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Geographical location affects size and materials used in the construction of European Pied Flycatcher(Ficedula hypoleuca) nests

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Avian Research 2019年第2期10卷 111-125页

作者： Kevin B.Briggs lucia E.Biddle D.Charles Deeming Joseph Banks Laboratories School of Life SciencesUniversity of Lincoln

Background: Nest construction is a key element of avian reproductive behaviour and the result is often a complex structure that is used for incubation of eggs, which represents an extended phenotype. It is known that nest construction is a plastic behaviour but the extent to which plasticity is observed in a single species with a wide geographical distribution is largely unknown. This study sought to better understand variation in nest size and composition across a very wide geographical area. The hypothesis suggested that location would affect size but not composition of nests of the European Pied Flycatcher (Ficedula hypoleuca). Methods: Nests and reproductive data were collected from seventeen study sites, spread over 6° of latitude and 3.3° of longitude on the island of Great Britain. Dimensions of nests were measured before they were deconstructed to determine the masses and types materials used in the outer nest and the cup lining. Results: Geographical variation was observed in base thickness of nests but not many other dimensions. Nests varied in composition but were mainly made of leaf, moss, bark, grass, root and fern. Moss was used more to the north and east of the study area compared with more leaf mass towards the south and west. The species of leaf and bark used in the nests varied between geographical locations. Additionally, the use of leaves or bark from a particular tree species did not reflect the incidence of the tree species in the immediate territory. Conclusions: This study showed that nest composition was affected by geographical location over a wide area. Variation between nests at each location was high and so it was concluded that differences in nest composition reflect individual selection of materials but evidence is such that it remains unclear whether this is deliberate to fulfil a specific role in the nest, or simply opportunistic with birds simply picking up materials with the appropriate characteristics as they find them outside the

关键词： Breeding success Ficedula hypoleuca Latitude Longitude Nest composition Nest size Nest structure

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Sarcopenia and nonalcoholic fatty liver disease: a causal relationship

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 144-147页

作者： lucia Pacifico Francesco Massimo Perla Claudio Chiesa Department of Pediatrics Sapienza University of RomeRomeItaly Institute of Translational Pharmacology National Research CouncilRomeItaly

Concurrent with the obesity epidemic,non-alcoholic fatty liver disease(NAFLD)is rapidly becoming the leading cause of chronic liver disease worldwide(1).NAFLD,particularly its histological phenotype non-alcoholic steatohepatitis(NASH),can progress to advanced liver disease,cirrhosis and hepatocellular carcinoma and indication for liver transplantation(2).Although remarkable advances have been made in the understanding of the pathophysiology of NAFLD,the exact mechanism of hepatic fat accumulation and the progression to NASH is not fully ***,in order to reduce the burden associated with these diseases,it is imperative that all major factors that contribute to the development of NAFLD are identified.

关键词： NAFLD becoming exact

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Impact of healthy plant-based diet on abdominal visceral and liver fat contents

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 136-138页

作者： lucia Pacifico Francesco Massimo Perla Claudio Chiesa Department of Maternal and Child health Sapienza University of RomeRomeItaly Institute of Translational Pharmacology National Research CouncilRomeItaly

Diet is an important modifiable risk factor for obesity and obesity-related complications,and there has been growing interest in plant-based diets,mainly defined as“vegetarian”diets,which have been associated with a lower prevalence rate of overweight/obesity as well as a lower risk of coronary heart disease,type 2 diabetes,other cardiometabolic diseases,and all-cause mortality(1).Such dietary patterns are also a major determinant of environmental sustainability(1).Of note,however,vegetarian diets can include less healthy plant foods,such as refined grains and sugar-sweetened beverages which have detrimental effects on health(2).

关键词： obesity mortality diseases

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Cognitive training in neurodegenerative diseases: a way to boost neuroprotective molecules?

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Neural Regeneration Research 2015年第11期10卷 1754-1755页

作者： Francesco Angelucci Carlo Caltagirone Alberto costa IRCCS Santa lucia Foundation Department of Clinical and Behavioural Neurology Department of Systemic Medicine Rome University Tor Vergata Niccolò Cusano University

Neurotrophins,and growth factors in general,are proteins which exert many actions in central nervous system *** promote the survival and neuronal function of neurons and exert neuroprotective effects in pathological models of neurodegenerative *** humans several clinical trials based on the use of these proteins have been carried out. Among them, it is worth to mention gene ther- apy especially in Parkinson＇s disease （PD）（Kordower and Bjorklund, 2013）, and a series of experiments using vectors capable of carrying neurotrophins in the selected target re- gion where they can exert their beneficial action （Ghosh et al., 2014）.

