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Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

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World Journal of Gastroenterology 2009年第20期15卷 2512-2519页

作者： Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e silva Robson Augusto Souza dos Santos Laboratory of Hypertension Department of Physiology Biological Sciences institute Federal University of Minas Gerais Av. Antonio Carlos 6627 Belo Horizonte MG 31270-901 Brazil Laboratory of Endocrinology Department of Medicine Faculty of Medicine Federal University of Minas Gerais Av. Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil Hospitalar Foundation of the State of Minas Gerais FHEMIG Belo Horizonte MG Brazil Department of Pediatrics Faculty of Medicine Federal University of Minas Gerais Av.Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil

AIM： To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system （RAS） components and hemodynamic changes. METHODS： Patients were allocated into 4 groups： mild-to-moderate liver disease （MLD）, advanced liver disease （ALD）, patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity （PRA）, angiotensin （Ang） Ⅰ, Ang Ⅱ, and Ang-（1-7） levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components. RESULTS： PRA and angiotensins were elevated in ALD when compared to MLD and controls （P 〈 0.05）. In contrast, Ang Ⅱ was significantly reduced in MLD. Ang-（1-7）/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-（1-7）/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation （0.52 ± 0.08 vs 0.38 ±0.04, P 〈 0.02）, whereas the peripheral circulating Ang Ⅱ/Ang Ⅰ ratio was elevated in comparison to splanchnic levels （0.18 ±0.02 vs 0.13 ±0.02, P 〈 0.04）. Ang-（1-7）/ Ang Ⅱ ratios positively correlated with cardiac output （r = 0.66） and negatively correlated with systemic vascular resistance （r = -0.70）. CONCLUSION： Our findings suggest that the relationship between Ang-（1-7） and Ang Ⅱ may play a role in the hemodynamic changes of human cirrhosis.

关键词： Renin-angiotensin system Liver cirrhosis Angiotensin-(1-7) Angiotensin Ⅱ Splanchnic circulation Angiotensin converting enzyme 2

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Towards a Link between Climate Extremes and Thermodynamic Patterns in the City of Rio de Janeiro-Brazil: Climatological Aspects and Identified Changes

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Journal of Geoscience and Environment Protection 2023年第8期11卷 131-160页

作者： Wanderson Luiz-silva Fabricio Polifke da silva Claudine pereira Dereczynski José Ricardo de Almeida França Department of Meteorology Institute of Geosciences Federal University of Rio de Janeiro Rio de Janeiro Brazil

Modification signs in extreme weather events may be directly related to alterations in the thermodynamic panorama of the atmosphere that need to be better understood. This study aimed to make a first interconnection between climate extremes and thermodynamic patterns in the city of Rio de Janeiro. Maximum and minimum air temperature and precipitation extreme indices from two surface meteorological stations (ABOV and STCZ) and instability indices based on temperature and humidity from radiosonde observations (SBGL) were employed to investigate changes in the periods 1964-1980 (P1), 1981-2000 (P2), and 2001-2020 (P3). Statistical tests were adopted to determine the significance and magnitude of trends. The frequency of warm (cold) days and warm (cold) nights are increasing (decreasing) in the city. Cold (Warm) extremes are changing with greater magnitude in ABOV (STCZ) than in STCZ (ABOV). In ABOV, there is a significant increase of +84 mm/decade in the rainfall volume associated with severe precipitation (above the 95th percentile) and most extreme precipitation indices show an increase in frequency and intensity. In STCZ, there is a decrease in extreme precipitation until the 1990s, and from there, an increase, showing a wetter climate in the most recent years. It is also verified in SBGL that there is a statistically significant increase (decrease) in air temperature of +0.1°C/decade (-0.2°C/decade) and relative humidity of +1.2%/decade (-3%/decade) at the low and middle (high) troposphere. There is a visible rising trend in most of the evaluated instability indices over the last few decades. The increasing trends of some extreme precipitation indices are probably allied to the precipitable water increasing trend of +1.2 mm/decade.

