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Health Education for Chronic Obstructive Pulmonary Disease (COPD): Observational Study

Open Journal of Therapy and Rehabilitation 2020年第3期8卷 60-71页

作者： Leigiane Alves Cardoso Roberta Lins Gonçalves Fernanda Figuerôa Sanches Maria do Socorro Lucena Cardoso Wilson de Souza Nogueira Edson de Oliveira Andrade Erik Coelho da Costa Denilsi Gomes Gonçalves Jaqueline de Sousa Veras Barbosa lucas normando da silva Elvis Geanderson Lima do Vale Postgraduate Program in Communication Sciences (PPGCCOM-UFAM) Manaus Brazil The Federal University of Amazonas (UFAM) Manaus Brazil Neonatal Intensive Care The Federal University of Amazonas (UFAM) Manaus Brazil The Strictu Sensu Postgraduate Program in Health Sciences (PPGCIS-UFAM) Manaus Brazil Graduating in Physical Education The Federal University of Amazonas (UFAM) Manaus Brazil

Health Education has shown itself as essential for the understanding of individuals about psychological and physical changes caused by diseases. The chronic obstructive pulmonary disease (COPD) is a severe public health problem, and it depends on health education measures for its control. A group of patients with COPD, in pneumatological medical treatment, were investigated to find information about the disease. An observational, descriptive and analytical study with analysis and application of a semistructured questionnaire to evaluate the individuals’ knowledge about the COPD. Collected data were registered and analyzed using Google Docs. The software used for the calculation of statistical measures was Microsoft Excel®. For the research participants’ characterization analysis, the use of grouped data for the frequency distribution of Sturges Rule was necessary. This study provided knowledge about which information a group of bearers of COPD receives at a college hospital providing treatment. The interviewed have an average age of 70 years old and most are women with education level between elementary and high school and diagnose time of 6.dana;">8

关键词： COPD Health Education Pulmonary Rehabilitation Communicational Ecosystems

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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： daniella da silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix

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BIOCELL 2025年第1期49卷 109-125页

作者： RENATA da silva CARNEIRO MATEUS HENRIQUE DE ALMEIda da COSTA JOSÉZILTON LIMA VERDE SANTOS VALDILÉIA TEIXEIRA UCHÔA LUCIANO da silva LOPES ANDERSON NOGUEIRA MENDES Laboratory of Science in Innovation and Technology-LACITEC Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil Laboratory of Natural Products and Bioprospecting Natural Sciences CenterState University of PiauíTeresina64018Brazil Laboratory of Experimental Neurochemistry Research-LAPNEX Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil

Neurodegenerative diseases are a major public health challenge,mainly affecting the elderly population and compromising their cognitive,sensory,and motor ***,available therapies focus on alleviating symptoms and slowing the progression of these conditions,but they do not yet offer a definitive *** this scenario,terpenes emerge as promising natural alternatives due to their neuroprotective *** compounds can reduce the formation of protein aggregates,neutralize free radicals,and inhibit pro-inflammatory enzymes,which are crucial factors in the development of neurodegenerative *** addition,terpenes also play an important role in the regulation and remodeling of the extracellular matrix,a key target for improving neuronal *** such as linalool,pinene,and eugenol,among others,have potential therapeutic effects by modulating inflammatory and oxidative stress processes,the main factors that contribute to the progression of these *** suggest that these compounds act on signaling pathways that regulate the extracellular matrix,improving neuronal integrity and,consequently,cognitive and motor *** work aims to review the potential of terpenes in the treatment of neurodegenerative disorders,with emphasis on their ability to regulate oxidative stress and inflammation,as well as to remodel the extracellular *** interaction between these mechanisms points to the promising use of terpenes as an innovative and natural therapeutic approach to combat these diseases.

关键词： Terpenes Neurodegenerative Disorders Extracellular matrix

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Fast Coordinated Power Control for Improving Inertial and Voltage Support Capability of Battery Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 280-295页

作者： Zhen Gong Chengxi Liu Filipe Faria da silva Yonghao Gui Claus Leth Bak School of Electrical Engineering and Automation Wuhan UniversityWuhan430072China Department of Energy Technology Aalborg University9220 AalborgDemark Department of Electronic Systems Aalborg University9220 AalborgDenmark

This paper proposes a fast coordinated power control method based on two augmented channels(AC)in battery energy storage system(BESS)to improve inertial and voltage support capability,i.e.,a frequency-reactive power channel(FRPC)and a voltage-real power channel(VRPC).For frequency control in the power distribution system with high resistance/inductance ratio,the coupling mechanism between rate of change of frequency(RoCoF)and required reactive power(RRP)of grids is analyzed,indicating RoCoF is proportional to ***,RoCoF is utilized in FRPC to generate reactive power for complementary inertial emulating ***,for voltage control,coupling characteristics between rate of change of voltage(RoCoV)and demanding real power(DRP)of grids is also studied,revealing RoCoV is proportional to ***,it can be adopted in VRPC to generate real power for complementary voltage ***,grid-voltage-modulated direct power control is selected as the inner power control loop to track power references with faster dynamic performance compared with traditional vector-oriented ***,simulations and hardware-in-loop experiments validate improvement in performance of grid frequency and voltage control based on the proposed method.

