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Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

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Military Medical Research 2023年第5期10卷 699-725页

作者： daniela Lopes Joana Lopes Miguel pereira-silva Diana Peixoto Navid Rabiee Francisco Veiga Omid Moradi Zhan-Hu Guo Xiang-Dong Wang Joao Conde Pooyan Makvandi Ana Claudia Paiva-Santos Department of Pharmaceutical Technology Faculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal REQUIMTE/LAQV Group of Pharmaceutical TechnologyFaculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal School of Engineering Macquarie UniversitySydneyNsW 2109Australia Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia Department of Chemistry Shahr-e-Qods BranchIslamic Azad UniversityTehran 374-37515Iran lntegrated Composites Laboratory(iCL) Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan University Shanghai Medical CollegeShanghai 200032China Faculdade de Ciencias Medicas NOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyFaculdade de Ciencias MedicasNOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal school of Engineering Institute for Bioengineeringthe University of EdinburghEdinburgh EH93JLUK.

A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes,such as natural cell membranes or subcellular structure-derived *** strategy endows cloaked nanomaterials with improved interfacial properties,superior cell targeting,immune evasion potential,and prolonged duration of systemic ***,we summarize recent advances in the production and application of exosomal membrane-coated *** structure,properties,and manner in which exosomes communicate with cells are first *** is followed by a discussion of the types of exosomes and their fabrication *** then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering,regenerative medicine,imaging,and the treatment of neurodegenerative ***,we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

关键词： Biomimetic Cell membrane coating Exosome Exosomal-membrane-coated nanoparticle Extracellular vesicle(EV)

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Lithic soils in the semi-arid region of Brazil:edaphic characterization and susceptibility to erosion

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Journal of Arid Land 2022年第1期14卷 56-69页

作者： Carlos R PINHEIRO JUNIOR Conan A SALVADOR Tiago R TAVARES Marcel C ABREU Hugo S FAGUNDES Wilk S ALMEIda Eduardo C silva NETO Lúcia H C ANJOS Marcos G pereira Federal Rural University of Rio de Janeiro(UFRRJ) Department of SoilsSeropédicaRio de Janeiro 23890Brazil Center for Nuclear Energy in Agriculture(CENA) University of São Paulo(USP)PiracicabaSão Paulo 13416Brazil Federal Institute of Education Science and Technology of Rondônia(IFRO)Rural ZoneAriquemesRondônia 78930Brazil

Soils(Leptosols or Epileptic Regosols)with lithic contact at a depth of 50 cm occupy almost 20%of the Brazilian semi-arid *** lithic soils are susceptible to erosion due to faster saturation of water-holding capacity during rainfall,which accelerates the beginning of ***,erosion traits of lithic soils in the semi-arid region of Brazil are less *** aim of this study was to characterize the soil and landscape attributes in areas with Neossolos Litólicos(Entisols)in the Caatinga biome to identify region of high susceptibility to *** showed that the soils were characterized by a sandy texture,soil structure with poor development and low content of organic *** attributes increase susceptibility to erosion and reduce water storage capacity,especially in the states of Cearáand *** these states,the content of rock fragments in the soil reaches 790 g/*** contents of silt and fine sand,high silt/clay ratio,predominance of Leptosols and strong rainfall erosivity were observed in Piauíand northwestern Ceará.A very high degree of water erosion was observed in the states of Pernambuco and Paraí*** the low degree of erosion observed in the state of Bahia,it is highly susceptible to erosion due to the predominance of very shallow soils,rugged relief and high values of rainfall *** vulnerability was observed in the state of Alagoas because of its more smoothed relief,greater effective soil depth,thicker A horizon of soil and lower rainfall *** general,the characteristics that intensify the susceptibility to erosion in the Caatinga biome are those soil structures with poor development or without aggregation,low contents of organic carbon,high contents of silt and fine sand,high values of silt/clay ratio and rugged relief in some *** study collected information contributing to a better characterization of soils with lithic contact in the semi-arid region of *** addition,regions with

关键词： Caatinga biome drylands erosive processes leptosols soil degradation

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Northeastern Brazilian Marine Atmospheric Corrosion Performances of Galvanized Steel and Copper Specimens

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Journal of Chemistry and Chemical Engineering 2011年第5期5卷 435-442页

作者： Kelly Jacqueline Campos Brambilla Princia Aparecida Morais pereira Kleber Franke Portella Paulo CosarInone Fernando Piazza Jose Maurilio da silva Guilherme Cunha da silva Sergio Luiz Henke Mairio Seixas Cabussu dailton Pedreira Cerqueira Rogerio Nascimento Salles Instituto de Tecnologia para o Desenvolvimento Departamento de Materiais Curitiba Parandz PoBox： 19067 81531-980 Brazil Companhia de Eletricidade da Bahia COELBA Departamento de Engenharia de Manuten96o Granjas Rura~ Pres. Vargas s/nSalvador BA 41.290-000 Brazil

