slab

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Laparoscopic natural orifice specimen extraction-colectomy: A systematic review

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World Journal of Gastroenterology 2014年第36期20卷 12981-12992页

作者： Albert M Wolthuis Anthony de Buck van Overstraeten andré d'Hoore department of Abdominal Surgery University Hospital Leuven 3000 Leuven Belgium

Over the last 20 years, laparoscopic colorectal surgery has shown equal efficacy for benign and malignant colorectal diseases when compared to open surgery. However, a laparoscopic approach reduces postoperative morbidity and shortens hospital stay. In the quest to optimize outcomes after laparoscopic colorectal surgery, reduction of access trauma could be a way to improve recovery. To date, one method to reduce access trauma is natural orifice specimen extraction(NOSE). NOSE aims to reduce access trauma in laparoscopic colorectal surgery. The specimen is delivered via a natural orifice and the anastomosis is created intracorporeally. different methods are used to extract the specimen and to create a bowel anastomosis. Currently, specimens are delivered transcolonically, transrectally, transanally, or transvaginally. Each of these NOSEprocedures raises specific issues with regard to operative technique and application. The presumed benefits of NOSE-procedures are less pain, lower analgesia requirements, faster recovery, shorter hospital stay, better cosmetic results, and lower incisional hernia rates. Avoidance of extraction site laparotomy is the most important characteristic of NOSE. Concerns associated with the NOSE-technique include bacterial contamination of the peritoneal cavity, inflammatory response, and postoperative outcomes, including postoperative pain and the functional and oncologic outcomes. These issues need to be studied in prospective randomized controlled trials. The aim of this systematic review is to describe the role of NOSE in minimally invasive colorectal surgery.

关键词： Laparoscopy Colorectal surgery Natural orifice specimen extraction Natural orifice specimen extraction-colectomy Transcolonic Transrectal Transanal Transvaginal Transanal minimally invasive surgery Gastrointestinal endoscopy

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Pyramiding disease resistance genes in elite winter wheat germplasm for Western Canada

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The Crop Journal 2019年第6期7卷 739-749页

作者： andréLaroche Michele Frick Robert J.Graf Jamie Larsen John d.Laurie Agriculture and Agri-Food Canada Lethbridge Research and Development CentreLethbridgeAlberta T1J 4B1Canada Agriculture and Agri-Food Canada Harrow Research and Development Centre2585 County Road 20HarrowOntario N0R 1G0Canada

We report on pyramiding different disease resistance genes against fungal pathogens in Canadian winter wheat germplasm based on available dNA markers and gene *** resistance represents a safe, economical and ecological method for protecting plants, growers and the health of consumers. Major diseases of wheat on the Canadian Prairies are common bunt, rusts(leaf, stem and stripe) and Fusarium head blight. Over the years markers for resistance genes against these diseases have been identified and used by the international wheat community. We describe markers that we have used to pyramid different resistance genes and indicate their presence in Canadian winter wheat cultivars issued from the winter wheat breeding program at the Agriculture and Agri-Food Canada,Lethbridge Research and development Centre, the only winter wheat breeding program in Western Canada actively delivering new varieties for all regions of the Canadian *** sources of resistance and identities of PCR primers and amplification conditions are indicated to enable the transfer and pyramiding of different resistance(R) genes to breeding lines. We conclude by reviewing new tools for identifying R genes in wheat and indicate how mutagenesis and gene editing can help future efforts to extend the protection offered by known R genes.

关键词： Bunt Gene pyramiding Wheat rusts Marker-assisted selection Triticum aestivum

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Mantle derived crystal-poor rhyolitic ignimbrites:Eruptive mechanism from geochemical and geochronological data of the Piedra Parada caldera,Southern Argentina

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Geoscience Frontiers 2018年第5期9卷 1529-1553页

作者： Eugenio Aragon Antonio Castro Juan diaz-Alvarado lucio Pinotti Fernando d'eramo Manuel demartis Jorge Coniglio Irene Hernando Carmen Rodriguez Centro de Investigaciones Geológicas(UNLP-CONICET) 1 N^o 644(1900)La PlataBuenos AiresArgentina departamento de Geología Universidad de Huelva21071 HuelvaSpain departamento de Geología Universidad de AtacamaCopayapu 485CopiapóChile departamento de Geología Universidad Nacional de Río Cuarto(UNRC-CONICET)Ruta 36 km 601Río CuartoCórdobaArgentina

