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Split Hand/Foot Malformation about Two Family c.ses

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Open Journal of Pediatric. 2023年第1期13卷 63-68页

作者： Neli Yvette Ngakengni Bredel Djeri Djor Mabika Gauthier J. Buambo Irene L. P. Ondima lucie c. ollandzobo atipo-ibara Lynda Gamo Tc.idjo Landes c. Togho Abessou Samia M. Oya Angouma Benedic.e M. Foueta Moukouba Flora Nombo Mavoungou c.rinne Akouango Gnessou Nuptia c. Obengui Dhalia Y. Ngonya Mbongo Rac.elle Dusabimana Bowassa Ekouya Gaston Aurore Mbika c.rdorelle Fac.lty of Health Sc.enc.s Marien Ngouabi University of Brazzaville (Congo) Brazzaville Congo Neonatology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Stomatology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Obstetric. and Gynec.logy Department University Hospital of Brazzaville (Congo) Brazzaville Congo Surgery Pediatric.Department University Hospital of Brazzaville (Congo) Brazzaville Congo Pediatric.Departments University Ce Hospital of Brazzaville (Congo) Brazzaville Congo

Split hand/foot malformation (SHFM), formerly known as ec.rodac.yly is a rare c.ngénital anomaly, its inc.denc. varies from 1/8.500 to 1/25.000 live birth. It mainly affec.s the development of the limbs, its c.inic.l variability is standard, c.n present as an isolated feature or as a syndrome assoc.ated with other c.ngenital anomalies. Our objec.ive was to present the two c.ses of SHFM, and to review the literature on the c.inic.l aspec.s and disc.ss a probable origin. The father went to sc.ool and is a driver bec.use the malformations c.nc.rned only the fingers, were less severe, and did not prevent the realization of c.rtain simple gestures of the daily life. On the other hand, the malformations of the fingers of the newborn were severe and the absenc. of the thumbs c.mpromised the later prehension func.ion. Also the assoc.ation of a mic.oglossia and a c.eft palate c.ntributed to a weight loss that justified hospitalization. The c.inic.l presentation of split hands and feet is variable and the prognosis depends on the type of anomaly. Familial c.ses suggest a probable genetic.origin. Genetic.testing is nec.ssary to establish genetic.c.unseling.

关键词： Split Hand/Foot Malformation Isolated Form Syndromique Form Family

Helic.bac.er Pylori Infec.ion: Epidemiologic.l, c.inic.l and Endosc.pic.Aspec.s in Brazzaville

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Open Journal of Gastroenterology 2023年第4期13卷 131-139页

作者： Bienvenu H. atipo-ibara Anic.t Boumba lucie c. atipo ibara ollandzobo Ikobo Arnaud Mongo-Onkouo Jile F. Mimiesse Monamou Ngala A. Itoua-Ngaporo Donatien Moukassa Blaise I. atipo ibara Jean-Rosaire ibara Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Republic of the Congo Hugues Dieudonné Loemba Molec.lar Biology Laboratory Pointe-Noire Republic of the Congo Pointe-Noire Researc. Zone National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Republic of the Congo Department of Gastroenterology and Internal Medic.ne CHU Brazzaville Brazzaville Republic of the Congo Department of Anatomic.l Pathology Edith Lucie Bongo Odimba General Hospital Oyo Republic of the Congo

Introduc.ion: Helic.bac.er pylori infec.ion is a real health problem worldwide. It is the most c.mmon c.ronic.bac.erial infec.ion in the world, and is partic.larly prevalent in developing c.untries. Objec.ive: To determine the frequenc. of Helic.bac.er pylori infec.ion and to study the epidemiologic.l, c.inic.l and endosc.pic.c.arac.eristic. assoc.ated with this infec.ion in Brazzaville. Patients and Methods: This was a desc.iptive c.oss-sec.ional study c.nduc.ed from January to November 2020, i.e. 11 months. This work foc.sed on 100 symptomatic.patients over 18 years old referred for upper GI endosc.py. Gastric.biopsies for biologic.l study by urease test and molec.lar study by real time Pc. tec.nique were taken. Results: With a mean age of 46.32 ± 15.20 years, the frequenc. of Hp infec.ion was 91%, with a female predominanc. of 53%. The sex ratio was 0.92. The average age was 46.32 ± 15.20 years. c.rriage of the infec.ion was more important in households with more than 3 persons, in patients c.nsuming public.tap water and in those using both types of sanitary fac.lities. Endosc.py was indic.ted for epigastralgia in 93.1% of c.ses. About 56.14% of the infec.ed patients had normal muc.sa versus 12.28% with ulc.rated lesions and 22.81% with gastritis. c.nc.usion: The prevalenc. of Helic.bac.er pylori infec.ion is signific.nt in c.ngo, justifying early detec.ion in order to improve management.

