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Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

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Neural Regeneration Research 2024年第5期19卷 935-936页

作者： Ricardo Gómez-Oliva Pedro nunez-Abades Carmen Castro Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investigación e Innovación en Biomedicina de Cádiz CadizSpain Departamento de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic *** is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)*** neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the ***,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate *** latter are cells that maintain a proliferative phenotype while in an immature ***,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

Task Offloading in Edge Computing Using GNNs and DQN

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2649-2671页

作者： Asier Garmendia-Orbegozo Jose David nunez-Gonzalez Miguel Angel Anton Department of Applied Mathematics University of the Basque Country UPV/EHUEibar20600Spain TECNALIA Basque Research and Technology Alliance(BRTA)San Sebastian20009Spain

In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer task *** many resource-constrained devices,the computation of many types of tasks is not feasible because they cannot support such computations as they do not have enough available memory and processing *** this scenario,it is worth considering transferring these tasks to resource-rich platforms,such as Edge Data Centers or remote cloud *** different reasons,it is more exciting and appropriate to download various tasks to specific download destinations depending on the properties and state of the environment and the nature of the *** the same time,establishing an optimal offloading policy,which ensures that all tasks are executed within the required latency and avoids excessive workload on specific computing centers is not *** study presents two alternatives to solve the offloading decision paradigm by introducing two well-known algorithms,Graph Neural Networks(GNN)and Deep Q-Network(DQN).It applies the alternatives on a well-known Edge Computing simulator called PureEdgeSimand compares them with the two defaultmethods,Trade-Off and Round *** showed that variants offer a slight improvement in task success rate and workload *** terms of energy efficiency,they provided similar ***,the success rates of different computing centers are tested,and the lack of capacity of remote cloud servers to respond to applications in real-time is *** novel ways of finding a download strategy in a local networking environment are unique as they emulate the state and structure of the environment innovatively,considering the quality of its connections and constant *** download score defined in this research is a crucial feature for determining the quality of a download path

关键词： Edge computing edge offloading fog computing task offloading

TiO_(2)/CuO Films Obtained by Citrate Precursor Method for Photocatalytic Application

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Materials Sciences and Applications 2011年第6期2卷 564-571页

作者： Leinig Perazolli luciana nunez Milady Renata Apolinario da Silva Guilherme Francisco Pegler Ademir Geraldo Cavalarri Costalonga Rossano Gimenes Marcia Matiko Kondo Maria Aparecida Zaghete Bertochi Microwave Sintering and Photocatalysis Laboratory Instituto de Quimica de AraraquaraUniv Estadual de Sao PauloAraraquaraBrazil UNIFEI-Federal University of Itajuba ItajubaBrazil

In the present work, the hybrid catalyst films of TiO2/CuO containing up to 10% in mol of copper were deposited onto glass surface. Precursor solutions were obtained by citrate precursor method. Films were porous and the average particle size was 20 nm determined by FEG-SEM analysis. The photocatalytic activities of these films were studied using Rhodamine B as a target compound in a fixed bed reactor developed in our laboratory and UV lamp. It was observed that the addition of copper to TiO2 increased significantly its photocatalytic activity during the oxidation of Rhodamine B. The degradation exceeded 90% within 48 hours of irradiation compared to 38% when pure TiO2 was used. Moreover, there was a reduction in the particles band gap energy when compared to that of pure TiO2. These results indicate that the TiO2/CuO films are promising catalysts for the development of fixed bed reactors to be used to treat effluents containing azo dyes.

