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Multiple Detector-Row CT in Gastric Cancer Staging: Prospective Study

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Journal of Cancer Therapy 2014年第14期5卷 1438-1449页

作者： Lorenzo Bruno Lucia Barni Gaia Masini Sabrina Pacciani Edvige lucarelli Antonella Masserelli Daniela Tomcykova Filippo Melli luca boni Giancarlo Freschi Paolo Bechi Surgery and Translational Medicine University of Florence Florence Italy Diagnostic Imaging 4 Azienda Ospedaliero-Universitaria Careggi Florence Italy Clinical Trials Coordinating Center Azienda Ospedaliero-Universitaria Careggi Florence Italy

The aim of this study was to evaluate the accuracy of multiple detector computed tomography (MDCT) in the preoperative staging of gastric cancer, prospectively comparing CT findings with pathological findings at surgery, in a single-center study. A total of 19 consecutive patients with primary cancer recruited between March and July 2014 were submitted to preoperative MDCT staging according to a standard protocol. All diagnostic procedures were performed by dedicated radiologists who were unaware of the final pathological results. Subsequently, 16 patients underwent surgical treatment and 15 were finally included in the study. The primary tumor was detected at CT in all 15 cases. CT results for T staging were in agreement with pathological findings in 12 of 15 cases, with overall accuracy of 80%. Stage-specific sensibility was high for advanced stages (sensibility for T1, T3, and T4 resulted 60%, 85.7%, and 100%, respectively), while earlier stages showed higher specificity (specificity for T1, T3, and T4 resulted 100%, 75%, and 91.7%, respectively). Overall N staging accuracy was 86.7%, with 13 of 15 patients correctly staged. Stage-specific sensibility was 75% for N0 and 100% for N3, while specificity was 100% for N0 and lower for advanced stages. Accuracy for peritoneal involvement was 100%. Our findings show a good performance of the diagnostic protocol performed with MDCT tested in this study.

关键词： Gastric Cancer MDCT Staging Oncologic Imaging

Complications Following Surgery for Gastric Cancer: Analysis of Prospectively Collected Data

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Journal of Cancer Therapy 2014年第14期5卷 1454-1466页

作者： Lorenzo Bruno Lucia Barni Sabrina Pacciani Gaia Masini Lorenzo Tofani Federica Tofani Filippo Melli Antonio Taddei Manuela Andonova Miloeva luca boni Giancarlo Freschi Paolo Bechi Department of Surgery and Translational Medicine University of Florence Florence Italy Clinical Trials Coordinating Center Azienda Ospedaliero-Universitaria Careggi Florence Italy

Background and Aims: The complication rate after surgery for gastric cancer varies according to the particular definition of morbidity, so it’s necessary to report them using a standardized method, the Clavien-Dindo system. The purpose of this study was to prospectively analyze all post-gastrectomy complications in patients with gastric adenocarcinoma according to the severity grade using Clavien-Dindo system, in order to identify risk factors for postoperative complications and their prognostic significance on survival. Methods: This study is based on data from 90 consecutive patients who underwent gastrectomy for gastric neoplasia between January 2010 and February 2014 at the same unit. 15 patients were excluded (benign tumors, GISTs, missing data). Complications were categorized according to the Clavien-Dindo classification (uncomplicated patients vs patients classified ≥Grade I). The following risk factors were studied: age, BMI, sex, operation method, extent of resection, duration of surgery, transfusions, TNM staging, and lymph node ratio. Multivariate logistic regression was used to evaluate the association between risk factors and presence of complications. To assess the effect on overall survival, after selection of covariates using backward elimination, the Cox proportional hazard model was applied. Results: Among these patients, 49 (65.3%) developed complications, stratified as follows: Grade I, 6 (8%);Grade II, 24 (32%);Grade III, 6 (8%);Grade IV, 13 (17.3%). The laparoscopic technique (OR = 0.050;95% CI = 0.005 - 0.550, p = 0.0143) and no transfusions (OR = 0.219;95% CI = 0.058 - 0.827, p = 0.0251) were found to reduce the incidence of postoperative complications in the multivariate analysis. With regard to the survival analysis, lymph node ratio, malnutrition, extended resection and presence of complications were significant predictors of reduced survival in the multivariate analysis. Conclusions: Some variables can predict the risk of postoperative co