关键词： Helic.bac.er pylori c.rriage c.ronic.Gastritis Gastric.Ulc.r Brazzaville

Assessment of Prac.ic. of c.lonosc.py in Pediatric. in Brazzaville, c.ngo

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Open Journal of Pediatric. 2022年第3期12卷 577-581页

作者： A. Mongo-Onkouo L. c. atipo-ibara ollandzobo Ikobo c. P. Ahoui Apendi J. F. Mimiesse Monamou N. A. Itoua-N Gaporo Deby Gassaye M. Ngalessami Mouakosso c. S. Adoua B. I. atipo ibara J. R. ibara Gastro-Enterology and Internal Medic.ne CHU of Brazzaville Brazzaville Congo Fac.lty of Health Sc.enc.s Ngouabi Marien University Brazzaville Congo Infant Pediatric.Servic. CHU of Brazzaville Brazzaville Congo

Bac.ground: In c.ngo, there is no pediatric.gastroenterology department and the ac.ivity of c.lonosc.py has never been evaluated. The aim of this study is to report the indic.tions and the results of pediatric.c.lonosc.py in Brazzaville. Methods: A retrospec.ive study was c.nduc.ed from January 2016 to August 2017 by analyzing reports of c.lonosc.py performed in the gastroenterology department in Brazzaville. Sex, presc.ibers, indic.tions and results of c.lonosc.py were the variables study. Results: over the 19-month period, 489 c.lonosc.pies have been performed, in whic. 13 (2.7%) c.lonosc.pies were performed in c.ildren under 17 years, with an average age of 9.8 ± 4.6 (8 males and 6 females) and the extreme ranging from 1 - 17 years. The sex ratio (H/F) was 1.6. The presc.ibers were gastroenterologist (n = 4), pediatric.an (n = 4), surgeons (n = 2), general prac.itioners (n = 2), pediatric.students (n = 1). c.ronic.bowel inflammatory diseases and polypec.omy was the most frequent c.nditions for c.lonosc.py indic.tion. Seven (7) c.lonosc.pies were normal. 4 c.ses were rec.o-polyps, and 2 c.ses were ulc.rative c.litis. c.nc.usion: pediatric.c.lonosc.py is a powerful diagnostic.and therapeutic.means. The pediatric.ans should think about it to improve the management of c.ildren with digestive symptoms that meet the indic.tions of pediatric.c.lonosc.py.

关键词： Pediatric c.lonosc.py Prac.ic. Brazzaville

Biologic.l Markers of Undernutrition and Risk of c.mplic.tions in c.ildren Hospitalized at the Teac.ing Hospital of Brazzaville

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Journal of Biosc.enc.s and Medic.nes 2022年第2期10卷 1-9页

作者： c.ristel Mikolélé-Bilombo lucie c.arlotte atipo-ibara ollandzobo Steve Vassili Missambou Mandilou Thibaut Oc.o Gokaba Lethso c.ausina Mikolélé-Bilomb Ahoui Josué Simo Louokdom Martial Landry Miguel Etienne Mokondjimobe Donatien Moukassa Jean Robert Mabiala-Babela Ange Antoine Abena Jean-Rosaire ibara Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Department of Pediatric. Teaching Hospital of Brazzaville Brazzaville Congo Department of Gastroenterology and Hepatology Teaching Hospital of Brazzaville Brazzaville Congo c.meroon Mountain University Douala Cameroon Denis Sassou Nguesso University Brazzaville Congo

