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Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population

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World Journal of Gastroenterology 2013年第13期19卷 2060-2064页

作者： Emiliano de Carvalho Almodova Walmar Kerche de Oliveira lucas faria Abraho machado Juliana Rigotto Grejo Thiago Rabelo da Cunha Wagner Colaiacovo Erika Veruska Paiva Ortolan Endoscopy Department Cancer Hospital of Barretos Surgery Post Graduate Course Botucatu Medical SchoolState of Sao Paulo University Surgery and Orthopedics Department Botucatu Medical SchoolState of Sao Paulo University Pathology Department Cancer Hospital of Barretos Endoscopy Department Botucatu Medical SchoolState of Sao Paulo University

AIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and *** cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/ year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate condition

关键词： Atrophic gastritis Esophagus Squamous cell carcinoma Risk factor Alcohol Tobacco

HER2 in gastric cancer: Comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays

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World Journal of Gastroenterology 2013年第38期19卷 6438-6446页

作者： lucas faria Abraho-machado Alexandre Andrade dos Anjos Jácome Durval Renato Wohnrath José Sebastio dos Santos Estela Cristina Carneseca José Humberto Tavares Guerreiro Fregnani Cristovam Scapulatempo-Neto Department of Pathology Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Department of Clinical Oncology Mater Dei HospitalBelo HorizonteMinas Gerais 30140-092Brazil Department of Gastrointestinal Surgical Oncology Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Department of Surgery and Anatomy University of S o Paulo-Ribeir o Preto School of MedicineRibeir o PretoSao Paulo 14049-900Brazil Biostatistician at Cancer Registry Department Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Researcher Support Center Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil

AIM:To compare the performance of three commercially available anti-human epidermalgrowth factor receptor 2(HER2)antibodies in whole-tissue sections and tissue microarrays(TMAs)of a series of gastric ***:We present a comparative analysis of three anti-HER2 antibodies(HercepTest,4B5 and SP3)using TMA and whole-tissue sections prepared from the same paraffin blocks of 199 gastric adenocarcinomas operated upon between January 2004 and December2008 at a Brazilian cancer *** data on the patients’age,sex,the anatomical location of the tumor and the Lauren’s histological classification were collected from clinical and pathological *** immunohistochemical(IHC)results were examined by two pathologists and the cases were classified as positive(3+),equivocal(2+)and negative(0 or 1+),according to the criteria of the IHC scoring system of gastric *** and whole-tissue sections were evaluated separately and *** cases yielding discordant IHC results and/or scored as 2+were subjected to dual-color in situ hybridization in order to determine the final HER2 *** determining the sensitivity and predictive value for HER2-positive status,we measured the accuracy of each antibody by calculating the area under the receiver operating characteristic(ROC)*** agreement between the results obtained using the TMAs and those obtained using the whole-tissue sections was assessed by means of Kappa ***:Intratumoral heterogeneity of HER2 expression was observed with all ***2-positive expression(3+)in the whole-tissue sections was observed in 23 cases(11.6%)using the 4B5 antibody,in 18 cases(9.1%)using the SP3 antibody and in 10 cases(5.1%)using the HercepTest *** the TMAs,11 positive cases(5.6%)were identified using SP3 antibody,9(4.6%)using the 4B5 antibody and 6(3%)using the HercepTest *** sensitivity using whole-tissue sections and TMA,respectively,was 95.2%and 42.9%with 4B5,90.5%and 66.7%

关键词： Gastric cancer Human epidermalgrowth factor receptor 2 Immunohistochemistry Whole-tissue sections Tissue microarray Trastuzumab

Distributed Energy Resource Scheduling with Focus on Demand Response Complex Contracts

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1172-1182页

作者： Pedro faria Zita Vale GECAD–Research Group on Intelligent Engineering and Computing for Advanced Innovation and Development R.Dr.António Bernardino de Almeida4314249-015PortoPortugal Polytechnic of Porto R.Dr.António Bernardino de Almeida4314249-015PortoPortugal

Demand response(DR)is a flexible way to improve distributed energy resource *** innovative contribution of this paper is to include complex contracts in the model,which can accommodate the constraints according to the special expectations of each *** contracts are included in the optimization of distributed energy resource scheduling to dispatch DR according to the expectations of ***-period DR events are *** this way,consumers can specify the limits on the time,power,and remuneration regarding participation in DR events,which has not been considered in the *** state of the art treats these aspects separately or uses a statistical approach,without providing consumers with options to combine their preferences regarding different aspects of their flexibility *** model has been validated for 218 consumers using several scenarios and different types of distributed generation,showing that it is possible to increase DR with respect to the preferences of consumers.

