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Treatment options for localised renal cell carcinoma of the transplanted kidney

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World Journal of Transplantation 2020年第6期10卷 147-161页

作者： Gloria Motta Mariano Ferraresso luca Lamperti Dhanai di paolo Nicholas Raison Marta Perego Evaldo Favi Urology IRCCS Policlinico San DonatoSan Donato Milanese 27288Italy Renal Transplantation Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy Department of Clinical Sciences and Community Health University of MilanMilan 20122Italy MRC Centre for Transplantation King’s College LondonLondon WC2R 2LSUnited Kingdom

Currently,there is no consensus among the transplant community about the treatment of renal cell carcinoma(RCC)of the transplanted *** recently,graftectomy was universally considered the golden standard,regardless of the characteristics of the *** to the encouraging results observed in native kidneys,conservative options such as nephron-sparing surgery(NSS)(enucleation and partial nephrectomy)and ablative therapy(radiofrequency ablation,cryoablation,microwave ablation,high-intensity focused ultrasound,and irreversible electroporation)have been progressively used in carefully selected recipients with early-stage allograft *** reports show excellent patient survival,optimal oncological outcome,and preserved renal function with acceptable complication ***,the rarity and the heterogeneity of the disease,the number of options available,and the lack of long-term follow-up data do not allow to adequately define treatment-specific advantages and *** role of active surveillance and immunosuppression management remain also *** order to offer a better insight into this difficult topic and to help clinicians choose the best therapy for their patients,we performed and extensive review of the *** focused on epidemiology,clinical presentation,diagnostic work up,staging strategies,tumour characteristics,treatment modalities,and follow-up *** research confirms that both NSS and focal ablation represent a valuable alternative to graftectomy for kidney transplant recipients with American Joint Committee on Cancer stage T1aN0M0 *** on T1bN0M0 lesions are scarce but suggest extra *** designed multi-centre prospective clinical trials are warranted.

关键词： Renal cell carcinoma Kidney transplant Graftectomy Nephron-sparing surgery Focal ablation Review

Surgery in biliary lithiasis: from the traditional “open” approach to laparoscopy and the“rendezvous” technique

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Hepatobiliary & Pancreatic diseases International 2017年第6期16卷 595-601页

作者： Giuseppe Tarantino paolo Magistri Roberto Ballarin Giacomo Assirati Antonio di Cataldo Fabrizio di Benedetto Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio Emilia 41124 ModenaItaly Department of General Surgery Sapienza-University of Rome 00189 Rome Italy Department of Surgical Sciences Organ Transplantation and Advanced Technologies University of Catania95124 Catania Italy

BACKGROUND:According to the current literature, biliary lithiasis is a worldwide-diffused condition that affects almost 20% of the general population. The rate of common bile duct stones(CBDS) in patients with symptomatic cholelithiasis is estimated to be 10% to 33%, depending on patient’s *** to stones in the gallbladder, the natural history of secondary CBDS is still not completely understood. It is not clear whether an asymptomatic choledocholithiasis requires treatment or not. For many years, open cholecystectomy with choledochotomy and/or surgical sphincterotomy and cleaning of the bile duct were the gold standard to treat both pathologies. Development of both endoscopic retrograde cholangiopancreatography(ERCP) and laparoscopic surgery,together with improvements in diagnostic procedures, influenced new approaches to the management of CBDS in association with *** SOURCES:We decided to systematically review the literature in order to identify all the current therapeutic options for CBDS. A systematic literature search was performed independently by two authors using Pub Med, EMBASE, Scopus and the Cochrane Library ***:The therapeutic approach nowadays varies greatly according to the availability of experience and expertise in each center, and includes open or laparoscopic common bile duct exploration, various combinations of laparoscopic cholecystectomy and ERCP and combined laparoendoscopic ***:Although ERCP followed by laparoscopic cholecystectomy is currently preferred in the majority of hospitals worldwide, the optimal treatment for concomitant gallstones and CBDS is still under debate, and greatly varies among different centers.

关键词： biliary obstruction bile duct stones gallstones endoscopic retrograde cholangiopancreatography laparoscopic cholecystectomy

Perihilar-cholangiocarcinoma: what really matters?

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 616-619页

作者： Fabrizio di Benedetto paolo Magistri Stefano di Sandro Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University Hospital of Modena“Policlinico”University of Modena and Reggio EmiliaModenaItaly

Treatment of peri-hilar cholangiocarcinoma(PHC)is one of the most critical challenges in the modern era of liver surgery(1).In addition to the highly demanding technique and insidious diagnostic work-up,the procedure ... 详细信息

关键词： operative carcinoma liver

Comprehensive,Continuous,and Vertical Measurements of Seawater Constituents with Triple-Field-of-View High-Spectral-Resolution Lidar

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Research 2024年第2期2023卷 191-201页