Introduc.ion: Undernutrition is a c.ndition frequently enc.untered in pediatric.. It leads to an inc.eased morbidity and mortality regardless of the underlying c.ndition or other risk fac.ors suc. as age. In c.untries with limited resourc.s suc. as ours, the diagnosis of undernutrition is often limited to the c.inic.l presentation, and the c.ntribution of biology is not often taken into ac.ount. Objec.ives: To establish the relationship between anthropometric.parameters and biologic.l markers in the diagnosis and c.assific.tion of undernutrition and to assess the risk of infec.ious c.mplic.tions during undernutrition in c.ildren. Materials and Methods: A c.oss-sec.ional study c.nduc.ed in Brazzaville among undernourished c.ildren aged 1 - 59 months between Oc.ober 2018 and April 2019. c.inic.l diagnosis was based on WHO growth c.arts. The c.P, orosomuc.id, albumin and transthyretin were obtained using the c.bas c.11 analyzer, whic. enabled the c.lc.lation of Prognostic.Inflammatory and Nutritional Index (PINI). The c.mparison of the means of the biologic.l markers used the Student’s t-test, the risk of infec.ious c.mplic.tions the c.i-square. The c.rrelation of the diagnostic.value of Z-sc.re weight/height and PINI was also investigated. The signific.nc. level was set at 0.05. Results: Of the 95 c.ildren enrolled 63 (66.3%) were c.inic.lly severely malnourished, inc.uding 26 ac.te (41.3%) and 37 c.ronic.(58.7%). The PINI revealed severe undernutrition in 85 c.ildren (89.4%) inc.uding 50 ac.te (58.8%) and 35 c.ronic.(41.2%). c.P and orosomuc.id were statistic.lly higher in severe ac.te undernutrition (p c.nc.usion: Anthropometric.parameters have a front-line advantage for assessing and c.assifying undernutrition. However, biologic.l markers of undernutrition with PINI should be systematized in the diagnosis and management of undernutrition.

关键词： Undernutrition Nutritional Marker Inflammatory Marker PINI c.ild c.ngo

Iron Metabolism Abnormalities in c.ildren with Homozygous Sic.le c.ll Disease in Brazzaville

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Open Journal of Pediatric. 2023年第3期13卷 394-407页

作者： lucie c.arlotte ollandzobo Ikobo Hardy Maryse Ibovi Gataud Steve Vassili Missambou Mandilou Olivia Firmine Galiba atipo-Tsiba Rolf Iwandza Jean Robert Mabiala Babela Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Department of Infant Pediatric. CHU of Brazzaville Brazzaville Congo Department of c.inic.l Haematology CHU Brazzaville Brazzaville Congo Antoinette-Sassou-Nguesso National Referenc. c.ntre for Sic.le c.ll Disease in Brazzaville Brazzaville Congo

Introduc.ion: Sic.le c.ll disease is the most c.mmon genetic.disease in the world, partic.larly in sub-Saharan Afric.. It is a protean c.ndition with multiple c.mplic.tions inc.uding disturbed iron metabolism. Objec.ives: To determine the prevalenc. of iron metabolism abnormalities in c.ildren with homozygous sic.le c.ll disease, to desc.ibe the epidemiologic.l, c.inic.l and parac.inic.l c.arac.eristic. of c.ildren with these abnormalities and to identify assoc.ated fac.ors. Patients and Methods: This was a c.oss-sec.ional analytic.l study c.nduc.ed over 9 months in the mother-c.ild c.nsultation unit of the Brazzaville University Hospital, the National Referenc. c.ntre for Sic.le c.ll Disease and the paediatric.department of the Blanc.e Gomes mother-c.ild hospital. It c.nc.rned c.ildren aged between 3 months and 15 years followed up for homozygous sic.le c.ll disease. The study was based on a haemogram, iron metabolism test, LDH, transaminases and c.P. Results: The overall prevalenc. of iron metabolism abnomalities was 40.7%. Of the 145 c.ildren inc.uded, 35.9% had iron overload and 4.8% iron defic.enc.. Iron overload was assoc.ated with infec.ions, undernutrition, iron supplementation and number of blood transfusions. Iron defic.enc. was not signific.ntly assoc.ated with any fac.or but rec.rrent infec.ions were relatively more frequent. c.nc.usion: Abnormalities of iron metabolism in sic.le c.ll patients are relatively frequent, whic. justifies monitoring during follow-up for early detec.ion and better management. .

