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Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies

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Acta Pharmaceutica Sinica B 2021年第4期11卷 925-940页

作者： Cláudia Pina costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina silva UCIBIO/REQUIMTE MedtechLaboratory of Pharmaceutical TechnologyDepartment of Drug SciencesFaculty of PharmacyUniversity of PortoPorto 4050-313Portugal CNC-Center for Neuroscience and Cell Biology Center for Innovative Biomedicine and Biotechnology(CIBB)University of CoimbraFaculty of Medicine(Pólo I)Coimbra 3004-504Portugal UC-University of Coimbra CIBBFaculty of PharmacyPólo Das Ciências da SaúdeCoimbra 3000-548Portugal FP-ENAS(UFP Energy Environment and Health Research Unit)CEBIMED(Biomedical Research Centre)Faculty of Health SciencesUniversity Fernando PessoaPorto 4249-004Portugal

The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the *** the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising *** addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc *** review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain *** on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal *** results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried *** the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the *** systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years.

关键词： Nose-to-brain delivery Intranasal administration Nanostructured lipid carriers NLC Solid lipid nanoparticles SLN Nanoemulsions In vivo studies Pharmacokinetic Pharmacodynamics

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Anti-inflammatory effects ofα-humulene andβ-caryophyllene on pterygium fibroblasts

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1903-1907页

作者： Magda Massae Hata Viveiros Márcia Guimarães silva JoséGalberto Martins da costa Anselmo Gomes de Oliveira Carolina Rubio Carlos Roberto Padovani Cláudia Aparecida Rainho silvana Artioli Schellini Department of Ophthalmology School of Medicine of BotucatuSão Paulo State University–UNESPBotucatuSao Paulo 18618-000Brazil Department of Pathology School of Medicine of BotucatuSão Paulo State University–UNESPBotucatuSao Paulo 01049-010Brazil Department of Biological Chemistry Regional University of CaririCratoCeará66100-900Brazil Department of Pharmacology School of Pharmaceutical SciencesSão Paulo State University–UNESPAraraquaraSao Paulo 01049-010Brazil Biological Sciences Institute of Biosciences of BotucatuSão Paulo State University–UNESPBotucatuSao Paulo 01049-010Brazil Department of Biostatistics São Paulo State University–UNESPBotucatuSao Paulo 01049-010Brazil

AIM:To investigate the anti-inflammatory effects of the sesquiterpenesα-humulene andβ-caryophyllene on pterygium ***:Primary cultures of pterygium fibroblasts were *** passage pterygium fibroblasts were exposed toα-humulene andβ-caryophyllene separately and *** cell viability was assessed by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT)assay at 12,24,48,and 72h after *** levels of the inflammatory cytokines interleukin(IL)-1β,IL-6,IL-8,tumor necrosis factor(TNF)-αand IL-10 in the conditioned culture medium were assessed by enzymelinked immunosorbent assay(ELISA)at 12,24 and 48h after *** were statistically analyzed using Friedman repeated measures analysis of variances on ***:The 25μmol/Lβ-caryophyllene induced significant decrease in the IL-6 production by pterygium fibroblasts 48h after the exposure(P=0.041).The levels of IL-1β,IL-8,IL-10,and TNF-αwere very low and had no statistically significant variations af ter exposure toα-humulene,β-caryophyllene,or both compounds ***:The exposure to 25μmol/L ofβ-caryophyllene significantly reduce the production of IL-6 by pterygium fibroblasts after *** sesquiterpene may be a potential alternative adjuvant agent for the treatment of pterygium.

关键词： pterygium fibroblasts β-caryophyllene α-humulene cytokines

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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco silva Rui Morais Armando Peixoto Rosa Coelho Pedro costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： Maria Luísa Cordeiro Santos Ronaldo Teixeira da silva Júnior Breno Bittencourt de Brito Filipe Antônio França da silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita costa dos Santos Carolina Ladeia Cirne Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV Behavioral intervention Nonpharmacological treatment Complementary medicine

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Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 1-8页

作者： Vidal Felix Navarro Torres Carlos Dinis da Gama Matilde costa e silva Paula Falcao Neves Qiang Xie Mining and Geo-resources Engineering Department of IST Technical University of Lisbon 1049-001 Portugal Faculty of Civil Engineering Chongqing University Chongqing 400045 China

The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been described. The traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m ×3.0 m pillars, while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m ×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high, to obtain a pillar section with an area of 3.0 m × 3.0 m. The stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor, more rock mass displacement, more extraction and selectivity ratios, and ore grade improvement, compared with the traditional technique. These results show that the selective technique is also more convenient. This proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram, gold, etc. such as the famous La Rinconada gold mine in the Peruvian Andes.

