检索结果-南通市图书馆

MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2016年第1期8卷 18-29页

作者： yasmin g hernandez aimee l lucas department of internal medicine icahn school of medicine at mount sinaiNew YorkNY 10029United States henry janowitz division of gastroenterology icahn school of medicine at mount sinaiNew YorkNY 10029United States

Pancreatic ductal adenocarcinoma(PDAC) is the 4^(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions(PanIN), intraductual papillary mucinous neoplasm(IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage Ⅳ to 50% for Stage Ⅰ. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs(miRNA) are small noncoding RNAs(18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA(mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four mi RNA biomarkers(miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miR NA dysregulation in PDAC and its precursor lesions, and advances that have been made in using miRNA as a biomarker for PDAC and its precursor lesions.

关键词： Pancreatic cancer MicroRNA Biomarkers Pancreatic intraepithelial lesions Intraductal papillarymucinous neoplasm

Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第32期20卷 11182-11198页

作者： Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee l lucas Henry D. Janowitz Division of Gastroenterology Icahn School of Medicine at Mount Sinai New York NY 10029 United States Division of Digestive and liver Diseases Columbia University College New York NY 10032 United States

Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields.

关键词： Pancreatic neoplasms Pancreas cancer screening Genetic predisposition to disease Hereditary breast and ovarian cancer syndrome lynch syndrome Peutz-Jeghers BRCA PAlB2 p16 Pancreatitis

Wild bacterial probiotics fed to larvae of mass-reared Queensland fruit fly[Bactrocera tryoni(Froggatt)]do not impact long-term survival,mate selection,or locomotor activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2020年第4期27卷 745-755页

作者： lucas A.Shuttleworth Mohammed Abul Monjur Khan Damian Collins Terry Osborne Olivia l.Reynolds New South Wales Department of Primary Industries Elizabeth Macarthur Agricultural InstituteMenangleAustralia Faculty of Agriculture DefDartment of EntomologyBangladesh Agricultural UniversityMymensinghBangladesh Graham Centre(an alliance between NSW Department of Primary Industries and Charles Sturt University) Wagga WaggaNew South WalesAustralia State Key laboratory of Ecological Pest Control for Fujian and Taiwan Crops Institute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhouChina

Queensland fruit fly[Bactrocera Uyoni(Froggatt),Diptera,Tephritidae]is the most devastating insect pest impacting Australian *** Sterile Insect Technique(SIT)is an important component of tephritid pest management ***,mass-rearing and irradiation(to render insects sterile)may reduce the fitness and performance of the insect,including the ability of sterile males to successfully compete for wild *** of the gut microbiome,including the supplementation with bacterial probiotics shows promise for enhancing the quality of mass-reared sterile flies,however there are fewer published studies targeting the larval *** this study,we supplemented the larval stage of mass-reared *** with bacterial *** tested several individual bacteria that had been previously isolated and characterized from the gut of wild *** larvae including Asaia sp.,Enterobacter sp.,lactobacillus sp.,leuconostoc *** also tested a consortium of all four of these bacterial *** fitness parameters tested included adult survival in field cages,laboratory mate selection of bacteria supplemented males by bacteria nonsupplemented females,and laboratory locomotor activity of adult *** of the bacterial probiotic treatments in the current study was significantly different to the control for field survival,mate selection or locomotor activity of adult ***,which agree with some of the other studies regarding bacterial probiotics fed to the larval stage of *** work is needed to determine if feeding the same,and/or other probiotics to adults,as opposed to larvae can positively impact survival,mating performance,mating competitiveness and locomotor activity of *** bacterial group(s)and function of bacterial species that increase fitness and competitiveness is also of interest to tephritid mass-rearing programs.

关键词： area wide integrated pest management mass-rearing mate choice Sterile Insect Technique Tephritidae

larval development and voracity of Eupeodes americanus (Diptera: Syrphidae): comparison of the focal prey Aphis gossypi (Hemiptera: Aphididae) and the banker prey Rhopalosiphum padi (Hemiptera: Aphididae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第2期31卷 575-586页

作者： Arlette Fauteux Antonio Onofre Soares Eric lucas laboratoire de lutte biologique Departement des sciences biologiquesUniversite du Quebec a Montreal(UQAM)MontrealQuebecCanada Faculty of Science and Technology Center for Ecology Evolution and Environmental ChangesAzorean Biodiversity Group(cE3c-ABG)&CHANGE-Global Change and Sustainability InstitutePonta DelgadaPortugal