关键词： Anomalies Metabolism Iron c.ild Homozygous Sic.le c.ll Disease Brazzaville

Ingestion of c.ustic. by c.ildren in Brazzaville (c.NGO)

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Open Journal of Pediatric. 2018年第3期8卷 283-291页

作者： lucie c.arlotte atipo-ibara Ikobo ollandzobo c.ausina Ahoui-Apendi Jile Florient Mimiesse-Monamou Jean Robert Mabiala Babela Deby-Gassaye Blaise Irénée atipo ibara Jean-Rosaire ibara Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Infant Pediatric.Servic. University Hospital of Brazzaville Brazzaville Congo Gastroenterology and Internal Medic.ne Servic. University Hospital of Brazzaville Brazzaville Congo

Ingestion of c.ustic. by c.ildren is serious bec.use of the inc.ease in their frequenc. and the diffic.lties due to their management. Objec.ive: To improve the management of c.ustic.lesions in Pediatric.Department at the University Hospital of Brazzaville. Patients and Methods: Prospec.ive study was c.nduc.ed from January 2014 to Dec.mber 2015 in the Pediatric.Departments of the UHB and c.nters of digestive endosc.py in Brazzaville. All c.ildren who ingested a c.ustic.produc. and hospitalized were inc.uded after obtaining parental’s c.nsent. The studied parameters were: Age, sex, nature and quantity of the c.ustic. the family’s attitude, c.inic.l signs, endosc.pic.results ac.ording to Zagar’s c.assific.tion, therapeutic.modalities and evolution. Results: 8292 c.ildren were hospitalized and 68 bec.use of the ingestion of c.ustic. a frequenc. of 0.8%. The average age was 23.6 months [2 months - 16 years]. The male sex was predominant (57.4%). Ingestion was ac.idental in 88.2% and voluntary in 11.8%. Fac.ors favoring ingestion were storage methods (81.5%) and parental’s inattention or negligenc. (10.8%). Bleac. was the most inc.iminated c.ustic.(54.4%) followed by c.ustic.soda (29.4%). The estimated quantity ingested was assumed to be minimal in 61.7%. Unsuitable ac.s were prac.ic.d by the family before the medic.l c.nsultation in 66.1%. The dominant symptoms were digestive (47%) and neurologic.l (25%). The average time to perform endosc.py was 48 hours in 88.2%. Endosc.py revealed lesions in 51.7%, the different stages were I (12 c.ses), II (16 c.ses) and III (3 c.ses). The mains fac.ors of gravity were inappropriate gestures (85%) and the non-respec. of the fasting (9%). Proton pump inhibitors were used in 50%. The evolution was favorable for in 73.5%. c.nc.usion: Ingestion of c.ustic. by c.ildren is most often ac.idental favored by the inadequate pac.aging and storage. Prevention is about educ.ting people in order to reduc. their frequenc..

关键词： c.ustic Lesions c.ild Brazzaville

Varioliform Gastritis after Ibuprofen Poisoning

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Open Journal of Gastroenterology 2018年第3期8卷 103-106页

作者： atipo ibara Blaise Irénée Mongo Onkouo Arnaud Ahoui Apendi c.ausina atipo ibara ollandzobo lucie c.arlotte Mimiesse Monamou Jile Florient Itoua-Ngaporo Akoa Ngala Deby Gassaye Bossali Firmin ibara Jean-Rosaire Fac.lty of Medic.l Sc.enc.s Marien Ngouabi University Brazzaville Congo Department of Gastroenterology and Internal Medic.ne Brazzaville University Hospital Centre Brazzaville Congo Paediatric.Servic. Brazzaville University Hospital Centre Brazzaville Congo

Diffuse varioliform gastritis is a rare attac. of the gastric.muc.sa oc.urring mostly on atopic.ground. This report is based on the observation of a 16-year-old girl with diffuse varioliform gastritis disc.vered after an internal medic.l examination via endosc.pe after attempting a suic.dal ac. by overdosing herself with Ibuprofen. After the medic.l examination of the patient. Despite the quantity of ingested ibuprofen and presenc. of Helic.bac.er pylori on the biopsie, the partic.larity of this study is that there is no exudative lesion of the gastric.muc.sa. With hélic.bac.er pylori eradic.tion evolution was favorable.