关键词： mines and mining tungsten deposits productivity stability stoping

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The corpus cavernosum after treatment with dutasteride or finasteride： a histomorphometric study in a benign prostatic hyperplasia rodent model

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Asian Journal of Andrology 2018年第5期20卷 505-510页

作者： Marcello H A Da silva Waldemar S costa Francisco J B Sampaio Diogo B De Souza Urogenital Research Unit Rio de Janeiro State University Rio de Janeiro RJ 20551-030 Brazil

Erectile dysfunction is a common side effect of finasteride and dutasteride treatments. The objective of this study was to investigate the structural changes in the penis using a benign prostatic hyperplasia （BPH） rodent model treated with dutasteride or finasteride. Sixty male rats were divided into the following groups： C, untreated control rats; C ＋ D, control rats receiving dutasteride; C ＋ F, control rats receiving finasteride; H, untreated spontaneously hypertensive rats （SHRs）; H ＋ D, SHRs treated with dutasteride; and H ＋ F, SHRs treated with finasteride. Treatments were performed for 40 days, and penises were collected immediately thereafter. The organs were analyzed using histomorphometric methods to determine the cross-sectional penile area, as well as the surface density （Sv） of smooth muscle fibers, connective tissue, elastic system fibers, and sinusoidal spaces of the corpus cavernosum. The results were compared using a one-way ANOVA with Bonferroni＇s posttest. Groups C ＋ D and C ＋ F had a significantly smaller penile cross-sectional area, but more elastic system fiber Sv compared to Group C. Group C ＋ D showed less smooth muscle Sv, and Group H showed more connective tissue but a smaller sinusoidal space Sv in the corpus cavernosum compared to Group C. Groups H ＋ D and H ＋ F had less smooth muscle Sv than Group H. Group H ＋ D also had more connective tissue and elastic system fiber Sv than Group H. Both dutasteride and finasteride promoted penile modifications in the control rat penis, although this affect was ~reater in Group H animals. In this rodent model, dutasteride was the drug that most affected the corpus cavernosum.

关键词： animal models benign prostatic hyperplasia dutasteride erectile dysfunction finasteride penis

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镧系离子间无辐射能量传递速率的教程综述

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发光学报 2022年第12期43卷 1871-1891页

作者： Albano N Carneiro Neto Renaldo T Moura Jr Jorge A A Coelho Mauro E silva-Junior Janderson L costa Oscar L Malta Ricardo L Longo 阿威罗大学物理系和CICECO-阿威罗材料研究所阿威罗葡萄牙3810-193 南卫理公会大学化学系达拉斯美国75275-0314 帕拉伊巴联邦大学化学与物理系阿雷亚巴西58397-000 伯南布哥联邦大学基础化学系累西腓巴西50740-560 伯南布哥联邦大学材料科学研究生院累西腓巴西50670-901

在本教程综述中,我们重新阐述和表达了镧系离子间无辐射能量传递(ET)速率的理论形式,并且强调了考虑镧系离子本身特异性所引发的与Förster和Dexter理论不同之处。所给出的表达式遵循了Judd-Ofelt的4f-4f跃迁理论框架之下的Kushida方法,... 详细信息

在本教程综述中,我们重新阐述和表达了镧系离子间无辐射能量传递(ET)速率的理论形式,并且强调了考虑镧系离子本身特异性所引发的与Förster和Dexter理论不同之处。所给出的表达式遵循了Judd-Ofelt的4f-4f跃迁理论框架之下的Kushida方法,并计入了如下电多极机制:偶极-偶极(W_(d-d))、偶极-四极(W_(d-q))和四极-四极(W_(q-q))。更为重要的是,当前的机制也扩展包括了交换(W_(ex))和磁偶极子-磁偶极子(W_(md-md))作用,并经过改进进一步包含了屏蔽效应以及给出了F因子(费米黄金规则中的态密度)的解析表达式。与Kushida的原始方法类似,我们只考虑了强制电偶极子(FED)对Judd-Ofelt强度参数的贡献,并细节性地讨论了磁偶极-磁偶极相互作用的选择定则以及相关矩阵元的计算。此外,我们还以Tb(Ⅲ)-Eu(Ⅲ)和Yb(Ⅲ)-Er(Ⅲ)的能量传递速率计算为例,逐步展示了计算过程、主要的计算支撑信息以及所使用的计算脚本。

