检索结果-南通市图书馆

Long-term outcomes of interventions for radiation-induced xerostomia:A review

World Journal of Clinical Oncology 2019年第1期10卷 1-13页

作者： Sung Jun ma Charlotte I Rivers lucas m serra Anurag K Singh University at Buffalo The State University of New York Jacobs School of Medicine and Biomedical Sciences Department of Radiation medicine Roswell Park Comprehensive Cancer Center

Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms "xerostomia" and "radiation" or "radiotherapy"; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or *** use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions.

关键词： Xerostomia Radiation therapy Radiotherapy Head and neck cancer Quality of life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

引用

Journal of Energy Chemistry 2024年第4期91卷 99-110页

作者： marwan Laqdiem Julio García-Fayos Laura Almar Alfonso J.Carrillo Álvaro Represa Josém.López Nieto Sonia Escolástico David Catalán-martinez Jose m.serra Instituto de Tecnología Química(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(OTms)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTms could provide oxygen from different sources(air,water,CO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,OTms can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTm material(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the OTm is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.The O_(2)permeation flux reached for the electrified membranes was~3.7 NmL min^(-1)cm^(-2),corresponding to the flux obtained with an OTm non-electrified at 900℃.The influence of depositing a porous Ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(CmR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect mixed ionic-electronic conductors Catalytic membrane reactors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aging impairs the osteocytic regulation of collagen integrity and bone quality

引用

Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman serra Kaya Neha Dole Nadja m.maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Simon melov Simon Tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Personalized nutrition to mitigate inflammation in genetically predisposed individuals: a secondary analysis of the Danish PREVENTOmICS intervention

引用

Food Science and Human Wellness 2024年

作者： Sebastià Galmés Andreu Palou-march Kristina Pigsborg mona Adnan Aldubayan Sophia m.O.Gormsen Alberto Calleja Joan Trabal Vanesa martínez Biotza Gutiérrez Josep m.Del Bas Faidon magkos Francisca serra Eurecat， Centre tecnològic de Catalunya， Biotechnology Area Avd Universitat 1 Laboratory of molecular Biology， Nutrition and Biotechnology (Nutrigenomics， Biomarkers and Risk Evaluation-NuBE)， University of the Balearic Islands Health Research Institute of the Balearic Islands (IdISBa) CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN)， Carlos III Health Institute (ISCIII) Alimentómica S.L.， Camí de na Pontons.s/n (Pol.11，Parc 3) Department of Nutrition， Exercise and Sports， Faculty of Science， University of Copenhagen Department of Clinical Nutrition， College of Applied medical Sciences， King Saud bin Abdulaziz University for Health Sciences R&D， Food & Culinary Department Simple Feast Leitat Technological Center C/Innovació 2 Creaciones Aromáticas Industriales SA， Cuatrecasas i Arumí， Sant Quirze del Valles

Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements. This study aimed to ascertain the utmost effectiveness of personalized interventions by aligning dietary adjustments with both the genotype and metabolotype of individuals. Therefore， we assessed here the usefulness of a polygenic score (PGS) characterizing a potential pro-inflammatory profile (PGSi) as a nutrigenetic tool to discern individuals from the Danish PREVENTOmICS cohort that could better respond to precision nutrition (PN) plans， specifically targeted at counteracting the low-grade inflammatory profile typically found in obesity. The cohort followed a PN plan to counteract the pro-inflammatory profile (PNi group) or generic dietary recommendations (Control) for 10 weeks. PGSi was applied for genetic stratification (Low/High). The effects of the intervention on anthropometrics and biomarkers related to inflammatory profile and carbohydrate metabolism were assessed. Around 30% of subjects had a high genetic predisposition to pro-inflammatory status (high-PGSi). These individuals demonstrated the most effective response to the dietary plan， experiencing improved body composition， with significant decreases in body weight (△: -4.84%; p=0.039) and body fat (△: -4.86%; p=0.007)， and beneficial changes in pro- and anti-inflammatory biomarkers， with significant increases in IL-10 (△: 71.3%; p=0.025) and decreases in TNF-α (△: -3.0%; p=0.048)， CRP (△: -31.1%)， ICAm1 (△: -5.8%)， and mCP1 (△: -4.2%) circulating levels， compared to low-PGSi individuals. Both phenotypic and genetic stratification contributed to a better understanding of metabolic heterogeneity in response to diet. This approach allows for refinement of the prediction of individual requirements and potentially for better management of obesity.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Atmospheric Pollutants in a Commercial Region of Fortaleza, Ceará, Brazil: Integration of Health, Environment and Economy in Urban Planning to Improve Air Quality