关键词： Climate Change Climatology Instability Indices Precipitation Extremes Temperature Extremes

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Assessing tree crown fire damage integrating linear spectral mixture analysis and supervised machine learning on Sentinel-2 imagery

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International Journal of Digital Earth 2023年第1期16卷 3162-3198页

作者： Giandomenico De Luca Giuseppe Modica Joao M.N.silva Salvatore Praticò JoséM.C.pereira Dipartimento di Agrari1 Universitàdegli Studi Mediterranea di Reggio Calabri1Reggio Calabri1Italy Dipartimento di Scienze veterinarie Universitàdegli Studi di Messin1Messin1Italy Forest Research Centre School of AgricultureUniversity of LisbonLisbonPortugal

Crown fire damage is a mixture of three principal fire-related components:charred material,scorched foliage,and unaltered green *** study estimated the abundance of these physical alterations in two immediate post-fire Mediterranean forest contexts(Portugal and Italy)by applying linear spectral mixture analysis(LSMA)on Sentinel-2 *** tree crowns fire damage was subsequently mapped,integrating fractional abundance information in a random forest(RF)algorithm,comparing the accuracy resulting from the adoption of generic or image spectral libraries as the primary investigative *** image-derived endmembers resulted in more effectiveness in terms of fire-related components abundance quantification(LMSAderived RMSE<0.1),the F-scores always were≥90%whether generic endmembers or image endmembers derived information was *** environmental heterogeneity of the two study areas affected the fire severity gradients,with a prevalence of the charred(PT)(45–46%)and green class(IT)(44–53%).Post-fire temporal monitoring was initialized by applying the proposed strategies,and the preliminary results showed a positive recovery trend in forest vegetation from the first year following the fire event,with a reduced charcoal predominance and an increasing proportion of green components.

关键词： Post-fire assessment fire severity post-fire vegetation recovery random forest(RF) scikit-learn fraction image extraction spectral unmixing endmembers crown fire damage mapping fully constrained least squares pixel purity index

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Three-Dimensional Shear Wave Velocity Structure of the Northeastern Brazilian Lithosphere

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International Journal of Geosciences 2016年第6期7卷 849-872页

作者： Jorge Luis de Souza Newton pereira dos Santos Carlos da silva Vilar Coordena?ao de Geofísica MCTI/Observatório Nacional Rio de Janeiro Brazil Departamento de Física da Terra e do Meio Ambiente Universidade Federal da Bahia (UFBA) Brazil

A large number of Rayleigh wave dispersion curves recorded at twenty three seismic stations was used to investigate the 3-D shear wave velocity structure of the northeastern Brazilian lithosphere. A simple procedure to generate a three-dimensional image of Mohorovicic;discontinuity was applied in northeastern Brazil and the Moho 3-D image was in agreement with several isolated crustal thicknesses obtained with different geophysical methods. A detailed 3-D S wave velocity model is proposed for the region. In the crust, our model is more realist than CRUST2.0 global model, because it shows more details either laterally or in depth than global model, i.e., clear lateral variation and gradual increase of S wave velocity in depth. Down to 100 km depth, the 3-D S wave velocity model in northeastern Brazil is dominated by low velocities and this is consistent either with heat flow measurements or with measurements of the flexural strength of the lithosphere developed in the South American continent. Our 3-D S wave velocity model was also used to obtain the lithosphere thickness in each cell of the northeastern Brazil and the results were consistent with global studies about the Lithosphere-Asthenosphere Boundary worldwide.

关键词： Rayleigh Waves Group-Velocity Tomography Three-Dimensional Shear Wave Velocity Lithosphere Spatial Resolution Northeastern Brazil

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Clusia nemorosa的叶提取物通过肾上腺素系统依赖机制对大鼠的镇痛作用(英文)

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中国天然药物 2013年第4期11卷 385-390页

作者： Jamylle Nunes de Souza Ferro Juliane pereira da silva Lucia Maria Conserva Emiliano Barreto Laboratório de Biologia Celular Universidade Federal de AlagoasMaceió 57072-970ALBrazil Laboratório de Pesquisa em Química dos Produtos Naturais Universidade Federal de AlagoasMaceió 57072-970ALBrazil