关键词：无辐射能量传递镧系理论计算 Ln-Ln能量传递速率选择定则

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Strategic Analysis of a Regulatory Conflict Using Dempster-Shafer Theory and AHP for Preference Elicitation

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Journal of Systems Science and Systems Engineering 2019年第4期28卷 415-433页

作者： Maisa M. silva Keith W. Hipel D. Marc Kilgour Ana Paula C. S. costa Department of Management Engineerin& Universidade Federal de Pernambuco Recife Brazil Department of Systems Design Engineering University of Waterloo Waterloo Canada Department of Mathematics Wilfrid Laurier UniversityWaterloo Canada

Dempster-Shafer Theory (DST) and the Analytic Hierarchy Process (AHP) are integrated in order to elicit preference information from experts regarding decision makers (DMs) involved in a regulatory conflict. More precisely, DST is used for combining expert knowledge regarding preferences of a specific DM (the regulatory body), and AHP is employed for ranking feasible states in the conflict for this same DM. In order to illustrate how this preference elicitation proposal can be conveniently implemented in practice within the Graph Model for Conflict Resolution (GMCR), it is applied to a real construction dispute located in the city of Ipojuca, Brazil. The conflict is modeled with three DMs: support, opposition, and the regulatory body. Results show that the new preference methodology possesses many inherent advantages including high flexibility the ability to capture uncertainty or even ignorance about preferences, the possibility of combining expert knowledge with respect to missing preferences, and a substantial reduction in the number of pairwise comparisons of states required to express preference information.

关键词： Regulatory conflict graph model for conflict resolution absence of preference information DST-AHP

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决定巴西Espinhaco生物圈保护区森林-草地变化的环境因素

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Journal of Plant Ecology 2023年第5期16卷 13-25页

作者： Thais Ribeiro costa Cristiane Coelho de Moura Leovandes Soares da silva Anne Priscila Dias Gonzaga AndréRodrigo Rech Evandro Luiz Mendonga Machado Department of Forest Sciences Federal University of Vales do Jequitinhonha e Mucuri-Campus JKRodovia MGT 367Km 583n 5.000Alto da JacubaDiamantina/MGCEP39100-000Brazil

关于热带雨林(对火敏感)和开放地层(耐火)之间边界所涉及过程的认识对于保护生物多样性和生态系统服务至关重要,尤其是在气候变化和人为压力增加的情况下。本文调查了位于巴西东南部的Espinhaco生物圈保护区内的森林岛屿和湿润草原同时... 详细信息

关于热带雨林(对火敏感)和开放地层(耐火)之间边界所涉及过程的认识对于保护生物多样性和生态系统服务至关重要,尤其是在气候变化和人为压力增加的情况下。本文调查了位于巴西东南部的Espinhaco生物圈保护区内的森林岛屿和湿润草原同时出现的主要环境因素。我们使用costa(2018)布置的永久样地来收集森林岛屿的土壤变量(水分和化学性质)。对于湿润草原的采样,我们从岛屿边缘沿不同方向设置了4条30m的线。随后,我们在每条线上划了3个点,每个点相距10m,每个区域共12个点。我们还调查了处理火烧前后的植被覆盖情况,并对环境变量进行均值检验和主成分分析。研究结果显示,森林岛屿土壤中钾、盐基总量、阳离子交换容量和有机质的值均高于湿润草地。因此,两种植被类型之间的边界定义似乎主要与土壤肥力和水分梯度有关。在对这些地区进行火烧处理后,在岛屿边缘附近没有发现树木个体的再生。因此,这些研究结果表明,由于明确的土壤气候条件,森林岛屿无法扩张。因此,这些环境应该成为设计公共保护政策的目标焦点,因为它们增加了山地岩石草原植被景观的复杂性。

关键词：湿地土壤气候梯度岛屿森林综合火灾管理有机土

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Introduction to the special issue on “COVID-19”

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Geoscience Frontiers 2022年第6期13卷 208-209页

作者： Luis F.O.silva Weijun Li Teresa Moreno Department of Civil and Environmental Universidad de la CostaCUC Department of Atmospheric Sciences School of Earth SciencesZhejiang University Institute for Environmental Assessment and Water Research Consejo Superior de Investigaciones Científicas

COVID-19 pandemic is wreaking havoc and bringing the whole world into a standstill in an unprecedented fashion. Joint efforts from multiple sectors to address the various aspects of environment and public health through usage of green technologies have become essential. The application of cleaner and effective technologies can be expanded to management and control, pollution mitigation and valorization of waste. In this Special Issue of Geoscience Frontiers, we present contributions addressing the interactions of COVID-19 in relation to environment and human health.

关键词： bringing expanded COV

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