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Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease

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Neuroscience Bulletin 2020年第11期36卷 1299-1314页

作者： Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro lucas bonfim marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich Department of Biochemistry Institute of ChemistryUniversity of Sao PauloAv.Prof.Lineu Prestes 74&Sao PauloSP 05508-000Brazil Key Laboratory of Sichuan Province for Acupuncture and Chronobiology Chengdu 610075China Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Sechenov First Moscow State Medical University Moscow 119992Russia Rudolf-Boehm-Institut ftir Pharmakologie und Toxikologie Universitat LeipzigLeipzig 04107Germany International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China

Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,*** review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative *** adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor ***,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor *** interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal ***,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD.

关键词： Purinergic receptor Central nervous system Huntington’s disease Parkinson’s disease 6-hydroxydopamine

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Diversity of filamentous fungi in leaf litter and aerial litter in semideciduous forest,Bahia,Brazil

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Journal of Forestry Research 2015年第2期26卷 479-485页

作者： Marcos Fabio Oliveira marques Edemir Barbosa dos Santos Luis Fernando Pascholati Gusmaao Laborato rio de Biologia Molecular de Fungos Universidade do Estado da BahiaCampus VIIBr 407Km 127Rod.Lomanto JuoniorSenhor do BonfimBA 44230-000Brazil Laboratorio de Micologia (LAMIC) Universidade Estadual de Feira de SantanaCaixa Postal 252Feira de SantanaBA 44036-900Brazil

The fungi have wide distribution in ecosystems and can be found colonizing various substrates,where they act as efficient decomposers,participating in cycling of *** present study aimed to assess the diversity,richness and composition of filamentous fungi in leaf litter and aerial litter in a semi-deciduous forest in the Chapada Diamantina,Bahia,*** of leaf litter and aerial litter were collected monthly from October/2009 to September/2010 in eight installments in the studied *** samples were washed,placed in moist chambers and incubated.47 taxa were identified,37 in leaf litter and 35 in aerial litter,with 25 species common to both.A similarity of 69 % according to Sorensen *** similarity was considered low when the sample points were compared to the same *** fungi showed sporadic intervals.

关键词： Plant debris Species richness Tropical microfungi

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Sebacina aureomagnifica(Sebacinales,Basidiomycota):an unexpected discovery from the Brazilian Caatinga

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Studies in Fungi 2017年第1期2卷 157-161页

作者： Wartchow F SáMCA Conceição LB Silva DRC marques MFO Universidade Federal da Paraíba Departamento de Sistemática e Ecologia/CCENCEP:58051-900João PessoaPBBrazil Universidade Federal do Rio Grande do Norte Departamento de Botânica e ZoologiaPós-Graduação em Sistemática e EvoluçãoCampus UniversitárioLagoa NovaCEP 59072-970NatalRNBrazil Universidade Estadual de Feira de Santana Departamento de Ciência BiológicasPrograma de Pós-Graduação em BotânicaAvenida Transnordestinas/nNovo Horizonte44036-900Feira de SantanaBrazil Universidade do Estado da Bahia Departamento de EducaçãoCampus VIIRod.Lomanto JúniorBr 407Km 127CEP:48970-000Senhor do BonfimBABrazil

Sebacina aureomagnifica,recently described from Atlantic Forest is recorded for the first time from the Brazilian Caatinga Biome of Bahia,*** description,photographs of the basidiome,drawings of the microstructures an... 详细信息

关键词： Agaricomycetes Neotropic Sebacinaceae taxonomy

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