关键词： TiO_(2)/CuO Citrate Precursor Method Thin Film Rhodamine B Photocatalytic Oxidation

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.nunez Ru C.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1820-1831页

作者： Aakilah S.Hernandez Gabriel A.Zayas Eduardo E.Rodriguez Kaitlyn M.Sarlo Davila Fahad Rafiq Andrea N.nunez Cristiane Goncalves Titto Raluca G.Mateescu Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Animal Sciences University of FloridaGainesvilleFLUSA. Ruminant Diseases and Immunology Research Unit National Animal Disease CentersUnited States Department of Agriculture1920 Dayton AvenueAmesIA 50010USA. Department of Animal Science Iowa StateAmesIAUSA School of Animal Sciences and Food Engineering University of Sao PauloAv Duque de Caxias Norte 225PirassunungaSao Paulo 13635‑900Brazil

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around$369 million being lost annually due to reduced *** stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production *** utilize various physiological mechanisms such as sweating to regulate internal *** in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater *** This study used 2,401 Brangus cattle from two commercial ranches in *** phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area,sweat gland depth,and sweat gland *** animals were genotyped with the Bovine GGP F250K,and BLUPF90 software was used to estimate genetic parameters and for Genome Wide Association *** Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics,allowing producers the ability to select for favorable sweat gland properties.A weighted single-step GWAS using sliding 10 kb windows identified multiple quantitative trait loci(QTLs)explaining a significant amount of genetic *** located on BTA7 and BTA12 explained over 1.0%of genetic variance and overlap the ADGRV1 and CCDC168 genes,*** variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat *** of Origin Alleles(BOA)were predicted using local ancestry in admixed populations(LAMP-LD),allowing for identification of markers'origin from either Brahman or Angus ancestry.A BOA GWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland pheno

关键词： GWAS Heritability Skin Thermotolerance

Fundamentals and application in phytoremediation of an efficient arsenate reducing bacterium Pseudomonas putida ARS1

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Journal of Environmental Sciences 2024年第3期137卷 237-244页

作者： Ze-Wen Wang Guang Yang Jian Chen Yaoyu Zhou Avelino nunez Delgado Hui-Ling Cui Gui-Lan Duan Barry P.Rosen Yong-Guan Zhu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Cellular Biology and Pharmacology Florida International UniversityHerbert Wertheim College of MedicineMiamiFL33199USA University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China Department of Soil Science and Agricultura Chemistry Engineering Polytechnic SchoolUniversity of Santiago de CompostelaCampus Univ.s/n27002LugoSpain

Arsenic is a ubiquitous environmental ***-mediated arsenic biotransformations significantly infuence arsenic mobility and *** transformations by soil and aquatic organisms have been well documented,while little is known regarding effects due to endophytic *** endophyte Pseudomonas putida ARS1 was isolated from rice grown in arsenic contaminated *** ARS1 shows high tolerance to arsenite(As(Ⅲ))and arsenate(As(V)),and exhibits efficient As(V)reduction and As(Ⅲ)effux *** exposed to 0.6 mg/L As(V),As(V)in the medium was completely converted to As(Ⅲ)by *** ARS1 within 4 *** sequencing showed that *** ARS1 has two chromosomal arsenic resistance gene clusters(arsRCBH)that contribute to efficient As(V)reduction and As(Ⅲ)effux,and result in high resistance to *** globosa is a strong arsenic accumulator with high potential for arsenic phytoremediation,which takes up As(Ⅲ)more efficiently than As(V).Co-culture of *** ARS1 and *** enhanced arsenic accumulation in *** by 69%,and resulted in 91%removal of arsenic(at initial concentration of 0.6 mg/L As(V))from water within 3 *** study provides a promising strategy for in situ arsenic phytoremediation through the cooperation of plant and endophytic bacterium.

关键词： Arsenic Pseudomonas putida Arsenate reduction Endophyte Wolffia globosa Phytoremediation

超声辅助乙醇提取富硒金花葵花朵中的硒及抗氧化活性分析

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食品工业科技 2024年第16期45卷 201-208页

作者：张文开鲍征宇 Diego Armando PINZON nunez 邵玲玲徐峰张宏宇赵月华田欢中国地质大学(武汉)材料与化学学院湖北武汉430000 安康国硒源科技有限公司陕西安康725000 紫阳中地大硒科技有限公司陕西安康725000 西北大学地质学系陕西西安710000 武汉测绘研究院湖北武汉430000

