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Long-term monitoring of active large-scale landslides for non-structural risk mitigation-integrated sensors and web-based platform

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Journal of Mountain Science 2025年第1期22卷 1-15页

作者： CATELAN Filippo Tommaso BOSSI Giulia schenato luca TONDO Melissa CRITELLI Vincenzo MULAS Marco CICCARESE Giuseppe CORSINI Alessandro TONIDANDEL David MAIR Volkmar MARCATO Gianluca Research Institute for Geo-Hydrological Protection(IRPI) National Research Council(CNR)Padova 35127Italy Department of Chemical and Geological Sciences University of Modena and Reggio EmiliaModena 41125Italy Department of Information Engineering University of PadovaPadova 35131Italy Department of Biological Geological and Environmental SciencesUniversity of BolognaBologna 67-40126Italy Office for Geology and Building Materials Testing Autonomous Province of BolzanoCardano 39053Italy

Large-scale deep-seated landslides pose a significant threat to human life and ***,closely monitoring these landslides is crucial for assessing and mitigating their associated *** this paper,the authors introduce the So Lo Mon framework,a comprehensive monitoring system developed for three large-scale landslides in the Autonomous Province of Bolzano,Italy.A web-based platform integrates various monitoring data(GNSS,topographic data,in-place inclinometer),providing a user-friendly interface for visualizing and analyzing the collected *** facilitates the identification of trends and patterns in landslide behaviour,enabling the triggering of warnings and the implementation of appropriate mitigation *** So Lo Mon platform has proven to be an invaluable tool for managing the risks associated with large-scale landslides through non-structural measures and driving countermeasure works *** serves as a centralized data repository,offering visualization and analysis *** information empowers decisionmakers to make informed choices regarding risk mitigation,ultimately ensuring the safety of communities and infrastructures.

关键词： Web-based platform South Tyrol landslides Long term monitoring Risk mitigation

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Towards hydrometeorological thresholds of reservoir-induced landslide from subsurface strain observations

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Science China(Technological Sciences) 2024年第6期67卷 1907-1922页

作者： YE Xiao ZHU HongHu WANG Jia ZHENG WanJi ZHANG Wei schenato luca PASUTO Alessandro CATANI Filippo School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China Department of Geosciences University of PadovaPadova35131Italy School of Geosciences and Info-Physics Central South UniversityChangsha410083China Department of Information Engineering University of PadovaPadova35131Italy National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy

Synergistic multi-factor early warning of large-scale landslides is a crucial component of geohazard prevention and mitigation efforts in reservoir *** forecasting and early warning based on surface displacements have been widely ***,the lack of direct subsurface real-time observations limits our ability to predict critical hydrometeorological conditions that trigger landslide *** this paper,we leverage subsurface strain data measured by high-resolution fiber optic sensing nerves that were installed in a giant reservoir landslide in the Three Gorges Reservoir(TGR)region,China,spanning a whole hydrologic year since February *** spatiotemporal strain profile has preliminarily identified the slip zones and potential drivers,indicating that high-intensity short-duration rainstorms controlled the landslide kinematics from an observation *** the time lag effect,we reexamined and quantified potential controls of accelerated movements using a data-driven approach,which reveals immediate response of landslide deformation to extreme rainfall with a zero-day *** identify critical hydrometeorological rules in accelerated movements,accounting for the dual effect of rainfall and reservoir water level variations,we thus construct a landslide prediction model that relies upon the boosting decision tree(BDT)algorithm using a dataset comprising daily rainfall,rainfall intensity,reservoir water level,water level fluctuations,and slip zone strain time *** results indicate that landslide acceleration is most likely to occur under the conditions of mid-low water levels(i.e.,57.9 mm and rainfall intensity>24.4 mm/h).Moreover,this prediction model allows us to update hydrometeorological thresholds by incorporating the latest monitoring *** on the shoulder of this landslide case,our study informs a practical and reliable path

关键词： slow-moving landslide fiber-optic monitoring subsurface strain hydrometeorological threshold extreme weather

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Thermo-hydro-poro-mechanical responses of a reservoir-induced landslide tracked by high-resolution fiber optic sensing nerves

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1018-1032页

作者： Xiao Ye Hong-Hu Zhu Gang Cheng Hua-Fu Pei Bin Shi luca schenato Alessandro Pasuto School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Computer Science North China Institute of Science and Technology(National Safety Training Center of Coal Mines)Beijing101601China State Key Lab of Coastal and Offshore Engineering Department of Geotechnical EngineeringDalian University of TechnologyDalian116024China National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy Department of Information Engineering University of PadovaPadova35131Italy