作者： Kai Zhang Yatong Chen Hongkai Zhao Zhongping Lee Emmanuel Boss Iwona Stachlewska Davide dionisi Cedric Jamet paolo D.Girolamo Aleksey Malinka Chengchong Jiang Hongda Wu Lingyun Wu Feitong Chen Xiaolei Zhu Nanchao Wang Chuxiao Chen Qun Liu Lan Wu Yudi Zhou Weibiao Chen Dong Liu Ningbo Research Institute State Key Laboratory of Modern Optical InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological lnnovation Center Zhejang UniversityHangzhou 311200China Donghai Laboratory.Zhoushan 316021 China State Key Lab of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China School of Marine Sciences University of MaineOronoME 04469-5741USA Faculty of Physics University of WarsawWarsaw 02093Poland institute of Marine Sciences Italian National Research CouncilRome 00133Italy Universitédu Littoral Cote d'Opale CNRSUniv.LilleIRDUMR 8187-LOG-Laboratoire d'Oceanologie et de GéosciencesWimereux F-6293 Francen Institute Scuola di Ingegneria Universita della BasilicataPotenza 85100Italy Institute of Physics National Academy of Sciences of BelarusMinsk 220072Belarus Key Laboratory of Space Laser Communication and Detection Technology Shanghai lnstitute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Inteligent Optics&Photonics Research Center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Jiaxing 314000China

Measuring the characteristics of seawater constituent is in great demand for studies of marine ecosystems and ***,existing techniques based on remote sensing or in situ samplings present various tradeoffs with regard to the diversity,synchronism,temporal-spatial resolution,and depth-resolved capacity of their data ***,we demonstrate a novel oceanic triple-field-of-view(FOV)high-spectral-resolution lidar(HSRL)with an iterative retrieval *** technique provides,for the first time,comprehensive,continuous,and vertical measurements of seawater absorption coefficient,scattering coefficient,and slope of particle size distribution,which are validated by simulations and field ***,it depicts valuable application potentials in the accuracy improvement of seawater classification and the continuous estimation of depth-resolved particulate organic carbon *** triple-FOV HSRL with high performance could greatly increase the knowledge of seawater constituents and promote the understanding of marine ecosystems and biogeochemistry.

关键词： lidar Vertical seawater

Hollow micro- and nano-particles by gas foaming

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Nano Research 2014年第7期7卷 1018-1026页

作者： Silvia Orsi Ernesto di Maio Salvatore lannace paolo A. Netti Center for Advanced Biomaterials for Health Care Istituto Italiano di Tecnologia (IIT@CRIB) Largo Barsanti e Matteucci 50 Napoli 80125 Italy dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industfiale and Interdisciplinary Research Centre on Biomaterials (CRIB) Universita degli Studi di Napoli Federico II P.le Tecchio 80 Napoli 80125 Italy Institute for Polymers Composites and Biomaterials Consiglio Nazionale delle Ricerche P.le E. Fermi 1 Portici (Na) 80055 Italy

This paper presents the results of a first successful attempt to produce hollow micro- and nano-particles of a large variety of materials, dimensions, shapes and hollow attributes by using an environmentally friendly and cheap technology, common in polymer processing and known as gas foaming. The central role played by ad hoc polymeric hollow micro- and nano-particles in a variety of emerging applications such as drug delivery, medical imaging, advanced materials, as well as in fundamental studies in nanotechnology highlights the wide relevance of the proposed method. Our key contribution to overcome the physical lower bound in the micro- and nano-scale gas foaming was to embed, prior to foaming, bulk micro- and nano-particles in a removable and deformable barrier film, whose role is to prevent the loss of the blowing agent, which is otherwise too fast to allow bubble formation. Furthermore, the barrier film allows for non-isotropic deformation of the particle and/or of the hollow, affording non-spherical hollow particles. In comparison with available methods to produce hollow micro- and nano-particles, our method is versatile since it offers independent control over the dimensions, material and shape of the particles, and the number, shape and open/closed features of the hollows. We have gas- foamed polystyrene and poly-（lactic-co-glycolic） acid particles 200 ~m to 200 nm in size, spherical, ellipsoidal and discoidal in shape, obtaining open or closed, single or multiple, variable in size hollows.

关键词： hollow nanoparticles microparticles gas foaming

Extreme Antarctic Cold of Late Winter 2023

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Advances in Atmospheric Sciences 2024年第10期41卷 1873-1880页

作者： Anastasia J.TOMANEK David E.MIKOLAJCZYK Matthew A.LAZZARA Stefano di BATTISTA Minghu diNG Mariana FONTOLAN LITELL David H.BROMWICH Taylor P.NORTON Linda M.KELLER Lee J.WELHOUSE Antarctic Meteorological Research and Data Center Space Science and Engineering CenterUniversity of Wisconsin-MadisonMadisonWisconsin 53706USA Department of Physical Sciences School of EngineeringScienceand MathematicsMadison Area Technical CollegeMadisonWisconsin 53704USA Meteogiornale via Paolo Diacono9Milano 20133Italy State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Byrd Polar and Climate Research Center The Ohio State UniversityColumbusOhio 43210USA Department of Geography The Ohio State UniversityColumbusOhio 43210USA