Copper, in turn, is the most useful material in the field of electricity, especially in electrical contacts. Already, the zinc is the most useful metal in atmospheric exposure conditions which is used in sheet form as castings, but whose most important application is as a coating for corrosion protection of steel structures. Salvador, it has disadvantages as an environment conducive to corrosion, by setting up a wet surface time t4, high corrosive environment （C4）. This work was proposed to study the performance of these metals compared to the effects of air pollution of an industrial site. For both atmospheric corrosion sites （ACS） were implanted natural weathering standard in order to assess the aggressiveness of atmospheric contaminants on the performance of metal specimens （galvanized steel and copper）. In determining their corrosion rates which were analyzed for sulfate and chloride ions, atmospheric, given the proximity of this ACS to the seafront, due to these propitiate the acceleration of corrosion. The results allowed observation that the average local concentration of the sulfate was higher than the chloride, because of the proximity of the pollutant source, and that the corrosion rate of galvanized steel was more significant than 61.5% of copper.

关键词： Atmospheric corrosion copper galvanized steel performance.

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Seaweeds’nutraceutical and biomedical potential in cancer therapy:a concise review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 189-212页

作者： João Cotas Diana Pacheco Ana M.M.Gonçalves Paulo silva Loïc G.Carvalho Leonel pereira University of Coimbra MARE-Marine and Environmental Sciences CentreDepartment of Life SciencesCalçada Martim de FreitasCoimbra 3000-456Portugal Department of Biology and CESAM University of AveiroAveiro 3810-193Portugal UCIBIO-REQUIMTE Departamento de QuímicaFaculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparica 2829-516Portugal The James Hutton Institute Dundee DD25DAScotlandUK Heriot-Watt University Edinburgh EH144ASScotlandUK.

Seaweeds have been a food source since ancient times(600 BC)and are still widely used in Asia,mainly in traditional Chinese medicine and Japanese folk ***,seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market *** have been referenced as feasible solutions in finding new potential compounds and therapies in prevention,control,and reduction of cancer development due to the multirole of some bioactive components(e.g,phenolic compounds and sulphated polysaccharides).Moreover,seaweeds are rich in important health-promoting molecules[such as poly and highly unsaturated fatty acids(PUFAs and HUFAs),essential amino acids,vitamins,and dietary fibers]and minerals(calcium,iron,iodine,magnesium,phosphorus,potassium,zinc,copper,manganese,selenium,and fluoride).In this review,the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached,as well as nutraceutical properties of seaweed to promote cell homeostasis.

关键词： Seaweed compounds nutraceutical bioactive molecules cancer prevention cancer treatment

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Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis

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Journal of Diabetes Mellitus 2016年第4期6卷 230-246页

作者： Liliane silvano Araújo Marcos Vinícius da silva Crislaine Aparecida da silva Maria Luiza Reis Monteiro Lívia Helena de Morais pereira Laura Penna Rocha Rosana Rosa Miranda Corrêa Marlene Antônia Reis Juliana Reis Machado General Pathology and Nephropathology Service Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro Uberaba Brazil Immunology Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro Uberaba Brazil General Pathology Institute of Tropical Pathology and Public Health of Federal University of Goiás Goiania Brazil

Diabetic Nephropathy (DN) is considered the main cause of end stage kidney disease around the world. However, its pathogenesis is not completely established. More than just a direct consequence of chronic glycemic changes, recent studies had suggested Diabetic Nephropathy could be considered an inflammatory disease. It has been shown that concentrations of pro-inflammatory cytokines, as IL-1, IL-6, IL-18, IL-33, IFN-γ and TNF-α actively participate in development and progression of DN, and thus, are involved in pathogenesis. Besides, changes in acquired immune response, especially the presence of cellular immune response profiles of pro-inflammatory and effector nature, mainly Th1 and Th17, as the imbalance between interaction of cytokines and T regulatory cells, foment the onset and progression of DN. Here we summarize the main evidences that support the critical role of the immune system in this condition. These new conceptual advances in DN understanding are essential for development of new the rapeutical strategies and prognostic factors, which could be protagonists or adjuvants to the current ones, leading ultimately to a better clinical management of DN patients.