关键词： Gastric Cancer Complications Clavien-Dindo Classification Survival Probability

indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery:State of the art and future directions

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World Journal of Gastroenterology 2018年第27期24卷 2921-2930页

作者： Gian luca Baiocchi Michele Diana Luigi boni Department of Clinical and Experimental Sciences University of BresciaBrescia 25125Italy IHU-Strasbourg Institute of Image-Guided SurgeryStrasbourg 67000France General and Emergency Surgery IRCCS-Ca’Granda-Policlinico HospitalMilan 20122Italy

In recent years, the use of fluorescence-guided surgery(FGS) to treat benign and malignant visceral, hepatobiliary and pancreatic neoplasms has significantly increased. FGS relies on the fluorescence signal emitted by injected substances(fluorophores) after being illuminated by ad hoc laser sources to help guide the surgical procedure and provide the surgeon with real-time visualization of the fluorescent structures of interest that would be otherwise invisible. This review surveys and discusses the most common and emerging clinical applications of indocyanine green(ICG)-based fluorescence in visceral, hepatobiliary and pancreatic surgery. The analysis, findings, and discussion presented here rely on the authors' significant experience with this technique in their medical institutions, an up-to-date review of the most relevant articles published on this topic between 2014 and 2018, and lengthy discussions with key opinion leaders in the field during recent conferences and congresses. For each application, the benefits and limitations of this technique, as well as applicable future directions, are described. The imaging of fluorescence emitted by ICG is a simple, fast,relatively inexpensive, and harmless tool with numerous different applications in surgery for both neoplasms and benign pathologies of the visceral and hepatobiliary systems. The ever-increasing availability of visual systems that can utilize this tool will transform some of these applications into the standard of care in the near future. Further studies are needed to evaluate the strengths and weaknesses of each application of ICG-based fluorescence imaging in abdominal surgery.

关键词： indocyanine green fluorescence imaging gastrointestinal surgery liver surgery biliary surgery pancreatic surgery visceral perfusion biliary anatomy peritoneal carcinomatosis

Performance evaluation of the incorporation of different wire meshes in between perforated current collectors and membrane electrode assembly on the Passive Direct methanol fuel cell

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Chinese Journal of Chemical Engineering 2021年第4期34卷 360-367页

作者： Muralikrishna boni S.Srinivasa Rao G.Naga Srinivasulu Department of Mechanical Engineering National Institute of Technology WarangalWarangalTelanganaIndia

Passive Direct methanol fuel cells(DMFC)are more suitable for charging small capacity electronic *** passive DMFC,the fuel and oxidant are supplied by diffusion and natural convection process on the anode and cathode sides *** collectors(CC)play a vital importance in fuel cell *** paper presents the combined impact of perforated and wire mesh current collectors(WMCC)on passive DMFC *** types of open ratios of perforated current collectors(PCC),such as 45.40%,55.40%and 63.40%and two types of wire mesh current collectors with open ratios of 38.70%and 45.40%were chosen for the experimental work.A combination of TaguchiL9 rule is considered.A combination of three PCC and two WMCC on both anode and cathode was *** concentration was varied from 1 mol·L^(-1)-5 mol·L^(-1)for nine combinations of PCC and *** the experimental results,it is noticed that the combination of PCC and WMCC with an open ratio of 55.40%and 38.70%incorporated passive DMFC produced peak power density at 5 mol·L^(-1)of methanol *** passive DMFC performance was evaluated in terms of maximum power density and maximum current *** combined current collectors of PCC and WMCC open ratios of 55.40%+38.70%have more stable voltage than single PCC of open ratio 63.40%at 4 mol·L^(-1)of methanol concentration.

