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Toward a definition of colonic inertia

World Journal of Gastroenterology 2004年第17期10卷 2465-2467页

作者： Gabrio Bassotti Giuseppede Roberto luca sediari Antonio Morelli Gastroenterology and Hepatology section Department of Clinical and Experimental MedicineUniversity of Perugia Medical SchoolPerugia 06131Italy

Chronic constipation is a relatively frequent symptom; among its subtypes, the so called-colonic inertia represents a disease condition that is often considered for surgery. However, to date, there has been no agreement on definition of colonic inertia, and a literature review showed that this definition was given to numerous entities that differ from each *** this paper these concepts are reviewed and a more stringent definition of colonic inertia is proposed.

关键词： Gastrointestinal Motility Chronic Disease Constipation Humans

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Normal aspects of colorectal motility and abnormalities in slow transit constipation

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World Journal of Gastroenterology 2005年第18期11卷 2691-2696页

作者： Gabrio Bassotti Giuseppe de Roberto Danilo Castellani luca sediari Antonio Morelli Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Medical School Perugia Italy

Human colonic motility is a relatively difficult topic to investigate. However, the refinement of manometric techniques in recent years enabled us to study both the proximal and distal segments of the viscus. The present paper reviews our knowledge about normal aspects of colorectal motility in man and the abnormalities found in slow transit constipation (STC), one of the most frequent and difficult to treat subtypes of constipation. An internetbased search strategy of the Medline and Science Citation Index was performed using the keywords colon, colonic, colorectal, constipation, slow transit, motility, rectal, rectum in various combinations with the Boolean operators AND, OR and NOT. Only articles related to human studies were used, and manual cross-referencing was also performed. Most of colonic motor activity is represented by single nonpropagated contractions, rarely organized in bursts; this activity is maximal during the day, especially after waking and following meals. In addition, a specialized propagated activity with propulsive features is detectable, represented by high-and low-amplitude propagated contractions. In the severe form of constipation represented by the slow transit type, the above motor activity is completely deranged. In fact, both basal segmental activity (especially in response to meals) and propagated activity (especially that of high amplitude) are usually decreased, and this may represent a physiologic marker of this disorder. Human colonic motor activity is quite a complex issue, still only partly understood and investigated, due to anatomic and physiological difficulties. In recent years, however, some more data have been obtained, even in proximal segments. These data have helped in elucidating, although only in part, some pathophysiological mechanisms of chronic constipation, and especially of the STC subtype.

关键词： Colonic motility Constipation Slow transit

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