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Laparoscopic resection of primary retroperitoneal schwannoma:A case report

World Journal of Clinical Cases 2020年第18期8卷 4114-4121页

作者： Marcelo AF ribeiro Jr Yasmin GB Elias Samara de S Augusto Paola R Néder Cássia TK Costa Andressa D Maurício Adriano P sampaio Alexandre Z Fonseca General Surgery and Trauma Department Catholic University of São Paulo–PUC-Sorocaba and Moriah HospitalSão Paulo 04083-002São Paulo CEPBrazil Department of Surgery Medical SchoolSanto Amaro UniversitySão Paulo 04743-030São Paulo StateBrazil General Surgery and Trauma Department Moriah HospitalSão Paulo 04083-002São Paulo StateBrazil

BACKGROUND Schwannomas are rare,often benign,tumors deriving from Schwann cells that have low incidence in the retroperitoneal region(0.5%to 5%).Their diagnosis is hardly confirmed at early stage due to lack of specific features in signs,symptoms and imaging ***,it is necessary performing guided punch biopsy in order to identify *** removal is the treatment of choice due to its low sensitivity to radiation and *** SUMMARY Forty-seven years old female patient who was hospitalized for elective orthopedic procedure,without complications,evolved with severe pain in the lower limbs,thigh and gluteal region associated with neurogenic *** pain required magnetic resonance imaging(MRI)of the lumbar spine,which showed epidural collection with dural compression and massive heterogeneous perihepatic nodular *** surgical team opted for draining the collection,as well as requested an MRI of the abdomen and pelvis,whose analysis showed expansive lesion in the retroperitoneum,in close contact with the inferior vena cava and with the right renal vein.A guided puncture was performed for diagnostic clarification,which showed immunohistochemical profile compatible with *** selected treatment comprised retroperitoneum tumor resection in association with laparoscopic *** patient was discharged and remained stable after 4-mo follow-up;she remains under followup to check the need of cancer *** Schwannoma features requires surgical treatment based on laparoscopic resection,which often presents low relapse rates and optimistic prognosis.

关键词： Neurilemmoma Neoplasms Retroperitoneal space Laparoscopy Case report

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Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de Almeida Fernandes Guilherme de Freitas Camoes Diana Ferreira Carolina Queijo Carlos Fontes-ribeiro Lino Gongalves Rui Pina Natalia Antonio Department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED ***: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;P<0.001) and were more frequently on QT prolonging drugs(77.3%;P=0.025). Main contributing factor was intake of antibiotics(odds ratio [OR] 4.680) followed by female gender(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

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Relaxation of Certain Integral Functionals Depending on Strain and Chemical Composition

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Chinese Annals of Mathematics,Series B 2013年第4期34卷 491-514页

作者： Ana Margarida ribeiro Elvira ZAPPALE Departamento de Matema'tica and CMA Faculdade de Ci encias e Tecnologia - Universidade Nova de Lisboa D. I. In. Universita’ degli Studi di Salerno

The authors provide a relaxation result in BV×Lq, 1≤q<+∞ as the first step towards the analysis of thermochemical equilibria.

关键词：积分泛函化学成分应变平衡分析热化学

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Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release

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Journal of Integrative Medicine 2022年第2期20卷 153-162页

作者： Célia Cristina Malaguti Figueiredo Amanda da Costa Gomes Filipe Oliveira Granero Joao Luiz Bronzel Junior luciana Pereira Silva Valdecir Farias Ximenes Regildo Márcio Goncalves da Silva Institute of Chemistry São Paulo State UniversityAraraquaraSão Paulo 14800-060Brazil Educational Foundation of the City of Assis AssisSão Paulo 19807-130Brazil Department of Chemistry School of SciencesSão Paulo State UniversityBauruSão Paulo 17033-360Brazil Department of Biotechnology School of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão Paulo 19806-900Brazil