关键词： Passive DMFC Perforated current collector Wire mesh current collector Methanol concentration Fuel cell performance

Numerical Blow-up for a Nonlinear Heat Equation

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Acta Mathematica Sinica,English Series 2011年第5期27卷 845-862页

作者： Firmin K. N'GOHISSE Theodore K. boni Universite d'Abobo-Adjame UFR-SFA Departement de Mathematiques et Informatique 01 BP 1003 Abidjan 01 Cdte d'Ivoire Institut National Polytechnique Houphouet-Boigny de Yamoussoukro BP 1093 Yamoussoukro Cote d'Ivoire

This paper concerns the study of the numerical approximation for the following initialboundary value problem{ut-uzx=f（u）,t∈（0,1）,t∈（0,T） u（0,t）=0,t∈（0,1）,t∈（0,T） u（x,0）=u0（x）,x∈（0,1）where f（s） is a positive, increasing, C1 convex function for the nonnegative values of s, f（0）〉0, f∞ds/f（s）〈∞, u0∈C1（[0, 1]）, u0（0） = 0, u＇0（1）=0. We find some conditions under which the solution of a semidiscrete form of the above problem blows up in a finite time and estimate its semidiserete blow-up time. We also prove the convergence of the semidiscrete blow-up time to the theoretical one. A similar study has been also undertaken for a discrete form of the above problem. Finally, we give some numerical results to illustrate our analysis.

关键词： Semidiscretization blow-up numerical blow-up time nonlinear heat equations

Bisacodyl plus split 2-L polyethylene glycol-citrate-simethicone improves quality of bowel preparation before screening colonoscopy

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World Journal of Gastroenterology 2013年第33期19卷 5493-5499页

作者： Flavio Valiante Angelo Bellumat Manuela De Bona Michele De boni Department of Gastroenterology and Digestive Endoscopy S Maria del Prato Hospital

AIM:To compare the bowel cleansing efficacy,tolerability and acceptability of split 2-L polyethylene glycol(PEG)-citrate-simethicone(PEG-CS)plus bisacodyl(BIS)vs 4-L PEG for fecal occult blood test-positive screening ***:This was a randomised,observer-blind comparative *** hundred and sixty-four subjects underwent screening colonoscopy(mean age 62.5±7.4years,male 61.7%).The primary objective of the study was to compare the bowel cleansing efficacy of the two ***:BIS plus PEG-CS:3 tablets of 5-mg BIS at 16:00,PEG-CS 1-L at 19:00 and 1-L at7:00,4-L PEG:3-L at 17:00,and 1-L at 7:*** was carried out after 11:00,at least 3 h after the completion of bowel *** cleansing was evaluated using the Harefield Cleansing ***:Bowel preparation was successful for 92.8%of subjects in the PEG-CS group and for 92.1%of subjects in the 4-L PEG(RR=1.01;95%CI:0.94-1.08).BIS+PEG-CS was better tolerated than 4-L PEG.A greater rate of patients in the BIS+PEG-CS group had no difficulty and/or were willing to repeat the same preparation compared to split-dose 4-L PEG *** in the BIS+PEG-CS group rated the prep as good or satisfactory in 90.6%as compared to 77%in the 4-L PEG(P=0.003).Subjects receiving BIS+PEGCS stated they fully adhered to instructions drinking all the 2-L solution in 97.1%compared with 87.3%in the4-L PEG(P=0.003).CONCLUSION:BIS plus split 2-L PEG-CS was as effective as but better tolerated and accepted than split4-L PEG for screening *** new procedure may increase the positive attitude and participation to colorectal cancer screening colonoscopy.

关键词： Colonoscopy Colon cleansing Bowel preparations Polyethylene glycol Simethicone Bisacodyl

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意德拉半固态流变压铸技术

特种铸造及有色合金 2009年第2期29卷 I0009-I0010页

作者： Roberto boni 王杰意德拉集团有限公司

意德拉半固态流变压铸工艺与其他半固态压铸工艺的区别,在于它可以利用常规合金,使用现有的压铸设备和工艺,就能减少气孔、缩短压射循环周期时问并延长模具寿命。压铸件成本的降低不仅来自这些优势,还来自于减少的后序铸件的处理,例如... 详细信息

意德拉半固态流变压铸工艺与其他半固态压铸工艺的区别,在于它可以利用常规合金,使用现有的压铸设备和工艺,就能减少气孔、缩短压射循环周期时问并延长模具寿命。压铸件成本的降低不仅来自这些优势,还来自于减少的后序铸件的处理,例如取消浸渗和减少机加工。