关键词： Augmented channels direct power control frequency-reactive power channel(FRPC) inertial and voltage support voltage-real power channel(VRPC)

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Impact of curcumin on gut microbiome

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World Journal of Experimental Medicine 2025年第1期15卷 41-52页

作者： Sangeetha Balaji Naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Sathish Muthu Gabriel silva Santos lucas Furtado da Fonseca JoséFábio Lana Department of General Medicine Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Karpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia

The intricate interplay between natural compounds like curcumin and the gut microbiome has gained significant attention in recent years due to their potential therapeutic implications in various health ***,a polyphenolic compound derived from turmeric,exhibits diverse pharmacological properties,including anti-inflammatory,antioxidant,and anticancer *** how curcumin modulates gut microbiota composition and function is crucial for elucidating its therapeutic *** review examines the current literature on the interactions between curcumin and the gut microbiome.A systematic search of relevant databases was conducted to identify studies investigating the effects of curcumin on gut microbial diversity and *** findings from studies exploring curcumin's efficacy in neurological disorders,gastrointestinal diseases,and metabolic dysfunction are synthesized and *** have demonstrated that curcumin supplementation can modulate gut microbiota composition and function,leading to beneficial effects on gut health and *** underlying curcumin's therapeutic effects include immune modulation,neuroprotection,and inflammation ***,challenges such as poor bioavailability and safety concerns remain significant hurdles to *** interactions between curcumin and the gut microbiome hold promise for therapeutic interventions in a diverse range of health *** research is needed to optimize curcumin formulations,improve bioavailability,and address safety concerns.

关键词： Gut microbiome Curcumin Neuroprotection Bioavailability

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Importance of neonatal screening:A case study of sickle cell disease and cystic fibrosis coexistence

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World Journal of Clinical Pediatrics 2025年第1期14卷 113-118页

作者： Nathalia Noyma Sampaio Magalhães lucas Barra Mathiasi daniela de Oliveira Werneck Rodrigues Department of Pediatrics Faculdade de Ciências Médicas e da Saúde de Juiz de ForaJuiz de Fora 36033-003Brazil Department of Internal Medicine Rede D'Or Rio de JaneiroRio de Janeiro 22270-010Brazil Department of Hematology Fundação HemominasJuiz de Fora 36010-560MGBrazil Department of Internal Medicine Universidade Presidente Antônio Carlos-Faculdade de Medicina Juiz de ForaJuiz de Fora 36010-560Minas GeraisBrazil

BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other *** cell disea-se is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin *** is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane re-gulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface *** is crucial for early diagnosis and management,which ensures a better quality of *** To report a case of the coexistence of sickle cell anemia(SCA)and CF and perform an integrative literature *** This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical *** authors identified only 5 cases of SCA associated with *** clinical trials or review articles were identified considering the rarity of the coexistence of these two *** Herein,the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive *** diagnosis of CF was confirmed by the Coulometry Sweat *** rarity of the co-occurrence of these two severe genetic pathologies(CF and SCA)is a challenge for medical *** This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.

关键词： Sickle cell disease Sickle cell anemia Children Cystic fibrosis Neonatal Screening Case reports

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Ischemic colitis with small-vessel occlusion,simultaneous total colectomy and liver transplantation:A case report

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World Journal of Transplantation 2025年第2期15卷 337-343页

作者： Leonardo Yuri Kasputis Zanini Fabiana Roberto Lima Michel Ribeiro Fernandes Paola Sofia Espinoza Alvarez Marcello de Souza silva Antônio Paulo Ramos Martins Filho Tomazo Antonio Prince Franzini lucas Souto Nacif Department of Surgery Federal University of São PauloSão Paulo 04023-062Brazil Department of Liver and Gastrointestinal Transplant Hospital 9 de JulhoSão Paulo 01409-002Brazil Department of Pathology University of São Paulo School of MedicineSão Paulo 05403-900Brazil Department of Surgical Pathology Hospital 9 de JulhoSão Paulo 01409-002Brazil Department of Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Department of Endoscopy Hospital 9 de JulhoSão Paulo 01409-002Brazil