关键词： BDNF a way to boost neuroprotective molecules Cognitive training in neurodegenerative diseases

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Hot-Electron Effects in InAs Nanowire Josephson Junctions

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Nano Research 2011年第3期4卷 259-265页

作者： Stefano Roddaro Andrea Pescaglini Daniele Ercolani lucia Sorba Francesco Giazotto Fabio Beltram NEST Istituto Nanoscienze-CNR and Scuola Normale Superiore P. za S. Silvestro 12 1-56127 Pisa Italy IIT@NEST Center for Nanotechnology Innovation P. za S. Silvestro 12 1-56127 Pisa Italy

The controlled tailoring of the energy distribution in an electron system opens the way to interesting new physics and device concepts, as demonstrated by research on metallic nanodevices during recent years. Here we investigate how Josephson coupling in a superconductor-InAs nanowire junction can be tuned by means of hot-electron injection and we show that a complete suppression of superconductive effects can be achieved using a power as low as 100 pW. Nanowires offer a novel design freedom as they allow axial and radial heterostructures to be defined as well as control over doping profiles, which can be crucial in the development of devices--such as nanorefrigerators--where precisely controlled and predictable energy barriers are mandatory. Our work provides estimates for unknown key thermal and electrical parameters, such as the electron-phonon coupling, in our InAs nanostructures.

关键词： Nanowire hot-electron Josephson effect InAs heat conduction

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Green synthesis,characterization,and catalytic application of a supported and magnetically isolable copper-iron oxide-sodium alginate

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Green Synthesis and Catalysis 2022年第2期3卷 179-184页

作者： Elmira Kalantari lucian lucia Nathalie Lavoine Department of Forest Biomaterials College of Natural ResourcesNorth Carolina State UniversityRaleighNC 27695United States Department of Chemistry College of SciencesNorth Carolina State UniversityRaleighNC 27695United States State Key Laboratory of Biobased Materials&Green Papermaking Qilu University of Technology/Shandong Academy of SciencesJinan 250353China

Herein,we report a green and facile preparation and characterization procedure of copper nanoparticles stabilized on magnetically separable sodium alginate support(Cu NPs-Fe_(3)O_(4)-SAlg)using Silybum marianum seeds extract and investigate their catalytic reductive chemistry for reduction of environmental ***,the phytochemical content of the plant extract are responsible to biosynthesis of copper(Cu)nanoparticles and their stabilization by functionalizing the surface of magnetic *** of the biocatalyst was undertaken with FT-IR,XPS,XRD and STEM equipped with EDS.A standard suite of model compounds on which the reductive chemistry was tested were 4-nitrophenol(4-NP),potassium hexacyanoferrate(K3[Fe(CN)6]),and a variety of organic dyes including Congo Red(CR).The as-synthesized Cu NPs-Fe_(3)O_(4)-SAlg catalyst was highly effective in reducing 4-NP to 4-aminophenol in water and in the presence of sodium borohydride as a reducing ***,a high reduction performance was observed with CR and K3[Fe(CN)6]in presence of the Cu NPs-Fe_(3)O_(4)-SAlg *** catalyst acted within 190 and 35 s respectively,at room temperature in the presence of ***,the Cu NPs-Fe_(3)O_(4)-SAlg catalyst is a highly efficient catalyst which is also reusable due to its magnetic *** work reports a green synthesis of a high-performance Cu NPs-Fe_(3)O_(4)-SAlg catalyst using an environmental friendly method for reduction of 4-NP,CR,and K3[Fe(CN)6]over a short time.

关键词： Biocatalyst Green synthesis Sodium alginate Organic dyes Copper nanoparticles

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Bone marrow derived stem cells for the treatment of end-stage liver disease

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World Journal of Gastroenterology 2014年第27期20卷 9098-9105页

作者： Cristina Margini Ranka Vukotic lucia Brodosi Mauro Bernardi Pietro Andreone Dipartimento di Scienze mediche e Chirurgiche Unità Operativa di Semeiotica Medica University of Bologna

End-stage disease due to liver cirrhosis is an important cause of death worldwide. Cirrhosis results from progressive, extensive fibrosis and impaired hepatocyte regeneration. The only curative treatment is liver transplantation, but due to the several limitations of this procedure, the interest in alternative therapeutic strategies is increasing. In particular, the potential of bone marrow stem cell(BMSC) therapy in cirrhosis has been explored in different trials. In this article, we evaluate the results of 18 prospective clinical trials, and we provide a descriptive overview of recent advances in the research on hepatic regenerative medicine. The main message from the currently available data in the literature is that BMSC therapy is extremely promising in the context of liver cirrhosis. However, its application should be further explored in randomized, controlled trials with large cohorts and long follow-ups.