引用

Journal of Geoscience and Environment Protection 2024年第5期12卷 92-112页

作者： mônica Giovana Alves Cardoso Ratts Brenna Kessy Silva Lima Gilvan Ribeiro dos Santos Fladimir de Lima Gondim Rinaldo Santos Araújo mona Lisa moura de Oliveira Francisco Sales Ávila Cavalcante Daniel Silveira serra Science and Technology Center State University of Cear&#225 Cear&#225 Brazil Department of Chemistry and Environment Federal Institute of Cear&#225 Cear&#225 Brazil Center of Technological Sciences State University of Cear&#225 Cear&#225 Brazil

The accelerated growth of the vehicular fleet, the modernization of large urban centers, and the few adjustments to the road network in Fortaleza have intensified the problems of traffic and emissions of atmospheric pollutants, highlighting the necessity for strategic urban planning initiatives to address the escalating issues of traffic and pollution. With the objective of analyzing the indices of concentrations of atmospheric pollutants and estimating how these levels can affect human health, this work consists of a study of the analysis of air quality in the intense trade region of Fortaleza. For this, the analysis zone was divided into three perimeters (major - medium - minor), where each perimeter was analyzed at 7 am, 12 noon and 5 pm. Concentrations of the type of O3, particulate matter (Pm2.5 and Pm10), CO2 and HCHO were collected. Our results demonstrate that most of the analyses are within the limits of current legislation;however, at certain times and perimeters, the analyses of CO2 and HCHO exceeded the established limits. In view of the above, we conclude that public policies to control air quality are necessary to reduce the damage to human health and the environment caused by pollutants.

关键词： Air Quality Urban Planning Particulate material Health Impacts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solar-driven CO_(2) conversion to methane and methanol using different nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

引用

Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian D.moura Torquato Juliana Fde Brito Gustavo A.Andolpho mateus A.Gonçalves Leonardo D.De Angelis lucas D.Germano Susana I.Córdoba de Torresi Teodorico C.Ramalho maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of molecular modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μm cm^(-2))and 27.8%(50.4μm cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(GC-mS)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction DFT calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Viscoelastic models revisited:characteristics and interconversion formulas for generalized Kelvin-Voigt and maxwell models

引用

Acta mechanica Sinica 2019年第6期35卷 1191-1209页

作者： A.serra-Aguila J.m.Puigoriol-Forcada G.Reyes J.menacho Passive Safety Department Applus+IDIADA Spain Tarragona HQSanta OlivaL'AlbomarPO Box 2043710 TarragonaSpain IQS-School of Engineering Universitat Ramon LlullVia Augusta 39008017 BarcelonaSpain

Generalized Kelvin-Voigt and maxwell models using Prony series are some of the most well-known models to characterize the behavior of *** simulation software for viscoelastic materials generally implement only some material ***,for the practice of the engineer,it is very useful to have formulas that establish the equivalence between different *** the existence of these relationships is a well-established fact,moving from one model to another involves a relatively long *** article presents a development of the relationships between generalized Kelvin-Voigt and maxwell models using the aforementioned series and their respective relaxation and creep coefficients for one and two *** relationship between the singular points(maximums,minimums and inflexion points)is also included.