BACKGROUND The colon is the hollow viscera that proportionally has the lowest vascular supply and is more predisposed to ischemic *** the context of end-stage liver disease,various components may explain this group's greater predisposition to colonic ischemic ***,portal hypertension generates a process of coagulopathy,impairing local *** case report describes a case of ischemic colitis with small-vessel occlusion found during liver transplantation in a patient with decompensated end-stage liver *** SUMMARY A 64-year-old man with liver cirrhosis due to non-alcoholic steatohepatitis and hepatocellular *** patient underwent liver transplantation due to hepatic *** donor was a 53-year-old man who had died of a hemorrhagic *** examination revealed diffuse ischemic colitis with significant distention and *** to the condition of the colon,a subtotal colectomy was *** transplantation with warm ischemia time of 35 minutes,cold ischemia of 6 hours 30 minutes and total ischemia time of 7 hours 5 *** patient improved clinically with oral tract function and physiotherapy,but unfortunately,he developed a bloodstream infection,a new septic shock and died six months after *** Simultaneous total colectomy and orthotopic liver transplantation represent a rare *** events have a high mortality rate in the general population and are particularly important in cirrhotic patients.

关键词： Ischemic colitis Liver transplantation End-stage liver disease Acute-on-chronic liver failure Case report

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Toxicological effects of mining hazard elements

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Energy Geoscience 2022年第3期3卷 255-262页

作者： Leonardo lucas da silva-Rego Leonardo Augusto de Almeida Juciano Gasparotto Instituto de Ciencias Biomedicas-Universidade Federal de Alfenas AlfenasMinas GeraisRua Gabriel Monteiro da Silva700CEP:37130-001Centro-Alfenas/MGBrazil

Mining plays a prominent role in the economy worldwide since human efforts have been more concentrated in extraction than recycling of natural *** composed of various minerals vary according to the geological *** are raw materials for the conventional industries or fossil fuels for power *** can also be used in new *** mining industry triggers intense environmental *** exposure to multiple small particles from mining effluent,such as dust,uranium,iron,lead,zinc,silicon,titanium,sulfur,nitrogen,platinum,chromium,vanadium,manganese,and mercury,is a health *** elements can have several pathological effects,such as respiratory and cardiovascular,multiple chronic inflammation,and neurodegenerative ***,mining results in severe soil,water(surface and aquifer),and air contamination,reaching large areas far away from the *** of mining companies,with the recovery of ancient mined areas during the early development of environmental laws and regulations,compromises environmental integrity for more extended periods,increasing coverage of the affected *** review evaluates the toxicological effects on humans exposed to the mining wastes and the impact of these compounds on the *** results of our evaluation can be used by the government,manufacturers,scientists,private environmental organizations,decision-makers,and readers from different areas of knowledge to explore the potential risk of mining to the ecosystem and human health.

关键词： Mining operation Toxicology Environmental impact Ecosystem Human health

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Oregano and Rosemary Essential Oils in Collagen Fiber and Polyvinyl Alcohol Films: Application as Biodegradable Active Packaging for Ready-to-Eat Meat Products

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Food and Nutrition Sciences 2025年第1期16卷 1-27页

作者： Suslin Raatz Thiel Cássio Poerschke Rodrigues José Dilson Francisco da silva Mari Silvia Rodrigues de Oliveira Stephanie Reis Ribeiro Rosa Cristina Prestes Ernesto Hashime Kubota Roger Wagner Renius Mello Department of Food Science and Technology Universidade Federal de Santa Maria Rio Grande do Sul Brazil

Developing packaging using biomaterials offers a solution to the problem of solid plastic waste in urban areas. However, selecting suitable materials remains challenging, particularly when the packaging is intended for food products with high moisture content, such as meat. In response to this challenge, a novel film comprising a blend of collagen fiber and polyvinyl alcohol, supplemented with varying concentrations of oregano and rosemary essential oils, was developed. The mechanical properties, in vitro antioxidant activity, and chemical composition of these collagen fiber and polyvinyl alcohol films, enhanced with oregano and rosemary essential oils, were thoroughly characterized. The compounds γ-terpinene and ρ-cymene played a significant role in the antioxidant activity of the packaging. The impact of this active packaging on the quality of sliced mortadella was evaluated over 0, 3, 6, and 9 days of refrigeration. Time significantly influenced most of the variables examined. The concentration of essential oils (0%, 2%, 4%, and 6%) significantly affected the moisture level, water activity, pH, and Escherichia coli count in the packaged product. For lipid oxidation analysis, the type of essential oil proved significant, with oregano essential oil demonstrating superior activity. A pro-oxidant effect was noted in products with 6% rosemary essential oil. Packages containing essential oils from oregano and rosemary exhibited lower E. coli counts. Films enriched with essential oils showed a higher rate of biodegradation.

关键词： Lipid Oxidation Escherichia coli Principal Component Analysis Bioactive Compounds Shelf Life Mechanical Properties

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