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Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model

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World Journal of Gastroenterology 2020年第43期26卷 6782-6794页

作者： Denise Sayuri Calheiros Silveira luciana chain veronez Luis Carlos Lopes-Junior Elen Anatriello Mariangela Ottoboni Brunaldi Gabriela Pereira-da-Silva Department of Biochemistry and Immunology University of São Paulo at Ribeirão Preto Medical SchoolRibeirão Preto 14049-900SPBrazil Health Sciences Center Federal University of Espírito Santo-UFESVitória 29043-900ESBrazil Institute of Science and Technology Federal University of São PauloUNIFESPSão Josédos Campos 12231-280SPBrazil Department of Pathology and Forensic Medicine University of São PauloRibeirao Preto 14040-902SPBrazil Department of Maternal-Infant Nursing and Public Health University of São Paulo at Ribeirão Preto College of NursingRibeirão Preto 14040-902SPBrazil

BACKGROUND Colitis-associated cancer(CAC)accounts for 2%-3%of colorectal cancer(CRC)cases preceded by inflammatory bowel diseases(IBD)such as Crohn's disease and ulcerative *** microbiota has been reported to play a central role in the pathogenesis of IBD and ***,numerous prebiotics and probiotics have being investigated as antitumor agents due to their capacity to modulate inflammatory *** studies have indicated that lactic acid bacteria could be successfully used in managing sporadic CRC,however little is known about their role in *** To investigate the effect of the probiotic Lactobacillus bulgaricus(***)during the development of an experimental model of colitis associated colon cancer(CAC).METHODS C57BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg),followed by three cycles of sodium dextran sulphate diluted in water(5%w/v).Probiotic group received daily *** inflammation was determined by scoring clinical *** levels were determined from colon and/or tumor samples by ELISA BD OptEIATM *** level of significance was set at P<*** were generated and statistical analysis performed using the software GraphPad Prism *** *** treatment inhibited of total tumor volume and mean size of *** addition,the probiotic also attenuated the clinical signs of intestinal inflammation inducing a decrease in intestinal and tumor levels of IL-6,TNF-α,IL-17,IL-23 and IL-1β.CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on *** regulates the inflammatory response and preventing CAC.

关键词： Lactobacillus bulgaricus Colitis-associated cancer Colorectal cancer Carcinogenesis Probiotics Inflammation

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Textile industry innovations in dyeing and finishing processes:Minimizing environmental impact

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China Textile 2024年第4期 43-47页

作者： Textile Value chain

Textiles are one of the oldest industries in the world which has been manufacturing fabrics and materials needed for various ***,the industry has been confronted with some problems regarding its pollution;specifically the dyeing and finishing *** for the given issues,there has been a trend in recent years to come up with more environmentally friendly solutions.

关键词： finishing dyeing impact

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How do advancements in technology affect the development and use of textile binders?

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China Textile 2024年第4期 24-25页

作者： Textile Value chain

The textile industry is constantly evolving,and advancements in technology are playing a pivotal role in shaping the development and use of textile *** to Reports and Insights,the global textile binder market is expected to reach a value of USD 5.33 billion by 2032,exhibiting a healthy CAGR of 4.4%.This growth is fueled by a confluence of factors,with technological innovation at the ***'s delve into how these advancements are impacting the landscape of textile binders。

关键词： advancement landscape technology

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Negative enthalpy alloys and local chemical ordering:a concept and route leading to synergy of strength and ductility

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National Science Review 2024年第4期11卷 172-184页

作者： Zibing An Tao Yang Caijuan Shi Shengcheng Mao Lihua Wang Ang Li Wei Li Xianmeng Xue Ming Sun Yifan Bai Yapeng He Fuzeng Ren Zhouguang Lu Ming Yan Yang Ren chain-Tsuan Liu Ze Zhang Xiaodong Han Beijing Key Lab of Microstructure and Property of Advanced Materials College of Materials Science &Engineering Beijing University of Technology Department of Materials Science and Engineering City University of Hong Kong Key Laboratory of Partial Acceleration Physics& Technology Institute of High Energy PhysicsChinese Academy of Sciences Department of Materials Science &Engineering Southern University of Science and Technology Department of Physics City University of Hong Kong State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Solid solutions are ubiquitous in metals and alloys. Local chemical ordering(LCO) is a fundamental sub-nano/nanoscale process that occurs in many solid solutions and can be used as a microstructure to optimize strength and ductility. However, the formation of LCO has not been fully elucidated, let alone how to provide efficient routes for designing LCO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LCO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LCO components are formed in negative enthalpy refractory high-entropy alloys(RHEAs). In contrast to conventional ‘trial-and-error' approaches, the control of LCO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength(1160 MPa) and uniform ductility(24.5%) under tension at ambient temperature, which are among the best reported so far. LCO can promote dislocation cross-slip, enhancing the interaction between dislocations and their accumulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.