Objective:The present study investigated antiglycation and antioxidant activities of crude dry extract and saponin fraction of Tribulus *** also developed a method of microencapsulation and evaluated antiglycation and antioxidant activities of crude dry extract and saponin fraction before and after microcapsule ***:Antiglycation activity was determined by relative electrophoretic mobility(REM),free amino groups and inhibition of advanced glycation end-product(AGE)*** activity was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),ferric ion-reducing antioxidant power(FRAP),nitric oxide(NO)and thiobarbituric acid reactive species(TBARS)*** were prepared using maltodextrin as wall material and freeze-drying as encapsulation *** characterization of microcapsules was evaluated by scanning electron microscopy,and encapsulation efficiency and microcapsule release were determined by total saponins *** and antioxidant assays were performed using crude dry extract and saponin fraction of *** before and after ***:Saponin fraction showed an increase of 32.8%total ***-performance liquid chromatography-mass spectrometry analysis showed the presence of saponins in the obtained *** evaluation by REM demonstrated that samples before and after release presented antiglycation activity similar to bovine serum albumin treated with ***,samples inhibited AGE formation,highlighting treatment with saponin fraction after release(89.89%).Antioxidant tests demonstrated antioxidant activity of the *** dry extract before encapsulation presented the highest activities in DPPH(92.00%)and TBARS(32.49%)*** fraction before encapsulation in FRAP test(499μmol Trolox equivalent per gram of dry sample)and NO test(15.13μmol nitrite formed per gram of extract)presented the highest ***:This study presen

关键词： Glycation Microencapsulation Oxidative stress Saponins Tribulus terrestris

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TWO ALGORITHMS FOR LC^1 UNCONSTRAINED OPTIMIZATION

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Journal of Computational Mathematics 2000年第6期18卷 621-632页

作者： Wen-yu Sun R.J.B.de sampaio Jin-Yun Yuan School of Mathematics and Computer Science Nanjing Normal UniversityNanjing 210097China Applied Informatics Program Pontifical Catholic University of ParanaCuritibaPR81611-970Brazil Department of Mathematics Federal University of ParanaCuritibaPR81531-990Brazil

Presents two algorithms for LC unconstrained optimization problems which use the second order Dini upper directional derivative. Simplicity of the methods to use and perform; Discussion of related properties of the it... 详细信息

关键词： nonsmooth optimization directional derivative Newton-like method convergence trust region method

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Oligodendrocytes in a dish for the drug discovery pipeline:the risk of oversimplification

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Neural Regeneration Research 2021年第2期16卷 291-293页

作者： Vito Antonio Baldassarro luciana Giardino Laura Calzà Health Science and Technologies Interdepartmental Center for Industrial Research(HST-ICIR) University of BolognaBolognaItaly Department of Veterinary Medical Sciences University of BolognaIRET FoundationBolognaItaly Department of Pharmacy and Biotechnology University of BolognaMontecatone Rehabilitation InstituteBolognaItaly

Myelination,remyelination and demyelination:modeling the in vitro drug discovery pipeline:Demyelination is a multifactorial event occurring in diseases primarily involving myelin forming cells(oligodendrocytes,OLs)and their precursors(oligodendrocyte precursor cells,OPCs)such as multiple sclerosis,but is also involved in the pathology of other central nervous system(CNS)injuries and diseases,such as neonatal encephalopathy。

关键词： cytes injuries diseases

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Gastric cancer with concurrent pancreatic schwannoma: A casereport

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World Journal of Gastrointestinal Pathophysiology 2022年第3期13卷 107-113页

作者： Mateus Barradas ribeiro Emerson Shigueaki Abe AndréKondo Adriana Vaz Safatle-ribeiro Marina Alessandra Pereira Bruno Zilberstein Ulysses ribeiro Jr Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSao Paulo 01249000Brazil

BACKGROUND The differential diagnosis of abdominal masses is somewhat troublesome,especially when there is a malignancy to be *** report herein a unique case of gastric adenocarcinoma concurrent with a pancreatic *** assessment of intraoperative findings is essential for adequate tumor staging and to decide the proper management of a concurrent pancreatic *** SUMMARY Computed tomography scan performed for gastric cancer staging revealed a solid and cystic pancreatic mass that had no signs of local *** resection of the pancreas was decided preoperatively since a radical approach of the gastric tumor could be *** were no signs of distant metastases,and the large pancreatic mass was in contact with the posterior gastric *** study revealed a pancreatic schwannoma,which is an uncommon neoplasm that arises from Schwann cells around peripheral *** Therefore,pancreatic masses deserve special attention regarding the differential diagnosis in patients with gastric *** presence of a large pancreatic mass should not preclude the potentially curative intent of the gastric cancer treatment.

