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Advancing pediatric exercise research:A focus on immunomics and cutting-edge technologies

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Journal of Sport and Health Science 2024年第5期13卷 679-681页

作者： Abel Plaza-Florido Alejandro lucia Shlomit Radom-Aizik Pediatric Exercise and Genomics Research Center Department of PediatricsSchool of MedicineUniversity of California at IrvineIrvineCA 92617USA Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Physical Activity Health Research Group(“PaHerg”) Research Institute of Hospital 12 de Octubre(“imas12”)Madrid 28041Spain

*** importance of immunomics in pediatric exercise research The profound effect that"acute"or"regular"exercise(i.e.,a single exercise session or repeated sessions over time,respectively)exerts on the immune system has been widely recognized.1 Acute exercise is largely"immuno-enhancing"(e.g.,it may even improve vaccine responses in"at-risk"patients),whereas regular exercise reduces the risk of chronic conditions(not only obesity,diabetes,or cardiovascular diseases,but also several types of cancer)partly due to its anti-inflammatory effects.

关键词： pediatric Acute vaccine

Improving colorectal cancer screening programs

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World Journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar J Cordero lucia mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in molecular medicine and Chronic Diseases(CimUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World Journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

Anticancer effects of exercise:Insights from single-cell analysis

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Journal of Sport and Health Science 2024年第5期13卷 676-678页

作者： Abel Plaza-Florido Alejandro lucia Shlomit Radom-Aizik Carmen Fiuza-Luces Pediatric Exercise and Genomics Research Center Department of PediatricsSchool of MedicineUniversity of California IrvineIrvineCA 92617USA Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Physical Activity and Health Research Group(“PaHerg”) Research Institute of the Hospital 12 de Octubre(“imas12”)Madrid 28041Spain

A recent special topic in the Journal of Sport and Health Science reported the health benefits conferred by traditional and innovative m-health exercise and multimodal programs with respect to several types of cancer.... 详细信息

关键词： protective exercise modal

Exercise benefits meet the esophagus

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Journal of Sport and Health Science 2024年第5期13卷 685-686页

作者： Alejandro Santos-Lozano Pedro L.Valenzuela Carmen Fiuza-Luces Alejandro lucia i+HeALTH European University Miguel de CervantesValladolid 47012Spain Research Institute of the Hospital 12 de Octubre(“imas12”) Madrid 28041Spain Department of Systems Biology University of AlcalaAlcala de Heranes 28801Spain Faculty of Sport Sciences Universidad Europea de MadridVillaviciosa de Odon(Madrid)28670Spain

Gastroesophageal reflux disease(GERD)is defined by recurrent and troublesome heartburn and effortless regurgitation or by the specific complications of this condition—that is,esophagitis,esophageal peptic strictures,and Barrett esophagus.1Although GERD is caused by gastric contents'reaching the esophagus,gastric juices can also reach other anatomical locations(pharynx,mouth,larynx,and airways),leading to(or worsening)extra-esophageal conditions(notably asthma)or symptoms(e.g.,wheezing,cough).1 Together with obesity,GERD is the main risk factor for gastroesophageal malignancies.

关键词： esophagus esophageal Barrett

Familiar Ghosts: Imagining Lives, Re-imagining the Nation, Inventing the Future

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Journal of Foreign Languages and Cultures 2024年第1期8卷 31-47页

作者： lucia BOLDRINI University of London

This article focuses on novels that,located on the boundary between biography,autobiography and fiction,between detailed archival historical research and imagination,between the documentary and the speculative,seek to reconstruct the life of an ancestor of the writer-narrator to reflect on the traumas,exploitation,hopes,and desires of generations who,in their diasporas,also helped create their modern nations,or whose story challenges the exclusions on which the concept of the nation has been *** texts discussed are melania mazzucco's Vita,Vona Groarke's Hereafter:The Telling Life of Ellen O'Hara,Wu ming 2 and Antar mohamed's Timira:Romanzo meticcio,and maryse Conde's Victoire,les saveurs et les *** their center is the negotiation between the individual truth and the relational story across generations on the one hand,and,on the other hand,the tracing of collective histories such as those of nation,of colonization,of diaspora,of internal and external displacement,of rights and emancipation(the downtrodden,the poor,women,the migrant,the refugees),of the origins of dispossession and the permanence of its *** the core of the narratives is also the ghostliness of the erased(from history,from memory,from citizenship),the departed(in the sense of being dead and of having traveled away),and the in-between(generic:between the historical and documentary on the one hand,and the novelistic,the fable,fantasy on the other;geographical:between countries,between places,nationalities,national affiliations;historical:across generations;racial:the mestizo,the mulatto).It is,specifically,the biofictional imagination that enables these diasporic,transnational,transracial accounts to open up the possibility of a different,liberating future,by offering the space to imagine such a future,but also by recognizing,through its explicit acknowledgement of its recourse to fictionality,that it does not aim to construct a new myth to replace historical fact,but that it invites all