Previous studies on the genus Clusia have shown anti-inflammatory and antiproliferative effects of the leaf extracts,but its antinociceptive activity has never been *** the present study,the antinociceptive activity of the hexane extract of the leaves of Clusia nemorosa ***,called HECn,was *** activity was evaluated using acetic acid-induced writhing,formalin,and hot-plate *** experiments were carried out on male Swiss *** extract(1 400 mg kg 1),given by intraperitoneal route(i.p.) 1 h prior to testing,produced a dose-dependent inhibition on the number of abdominal writhings,with an ID50 of 62 mg kg *** addition,HECn was able to prevent the visceral pain induced by acetic acid in mice for at least 2 *** the formalin test,HECn had no effect in the first phase,but produced an analgesic effect on the second phase with the inhibition of licking *** HECn did not show a significant analgesic effect in the hot plate *** with yohimbine attenuated the antinociceptive effect induced by HECn in the writhing ***,naloxone,atropine,or haloperidol did not affect antinociception induced by HECn in the writhing ***,these results indicate that the extract from the leaves of Clusia nemorosa produces antinociception in models of chemical pain through mechanisms that suggest participation of the adrenergic systems pathway.

关键词：实验药理学药理病理作用天然药物

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Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

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World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： Andre Castro lyra Milena Botelho pereira Soares luiz Flavio Maia da silva Marcos Fraga Fortes André Goyanna Pinheiro silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM： To evaluate the safety and feasibility of bone marrow cell （BMC） transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS： Ten patients （eight males） with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS： The median age of the patients was 52 years （range 24-70 years）. All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 （2.19 ± 0.9） and 4 mo （2.10 ± 1.0） after cell transplantation that baseline levels （238 ± 1.2）. Albumin levels 4 mo after BMC infusion （3.73 ± 0.5） were higher than baseline levels （3.47 ± 0.5）. International normalized ratio （INR） decreased from 1.48 （SD = 0.23） to 1.43 （SD = 0.23） one month after cell transplantation. CONCLUSION： BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词： Bone marrow Cell transplantation Liverfailure Stem cell Cirrhosis

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Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo JoséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini Pinto Anete pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil Department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

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Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients

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World Journal of Gastroenterology 2008年第44期14卷 6824-6830页

作者： Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e silva Robson Augusto Souza Santos Laboratório de Hipertenso Departamento de Fisiologia e BiofísicaICB-UFMGAv. Antonio Carlos6627Belo HorizonteMG31270-901Brazil Laboratório de Endocrinologia Departamento de Clínica MédicaFaculdade de Medicina-UFMGAv. Alfredo Balena190Belo HorizonteMG30130-100Brazil Departamento de Pediatria Faculdade de MedicinaUniversidade Federal de Minas Gerais (UFMG)Av. Alfredo Balena190Belo HorizonteMG30130-100Brazil

AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) ***:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio.

关键词： β-blockade Cirrhosis Renin angiotensinsystem Angiotensin-(1-7)

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Early Life Stress as Factor for Use of Psychoactive Substances: Integrative Review

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Open Journal of Nursing 2016年第11期6卷 921-936页

作者： Larissa Bessani Hidalgo Gimenez Renata Cristina de Campos pereira Silveira danilo Caetano Albino da silva Edilaine Cristina da silva Gherardi-Donato Department of Psychiatric Nursing and Human Sciences University of S&atildeo Paulo at Ribeir&atildeo Preto College of Nursing Ribeirao Preto Brazil Departament of Fundamental Nursing University of S&atildeo Paulo at Ribeir&atildeo Preto College of Nursing Ribeirao Preto Brazil Itapevi Diagnostic Imaging Center S&atildeo Paulo Brazil