Trace elements, isotopic modeling and U-Th-Pb SHRIMP zircon age constraints are used to reconstruct the eruption history and magmatic processes of the Piedra Parada Caldera. In the early Eocene, the crystal-poor Barda Colorada ignimbrite(BCI), having >>15% micro-porphyritic crystals with respect to magmatic components, erupted a volume estimated in more than 300 km^3. The Piedra Parada caldera is located in the Patagonian Andes foreland, at the southern end of the calderas field of the Pilcaniyeu Volcanic Belt(PVB). This belt is related to an extensional tectonic setting as a result of the collision of the Farallon-Aluk ridge with South America, which enabled the development of a transform ocean/continental plate margin followed by the detachment of the Aluk plate and the opening of a slab window. The BCI extra-caldera Plateau is a >100 m thick deposit, having a lower unit with high silica(Si O_2> 76 wt.%),potassium poor rhyolitic composition(trondhjemitic like magma), and an upper unit with normal to high potassium rhyolitic composition(granitic like magma). A trace elements modeling of the BCI units shows that the BCI lower and upper units did not evolve from fractionation or immiscibility in the shallow magma reservoir. The BCI also have a primitive isotopic signature(initial87 Sr/86 Sr =0.7031-0.7049 and ε_(Nd)= +3.4 to +3.65). Thus, tectonic, compositional and isotopic constraints suggest the fast ascent of high silica magmas to a shallow reservoir, and point to an upper mantle origin for these rhyolitic magmas in a transitional(Orogenic-Anorogenic) tectono-magmatic setting. U-Th-Pb SHRIMP zircon crystallization ages of the Syn-caldera stage BCI units(56 -51.5 Ma) show a protracted life of 5 Ma for this caldera reservoir. The age of 52.9 ± 0.3 Ma is considered the best fit for the possible maximum age for the caldera collapse. The Late-caldera magmatism has trachyandesitic and rhyolitic *** trace element modeling suggests that these rhyolites evolv

关键词： Mantle derived rhyolite Crystal-poor ignimbrite Bimodal volcanism Slab window volcanism K poor-rhyolite

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detection of ARV-Resistant Mutants in HIV-1-Infected Individuals in a Context of Systematic Switching to an Association Based on dolutegravir in Abidjan, Côte d’Ivoire

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American Journal of Molecular Biology 2024年第3期14卷 138-151页

作者： Odegue Kpadraux danielle Kakou-Ngazoa Solange dechi Jean-Jacques Renaud diallo Zelica Sina Kouamé Mireille Sylla Aboubacar Tossea Koui Stéphane Kouakou Venance Adagba Marius Apia N’Chouo Kouamé Basile Touré Offianan andré dosso Mireille Molecular Biology Platform Institut Pasteur Abidjan Cte dIvoire Laboratory of the Regional Blood Transfusion Center Yamoussoukro Cte dIvoire department of Infectious and Tropical diseases University Hospital Treichville Abidjan Cte dIvoire Laboratory of the Regional Blood Transfusion Center San-Pdro Cte dIvoire department of Epidemic Virus Institut Pasteur Abidjan Cte dIvoire department of Parasitology Mycology Institut Pasteur Abidjan Cte dIvoire department of Bacteriology-Virology Institut Pasteur Abidjan Cte dIvoire

The emergence of antiretroviral resistance mutations represents a major threat to the achievement of national and global goals for the elimination of HIV-1 infection. The global strategy in 2019 in Cte d'Ivoire is a new national policy for the management of people living with HIV with the administration of dolutegravir (dTG)-based fixed-dose combination. The aim of our study was to evaluate HIV-1 resistance to antiretrovirals (ARVs) in infected adult subjects in Cte d’Ivoire in the context of a systematic switch to a dTG-based combination. Between February 2022 and October 2023, a cross-sectional survey with random sampling was conducted in 06 services caring for people living with HIV. A total of 139 participants were included in the study. Adults with a viral load ≥ 1000 copies/mL were tested for HIV-1 ARV resistance mutations. Molecular analyses were performed using protocol of ANRS-MIE (National Agency for Research on AIdS and emerging infectious diseases). The interpretation is performed by HIVGRAd (https://***/cms/grade/). The frequencies of HIV-1 resistance to non-nucleotide reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), integrase inhibitors (IINTs) and protease inhibitors (PIs) were 82%, 73%, 19% and 11% respectively. The main mutations observed in the different classes were K103N (45%), M184V (64%), E157Q (19%) and L10V/M46I/A71V/I54V (6%) respectively. This study reveals the emergence of resistance to dTG-based fixed-dose combinations, favored by high rates of resistance to NRTIs and NNRTIs. This finding underlines the need for enhanced viral load monitoring and HIV-1 genotyping tests to guide the choice of NRTIs for combination therapy. In addition, monitoring for mutations to second-generation NRTIs is essential, given the scale-up of dTG-based regimens currently underway in Cte d’Ivoire.