关键词： Stomach neoplasms Gastric adenocarcinoma Schwannoma Pancreas Case report

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Nonmonotone adaptive trust region method based on simple conic model for unconstrained optimization

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Frontiers of Mathematics in China 2014年第5期9卷 1211-1238页

作者： Lijuan ZHAO Wenyu SUN Raimundo J. B. de sampaio School of Mathematical Sciences Jiangsu Key Laboratory for NSLSCS Nanjing Normal University Nanjing 210023 China Department of Social Science Teaching Nanjing Institute of Railway Technology Nanjing 210031 China PPGEPS Pontifical Catholic University of Parana (PUCPR) Curitiba Parana Brazil

We propose a nonmonotone adaptive trust region method based on simple conic model for unconstrained optimization. Unlike traditional trust region methods, the subproblem in our method is a simple conic model, where the Hessian of the objective function is approximated by a scalar matrix. The trust region radius is adjusted with a new self-adaptive adjustment strategy which makes use of the information of the previous iteration and current iteration. The new method needs less memory and computational efforts. The global convergence and Q-superlinear convergence of the algorithm are established under the mild conditions. Numerical results on a series of standard test problems are reported to show that the new method is effective and attractive for large scale unconstrained optimization problems.

关键词： Nonmonotone technique conic model trust region method largescale optimization global convergence

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Genomic Perspectives on the Emerging SARS-CoV-2 Omicron Variant

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 60-69页

作者： Wentai Ma Jing Yang Haoyi Fu Chao Su Caixia Yu Qihui Wang Ana Tereza ribeiro de Vasconcelos Georgii A.Bazykin Yiming Bao Mingkun Li CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Laboratorio de Bioinformatica Laboratorio Nacional de Computacao CientıficaPetropolis 25651-075Brazil Skolkovo Institute of Science and Technology Moscow 121205Russia Kharkevich Institute for Information Transmission Problems of the Russian Academy of Sciences Moscow 127051Russia Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650201China

A new variant of concern for SARS-CoV-2,Omicron(B.1.1.529),was designated by the World Health Organization on November 26,*** study analyzed the viral genome sequencing data of 108 samples collected from patients infected with ***,we found that the enrichment efficiency of viral nucleic acids was reduced due to mutations in the region where the primers anneal ***,the Omicron variant possesses an excessive number of mutations compared to other variants circulating at the same time(median:62 vs.45),especially in the Spike *** in the Spike gene confer alterations in 32 amino acid residues,more than those observed in other SARS-CoV-2 ***,a large number of nonsynonymous mutations occur in the codons for the amino acid residues located on the surface of the Spike protein,which could potentially affect the replication,infectivity,and antigenicity of ***,there are 53 mutations between the Omicron variant and its closest sequences available in public *** of these mutations were rarely observed in public databases and had a low mutation *** addition,the linkage disequilibrium between these mutations was low,with a limited number of mutations concurrently observed in the same genome,suggesting that the Omicron variant would be in a different evolutionary branch from the currently prevalent *** improve our ability to detect and track the source of new variants rapidly,it is imperative to further strengthen genomic surveillance and data sharing globally in a timely manner.

关键词： Omicron Genomics Mutation Variant of concern SARS-CoV-2

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Spectroscopy of a Gamma Irradiated Poly(Acrylic Acid)-Clotrimazole System

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Chinese Physics Letters 2011年第12期28卷 274-277页

作者： M.Todica C.V.Pop luciana Udrescu Traian Stefan Faculty of Physics Babes-Bolyai University400084 Cluj-NapocaRomania

A poly(acrylic acid)-clotrimazole system,gamma irradiated at different doses,is investigated by Raman *** of the spectrum of the polymeric matrix appear for doses of radiation greater than 333 Gy,whereas the spectrum of clotrimazole remains unaffected at these doses of *** changes correlate with modification of the vibration modes of COOH and CH_(2) groups of a polymeric matrix after irradiation.

关键词： spectroscopy polymeric matrix

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