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Emerging environmental stressors and oxidative pathways in marine organisms:Current knowledge on regulation mechanisms and functional effects

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BIOCELL 2022年第1期46卷 37-49页

作者： MAURA BENEDETTI MARIA ELISA GIULIANI MARICA MEZZELANI ALESSANDRO NARdi lucia PITTURA STEFANIA GORBI FRANCESCO REGOLI dipartimento di Scienze della Vitaedell’Ambiente UniversitàPolitecnica delle MarcheAncona60131Italy

Oxidative stress is a critial condition derived from the imbalance between the genention of reactive oxygen species and the sophisticated network of antioidant *** pollut ants and envronmental factors can afet this system through connected mechanisms,indirect relationships,and cascade effects from pre-transcriptional to catalytic level,by either enhancing intracellular ROS formation or impairing antioxidant *** review summariaces the current kmnowledge on the pro oxidant challenges from emerging environmental stressors threatening marine organisms,such as pharmaceutials microplastics and dimate related ocean *** will be placed on oxidative pathways,including signaling proteins and transcription factors involved in regulation of antioxidant *** insights and lack of knowdedge will be pointed out by presenting single and combined efects of multiple stessors,unraveling questions to be adresed by future resarch in marine ectoicology.

关键词： Antioxidant Pharmaceuticals Microplastics/Nanoplastics Ocean acidification Thermal stress

Scanning gate imaging of quantum point contacts and the origin of the 0.7 anomaly

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Nano Research 2015年第3期8卷 948-956页

作者： Andrea lagallo Nicola Paradiso Stefano Roddaro Christian Reichl Werner Wegscheider Giorgio Biasiol lucia Sorba Fabio Beltram Stefan Heun National Enterprise for Nanoscience and Nanotechnology (NEST) Istituto Nanoscienze-CNR and Scuola Normale Superiore Piazza San Silvestro 12 56127 Pisa Italy Istituto Offcina dei Materiali CNR Laboratorio TASC 34149 Trieste Italy Solid State Physics Laboratory ETH Zurich Schafmattstrasse 16 8093 Zurich Switzerland

The origin of the anomalous transport feature appearing at a conductance G 0.7× （2e2/h） in quasi-lD ballistic devices-the so-called 0.7 anomaly-represents a long standing puzzle. Several mechanisms have been proposed to explain it, but a general consensus has not been achieved. Proposed explanations have been based on quantum interference, the Kondo effect, Wigner crystallization, and other phenomena. A key open issue is whether the point defects that can occur in these low-dimensional devices are the physical cause behind this conductance anomaly. Here we adopt a scanning gate microscopy technique to map individual impurity positions in several quasi-lD constrictions and correlate these with conductance characteristics. Our data demonstrate that the 0.7 anomaly can be observed irrespective of the presence of localized defects, and we conclude that the 0.7 anomaly is a fundamental property of low-dimensional systems.

关键词： two-dimensional electrongas (2-DEG) scanning gate microscopy 0.7 anomaly

“Love Is Strong, and You＇re so Sweet”： JAGGER Is Essential for Persistent Synergid Degeneration and Polytubey Block in Arabidopsis thaliana

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Molecular Plant 2016年第4期9卷 601-614页

作者： Ana Marta Pereira Margarida Sofia Nobre Sara Cristina Pinto Ana lucia Lopes Mario Luis Costa Simona Masiero Silvia Coimbra Departamento de Biologia Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre 4169-007 Porto Portugal Plant Functional Genomics Group Biosystems and Integrative Sciences Institute (BiolSI) 4169-007 Porto Portugal dipartimento di BioScienze Universita degli Studi di Milano 20133 Milan Italy Present address: Institute of Plant Biology and ZUrich-Basel Plant Science Center University of ZUrich Zolikerstrasse 107 8008 Zurich Switzerland

Successful double fertilization and subsequent seed development in flowering plants requires the delivery of two sperm cells, transported by a pollen tube, into the embryo sac of an ovule. The embryo sac cells tightly control synergid cell death, and as a result the polyspermy block. Arabinogalactan proteins are highly glycosylated proteins thought to be involved in several steps of the reproductive process. We show that JAGGER, Arabinogalactan Protein 4, is an important molecule necessary to prevent the growth of multiple pollen tubes into one embryo sac in Arabidopsis thaliana. In jagger, an AGP4 knockout mutant, the pistils show impaired pollen tube blockage as a consequence of the survival of the persistent synergid. JAGGER seems to be involved in the signaling pathway that leads to a blockage of pollen tube attraction. Our results shed light on the mechanism responsible for preventing polyspermy in Arabidopsis and for safe- guarding successful fertilization of all ovules in one pistil, ensuring seed set and the next generation.