为促进优质天然富硒植物资源的科学开发利用,本文选取富硒金花葵为研究对象,采用氢化物发生-原子荧光光谱法(Hydride Generation-Atomic Fluorescence Spectrometry,HG-AFS)检测不同植物器官样品中的硒含量,超声波辅助乙醇提取金花葵花... 详细信息

为促进优质天然富硒植物资源的科学开发利用,本文选取富硒金花葵为研究对象,采用氢化物发生-原子荧光光谱法(Hydride Generation-Atomic Fluorescence Spectrometry,HG-AFS)检测不同植物器官样品中的硒含量,超声波辅助乙醇提取金花葵花朵中的含硒有机活性组分并使用响应面法优化获得最佳提取工艺,同时对含硒提取物开展抗氧化活性研究。结果显示,金花葵各器官中硒含量从高到低依次为叶、果、花、根和茎,分别为21.99、14.29、12.93、10.90和10.23 mg/kg。响应面优化结果表明,含硒有机活性成分最佳提取参数为提取温度40℃、固液比1:60、提取时间40 min、超声功率350 W、乙醇浓度50%(V/V)和提取次数1次。在最佳提取参数下,硒的提取率为35.65%±0.65%。DPPH抗氧化活性测定结果显示,含硒有机活性成分的半抑制浓度(IC_(50))为0.048 mg/mL(硒元素浓度为0.79μg/mL),羟基自由基清除实验显示样品浓度为8 mg/mL时达到最大清除率97%,IC_(50)为0.56 mg/mL,还原力实验表明样品的还原能力随样品浓度的增大而增强。证明金花葵的含硒乙醇提取物具有良好的抗氧化能力。本研究可以为合理利用富硒金花葵和研发加工富硒农副作物提供一些理论依据。

关键词：金花葵硒含硒活性成分提取工艺优化响应面抗氧化活性

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Meteorological drought features in northern and northwestern parts of Mexico under different climate change scenarios

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Journal of Arid Land 2017年第1期9卷 65-75页

作者： Carlos ESCALANTE-SANDOVAL Pedro nunez-GARCIA Faculty of Engineering National Autonomous University of Mexico Cd. Universitaria Coyoacan 04510 Mexico

Meteorological drought has been an inevitable natural disaster throughout Mexican history and the northern and northwestern parts of Mexico（i.e., the studied area）, where the mean annual precipitation（MAP） is less than 500 mm, have suffered even more from droughts in the past. The aim of this study was to conduct a meteorological drought analysis of the available MAP data（1950–2013） from 649 meteorological stations selected from the studied area and to predict the drought features under the different IPCC-prescribed climate change scenarios. To determine the long-term drought features, we collected 1×10~4 synthetic samples using the periodic autoregressive moving average（PARMA） model for each rainfall series. The simulations first consider the present prevailing precipitation conditions（i.e., the average from 1950 to 2013） and then the precipitation anomalies under IPCC-prescribed RCP 4.5 scenario and RCP 8.5 scenario. The results indicated that the climate changes under the prescribed scenarios would significantly increase the duration and intensity of droughts. The most severe impacts may occur in the central plateau and in the Baja California Peninsula. Thus, it will be necessary to establish adequate protective measures for the sustainable management of water resources in these regions.

关键词： meteorological drought synthetic simulation climate change water stress evapotranspiration

New perspectives in iron chelation therapy for the treatment of Parkinson’s disease

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Neural Regeneration Research 2019年第11期14卷 1905-1906页

作者： Marco T. nunez Pedro Chana-Cuevas Faculty of Sciences Universidad de ChileSantiagoChile Movement Disorders Center Universidad de Santiago de ChileSantiagoChile

Neurodegenerative diseases with an iron accumulation component: A wide variety of neurological diseases are characterized by the accumulation of iron in different areas of the central nervous system, include Parkinson’s disease, Huntington disease, Alzheimer’s disease, Friedreich’s ataxia, amyotrophic lateral sclerosis, pantothenate kinase-associated neurodegeneration and other neuropathologies associated with brain iron accumulation (Hayflick et al., 2018).

关键词： Parkinson Huntington Friedreich Alzheimer