关键词： Diabetic Nephropathy Cytokines Cellular Immunity

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Unprecedented Low-Cost Hybrid Material for CO2 and CH4 Separation

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Journal of Chemistry and Chemical Engineering 2015年第5期9卷 318-323页

作者： Murilo pereira Moises Joziane Gimenes Meneguin Cleiser Thiago pereira da silva Vicente Lira Kupfer Pedro Augusto Arroyo Andrelson Wellington Rinaldi Emerson Marcelo Girotto Silvia Luciana Favaro Eduardo Radovanovic Department of Chemical State University of Maring6 Maringa 87020-900 Brazil Department of Chemical Engineering State University of Maringa Maring6 87020-900 Brazil Department of Mechanical Engineering State University of Maringa Maring6 87020-900 Brazil Federal University Technological of Parana Apucarana 86812-460 Brazil

The zeolite synthesis using waste as silicon source is a promising low-cost process. Sugarcane bagasse ash is a hazardous solid waste generated in large amounts in the sugar industry. Thus, development of new procedures for its productive reuse is relevant. Therefore, this waste was used to prepare a new ZCNT （zeolite/carbon nanotube material）. In this work, ZCNT was applied in a CO2/CH4 separation. The adsorption took place at 303 K under pressure of 0.1 until 20 bar and the data were fitted by Langmuir, Toth and Freundlich equations. The adsorbed amount at 20 bar found was 4.7 mmol of CO2/g and 4.1 mmol of CH4/g; at 3 bar the adsorbed amount was 4.1 mmol of COJg and 1.2 mmol of CHa/g. This result indicates that ZCNT has potential application in COJCH4 separation at low pressures.

关键词： Gas adsorption biogas purification porous materials.

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Changes in Muscle and Collagen Fibers of Fish after Exposure to Urban Pollutants and Biodegradable Detergents

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Microscopy Research 2015年第3期3卷 33-40页

作者： Cynthia Medina Ciamarro Bruno Fiorelini pereira Rebeca Mamede da silva Alves Joao Rodolfo Tuckumantel Valim Dimitrius Leonardo Pitol Flavio Henrique Caetano Instituto de Biociencias Universidade Estadual Paulista“Julio de Mesquita Filho”—UNESPCampus Rio ClaroRio ClaroBrazil Centro de Ciencias Biologicas e da Saude Universidade Federal do Oeste da Bahia—UFOBCampus BarreirasBarreirasBrazil Faculdade de Odontologia de Ribeirao Preto Universidade de Sao Paulo—FORP/USPCampus Ribeirao PretoRibeirao PretoBrazil

Fish populations are sensitive to environmental impact resulting from many factors, as an introduction of exotic species, industrial or residual waste, oil spills, pesticides or other agents that can directly affect the ecology and species survival. Astyanax altiparanae is pelagic and active swimmer specie and can have serious implications on its way of life as changes in muscle structure of fish may occur since the presence of pollutants in the water. In this study we analyze the alterations in Muscle and collagen fibers of the pectoral muscles and pollutants exposed flows contained in water with biodegradable detergents, and water coming from the Blue Lake, River clear-SP (2o24'39"S, 47o33'39"E) diluted. Effects of these exposures were analyzed during the period of seven and thirty days. Compared with acclimatized fish (Astyanax altiparanae) with pure water from an artesian well, the muscle fibers morphology and collagen concentration on them have changed due to the exposure to urban pollutants and biodegradable detergents.

关键词： Astyanax altiparanae Biodegradable Detergents Pollutants

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The Action of p-Synephrine on Lipid Metabolism in the Perfused Rat Liver

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Journal of Biosciences and Medicines 2017年第5期5卷 8-21页

作者： Juliany Fontoura da silva-pereira Andrea Luiza de Oliveira Valoto Livia Bracht Geferson de Almeida Goncalves Rosane Marina Peralta Adelar Bracht Department of Biochemistry University of MaringaMaringaBrazil Faculdade Integrado Campo MouraoBrazil