Extreme cold temperatures were observed in July and August 2023,coinciding with the WINFLY(winter fly-in)period of mid to late August into September 2023,meaning aircraft operations into McMurdo Station and Phoenix Airfield were adversely ***,with temperatures below−50℃,safe flight operation was not possible because of the risk of failing hydraulics and fuel turning to gel onboard the *** cold temperatures were measured across a broad area of the Antarctic,from East Antarctica toward the Ross Ice Shelf,and stretching across West Antarctica to the Antarctic Peninsula.A review of automatic weather station measurements and staffed station observations revealed a series of sites recording new record low *** separate cold phases were identified,each a few days in duration and occurring from mid-July to the end of August 2023.A brief analysis of 500-hPa geopotential height anomalies shows how the mid-tropospheric atmospheric environment evolves in relation to these extreme cold *** monthly 500-hPa geopotential height anomalies show strong negative anomalies in *** of composite geopotential height anomalies during each of the four cold phases suggests various factors leading to cold temperatures,including both southerly off-content flow and calm atmospheric *** the atmospheric environment that leads to such extreme cold temperatures can improve prediction of such events and benefit Antarctic operations and the study of Antarctic meteorology and climatology.

关键词： Antarctica extreme cold temperature automatic weather station networks

Stratigraphic analysis of intercalated graphite electrodes in aqueous inorganic acid solutions

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Nano Research 2022年第2期15卷 1120-1127页

作者： Stefania De Rosa paolo Branchini Valentina Spampinato Alexis Franquet Rossella Yivlialin Lamberto Duo Gianlorenzo Bussetti luca Tortora LASR3 Surface Analysis Laboratory INFN Roma Trevia della Vasca Navale 8400146 RomeItaly Department of Mathematics and Physics Roma Tre Universityvia della Vasca Navale 8400146 RomeItaly Imec Kapeldreef 75B-3001 LeuvenBelgium Helmholtz-Zentrum Berlin fiir Materialen und Energie GmbH Institute for Solar Fuels(EE-IF)Hahn-Meitner-Platz 1D-14109 BerlinGermany Department of Physics Politecnico di MilanoPiazza Leonardo da Vinci 321-20133 MilanoItaly Department of Science Roma Tre Universityvia della Vasca Navale 8400146 RomeItaly

A detailed stratigraphic investigation of the intercalation mechanism when graphite electrodes are immersed inside diluted perchloric(HClO_(4))and sulfuric(H_(2)SO_(4))electrolytes is obtained by comparing results when graphite crystals are simply immersed in the same acid *** combining time-of-flight secondary ion mass spectrometry(ToF-SIMS)and in-situ atomic force microscopy(AFM),we provide a picture of the chemical species involved in the intercalation *** depth intensity profile of the ion signals along the electrode crystal clearly shows a more complex mechanism for the intercalation process,where the local morphology of the basal plane plays a crucial *** anions are mostly located within the first tens of nanometers of graphite,but electrolytes also diffuse inside the buried layers for hundreds of nanometers,the latter process is also aided by the presence of mesoscopic crystal *** material from the electrolyte solution was found localized in well-defined circular spots,which represent preferential interaction ***,blister-like micro-structures similar to those observed on the highly oriented pyrolytic graphite(HOPG)surface were found in the buried layers,confirming the equivalence of the chemical condition on the graphite surface and in the underneath layers.

关键词： highly oriented pyrolytic graphite(HOPG) intercalation graphite graphene time-of-flight secondary ion mass spectrometry(ToF-SIMS) atomic force microscopy(AFM)

Use of robotics in liver donor right hepatectomy

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 231-232页

作者： Fabrizio di Benedetto paolo Magistri Karim JHalazun Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModenaMOItaly Department of Medical and Surgical Sciences and Translational Medicine Faculty of Medicine and PsychologySapienza University of RomeRomeRMItaly division of Liver Transplantation and Hepatobiliary Surgery Department of SurgeryWeill Cornell Medical CollegeNew YorkNYUSA

We read with great interest the paper by Chen and colleagues entitled "Use of robotics in liver donor right hepatectomy" (1). The authors currently represent the leading group performing robotic living donor liver pro... 详细信息

关键词： donor liver hepatectomy

Chasing the right path: tips, tricks and challenges of robotic approach to posterior segments

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 512-514页

作者： Fabrizio di Benedetto Giuseppe Tarantino paolo Magistri Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModenaMOItaly

The advent of minimally invasive technologies to approachliver diseases changed some paradigms of liver surgeryduring the last two *** allow to safely treatpatients with poor liver function,portal hypertension andcirrhosis,reducing the risk of decompensation(1).However,those potential benefits resulted to be in contrast with theactual application of such technologies in the real-life(2,3).

关键词： liver diseases surgery