关键词： Complex contracts demand response distributed generation virtual power player

Multiple Tuned Mass Damper Based Vibration Mitigation of Offshore Wind Turbine Considering Soil–Structure Interaction

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China Ocean Engineering 2017年第4期31卷 476-486页

作者： Mosaruf HUSSAN faria SHARMIN Dookie KIM Department of Civil Engineering Kunsan National University 558 Daehak-ro Kunsan Jeonbuk 54150 Republic of Korea

The dynamics of jacket supported offshore wind turbine （OWT） in earthquake environment is one of the progressing focuses in the renewable energy field. Soil-structure interaction （SSI） is a fundamental principle to analyze stability and safety of the structure. This study focuses on the performance of the multiple tuned mass damper （MTMD） in minimizing the dynamic responses of the structures objected to seismic loads combined with static wind and wave loads. Response surface methodology （RSM） has been applied to design the MTMD parameters. The analyses have been performed under two different boundary conditions： fixed base （without SSI） and flexible base （with SSI）. Two vibration modes of the structure have been suppressed by multi-mode vibration control principle in both cases. The effectiveness of the MTMD in reducing the dynamic response of the structure is presented. The dynamic SSI plays an important role in the seismic behavior of the jacket supported OWT, especially resting on the soft soil deposit. Finally, it shows that excluding the SSI effect could be the reason of overestimating the MTMD performance.

关键词： soil-structure interaction multiple tuned mass damper vibration control response surface method jacket supported offshore wind turbine

Myelin positron emission tomography(PET) imaging in multiple sclerosis

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Neural Regeneration Research 2020年第10期15卷 1842-1843页

作者： Daniele de Paula faria Laboratory of Nuclear Medicine (LIM-43) Departamento de Radiologia e Oncologia Faculdade de Medicina Universidade de Sao Paulo

Multiple sclerosis(MS)is a neurodegenerative disease characterized by inflammation and *** are focused on encountering remyelination therapies that can be applied to delaying,or even decreasing,the motor and cognitive disabilities caused by the *** cellular/molecular changes in MS are dynamic,with inflammation,demyelination and remyelination inducing progressive neurodegenerative changes in the central nervous system,as a ***,the imaging methods for accompanying the process are,as yet,shortcoming.

关键词： inflammation sclerosis myelin

Jonathan C. Gold, Paving the Great Way： Vasubandhu＇s Unifying Buddhist Philosophy （edited by Joseph A. faria）

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Frontiers of Philosophy in China 2015年第3期10卷 517-521页

作者： Joseph A. faria Kathmandu University

Vasubandhu （fourth-fifth century C.E.） is undoubtedly one of the most influential Buddhist scholars to have appeared on the Indian sub-continent.

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Designing and Evaluating a Collaborative Knowledge Management Framework for Leaf Disease Detection

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Computer Systems Science & Engineering 2022年第8期42卷 751-777页

作者： Komal Bashir Mariam Rehman Afnan Bashir faria Kanwal Department of Computer Science Lahore College for Women UniversityLahore54000Pakistan Department of Information Technology Government CollegeFaisalabad54000Pakistan Engage Research Lab School of Law and SocietyUniversity of the Sunshine CoastSippy DownsQLD 4556Australia