关键词： negative enthalpy alloys local chemical ordering strength ductility dislocation

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Ultrahigh-strength steels strengthened by nanoparticles

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Science Bulletin 2017年第15期62卷 1043-1044页

作者： Zengbao Jiao chain-Tsuan Liu Department of Mechanical Engineering The Hong Kong Polytechnic University Center for Advanced Structural Materials College of Science and Engineering City University of Hong Kong

Ultrahigh-strength steels are highly desirable for a wide range of engineering *** them,maraging steels represent an important class of high-alloyed and almost carbon-free ultrahigh-strength steels,the hardening of wh... 详细信息

关键词：超高强度钢纳米颗粒增强马氏体时效钢金属纳米粒子无碳合金

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Rate Dependence of Serrated Flow and Its Effect on Shear Stability of Bulk Metallic Glasses

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Journal of Iron and Steel Research International 2016年第1期23卷 24-30页

作者： Bao-an SUN chain-tsuan LIU Yong YANG Centre for Advanced Structural Materials Department of Mechanical and Biomedical EngineeringCity University of Hong Kong

The rate dependence of serrated flow and its effects on the stability of shear banding were systematically investigated in a prototypic bulk metallic *** was found that with the increase of external strain rate,the serrated flow is gradually suppressed and could completely disappear at a critical strain *** serration size,characterized by the mean stress drop amplitude,decreases inversely with the strain rate,while the waiting time for serration decreases with the strain rate in a power-law *** rate dependence of the serrated flow has important effects on the dynamics and stability of shear banding process,and leads to an optimal plasticity achieved around the critical strain rate for the disappearance of serrated *** results are discussed and interpreted in terms of the microscopic deformation theory and the stick-slip dynamics of shear banding for bulk metallic glasses.

关键词： serrated flow bulk metallic glass shear band ductility stick-slip

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Critical Shear Offset of Fracture in a Zr-based Metallic Glass

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Journal of Iron and Steel Research International 2016年第1期23卷 53-56页

作者： Zhi-yuan LIU Yong YANG chain-tsuan LIU Shenzhen Key Laboratory of Advanced Manufacturing Technology for Mold & Die Department of Mechanical and Electronic EngineeringShenzhen University Centre for Advanced Structural Materials Department of Mechanical and Biomedical EngineeringCollege of CSECity University of Hong Kong

The nanoscale shear band operation process of Zr_（55）Pd_（10）Cu_（20）Ni_5Al_（10） metallic glass（MG）was reined in by constant force during well-designed loading-holding-unloading cyclic microcompression *** the test,it is revealed that the whole shear banding process involves three stages：shear band initiation,shear sliding and shear band *** on the energy balance principle,the size-affected speed of shear sliding is *** energy originated from the shear sliding leads to heat-up of the shear plane;therefore,the temperature in shear band increases with the size of shear offset caused by the energy accumulation during shear *** the glass transition temperature as the critical temperature of fracture for the Zr-based MG,the critical shear offset is predicted to be approximately 190μm,fully in line with the experimental *** directly proved that the fracture of the MG is caused by the temperature rise during shear sliding.

