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Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil

Infectious Diseases of Poverty 2017年第1期6卷 1043-1053页

作者： Benigno A.M.Rocha Adriana O.Guilarde Angela F.L.T.Argolo Marianna Peres Tassara lucimeire ada silveira Isabela C.Junqueira Marilia D.Turchi Valeria C.R.Feres Celina M.T.Martelli Institute of Tropical Pathology and Public Health Federal University of GoiasGoianiaBrazil Faculty of Pharmacy Federal University of GoiasGoianiaBrazil School of Nursing State University of GoiasCeresBrazil

Multilingual abstracts:Please see Additional file 1 for translations of the abstract into the five official working languages of the United ***:Currently,in Brazil,there is a co-circulation of the four dengue(DENV-1 to DENV-4)*** study aimed to assess whether different serotypes and antibody response patterns were associated with the severity of the disease during a dengue outbreak,which occurred in 2012/2013 in centre of ***:We conducted a prospective study with 452 patients with laboratory confirmed dengue in central Brazil,from January 2012 to July *** clinical outcome was the severity of cases:dengue,dengue with warning signs,and severe *** patients were evaluated at three different *** sampling for laboratory testing and confirmatory tests for dengue infection were *** performed a multinomial analysis considering the three categories of the dependent variable,as outlined *** odds ratios(ORs)were calculated.A multinomial logistic regression model was applied for variables with a P-value<*** analysis was performed with STATA 12.0 ***:Four hundred fifty-two patients(452/632,71.5%)were diagnosed with *** dengue virus(DENV)serotypes were identified in 243 ***-4 was detected in 135 patients(55.6%),DENV-1 in 91(37.4%),DENV-3 in 13(5.3%),and DENV-2 in 4(1.6%).Patients with the DENV-1 serotype were more prone to present with several clinical and laboratory features as compared with DENV-4 patients,including spontaneous bleeding(P=0.03),intense abdominal pain(P=0.004),neurological symptoms(P=0.09),and thrombocytopenia(P=0.01).Secondary infection was more predominant among DENV-4 cases(80.0%)compared with DENV-1 cases(62.3%)(P=0.03).The univariate analysis showed that females(OR=2.12;95%CI:1.44-3.13;P<0.01)had a higher risk of having dengue with warning *** multinomial analysis showed that severe dengue cases with secondary infection had an adjusted OR o

关键词： Dengue Secondary infection Severe dengue Dengue type 4 Brazil

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