Purpose: To identify, analyze and synthetize the scientific evidences that support Early Life Stress (ELS) diagnosis using the Childhood Trauma Questionnaire (CTQ), since it assumes the use of psychoactive substances later in adolescence and adulthood. Individuals that experienced some form of childhood stress may present, in adulthood, consequences that manifest into mental disorders such as problematic use of psychoactive substances. Methods: An integrative review of the literature on the subject in the databases: PubMed, Web of Science, LILACS and Psycinfo, regards studies that have been indexed in the last ten years (2003-2014). Combination of controlled and uncontrolled factors in the use and abuse of psychoactive substances, CTQ and ELS adapted to each database. Findings: The alcohol was the most used drug by the participating subjects of these research;mostly, the use of psychoactive drugs, started when they were still in adolescence;ELS and the later use of psychoactive drugs can be found more frequently in female;the lack of internal resources for dealing with stress in adulthood after ELS occurrence may have as a consequence the use of psychoactive drugs as a coping mechanism. Conclusions: It was possible to identify scientific evidences that support the ELS diagnosis, measured by the CTQ, as a determining factor for the use and abuse of alcohol and/or other psychoactive drugs in adolescence and adulthood. Implications: Investigate the ELS as a strategy to improve the therapeutic project of patients in nursing care, which will be built based on scientific evidence, so it can be more effective.

关键词： Childhood Trauma Questionnaire Early Life Stress Evidence-Based Practice Substance Abuse

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Ecological implications of twentieth century reforestation programs for the urban forests of São Paulo, Brazil: a study based on litterfall and nutrient cycling

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Ecological Processes 2021年第1期10卷 367-379页

作者： Maurício Lamano Ferreira Marcelo Ferreira Barbosa Eduardo pereira Cabral Gomes Ana Paula Branco do Nascimento Edgar Fernando de Luca Karina Gonçalves da silva Ulisses Bezerra França Plínio Barbosa de Camargo Raffaele Lafortezza Master’s Program in Health Promotion Adventist University of São PauloSão PauloSPBrazil. Master’s Program in Geoenvironmental Analysis University of GuarulhosGuarulhosSPBrazil. Department of Health Faculty of Biological ScienceUniversity Nove de Julho(UNINOVE)São PauloSPBrazil. Institute of Botany(IBT/SP) São PauloSPBrazil. Department of Civil Engineering São Judas Tadeu UniversitySão PauloSPBrazil. Institute of Forestry(IF/SP) São PauloSPBrazil. Centro de Energia Nuclear na Agricultura(CENA/USP) University of São PauloPiracicabaSPBrazil. Prefeitura da cidade de São Paulo(Secretaria do Verde e Meio Ambiente) São PauloSPBrazil Department of Agricultural and Environmental Sciences University of Bari Aldo MoroBariItaly. Department of Geography The University of Hong KongCentennial CampusPokfulam RoadHong KongHong Kong.

The focus of this study was to investigate the wide use of Eucalyptus spp.,an exotic plant with high allelopathic ability,in the reforestation programs of urban parks in São Paulo City,Brazil,over the last *** understand the implications of using Eucalyptus *** the city’s parks,this study aimed to compare nutrient cycling and litter decomposition between a mixed composition of litter(i.e.,native and exotic species)and the litter of a single species(i.e.,Eucalyptus).To accomplish this,newly deciduous leaves were collected from two native and two exotic species that are commonly used in the afforestation of São Paulo as well as from Eucalyptus *** mixed composition of litter yielded a higher dry mass loss and return of macro-and micronutrients to the forest *** decomposition constant(k)values were 0.00322 and 0.00207 g g^(−1) day^(−1) for the mixed composition and Eucalyptus spp.,*** time required for decomposition of 50 and 95%of deciduous material was 215 and 931 days,respectively,and for the mixed litterfall 334 and 1449 days,respectively,for Eucalyptus ***,the mixed litter exhibited greater dry mass loss and nutrient cycling in an urban forest of São Paulo City,since dry mass losses as well as speed and amount of nutrients returned to the forest floor were relatively higher compared to Eucalyptus *** cycling via Eucalyptus *** was less efficient than mixed composition of litter,demonstrating that reforestation programs carried out in the twentieth century using only one species may have had little *** results of this work emphasize the fact that in urban reforestation programs the City of São Paulo must consider the environmental and biogeographic characteristics of the species employed and use high levels of biodiversity,since the city lies in a megadiverse biome.

关键词： Tropical forest Exotic species Nutrient dynamics Ecosystem functioning

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