关键词： Viscoelasticity Dynamic mechanical analysis mechanical vibrations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases

引用

Neural Regeneration Research 2022年第4期17卷 741-747页

作者： serra Ozgen Judith Krigman Ruohan Zhang Nuo Sun Departments of Physiology and Cell Biology The Ohio State University Wexner Medical CenterColumbusOHUSA College of medicine Graduate Research in the Department of NeuroscienceThe Ohio State UniversityColumbusOHUSA Dorothy m.Davis Heart and Lung Research Institute The Ohio State University Wexner Medical CenterColumbusOHUSA College of Pharmacy Department of Graduate ResearchThe Ohio State UniversityColumbusOHUSA

mitochondria play a multidimensional role in the function and the vitality of the neurological *** the generation of neural stem cells to the maintenance of neurons and their ultimate demise,mitochondria play a critical role in regulating our neural pathways'homeostasis,a task that is critical to our cognitive health and neurological *** provide energy via oxidative phosphorylation for the neurotransmission and generation of an action potential along the neuron's *** paper will first review and examine the molecular subtleties of the mitochondria's role in neurogenesis and neuron vitality,as well as outlining the impact of defective mitochondria in neural *** authors will then summarize neurodegenerative diseases related to either neurogenesis or homeostatic *** of the significant detriment neurodegenerative diseases have on the quality of life,it is essential to understand their etiology and ongoing molecular *** mitochondrial role in neurogenesis and neuron vitality is *** and understanding this organelle's role in the genesis and homeostasis of neurons should assist in finding pharmaceutical targets for neurodegenerative diseases.

关键词： Alzheimer's disease autophagy mitochondria mitophagy neural stem cells neurodegenerative diseases neurogenesis Parkin Parkinson's disease PINK1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selective butyric acid production from CO_(2)and its upgrade to butanol in microbial electrosynthesis cells

引用

Environmental Science and Ecotechnology 2024年第1期17卷 119-127页

作者： meritxell Romans-Casas Laura Feliu-Paradeda michele Tedesco Hubertus V.m.Hamelers Lluis Bañeras m.Dolors Balaguer SebastiàPuig Paolo Dessì Institute of the Environment University of Girona.Campus MontiliviCarrer Maria Aurélia Capmany 69E-17003GironaSpain molecular microbial Ecology Group Institute of Aquatic EcologyUniversity of GironaMaria Aurelia Capmany 4017003GironaSpain Wetsus European Centre of Excellence for Sustainable Water TechnologyOostergoweg 98911MALeeuwardenthe Netherlands

microbial electrosynthesis(mES)is a promising carbon utilization technology,but the low-value products(i.e.,acetate or methane)and the high electric power demand hinder its industrial *** this study,electrically efficient mES cells with a low ohmic resistance of 15.7 mU m^(2)were operated galvanostatically in fed-batch mode,alternating periods of high CO_(2)and H2 *** promoted acetic acid and ethanol production,ultimately triggering selective(78%on a carbon basis)butyric acid production via chain *** average production rate of 14.5 g m^(-2)d^(-1)was obtained at an applied current of 1.0 or 1.5 mA cm^(-2),being megasphaera *** key chain elongating *** a second cell with the catholyte containing the enriched community resulted in butyric acid production at the same rate as the previous cell,but the lag phase was reduced by 82%.Furthermore,interrupting the CO_(2)feeding and setting a constant pH2 of 1.7e1.8 atm in the cathode compartment triggered solventogenic butanol production at a pH below *** efficient cell design resulted in average cell voltages of 2.6e2.8 V and a remarkably low electric energy requirement of 34.6 kWhel kg1 of butyric acid produced,despite coulombic efficiencies being restricted to 45%due to the cross-over of O_(2)and H2 through the *** conclusion,this study revealed the optimal operating conditions to achieve energy-efficient butyric acid production from CO_(2)and suggested a strategy to further upgrade it to valuable butanol.

关键词： Biocathode Bioelectrochemical system Chain elongation Hydrogen partial pressure megasphaera

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix

引用

World Journal of Gastroenterology 2009年第27期15卷 3431-3433页

作者： Khaled O Alsaad Stefano serra Runjan Chetty Depart-ment of Laboratory medicine and Pathobiology University of Toronto and University Health Network20 Elizabeth Street 11th Floor Eaton Wing Toronto Ontario M5G 2C4 Canada Department of Pathology and Laboratory medicine King Abdulaziz Medical City and College of Medicine King Saud bin Abdulaziz University for Health SciencesPO Box 22490 Riyadh 11426 MC 1122 Saudi Arabia

Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation. Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture. Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented. In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination.

关键词： Goblet cell carcinoid mucinous cystadenoma Vermiform appendix

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：