p-synephrine and p-octopamine were found to increase lipolysis in adipocytes. The present study approaches the question if these compounds, natural products of the bitter orange (Citrus aurantium fruit), increase lipolysis and fatty acid oxidation in the liver. Experiments were done in the perfused rat liver. Non-recirculating hemoglobin-free perfusion was done using the Krebs/ Henseleit-bicarbonate buffer (pH 7.4) as perfusion fluid. Both p-synephrine and p-octopamine, at the concentrations of 100 μM, were found to stimulate the hepatic triacylglycerol lipase by 40% and 51%, respectively. These seem to be the maximal stimulations possible in the liver. In the perfused liver, p-synephrine, when present at an initial concentration of 500 μM, was able to increase the non-esterified fatty acid release after one hour of recirculating perfusion. The effects of p-synephrine on the oxidation of exogenously supplied [1-14C]octanoate and [1-14C]oleate were minimal. Only oxygen uptake, already stimulated by octanoate or oleate, was additionally increased by the infusion of p-synephrine. These results contrast with those obtained in a previous study with p-octopamine, which increased the production of 14CO2 from both [1-14C]octanoate and [1-14C]oleate. Apparently only the oxidation of endogenous fatty acids is stimulated by p-synephrine. On the other hand, both p-synephrine and p-octopamine stimulate the hepatic triacylglycerol lipase to a much lesser extent than the adipocyte lipase. It can be concluded that p-synephrine affects much more carbohydrate metabolism in the liver than lipid metabolism.

关键词： Hepatic Lipid Metabolism Lipolysis Fatty Acid Release Fatty Acid Oxidation

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Evaluation of Soybean Cultivars of Contrasting Cycles according to the Level of Investment in Fertilization

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American Journal of Plant Sciences 2017年第12期8卷 2977-2994页

作者： Emerson Borghi Eduardo de Paula Simao álvaro Vilela de Resende Joao Carlos Cardoso Galvao Sebastiao Pedro da silva Neto André Ferreira pereira Embrapa Maize and Sorghum SeteLagoasBrazil Department of Plant Science Federal University of VicosaVicosaBrazil EmbrapaCerrados PlanaltinaBrazil

The objective of the present study was to characterize the duration of the phenological stages, the agronomic characteristics and grain yield in soybean cultivars with contrasting cycles and indeterminate growth type, submitted to different fertilization investment environments under no-tillage system in the central region of Minas Gerais. The work was conducted under field conditions, in an experimental area of Embrapa Maize and Sorghum, in Sete Lagoas, MG, in the harvest of 2015/2016. Ten soybean cultivars with different relative maturity groups (RMG) were studied, representing almost all RMG materials currently sown in Minas Gerais, in two environments with different levels of fertilizer investment. The variables were submitted to analysis of joint variance, in order to verify the existence of interaction between cultivars and investment in fertilization environments. Fertilizer investment levels influence grain yield of soybean cultivars of contrasting cycles. The higher height of the soybean plants implies higher lodging and lower grain yield. This situation is aggravated by the greater investment in fertilization. The difference between the cycles of the cultivars is in the duration of the vegetative stages, being greater in the later cultivars.

关键词： Glycine max L.(Merrill) Growth Habit Relative Maturity Group

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Agronomic Performance of Cultivars of Upland Rice in the Southern of the Region of Rondonia,Brazil

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Agricultural Sciences 2014年第6期5卷 513-518页

作者： Edimar Rodrigues Soares Robertt Fernandes Laercio da silva Londero Diego Lopes dos Santos Samara Cristina Sampaio Correa Everton Augusto Sampaio Correa Remy Carvalho dos Santos Ariel pereira Gomes Leandro Galon Fabiana Ferreira Pires Rosilene da silva Goncalves Department of Soil Science Sao Paulo State University(UNESP)JaboticabalBrazil Department of Agronomy Federal Institute of Education Science and Technology of Rondonia(IFRO)Colorado do OesteBrazil Department of Agronomy College Amazon(FAMA)VilhenaBrazil Agronomist Federal University Mato Grosso(UFMT)CuiabáBrazil Department Herbology Federal University of the Southern Border South(UFFS)ErechimBrazil

The upland rice is grown in most Brazilian states. However, in many of them the yield obtained is low. The choice of cultivar more suited to a particular environment can contribute to increased productivity of this crop. This research aimed to evaluate the performance of a hybrid cultivar of upland rice (Ecco) and five conventional cultivars (BRS Monarca, BRS Primavera, AN Cambará, BRS Sertaneja and BRS MG Curinga) in two environments (Vilhena and Cerejeiras). The tests were conducted in the agricultural year 2010/2011. We evaluated the following characteristics: tillering, panicle number per unit area, number of filled grains per panicle sterile, mass of grains per panicle, 1000 grain weight, grain yield (kg·ha-1) and whole grain yield. There was no cultivar x environment interaction for all traits. Greater tillering, higher panicle number per area, higher productivity and yield of whole grains in the municipality of Cerejeiras were observed, while the highest number of sterile grains per panicle was obtained in Vilhena. The hybrid Ecco highlighted in relation to all other cultivars is in relation to tillering, panicle number per area and grain yield. The municipality of Cerejeiras is the most suitable for the cultivation of upland rice.

关键词： Oryza sativa L. Hybrid Upland Rice Genotype x Environment

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