Unlike European species,the potential of Nearctic syrphids as biological control agents is still poorly ***,the American hoverfly,Eupeodes americanus(Wiedemann),has recently demonstrated promising traits as a biocontrol agent,notably against the foxglove aphid,Aulacorthum solani Kaltenbach,on *** present study aims to extend our knowledge of the American hoverfly by evaluating its potential as a biocontrol agent in a banker plant system against the melon aphid,Aphis gossypi Glover,in a greenhouse cucumber *** preimaginal development and voracity of *** were compared when preying upon the focal prey/pest(***)or the banker prey(bird cherry-oat aphid,Rhopalosiphum padi l.)by daily observations of larvae from egg to *** development time,survival rate,and occurrence of deformation were similar on both prey *** weight of third instar and pupae,however,was higher for larvae that fed on the banker *** ad libitum voracity of the syrphid larvae was generally very high and did not significantly differ between prey species,except for the third-instar larvae which consumed more focal *** suggest that a banker plant system involving the bird cherry-oat aphid may be a promising tactic for utilizing *** for melon aphid biocontrol.

关键词： american hoverfly banker plant system biological control bird cherry-oat aphid greenhouse cucumber melon aphid

Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第6期13卷 1036-1045页

作者： Sarah E.Walker Rachel Nottrodt lucas Maddalena Christopher Carter Gaynor E.Spencer Robert l.Carlone Department of Biological Sciences Brock University Department of Geosciences University of Calgary Biomedical Sciences Cambridge University Pre-Health Sciences Department Niagara College

Some adult vertebrate species,such as newts,axolotls and zebrafish,have the ability to regenerate their central nervous system（CNS）.However,the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not well *** evidence supports a role for retinoid signaling in the intrinsic ability of neurons,in these regeneration-competent species,to regrow after CNS ***,we demonstrated that a specific retinoic acid receptor（RAR）subtype,RARβ,mediates the effects of endogenous retinoic acid（RA）on neuronal growth and guidance in the adult newt CNS after ***,we now examine the expression of the retinoid X receptor RXRα（a potential heterodimeric transcriptional regulator with RARβ）,in newt tail and spinal cord *** show that at 21 days post-amputation（dpa）,RXRαis expressed at temporally distinct periods and in non-overlapping spatial domains compared to RARβ.Whereas RARβprotein levels increase,RXRαproteins level decrease by 21 dpa.A selective agonist for RXR,SR11237,prevents both this downregulation of RXRαand upregulation of RARβand inhibits tail and caudal spinal cord ***,treatment with a selective antagonist for RARβ,lE135,inhibits regeneration with the same morphological consequences as treatment with ***,lE135 treatment also inhibits the normal downregulation of RXRαin tail and spinal cord tissues at 21 *** results reveal a previously unidentified,indirect regulatory feedback loop between these two receptor subtypes in regulating the regeneration of tail and spinal cord tissues in this regeneration-competent newt.

关键词： retinoid X receptor spinal cord regeneration newt retinoic acid ependymoglia retinoic acid receptor

Phloem-Mobile AuxlIAA Transcripts Target to the Root Tip and Modify Root Architecture

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2012年第10期54卷 760-772页

作者： Michitaka Notaguchi Shmuel Wolf William J.lucas Department of Plant Biology College of Biological SciencesUniversity of CaliforniaDavisCA 95616USA JST ERATO Higashiyama live-Holonics Project Nagoya UniversityFuro-choChikusa-kuNagoyaauAichi 464-8602Japan The Robert H.Smith Institute of Plant Sciences and Genetics in Agriculture and the Otto Warburg Minerva Center for Agricultural Biotechnology The Hebrew University of JerusalemThe Robert H.Smith Faculty of AgricultureFood and EnvironmentRehovot 76100Israel

In plants, the phloem is the component of the vascular system that delivers nutrients and transmits signals from mature leaves to developing sink tissues. Recent studies have identified proteins, mRNA, and small RNA within the phloem sap of several plant species. It is now of considerable interest to elucidate the biological functions of these potential long-distance signal agents, to further our understanding of how plants coordinate their developmental programs at the whole-plant level. In this study, we developed a strategy for the functional analysis of phloem-mobile mRNA by focusing on IAA transcripts, whose mobility has previously been reported in melon （Cucumis melo cv. Hale＇s Best Jumbo）. Indoleacetic acid （IAA） proteins are key transcriptional regulators of auxin signaling, and are involved in a broad range of developmental processes including root development. We used a combination of vasculature-enriched sampling and hetero-grafting techniques to identify IAA18 and IAA28 as phloemmobile transcripts in the model plant Arabidopsis thaliana. Micro-grafting experiments were used to confirm that these IAA transcripts, which are generated in vascular tissues of mature leaves, are then transported into the root system where they negatively regulate lateral root formation. Based on these findings, we present a model in which auxin distribution, in combination with phloem-mobile Aux/IAA transcripts, can determine the sites of auxin action.