关键词： biofiction diaspora genealogical accounting ghosts life narratives national history transnationalism

Cardiovascular risk burden and disability:findings from the International mobility in Aging Study(ImIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David martinez-Aristizábal Carmen-lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos Santos Gomes Fernando Gomez Internal medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health Sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGROUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International mobility in Aging Study(ImIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(Pmore developed regions and having a higher educational level reduced the probability of disability during the follow-up time(Pmance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

Exerkine response to acute exercise:Still much to discover

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Journal of Sport and Health Science 2024年第6期13卷 759-760页

作者： Pedro L.Valenzuela Beatriz Rivas-Baeza Carmen Fiuza-Luces Alejandro lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Centro de Salud Luis Vives Alcala de HenaresMadrid 28803Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain

Strong evidence supports the benefits of regular physical activity/exercise for the prevention and management of numerous non-communicable diseases.^(1,2)However,despite important advances(particularly the implementation of complex“omics”approaches),the underlying molecular mechanisms remain to be clearly *** the past decade,the role of exerkines—a myriad of signaling moieties(e.g.,mainly cytokines but also other small peptides,peptides,nucleic acids,lipids,or metabolites,among others)released by muscles(myokines)and other tissues in response to exercise that induces endocrine(at the multisystem level),paracrine,or autocrine effects—has gained attention.^(3,4)Indeed it has been proposed that some of the salutary effects of regular exercise(i.e.,repeated sessions of acute exercise)might be due,at least partly,to the progressive accumulation of frequent,acute episodes of exerkine release.^(5)

关键词： gained multisystem prevention

Hypothalamic circuits and aging:keeping the circadian clock updated

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Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa Vázquez-Lizarraga lucia mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-montoya Erick Carreño-Vázquez Ricardo Orozco-Solis Instituto Nacional de medicina Genómica(INmEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

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Current Zoology 2024年第1期70卷 1-12页

作者： lucia V.Sommaro Juan J.martinez marina B.Chiappero Andrea R.Steinmann Cristina N.Gardenal JoséW.Priotto Laboratorio de Ecologia Evolutiva y Biogeografia Instituto de Ecorregiones Andinas(INECoA)Universidad Nacional de Jujuy-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)San Salvador de JujuyJujuyArgentina Instituto de Diversidad y Ecologia Animal(IDEA) Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)and Universidad Nacionalde CordobaCordobaArgentina Catedra de Genética de Poblaciones y Evolucion Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaCordobaArgentina Grupo de Investigaciones en Ecologia Poblacional y Comportamental(GIEPCO) Instituto de Ciencias de la TierraBiodiversidad y Ambiente(ICBiA)Universidad Nacional de Rio Cuarto-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Rio CuartoCordobaArgentina

The sex-biased dispersal and kinship dynamics are important factors shaping the spatial distribution of individuals and are key parameters affecting a variety of ecological and evolutionary ***,we studied the spatial distribution of related individuals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal *** sampling was carried out from spring 2005 to winter 2006 in field borders of intensively managed *** data from 346 individuals with 9 microsatellites showed spatial genetic structure was weak for males,but not for *** results indicate a complex spatial kinship dynamic of related females across all ***,contrary to our expectations,dispersal distances decrease with the increase of the population ***,male dispersal distances were greater when population abundance increased and thus the availability of active *** disperse greater distances to mate and sire offspring with distant females as a possible inbreeding avoidance *** study shows that *** is capable of much greater scattering distances than previously reported and that dispersal occurs fluidly and without barriers across the *** indirect benefit of dispersal on individual fitness could be related to relaxing the competition in the natal area and increasing the mating *** study highlights the value of combining genetic relatedness,fieldwork observations,and behavioral data to estimate dispersal at a fine geographical scale.

关键词： dispersal distances kinship dynamics microsatellite small mammals spatial autocorrelation