Thermo-poro-mechanical responses along sliding zone/surface have been extensively ***,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond the slip surface to progressive ***,we aim to investigate the subsurface multiphysics of reservoir landslides under two extreme hydrologic conditions(*** and dry),particularly within sliding *** on ultra-weak fiber Bragg grating(UWFBG)technology,we employ specialpurpose fiber optic sensing cables that can be implanted into boreholes as“nerves of the Earth”to collect data on soil temperature,water content,pore water pressure,and *** Xinpu landslide in the middle reach of the Three Gorges Reservoir Area in China was selected as a case study to establish a paradigm for in situ thermo-hydro-poro-mechanical *** UWFBG-based sensing cables were vertically buried in a 31 m-deep borehole at the foot of the landslide,with a resolution of 1 m except for the pressure *** reported field measurements covering the period 2021 and 2022 and produced the spatiotemporal profiles throughout the *** show that wet years are more likely to motivate landslide motions than dry *** annual thermally active layer of the landslide has a critical depth of roughly 9 m and might move downward in warmer *** dynamic groundwater table is located at depths of 9e15 m,where the peaked strain undergoes a periodical response of leap and withdrawal to annual hydrometeorological *** interface behaviors may support the interpretation of the contribution of reservoir regulation to slope stability,allowing us to correlate them to local damage events and potential global *** paper also offers a natural framework for interpreting thermo-hydro-poro-mechanical signatures from creeping reservoir bank slopes,which may form the basis for a landslide monitoring and early warning system.

关键词： Reservoir landslide Thermo-hydro-poro-mechanical response Ultra-weak fiber bragg grating(UWFBG) subsurface evolution Engineering geological interface Geotechnical monitoring

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Trans-jugular intrahepatic portosystemic stent shunting benefits and limits

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 307-309页

作者： Salvatore Stefano Sciarrone Lucia Fini luca De luca Department of Surgery Gastroenterology and Digestive Endoscopy UnitASST Santi Paolo e CarloUniversity of MilanMilan 20142LombardyItaly

Trans-jugular intrahepatic portosystemic stent shunting(TIPSS)has been in use for many years with great results and many *** procedure essentially involves the insertion of a metal covert stent to create an Hepato-Hepatic portosystemic *** time,TIPSS has become the subject of many studies aimed at examining its clinical utility and evaluating the results of using TIPSS to manage complications related to portal *** the outset,this procedure has been met with hope and enthusiasm and give the chance to consider another possibility to treat the complications of portal hypertension without the use of *** that TIPSS is an attractive alternative to shunt surgery because it does not require the use of general anesthesia or laparotomy,in fact this method is applicable to many patients with severe liver disease not suitable for *** has been studied for the management of variceal bleeding,ascites,hepatic hydrothorax,hepatorenal syndrome,and other types of ***,some drawbacks of the TIPSS,such as shunt stenosis and hepatic encephalopathy,have also been reported in the *** the basis of the available evidence and the new epidemiological findings regarding liver disease,the following question may be posed:What is the place of TIPSS in current clinical practice?

关键词： Hepatic compensation Decompensation Trans-jugular intrahepatic portosystemic stent-shunt Bleeding Ascites

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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： Marco Ghibaudi Enrica Boda luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

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Biological processes involved in mechanical force transmission in connective tissue:Linking bridges for new therapeutic applications in the rehabilitative field

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BIOCELL 2025年第1期49卷 1-5页

作者： AUGUSTO FUSCO STEFANO BONOMI luca PADUA UOC Neuroriabilitazione ad Alta Intensità Fondazione Policlinico Universitario A.Gemelli IRCCSRome00168Italy Department of Geriatrics and Orthopedics UniversitàCattolica del Sacro CuoreRome00168Italy

Connective tissue is a dynamic structure that reacts to environmental cues to maintain homeostasis,including mechanical *** load influences extracellular matrix(ECM)—cell interactions and modulates cellular ***-regulation processes involve matrix modification and cell activation to preserve tissue *** ECM remodeling is crucial for force *** components are involved in force sensing and transmission,affecting cellular adhesion,motility,and gene *** mechanical loading helps to maintain tissue health,while imbalances may lead to pathological *** and passive movement,including manual mobilization,improves connective tissue elasticity,promotes ECM-cell homeostasis,and reduces *** rehabilitation,understanding mechanical-regulation processes is necessary for ameliorating and developing treatments aimed at preserving tissue elasticity and preventing *** this commentary,we aim to globally describe the biological processes involved in mechanical force transmission in connective tissue as support for translational studies and clinical applications in the rehabilitation field.

关键词： Connective tissue Cellular mechanotransduction Integrins Translational science

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Productive and metabolomic consequences of arginine supplementation in sows during different gestation periods in two different seasons

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Journal of Animal Science and Biotechnology 2025年第1期16卷 218-237页

作者： Sara Virdis Diana Luise Federico Correa luca Laghi Norma Arrigoni Roxana Elena Amarie Andrea Serra Giacomo Biagi Clara Negrini Francesco Palumbo Paolo Trevisi Department of Agricultural and Food Sciences University of BolognaViale G.Fanin 4440127 BolognaItaly Istituto Zooprofilattico Sperimentale Della Lombardia E Dell’Emilia Romagna(IZSLER)“Bruno Ubertini” Via Bianchi925124 BresciaItaly Department of Agriculture Food and EnvironmentUniversity of PisaVia del Borghetto 8056124 PisaItaly Department of Veterinary Medicine University of BolognaVia Tolara Di Sopra 5040064 Ozzano Dell’Emilia(BO)Italy.

