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Hepatotropic viruses:Is Roma population at risk?

World Journal of Gastroenterology 2021年第2期27卷 143-151页

作者： Anna Mrzljak lucija bajkovec Tatjana Vilibic-Cavlek Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Medicine County Hospital CakovecCakovec 40000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia

Roma people make up a significant ethnic minority in many European countries,with the vast majority living in Central and Eastern *** are a vulnerable population group in social,economic,and political *** migrations,life in segregated communities,substandard housing,poverty,and limited access to quality health care,including low immunization coverage,affect their health status and predispose them to various diseases,including viral *** A,B,and E are highly prevalent among Roma and mainly associated with low socioeconomic *** contrast,hepatitis C does not seem to be more frequent in the Roma *** efforts should be directed towards the implementation of screening programs,preventive measures,and treatment of viral hepatitis in Roma communities throughout Europe.

关键词： Roma population Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis E virus Europe

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Drug-induced gingival overgrowth in cardiovascular patients

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World Journal of Cardiology 2021年第4期13卷 68-75页

作者： lucija bajkovec Anna Mrzljak Robert Likic Ivan Alajbeg Institute of Emergency Medicine of Medimurje County Institute of Emergency Medicine of Međimurje CountyCakovec 40000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Unit for Clinical Pharmacology and TherapeuticsDepartment of Internal Medicine University Hospital Centre ZagrebZagreb 10000Croatia Department of Oral Medicine University of Zagreb School of Dental Medicine and University Hospital Centre ZagrebZagreb 10000Croatia

Drug-induced gingival overgrowth(DIGO)is a pathological growth of gingival tissue,primarily associated with calcium channel blockers and ***,it is mainly seen in cardiovascular and transplanted *** remains the main calcium channel blocker related to the development of this unpleasant *** for immunosuppress-ants,cyclosporin is the leading causative agent,whereas other drugs from this druggroup,including tacrolimus,have better safety *** collagen with inflammatory infiltrates is the histological hallmark of this *** factors are involved in the pathogenesis and can increase the risk,such as male gender,younger age,pre-existing periodontal inflammation,and concomitant use of other DIGO-inducing *** with DIGO may experience severe discomfort,trouble with speech and mastication,pain,and teeth loss,aside from cosmetic ***,these patients also have an increased risk for cardiovascular *** interdisciplinary approach and cooperation with dental care experts are necessary for patient *** includes discontinuing the drug and switching to one with a better profile,improving oral hygiene,and surgical removal of enlarged *** the potential of commonly used medications to cause DIGO and its effect on patients'health is necessary for early detection and adequate management of this complication.

关键词： Drug-induced gingival overgrowth Calcium channel blocker Nifedipine

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