关键词： Arabidopsis AUX/IAA lateral root development grafting phloem-mobile transcript.

Gas-phase electrocatalytic conversion of CO_2 to chemicals on sputtered Cu and Cu–C catalysts electrodes

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第4期28卷 46-53页

作者： N.Gutiérrez-Guerra J.A.González J.C.Serrano-Ruiz E.lópez-Fernández J.l.Valverde A.de lucas-Consuegra Departamento de Ingeniería Química Facultad de Ciencias y Tecnologías Químicas Universidad de Castilla-La Mancha Instituto Regional de Investigación Científica Aplicada (IRICA) and Departamento de Física Aplicada Universidad de Castilla-La Mancha Departamento de Ingeniería Universidad Loyola Andalucía

A novel gas-phase electrocatalytic cell containing a low-temperature proton exchange membrane(PEM)was developed to electrochemically convert CO_2into organic *** different Cu-based cathode catalysts(Cu and Cu–C)were prepared by physical vapor deposition method(sputtering)and subsequently employed for the gas-phase electroreduction of CO_2at different temperatures(70–90°C).The prepared electrodes Cu and Cu–C were characterized by X-ray diffraction(XRD),X-ray photoemission spectroscopy(XPS)and scanning electron microscopy(SEM).As revealed,Cu is partially oxidized on the surface of the samples and the Cu and Cu–C cathodic catalysts were comprised of a porous,continuous,and homogeneous film with nanocrystalline Cu with a grain size of 16 and 8 nm,*** influence of the applied current and temperature on the electro-catalytic activity and selectivity of these materials was *** the two investigated electrodes,the pure Cu catalyst film showed the highest CO_2specific electrocatalytic reduction rates and higher selectivity to methanol formation compared to the Cu–C electrode,which was attributed to the higher particle size of the former and lower Cu O/Cu *** obtained results show potential interest for the possible use of electrical renewable energy for the transformation of CO_2into valuable products using low metal loading Cu based electrodes(0.5 mg Cu cm^(-2))prepared by sputtering.

关键词： CO_2 valorization Electro-reduction Cu catalyst PEM Selectivity Methanol production

Molecular mechanisms underlying phosphate sensing, signaling, and adaptation in plants

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2014年第3期56卷 192-220页

作者： Zhaoliang Zhang Hong liao William J.lucas Department of Plant Biology College of Biological Sciences University of California State Key laboratory for Conservation and Utilization of Subtropical Agro‐Bioresources Root Biology Center South China Agricultural University

As an essential plant macronutrient, the low availability of phosphorus （P） in most soils imposes serious limitation on crop production. Plants have evolved complex responsive and adaptive mechanisms for acquisition, remobilization and recycling of phosphate （Pi） to maintain P homeostasis. Spatio-temporal molecular, physiological, and biochemical Pi deficiency responses developed by plants are the consequence of local and systemic sensing and signaling pathways. Pi deficiency is sensed locally by the root system where hormones serve as important signaling components in terms of developmental reprogramming, leading to changes in root system architecture. Root-to-shoot and shoot-to-root signals, delivered through the xylem and phloem, respectively, involving Pi itself, hormones, miRNAs, mRNAs, and sucrose, serve to coordinate Pi deficiency responses at the whole-plant level. A combination of chromatin remodeling, transcriptional and posttranslational events contribute to globally regulating a wide range of Pi deficiency responses. In this review, recent advances are evaluated in terms of progress toward developing a comprehen- sive understanding of the molecular events underlying control over P homeostasis. Application of this knowledge, in terms of developing crop plants having enhanced attributes for P use efficiency, is discussed from the perspective of agricultural sustainability in the face of diminishing global P supplies.

关键词： Adaptation crop engineering strategies hormone networks local and long-distance sensing phosphate P use efficiency stress responses systemic signaling transcriptional regulation transport systems

Satellite-enabled enviromics to enhance crop improvement

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende lee Hickey Cibele H.Amaral lucas l.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil TheCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(liDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information