关键词： Polytubey persistent synergid arabinogalactan proteins polyspermy

TCP14 and TCP15 Mediate the Promotion of Seed Germination by Gibberellins in Arabidopsis thaliana

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Molecular Plant 2015年第3期8卷 482-485页

作者： Francesca Resentini Amelia Felipo-Benavent lucia Colombo Miguel A. Blázquez David Alabadí Simona Masiero dipartimento di Bioscienze Università. degli Studi di Milano via Celoria 26 20133 Milano Italy Instituto de Biologfa Molecular y Celular de Plantas (CSIC-Universidacl Politécnica de Valencia) Ingeniero Fausto Elio sin 46022 Valencia Spain

Dear Editor,Seed germination is a major developmental transition in a plant＇s life that involves the concerted action of several genetic and physiological pathways （Holdsworth et al., 2008）, and mostly consists of the resumption of embryo growth after a long quiescence imposed during seed maturation. In mature seeds, germination is repressed by abscisic acid （ABA）, while favorable environmental conditions promote gibberellin （GA） biosynthesis and decrease ABA （Holdsworth et al., 2008）. The increase in GA levels is essential for the rupture of testa and endosperm （Lee et al., 2002）. The activation of cell division in the embryo is an integral part of germination that precedes the protrusion of the root through the seed coat. In Arabidopsis, this activation has been linked to significant early changes in the expression of cell-cycle elements （Masubelele et al., 2005）. In the root apical meristem （RAM）, GAs regulate cell divisions （Achard et al., 2009; 0beda-Tomás et al., 2009）. Similarly, the transcription factors （TFs） TEOSINTE BRANCHED1/ CYCLOIDEA/PROLIFERATING CELL FACTOR14 （TCP14） and TCP15 have been proposed to regulate cell proliferation （Kieffer et al., 2011）. Moreover, the activity of TCP14 is necessary to undergo seed germination and, remarkably, seeds lacking this activity are hypersensitive to the negative effects on germination of GA biosynthesis inhibitor paclobutrazol, suggesting a functional relationship between this TF and GAs （Tatematsu et al., 2008）. Taking these observations into account, we hypothesized that TCP14 and TCP15 mediate GA-dependent activation of the cell cycle during germination.

关键词： DELLA PROTEIN APEX

Guest editorial-soil erosion assessment, tools and data: A special issue from the Global Symposium on soil Erosion 2019

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International Soil and Water Conservation Research 2020年第4期8卷 333-336页

作者： Clara Lefèvre Richard M.Cruse lucia Helena Cunha dos Anjos Costanza Calzolari Nigussie Haregeweyn Global Soil Partnership Secretariat Food and Agriculture Organization of the United NationsViale delle Terme di CaracallaRomeItaly Department of Agronomy Iowa State UniversityAmesIA500011USA Department of Soils Federal University of Rio de JaneiroSeropédicaRJ23890-000Brazil Intergovernmental Technical Panel on Soils Food and Agriculture Organization of the United NationsRomeItaly CNR Institute for Bioeconomy Sesto FiorentinoItaly International Platform for Dryland Research and Education Tottori University1390 HamasakaTottori680-0001Japan

This special issue on soil erosion assessment,tools and data creation,consolidation and harmonization presents advances in soil erosion research with a focus on new tools that are being used to assess soil erosion *** publication includes eleven selected contributions presented at the Global Symposium on Soil Erosion(GSER,15-17 May 2019,Rome,Italy)dealing with erosion indicators'improvement,the use of remote sensing,nuclear techniques and geochemical fingerprinting as promising methods to assess soil losses,management practices that reduce soil erosion in vineyards and olive groves plantations and their modelling,and national and regional erosion assessments.

关键词： soil erosion dealing

Immunotherapy for the treatment of hepatocellular carcinoma: finally in clinical practice

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 252-255页

作者： Ciro Celsa lucia Cerrito Leonardo Stella Roberta Ciccia Giuseppe Cabibbo Francesca Romana Ponziani Section of Gastroenterology&Hepatology Department of Health PromotionMother and Child CareInternal Medicine and Medical SpecialtiesPROMISEUniversity of PalermoPalermoItaly Department of Surgical Oncological and Oral Sciences(Di.Chir.On.S.)University of PalermoPalermoItaly digestive disease Center-CEMAD Fondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly

Clinical guidelines for the prevention,diagnosis and management of human disease are evidence-based tools that rely on quality of clinical research,including data from randomized controlled clinical trials(RCTs)and real-world *** Society for Immunotherapy of Cancer(SITC)recently published a clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma(HCC)(1).