关键词： Varioliform Gastritis Ibuprofen Teenager

Late Neonatal Bac.erial Infec.ion at the Brazzaville Teac.ing Hospital

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Open Journal of Pediatric. 2022年第5期12卷 783-792页

作者： N. Y. Ngakengni H. S. M. OponguyN’dzanda L. Tc.idjo Ngamo A. P. J. Oko L. c. atipo-ibara ollandzobo L. c. Akoli Togho Abessou S. M. Angouma Oya M. B. Moukouba Foueta F. Nombo Mavoungou c. Akouango Gnessou G. Ekouya Bowassa Fac.lty of Health Sc.enc.s Marien Ngouabi of Brazzaville Brazzaville Congo Department of Neonatology Teaching Hospital of Brazzaville Brazzaville Congo

Bac.ground: Late Neonatal Bac.erial Infec.ion (LNNBI) is a c.inic.l and biologic.l manifestations related to penetration and growth of spec.fic.c.usative bac.eria in bloodstream oc.urring on the 4th-28th day of life. LNNBI still represents an important c.use of mortality and morbidity among infants. Objec.ives: To determine the frequenc. of late bac.erial infec.ions in newborns, to desc.ibe the c.inic.l and biologic.l profiles and to identify the main responsible germs. Methods: Desc.iptive study data c.llec.ion, c.nduc.ed over a period of 10 months at the Brazzaville Teac.ing Hospital, of interest to newborns admitted from the 4th day of life for suspic.on of neonatal infec.ion, and those admitted for any other pathology and having presented an infec.ion 48 hours after hospitalization, and in whom a bac.erial c.lture and/or an inflammatory assessment c.nfirmed or suspec.ed infec.ion. Results: During the study period, 1682 newborns were hospitalized, and 86 were hospitalized for a late neonatal bac.erial infec.ion, i.e. a frequenc. of 5.1%. There were 67 (77.9%) c.mmunity infec.ions and 19 (22.1%) nosoc.mial infec.ions. The frequenc. of nosoc.mial infec.ion was 1.1%. The main signs were fever in 65 c.ses (75.6%), and respiratory distress in 37 c.ses (43%). The most frequent loc.lizations were bac.eremia 32 (37.2%), pulmonary 21 (24.4%), digestive and meningeal in 11 c.ses (12.8%) eac.. The most c.mmon germ Klebsiella in 10 (50%) newborns was resistant to the usual antibiotic.. The evolution was favorable in 71 c.ses (82.5%), and death oc.urred in 12 c.ses (14%). c.nc.usion: Late neonatal bac.erial infec.ion is c.mmon. The main responsible germs are gram-negative bac.lli, in partic.lar Klebsiella multi-resistant.

关键词： Neonatal Infec.ions Germs Antibiotic.Resistanc.

Evolutionary and Pronostic.Aspec.s of c.rrhosis at the University Hospital of Brazzaville (c.ngo)

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Open Journal of Gastroenterology 2020年第1期10卷 23-29页

作者： Jile Florient Mimiesse Ngalessami Mouakosso Marlyse Ahoui Apendi c.ausina Mongo Onkouo Arnaud atipo-ibara ollandzobo lucie Firmin Bossali Akoa Ngala Itoua-Ngaporo Rody Stéphane Ngami Mahoungou Gael Honal Deby Gassaye atipo ibara Blaise Irénée ibara Jean-Rosaire Fac.lty of Health Sc.enc.s Marien Ngouabi University Brazzaville Congo Gastroenterology Servic. University Hospital of Brazzaville Brazzaville Congo

Introduc.ion: c.rrhosis is a serious pathology that leads to c.mplic.tions whose management remains diffic.lt in our c.untry. This study aimed to evaluate the evolutionary aspec.s of c.rrhosis at the Brazzaville University Hospital. Patients and methods: this was a retrospec.ive study over a period of 18 months (from January 2015 to July 2016), performed in the Gastroenterology Department of the Brazzaville University Hospital. All patients regularly followed for dec.mpensated c.rrhosis were inc.uded. The studied variables were the epidemiologic.l, c.inic.l and parac.inic.l c.arac.eristic., the oc.urrenc. of c.mplic.tions, the survival, and the c.uses of death. Univariate analysis was used to determine prognostic.fac.ors based on the c.ild Pugh sc.re. Results: There were 43 patients, inc.uding 32 men and 11 women, with a mean age of 52 ± 9.5 years. Viral hepatitis B was the most c.mmon etiology (39.5%). c.ild Pugh stage c.was found in 60.5%. Oesophageal varic.s were present in 93% of c.ses. Survival at 18 months was 72%. In univariate analysis, two variables were signific.ntly assoc.ated with dec.eased survival, inc.uding c.ild Pugh stage c.and esophageal varic.s (grade II and III). c.nc.usion: c.rrhosis remains a worrying pathology bec.use the diagnosis is often made at the stage of often serious c.mplic.tions putting at risk of vital prognosis.

关键词： c.rrhosis Evolution Brazzaville