关键词： Resistant Mutants dolutegravir HIV-1 Antiretrovirals Côte d’Ivoire

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Palaeogeography of a shallow carbonate platform:The case of the Middle to Late Oxfordian in the Swiss Jura Mountains

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Journal of Palaeogeography 2015年第3期4卷 251-268页

作者： andré Strasser Bernard Pittet Wolfgang Hug department of Geosciences University of Fribourg Université Lyon 1 UMR CNRS LGLTPE 5276Campus DouaBatiment Géode69622 VilleurbanneFrance Paléontologie A16 Section d'archéologie et paléontologieOffice de la cultureH?tel des Halles2900 PorrentruySwitzerland

The Oxfordian （Late Jurassic） carbonate-dominated ptatform outcropping in the Swiss Jura Mountains offers a good biostratigraphic, sequence-stratigraphic, and cyclostratigraphic framework to reconstruct changes in facies distribution at a time-resolution of 100 ka. It thus allows interpreting the dynamic evolution of this platform in much more detail than conventional palaeogeographic maps permit. As an example, a Middle to Late Oxfordian time slice is presented, spanning an interval of about 1.6 Ma. The study is based on 12 sections logged at cm-scale. The interpreted depositional environments include marginal-marine emerged ;ands, fresh-water lakes, tidal fiats, shallow lagoons, ooid shoals, and coral reefs. Although limestones dominate, marly intervals and dolomites occur sporadically. Major facies shifts are related to m-scale sea-level changes linked to the orbital short eccentricity cycle （100 ka）. The 20-ka precession cycle caused minor facies changes but cannot always be resolved. Synsedimentary tectonics induced additional accommodation changes by creating shallow basins where days accumulated or highs on which shoals or islands formed. Autocyclic processes such as lateral migration of ooid and bioclastic shoals added to the sedimentary record. CEimate changes intervened to control terrestrial run-off and, consequently, siliciclastic and nutrient input. Coral reefs reacted to such input by becoming dominated by microbialites and eventually by being smothered. Concomitant occurrence of siliciclastics anddolomite in certain intervals further suggests that, at times, it was relatively arid in the study area but there was rainfall in more northern latitudes, eroding the Hercynian substrate. These examples from the Swiss Jura demonstrate the highly dynamic and （geologically speaking） rapid evolution of sedimentary systems, in which tectonically controlled basin morphology, orbitally induced climate and sea-level changes, currents, and the ecology of the carbon

关键词： Swiss Jura Oxfordian carbonate platform facies evotution sequence stratigraphy cyclostratigraphy

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Mobility of Major and Trace Elements during the Bauxitization Processes in Ngaoundal Area (Adamawa Cameroon): Implication on Mining Perspectives

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Open Journal of Geology（地质学期刊） 2024年第1期

作者： andré Sini Harouna Boukari Ondoa Augustin désiré Balla djetenbe Beral Salomon Wangmené Awé Simon djakba Basga Jean Pierre Nguetnkam

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自主机器人使能技术在制造业中的应用（英文）

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期 403-431页

作者： ERd?S Gábor ABAI Kristóf BEREGI Richárd CSEMPESZ János CSERTEG Tamás GOdó Gábor HAJóS Mátyás HáY Borbála HORVáTH dániel HORVáTH Gergely JUNIKI ádám KEMéNY Zsolt KOVáCS andrás NACSA János PANITI Imre PEdONE Gianfranco TAKáCS Emma TIPARY Bence ZAHORáN László VáNCZA József 匈牙利研究网络计算机科学与控制研究所布达佩斯经济与技术大学制造科学与技术系 EPIC非盈利创新实验室厄特沃什·罗兰大学