关键词： Hepatocellular carcinoma immunotherapy immune-checkpoint inhibitors immune-related adverse events systemic therapies

Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition

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World Journal of Gastrointestinal Oncology 2017年第11期9卷 452-456页

作者： Filippo Antonini Liboria Laterza Lorenzo Fuccio Massimo Marcellini lucia Angelelli Sonia Calcina Corrado Rubini Giampiero Macarri Department of Gastroenterology A. Murri Hospital Polytechnic University of Marche Endoscopy Unit AUSL Department of Medical and Surgical Sciences S. Orsola-Malpighi Hospital University of Bologna Medical Oncology Principe di Piemonte Hospital Medical Oncology Mazzoni Hospital Department of Gastroenterology San Salvatore Hospital University of L’Aquila Department of Biomedical Sciences and Public Health Pathological Anatomy and Histopathology Polytechnic University of Marche

We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features. They may mimic both a primary gastric tumor or, less frequently, an *** case demonstrates the importance of EUS-FNB in distinguishing SETs and how this may alter treatment and prognosis.

关键词： Metastasis Subepithelial lesion Gastric cancer Ovarian Endoscopic ultrasonography

Virological and histological evaluation of intestinal samples in COVID-19 patients

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World Journal of Gastroenterology 2022年第44期28卷 6282-6293页

作者： Dajana Cuicchi Liliana Gabrielli Maria lucia Tardio Giada Rossini Antonietta D’Errico Pierluigi Viale Tiziana Lazzarotto Gilberto Poggioli Department of Medical and Surgical Sciences Surgery of the Alimentary TractIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicineMicrobiology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicinePathology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department for Integrated Infectious Risk Management Infectious Diseases UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Infectious diseases Unit Department for Integrated Infectious Risk ManagementUniversity of BolognaBologna 40138Italy Section of Microbiology Department of ExperimentalDiagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is the pathogen responsible for pandemic coronavirus disease 2019(COVID-19).It is a highly contagious virus which primarily affects the respiratory tract,nevertheless,the lungs are not the only target organs of the *** intestinal tract could represent an additional tropism site for *** observations have collectively suggested that enteric infections can occur in COVID-19 ***,the detection of viral RNA in gastrointestinal(GI)tissue samples has not been adequately investigated and results are *** To detect the presence of SARS-CoV-2 RNA in intestinal mucosa samples and to evaluate histological *** The COVID-19 patients hospitalized at an Italian tertiary hospital from April 2020 to March 2021 were evaluated for enrollment in an observational,monocentric *** study population was composed of two groups of adult *** the first group(biopsy group,30 patients),patients were eligible for inclusion if they had mild to moderate disease and if they agreed to have a rectal biopsy;in the second group(surgical specimen group,6 patients),patients were eligible for inclusion if they underwent intestinal resection during index ***-nine intestinal mucosal samples were *** Viral RNA was not detectable in any of the rectal biopsies performed(0/53).Histological examination showed no enterocyte damage,but slight edema of the lamina propria with mild inflammatory lymphoplasmacytic *** was no difference in inflammatory infiltrates in patients with and without GI ***-CoV-2 RNA was detected in fecal samples in 6 cases out of 14 cases examined(42.9%).In the surgical specimen group,all patients underwent emergency intestinal *** RNA was detected in 2 surgical specimens of the 6 examined,both of which were from patients with active neoplastic *** examination also pointed

关键词： COVID-19 SARS-CoV-2 Intestinal infection Intestinal samples Intestinal tropism Rectal samples

Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity

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Journal of Molecular Cell Biology 2014年第2期8卷 116-127页

作者： Annalisa Zecchin lucia Pattarini Maria Ines Gutierrez Miguel Mano Antonello Mai Sergio Valente Mike P. Myers Sergio Pantano Mauro Giacca Molecular Medicine Laboratory International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste Italy Istituto Pasteur-Fondazione cenci-Bolognetti Dipartimento di Chimica e Tecnologie del Farmaco Sapienza Universita' di Roma Rome Italy Protein Networks Laboratory International Centre for Genetic Engineering and Biotechno[ogy (ICGEB) Trieste Italy Biomolecular Simulations Group Institut Pasteur de Montevideo' Montevideo Uruguay U932 Immunity and Cancer Integrative Biology of Human Dendritic Cells and T Cells Laboratory Institute Curie Paris France

The tyrosine kinase receptor vascular endothelial growth factor receptor 2 （VEG FR2） is a key regulator of angiogenesis. Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop. These modifications are under dynamic control of the acetyltransferase p300 and two deacetyiases HDAC5 and HDAC6. We demonstrate that VEGFR2 acetylation essentially regulates receptor phosphorylation. In par- ticular, VEGFR2 acetylation significantly alters the kinetics of receptor phosphorylation after ligand binding, allowing receptor phos- phoryiation and intraceUular signaling upon proLonged stimulation with VEGF. Molecular dynamics simulations indicate that acetylation of the lysine in the activation loop contributes to the transition to an open active state, in which tyrosine phosphorylation is favored by better exposure of the kinase target residues. These findings indicate that post-translational modification by acetyiation is a critical mechanism that directLy affects VEGFR2 function.

关键词： acetylation angiogenesis p300 phosphorylation vascular endothelial growth factor