关键词： metallic glass shear band fracture temperature rise

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Synthesis and Characterization of Small Band-gap Conjugated Polymers - Poly(pyrrolyl methines)

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Chinese Chemical Letters 2002年第10期13卷 988-990页

作者： Wei YAN chain Shu HSU Yu WEI School of Environmental&Chemical Engineering Jiaotong UniversityXi'an 710049 Department of Applied Chemistry National Chiao Tung UniversityHsinchuTaiwan English Department Xi抋n University of Science&TechnologyXi'an 710049

A kind of small band-gap conjugated polymers-poly (pyrrolyl methines) and their precursors-(poly pyrrolyl methanes) have been synthesized by a simple method and characterized by (HNMR)-H-1, FT-IR, TGA and UV-Vis. These polymers can be dissolved in high polar solvents such as DMSO, DMF or NMP. The results reveals that the band-gap of the synthesized conjugated polymers are in the range of 0.96similar to1.14 eV and they all belong to the small band-gap polymers. The conductivity of doped products with iodine is in the range of semiconductor.

关键词： Small band-gap conducting polymer poly( pyrrolyl methine).

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Refractory high-entropy alloys:A focused review of preparation methods and properties

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Journal of Materials Science & Technology 2023年第11期142卷 196-215页

作者： Wei Xiong Amy X.Y.Guo Shuai Zhan chain-Tsuan Liu Shan Cecilia Cao Materials Genome Institute Shanghai UniversityShanghai 200444China Hong Kong Institute of Advanced Study City University of Hong KongKowloonHong KongChina

In recent years,high-entropy alloys(HEAs)have become prominent metallic materials due to their unique design strategies and excellent mechanical *** HEAs-inherent high-entropy,lattice-distortion,sluggish-diffusion,and cocktail effects make HEAs maintain high strength,oxidation resistance,corrosion resistance,wear resistance,and other excellent comprehensive properties,showing stronger competitiveness relative to traditional *** high-entropy alloys(RHEAs)are considered as a new kind of high-temperature materials with great application prospects due to their excellent mechanical properties and have the potential to replace nickel-based superalloy as the next generation of high-temperature *** reviewed the research status and preparation methods of RHEAs in recent years,including the metallurgical smelting,powder metallurgy,magnetron sputtering,and additive manufacturing *** microstructure and phase-transformation process of RHEAs were *** mechan-ical properties and main strengthening and toughening mechanisms of RHEAs,such as solid-solution strengthening,precipitation strengthening,and the transformation-induced plasticity(TRIP),were discussed,and the deformation mechanism of RHEAs was *** properties of RHEAs,including high strength,oxidation resistance,corrosion and wear resistance were *** will meet the huge market demand in the engineering materials field,but there are still many challenges,such as the tradeoff between high strength and high ductility,structural design,and performance optimization of RHEAs with brittle BCC *** believe that this combination of knowledge may shape the future of RHEAs and break through the mutually exclusive conundrum of high strength and high toughness for RHEAs.

关键词： Refractory high-entropy alloy Preparation technology Phase transformation Mechanical properties Strengthening and toughening mechanisms Deformation mechanisms

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Phase selection rules for complex multi-component alloys with equiatomic or close-to-equiatomic compositions

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自然杂志 2013年第2期35卷 85-96页

作者： GUO Sheng LIU chain T NationalAcademy of Engineering Center ofAdvanced Structural Materials Department of Mechanical and Biomedical Engineering College of Science and Engineering City University of Hong Kong Kowloon

Alloying greatly expands the amount of available materials beyond the naturally existing ones, and more importantly offers the material scientists opportunities to initiatively control the composition-structure-property relationship in materials. Since commonly used metallic materials are mostly multi-component alloys, the know-how of alloying through compositional control, certainly plays a critical role in designing materials with desired structure and properties. However, alloying in multi-component alloys is an extremely complicated issue, as the alloyed products could be the amorphous phase, various solid solutions and intermetallic compounds containing two or more alloy components. By narrowing down the scope of the multi-component alloys to those with equiatomic or close-to-equiatomic compositions only, and also aiming at framing out the rules that govern the phase selection upon alloying in multi-component alloys in a broad sense, we have identified here a simple and easily executable two-parameter scheme that can effectively predict the formation of the amorphous phase, solid solutions and intermetallic compounds, in multi-component alloys, simply from the given alloy compositions. We believe this scheme reveals a clear physical scenario governing the phase selection in multi-component alloys, helps to simplify the alloy design, and benefits the future development of advanced metallic alloys like bulk metallic glasses and high entropy alloys.

关键词：材料合金化结构特性金属化合物

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