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别... 详细信息

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别和预测、自动和自适应（重新）规划、团队合作，以及通过学习提高性能。本文总结了实现自主工业机器人技术的主要需求，提出了实现此类系统的通用工作流程，并介绍了HUN-REN SZTAKI最近在装配、焊接、打磨、拾取和放置以及机械加工等多个应用领域的广泛实践。这些解决方案的共同点是以通用的数字孪生概念为核心。最后，本文提出实现工业自主机器人解决方案的一般建议，并讨论了未来要研究的一些开放性问题。

关键词：工业机器人自动化数字孪生使能技术

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Bowel endometriosis: Colorectal surgeon's perspective in a multidisciplinary surgical team

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World Journal of Gastroenterology 2014年第42期20卷 15616-15623页

作者： Albert M Wolthuis Christel Meuleman Carla Tomassetti Thomas d'Hooghe Anthony de Buck van Overstraeten andré d'Hoore department of Abdominal Surgery University Hospital Leuven Leuven University Fertility Centre department of Obstetrics and Gynecology University Hospital Leuven

Endometriosis is a gynecological condition that presents as endometrial-like tissue outside the uterus and induces a chronic inflammatory reaction. Up to 15% of women in their reproductive period are affected by this condition. deep endometriosis is defined as endometriosis located more than 5 mm beneath the peritoneal surface. This type of endometriosis is mostly found on the uterosacral ligaments, inside the rectovaginal septum or vagina, in the rectosigmoid area, ovarian fossa, pelvic peritoneum, ureters, and bladder, causing a distortion of the pelvic anatomy. The frequency of bowel endometriosis is unknown, but in cases of bowel infiltration, about 90% are localized on the sigmoid colon or the rectum. Colorectal involvement results in alterations of bowel habits such as constipation, diarrhea, tenesmus, dyschezia, and, rarely, rectal *** diagnosis must be made in case of irritable bowel syndrome,solitary rectal ulcer syndrome,and a rectal tumor.A precise diagnosis about the presence,location,and extent of endometriosis is necessary to plan surgical *** laparoscopic treatment has become the standard of *** on the size of the lesion and site of involvement,fullthickness disc excision or bowel resection needs to be performed by an experienced colorectal *** outcomes,following bowel resection for severe endometriosis,regarding pain and recurrence rate are good with a pregnancy rate of 50%.

关键词： Endometriosis Colorectal endometriosis deeply infiltrative endometriosis Laparoscopy diagno-sis Treatment

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Store of value or speculative investment?Market reaction to corporate announcements of cryptocurrency acquisition

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Financial Innovation 2023年第1期9卷 3106-3136页

作者： andréd.Gimenes Jéfferson A.Colombo Imran Yousaf Banco Bradesco SA(NYSE:BBd B3:BBDC3)Cidade de DeusS/no Vila YaraOsascoSP 06029‑900Brazil São Paulo School of Economics Getulio Vargas Foundation(FGVEESPBrazil)474 Itapeva St.‑Bela VistaSão PauloSP 01332‑000Brazil College of Business and Public Management Wenzhou-Kean UniversityWenzhouChina Adnan Kassar School of Business Lebanese American UniversityBeirutLebanon

In this study,we analyze the stock market reaction to 35 events associated with 32 publicly traded companies from six countries that have announced cryptocurrency acquisitions,selling,or acceptance as a means of *** analysis focuses on traditional firms whose core business is unrelated to blockchain or *** find that the aggregate market reaction around these events is slightly positive but statistically insignificant for most event ***,when we perform heterogeneity analyses,we observe significant differences in market reaction between events with high(larger CARs)and low cryptocurrency exposure(lower CARs).Multivariate regressions show that the level of exposure to cryptocurrency("skin in the game")is a critical factor underlying abnormal returns around the *** analyses reveal that economically meaningful acquisitions of BTC or ETH(relative to firm’s total assets)drive the observed *** findings have important implications for managers,investors,and analysts as they shed light on the relationship between cryptocurrency adoption and firm value.

关键词： Corporate cryptocurrency acquisition Bitcoin Cryptocurrency Blockchain Market reaction

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