关键词： Liver cirrhosis Liver regeneration Hematopoietic stem cells Mesenchymal stem cells End stage liver disease

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Non-operative successful management of a perforated small bowel diverticulum

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World Journal of Gastroenterology 2014年第48期20卷 18477-18479页

作者： Melissa M Levack Maria lucia Madariaga Haytham MA Kaafarani Division of Trauma Department of Surgery SurgicalCritical Care Massachusetts General Hospital Harvard MedicalSchool Boston MA 02114 United States

Jejunoileal diverticula are rare and generally asymptomatic. In the few cases of patients who develop complications such as diverticulitis, perforation, obstruction, and/or hemorrhage, conventional treatment consists of surgical resection. We describe a case of perforated jejunoileal diverticulum with localized abscess and highlight the merits of surgical vs medical management. The patient is a 77-year-old male who presented with sharp, constant abdominal pain just inferior to the umbilicus. Administration of intravenous antibiotics results in complete and long-term resolution of the patient’s symptoms. In this report, we establish a framework for safely treating perforated small bowel diverticulum without surgical exploration.

关键词： Jejunal diverticula Diverticulitis Small bowel perforation Antibiotics Abscess

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Immune response to vaccines in children with celiac disease

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World Journal of Gastroenterology 2017年第18期23卷 3205-3213页

作者： Caterina Anania Francesca Olivero Alessandra Spagnolo Claudio Chiesa lucia Pacifico Policlinico Umberto I Sapienza University of Rome Department of Public Health and Infectious Diseases Sapienza University of Rome Institute of Translational Pharmacology National Research Council

Celiac disease(CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most potent intervention for infectious disease prevention. Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. The available literature indicates that the immunological response to vaccines in CD children does not differ markedly from that of general population and antibody titres are high enough to provide long-term protection, except for hepatitis B virus vaccine. In this article, we review and discuss the scarce literature in this field in order to provide clinical practice guidelines to achieve the most efficient monitoring of the response to vaccines in pediatric CD patients.

关键词： Celiac disease Children Infection Vaccines Hepatitis B vaccine HLA Gluten free diet

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Methodological factors affecting gas and methane production during in vitro rumen fermentation evaluated by meta-analysis approach

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Journal of Animal Science and Biotechnology 2017年第1期8卷 236-247页

作者： Laura Maccarana Mirko Cattani Franco Tagliapietra Stefano Schiavon lucia Bailoni Roberto Mantovani Department of Comparative Biomedicine and Food Science (BCA) University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy Department of Agronomy Food Natural resources Animals and Environment (DAFNAE) University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy

Effects of some methodological factors on in vitro measures of gas production（GP, mL/g DM）, CH4production（mL/g DM） and proportion（% CH4 on total GP） were investigated by meta-analysis. These factors were considered：pressure in the GP equipment（0 = constant; 1 = increasing）, incubation time（0 = 24; 1 = ≥ 48 h）, time of rumen fluid collection（0 = before feeding; 1 = after feeding of donor animals）, donor species of rumen fluid（0 = sheep; 1 =bovine）, presence of N in the buffer solution（0 = presence; 1 = absence）, and ratio between amount of buffered rumen fluid and feed sample（BRF/FS; 0 = ≤ 130 mL/g DM; 1 = 130–140 mL/g DM; 2 = ≥ 140 mL/g DM）. The NDF content of feed sample incubated（NDF） was considered as a continuous variable. From an initial database of 105 papers, 58 were discarded because one of the above-mentioned factors was not stated. After discarding 17 papers,the final dataset comprised 30 papers（339 observations）. A preliminary mixed model analysis was carried out on experimental data considering the study as random factor. Variables adjusted for study effect were analyzed using a backward stepwise analysis including the above-mentioned variables. The analysis showed that the extension of incubation time and reduction of NDF increased GP and CH4 values. Values of GP and CH4 also increased when rumen fluid was collected after feeding compared to before feeding（＋26.4 and ＋9.0 mL/g DM, for GP and CH4）,from bovine compared to sheep（＋32.8 and ＋5.2 mL/g DM, for GP and CH4）, and when the buffer solution did not contain N（＋24.7 and ＋6.7 mL/g DM for GP and CH4）. The increase of BRF/FS ratio enhanced GP and CH4production（＋7.7 and ＋3.3 mL/g DM per each class of increase, respectively）. In vitro techniques for measuring GP and CH4 production are mostly used as screening methods, thus a full standardization of such techniques is not feasible. However, a greater harmonization of analytical procedures（i.e., a reduction in the number of available protocols） would be usefu

关键词： Experimental factors Gas production In vitro rumen fermentation Meta-analysis Methane production

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