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Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin(CT)-induced apoptosis

Cell Research 2006年第3期16卷 306-312页

作者： Augusto Pessina Cristina Croera Nicoletta Savalli Arianna Bonomi Loredana Cavicchini Elisa Turlizzi Fabiana Guizzardi lucia guido Laura Daprai Maria GraziaNeri Institute of Microbiology University of MilanVia Pascal 3620133 MilanItaly ECVAM Institute for Health and Consumer ProtectionEuropean Commission Joint Research CentreIspra 21020Italy UCLA Department of AnesthesiologyLos AngelesCA 90095USA

The very different effects of Cholera Toxin (CT) on cell growth and proliferation may depend on the type of ganglio-side receptors in cell membranes and different signal transduction mechanisms triggered,but other functions relatedto the drug resistance mechanisms can not be *** effect of CT treatment on the "in vitro" clonogenicity,thePopulation Doubling Time (PDT),apoptosis,PKA activation and Bax and Bcl-2 expression was evaluated in WEHI-3Bcell line and its CT-resistant subclone (WEHI-3B/CTRES).In WEHI-3B parental cells the dramatic accumulation ofcAMP induced by CT correlated well with PKA activation,increased PDT value,inhibition of clonogenicity and apop-tosis.H-89 treatment inhibited PKA activation by CT but did not protect the cells from apoptosis and growth *** WEHI-3B/CTRES no significant CT-dependent accumulation of cAMP occurred with any increase of PKA activityand *** CT resistant cells (WEHI-3B/CTRES),Bcl-2 expression was down regulated by both CT or drug treatment(eg.,ciprofloxacin,CPX) although these cells were protected from CT-dependent apoptosis but not from *** from other cell models described,down regulation of Bcl-2 is proved to be independent on cAMPaccumulation and PKA *** observations support the implication of cAMP dependent kinase (PKA) in theinhibition of WEHI-3B cells growth and suggest that,in WEHI-3B/CTRES,Bcl-2 expression could be modulated byCT in the absence of cAMP *** in consideration of many contradictory data reported in literature,ourcell models(of one sensitive parental cell strain and two clones with different uncrossed specific resistance to CT andCPX)provides a new and interesting tool for better investigating the relationship between the CT signal transductionmechanisms and Bcl-2 expression and function.

关键词： cholera toxin Bcl-2 PKA apoptosis ciprofloxacin resistance

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Anisotropies of the g-factor tensor and diamagnetic coefficient in crystal-phase quantum dots in InP nanowires

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Nano Research 2019年第11期12卷 2842-2848页

作者： Shiyao Wu Kai Peng Sergio Battiato Valentina Zannier Andrea Bertoni guido Goldoni Xin Xie Jingnan Yang Shan Xiao Chenjiang Qian Feilong Song Sibai Sun Jianchen Dang Yang Yu Fabio Beltram lucia Sorba Ang Li Bei-bei Li Francesco Rossella Xiulai Xu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China CAS Center for Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing100049China Laboratorio NEST Scuola Normale Superiore and Istituto Nanoscienze-CNRPiazza S.Silvestro 12I-56127PisaItaly S3 Istituto Nanoscienze-CNRVia Campi 213/aModena41125Italy Dipartimento di Scienze Fisiche Informatiche e MatematicheUniversitàdegli Studi di Modena e Reggio EmiliaVia Campi 213/aModena41125Italy Beijing Key Lab of Microstructure and Property of Advanced Materials Beijing University of TechnologyPingleyuan No.100Beijing100024China Songshan Lake Materials Laboratory Dongguan523808China

Crystal-phase low-dimensional structures offer great potential for the implementation of photonic devices of interest for quantum information *** this context,unveiling the fundamental parameters of the crystal phase structure is of much relevance for several ***,we report on the anisotropy of the g-factor tensor and diamagnetic coefficient in wurtzite/zincblende(WZ/ZB)crystal-phase quantum dots(QDs)realized in single InP *** WZ and ZB alternating axial sections in the NWs are identified by high-angle annular dark-field scanning transmission electron *** electron(hole)g-factor tensor and the exciton diamagnetic coefficients in WZ/ZB crystal-phase QDs are determined through micro-photoluminescence measurements at low temperature(4.2 K)with different magnetic field configurations,and rationalized by invoking the spin-correlated orbital current *** work provides key parameters for band gap engineering and spin states control in crystal-phase low-dimensional structures in nanowires.

关键词： g-factor tensor diamagnetic coefficient crystal-phase quantum dot InP NWs

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Structure of Personality at Intrapsychic and Interpersonal Levels and Depression of Caregivers of Patients Affected by Alzheimer’s Disease: Which Psychotherapeutic Approach?

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Advances in Alzheimer's Disease 2018年第4期7卷 103-118页

作者： Giulietti Maria Velia Anna Vespa Stefano Berti guido Gori Marica Ottaviani Cristina Meloni Paolo Fabbietti Giuseppe Pelliccioni lucia Paciaroni Roberta Spatuzzi Department of Research INRCA-IRCCS National Institute of Science and Health for Aging Ancona Italy Department of Research Scientific and Technological Area INRCA-IRCCS National Institute of Science and Health for Aging Anco-na Italy Health Promotion Department Ancona Alzheimer Daily Center Florence Italy Biostatistical Center INRCA-IRCCS National Institute of Health and Science on Aging Ancona Italy U.O.C. Hospice/Palliative Care Departments Potenza Italy

Background: Many studies have underlined as caregiving for people with Alzheimer’s disease (AD) is highly stressful and has significant negative consequences. Objectives: The study of the structure of personality, can help to understand the association between depression, intrapsychic and interpersonal processes of caregivers of Alzheimer’s disease patients and what kind of intervention can be planned to favor the stress burden management. Methods: Case group: Caregivers (CG) (n = 75);control group, Subjects not Caregivers (nCG) (n. 104). Tests: SASB questionnaire (Structural Analysis of Interpersonal Behavior) describing intrapsychic and interpersonal processes of the structure of personality validated on the basis of DSMIV;CDQ questionnaires—depression. Results: Intrapsychic level: From the results it emerged that CGs had lower autonomy in their choices, and lower acceptance of their own feelings, and exercised greater self-control exhausting themselves toward predetermined goals, and more depression compared to the control group. They may be not able to achieve psychic equilibrium in the presence of stress: they may likely become disoriented and engage in behaviors that may be self-defeating. SASB-Cl = Autonomy (p 0.001);SASB-Cl2-Autonomy and Love (p 0.001), SASB-CL3-Love (p 0.001);SASB-Cl4 Love and control (p 0.001), SASB-CL5-Control (p = 0.015), SASB-Cl6-Control and hate (p 0.001), SASB-Cl7-Hate (p Conclusions: Intrapsychic characteristics such as tendency to depression, inability to being in contact with their own feelings, excessive self-control may be linked to difficulties in facing burden of care and indicate serious difficulties to adaptation to burden condition. The knowledge of these modalities could allow to plan a psychotherapeutic and multidisciplinary intervention aimed at facing and overcoming the psychological distress of the caregiver.

关键词： Caregiver Alzheimer Depression Intrapsychic Behaviours Interpersonal Behaviours Personality

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