关键词：压铸半固态流变压铸意德拉

Inflammatory bowel diseases and human reproduction:A comprehensive evidence-based review

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World Journal of Gastroenterology 2014年第23期20卷 7123-7136页

作者： Stefano Palomba Giuliana Sereni Angela Falbo Marina Beltrami Silvia Lombardini Maria Chiara boni Giovanni Fornaciari Romano Sassatelli Giovanni Battista La Sala Obstetrics and Gynecology Unit Department of ObstetricsGynecology and PediatricsAzienda Ospedaliera ASMNIstituto di Ricovero e Cura a Carattere Scientifico42123 Reggio EmiliaItaly Gastroenterology and Digestive Endoscopy Unit Department of Oncology and Advanced TechnologiesAzienda Ospedaliera ASMNIstituto di Ricovero e Cura a Carattere Scientifico42123 Reggio EmiliaItaly Medicine and Gastroenterology Unit Azienda Ospedaliera ASMNIstituto di Ricovero e Cura a Carattere Scientifico42123 Reggio EmiliaItaly Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto University of Modena and Reggio Emilia41124 ModenaItaly

To evaluate the effects of inflammatory bowel diseases(IBDs)on human reproduction,we reviewed the current literature using a systematic search for published studies(articles and/or abstracts)without limits for English *** searched on Medline(through PubMed),the Institute for Scientific Information,the Web of Science and the websites for the registration of controlled trials(http://***/).Bibliographies of retrieved articles,books,expert opinion review articles and reviewed bibliographies from subject experts were manually *** and abstracts were screened initially,and potential relevant articles were identified and *** possible,data were analyzed by comparing IBD patients vs healthy controls,and patients with active IBDs vs those with disease in *** effects of IBDs on female fertility,fertility in infertile couples,pregnancy and male infertility were examined *** with IBDs in remission have normal *** the moment,there is no established guideline for the preservation of fertility in women with IBD undergoing *** data are needed regarding guidelines for the management of these *** regarding IBDs and infertility are currently completely *** the prevalence of intestinal pathology in young adults of childbearing age,this field is of great scientific and clinical interest,opening up important future *** important and as yet unexplored point is the response to treatments for infertility in patients with *** particular,the question is whether the reproductive outcomes(clinical and biological)can be influenced by the IBD of one of the *** goals for successful reproductive outcomes in IBD population are correct counseling and disease *** significantly affect several reproductive aspects of human(female,male,couple)*** data are needed to develop guidelines for the clinical management of subjects of

关键词： Inflammatory bowel diseases Fertility Infertility Pregnancy

seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up

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World Journal of Gastroenterology 2016年第34期22卷 7748-7753页

作者： Stefano Rausei Laura Ruspi Federica Galli Vincenzo Pappalardo Giuseppe Di Rocco Francesco Martignoni Francesco Frattini Francesca Rovera Luigi boni Gianlorenzo Dionigi Department of Surgery University of Insubria

Seventh tumor-node-metastasis(TNM) classification for gastric cancer,published in 2010,introduced changes in all of its three parameters with the aim to increase its accuracy in prognostication. The aim of this review is to analyze the efficacy of these changes and their implication in clinical practice. We reviewed relevant Literature concerning staging systems in gastric cancer from 2010 up to March 2016. Adenocarcinoma of the esophago-gastric junction still remains a debated entity,due to its peculiar anatomical and histological situation: further improvement in its staging are required. Concerning distant metastases,positive peritoneal cytology has been adopted as a criterion to define metastatic disease: however,its search in clinical practice is still far from being routinely performed,as staging laparoscopy has not yet reached wide diffusion. Regarding definition of T and N: in the era of multimodal treatment these parameters should more influence both staging and surgery. The changes about T-staging suggested some modifications in clinical practice. Differently,many controversies on lymph node staging are still ongoing,with the proposal of alternative classification systems in order to minimize the extent of lymphadenectomy. The next TNM classification should take into account all of these aspects to improve its accuracy and the comparability of prognosis in patients from both Eastern and Western world.

关键词： Gastric cancer Staging system Tumor node-metastasis Prognostic factors Clinical practice