Knowledge Management(KM)has become a dynamic concept for inquiry in *** management of knowledge from multiple sources requires a systematic approach that can facilitate capturing all important aspects related to a particular discipline,several KM frameworks have been designed to serve this *** research aims to propose a Collaborative Knowledge Management(CKM)Framework that bridges gaps and overcomes weaknesses in existing *** paper also validates the framework by evaluating its effectiveness for the agriculture sector of Pakistan.A software LCWU aKMS was developed which serves as a practical implementation of the concepts behind the proposed CKMF *** aKMS served as an effective system for rice leaf disease detection and *** aimed to enhance CKM through knowledge sharing,lessons learned,feedback on problem resolutions,help from co-workers,collaboration,and helping *** were collected from 300 rice crop farmers by questionnaires based on *** Olfman model was used to estimate the effectiveness of *** tests were performed including frequency measures of variables,Cronbach’s alpha reliability,and Pearson’s *** research provided a KMS depicting KM and collaborative *** disease detection module was evaluated using the precision and recall method and found to be 94.16%*** system could replace the work of extension agents,making it a cost and time-effective initiative for farmer betterment.

关键词： Collaborative knowledge management framework jennex olfman km success model knowledge management rice disease detection

Particulate matter characterization in a steelworks using conventional sampling and innovative lidar observations

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Particuology 2016年第5期14卷 43-51页

作者： Benjamin Guinot Beatriz Gonzalez Julia Perim De faria Sumita Keclia Laboratoire d'Aerologie Universite de Toulouse CNRS Universite Paul-Sabatier 14 Avenue Edouard-Belin 31400 Toulouse France

Particulate matter （PM） emissions from steelworks cause public concern. Although end-of-pipe and pro- cess integrated measures have led to a significant drop in emissions of large particles from stacks, fine aerosols were not specifically considered, nor were emissions from fugitive and open sources. In this study, we deployed aerosol samplers together with a scanning ultra-violet （UV） lidar to characterize total suspended particles （TSP）, PM10, and PM2.5, in emissions from a large integrated steelworks in Spain over a 16-day period. We determined the content of carbonaceous, soluble inorganic, mineral dust, and metal species. A positive matrix factorization was carried out on our dataset. Despite mineral dust being predominant in all size fractions, the steelworks was clearly a source of carbonaceous species, resulting in production of secondary inorganic aerosols. In particular, stack emissions were a major contributor of fine particles, while open sources dominated the emissions of TSP, yielding up to 80% of particles larger than PM10. UV lidar provided 2D maps of aerosols in real time, with an ability to detect PM emissions and to visualize complex plumes. We suggest that air quality management of steelworks needs to focus on controlling large and coarse oarticle emissions, esoeciallv those from onen sources.

关键词： Fine aerosols Fugitive emissions Open sources Chemical composition Trace metals UV lidar

Herbivore performance and plant defense after sequential attacks by inducing and suppressing herbivores

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Insect Science 2019年第1期26卷 108-118页

作者： Elisa faria de Oliveira Angelo Pallini Arne Janssen Department of Entomology Federal University of VicosaVicosaMGBrazil Department of Entomology Federal University of Lavras LavrasMGBrazil Section Population Biology Institute for Biodiversity and Ecosystem DynamicsUniversity of Amsterdam Amsterdamthe Netherlands

It is well known that herbivore-induced plant defenses alter host plant quality and can affect the behavior and performance of later arriving *** of sequential attacks by herbivores that either suppress or induce plant defenses are less well *** sequentially infested leaves of tomato plants with a strain of the phytophagous spider mite Tetranychus urticae that induces plant defenses and the closely related Tetranychus evansi, which suppresses plant *** quality was quantified through oviposifion of both spider mite species and by measuring proteinase inhibitor activity using plant material that had been sequentially attacked by both herbivore ***-mite oviposifion data show that *** could suppress an earlier induction of plant defenses by ***,and *** could induce defenses in plants previously attacked by *** in 1 *** attacks by the second species did not result in further changes in *** inhibitor activity levels showed that *** suppressed the high activity levels induced by *** to constitutive levels in 1 day,and further suppressed activity to levels similar to those in plants attacked by *** *** by *** induced proteinase inhibitor activity in plants previously attacked by ***,eventually to similar levels as induced by *** ***,plant quality and plant defenses were significantly affected by sequential attacks and the order of attack does not affect subsequent performance,but does affect proteinase inhibitor activity *** on our results,we discuss the evolution of suppression of plant defenses.

关键词： plant defense plant-herbivore interactions plant quality sequential attack Tetranychus evansi Tetranychus urticae