Background The prolificacy of sows(litter size at birth)has markedly increased,leading to higher post-natal *** stress can exacerbate this *** plays an important role in several physiological pathways;its effect on gestating sows can depend on the period of *** study evaluated the effects of arginine supplementation on the productive performance and physiological status of sows during different gestation periods and seasons,using a multi-omics *** A total of 320 sows were divided into 4 groups over 2 seasons(warm/cold);a control group(CO)received a standard diet(including 16.5 g/d of arginine)and 3 other groups received the standard diet supplemented with 21.8 g/d of arginine(38.3 g/d of arginine)either during the first 35 d(Early35),the last 45 d(Late45)or through-out the entire gestation period(COM).The colostrum was analyzed for nutritional composition,immunoglobulins and metabolomic *** and feces were analyzed on d 35 and 106 for the metabolomic and microbial *** body weight and mortality were recorded at birth,d 6,d 26,and on d 14 *** Interactions between arginine and season were never *** Early35 group had a lower percent-age of stillborn(P<0.001),mummified(P=0.002)and low birthweight(LBW)piglets(P=0.02)than the CO *** Late45 group had a lower percentage of stillborn piglets(P=0.029)and a higher percentage of high birthweight piglets(HBW;P<0.001)than the CO *** COM group had a higher percentage of LBW(P=0.004)and crushed piglets(P<0.001)than the CO *** supplementation modifies the metabolome characterization of colos-trum,urine,and *** and nitric oxide pathways,as well as metabolites related to microbial activity,were influenced in all matrices.A slight trend in the beta diversity index was observed in the microbiome profile on d 35(P=0.064).Conclusions Arginine supplementation during early gestation reduced the percentage o

关键词： Colostrum Feces Microbiota Piglets’birth weight Stillborn Urine

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Genetic signatures of ERCC1 and ERCC2 expression,along with SNPs variants,unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

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Oncology Research 2025年第1期33卷 45-55页

作者： ENRICO CALIMAN SARA FANCELLI FEDERICO SCOLARI ADRIANO PASQUI CLARA MANNESCHI DANIELE LAVACCHI FRANCESCA MAZZONI FRANCESCA GENSINI VALERIA PASINI CAMILLA EVA COMIN luca VOLTOLINI SERENA PILLOZZI LORENZO ANTONUZZO Clinical Oncology Unit Careggi University HospitalFlorence50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence50134Italy Department of Health Sciences University of FlorenceFlorence50134Italy Medical Oncology Unit Careggi University HospitalFlorence50134Italy Department of Experimental and Clinical Biomedical Sciences“Mario Serio” University of FlorenceFlorence50134Italy Section of Anatomic Pathology Department of Health SciencesUniversity of FlorenceFlorence50139Italy Section of Surgery Histopathology and Molecular PathologyUniversity of FlorenceFlorence50139Italy Thoracic Surgery Unit Careggi University HospitalFlorence50134Italy

Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damage exerted by platinum *** in this repair mechanism may affect patients’*** and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease(ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit,Careggi University Hospital,Florence(Italy),from 2015 to *** expression analysis and single nucleotide polymorphism(SNP)characterization of three NER pathway genes—namely ERCC1,ERCC2,and ERCC5—were performed on patient tumor ***:Overall,elevated expression of ERCC genes was observed in SCLC patients compared to healthy *** with low ERCC1 and ERCC5 expression levels exhibited a better median progression-free survival(mPFS=7.1 vs.4.9 months,p=0.39 for ERCC1 and mPFS=6.9 vs.4.8 months,p=0.093 for ERCC5)and overall survival(mOS=8.7 vs.6.0 months,p=0.4 for ERCC1 and mOS=7.2 vs.6.2 months,p=0.13 for ERCC5).Genotyping analysis of five SNPs of ERCC genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the ERCC1 rs11615 SNP(p=0.24 for PFS and p=0.14 for OS)and of the rs13181 and rs1799793 ERCC2 SNPs(p=0.43 and p=0.26 for PFS and p=0.21 and p=0.16 for OS,respectively)compared to patients with homozygous mutant ***:The comprehensive analysis of ERCC gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： Small cell lung cancer(SCLC) Nucleotide excision repair(NER)pathway ERCC genes Single nucleotide polymorphisms(SNPs) Platinumchemotherapy(CT)

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Artificial intelligence in gastroenterology:Ethical and diagnostic challenges in clinical practice

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World Journal of Gastroenterology 2025年第10期31卷 144-150页

作者： Davide Ramoni Alessandro Scuricini Federico Carbone luca Liberale Fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy First Clinic of Internal Medicine Department of Internal MedicineItalian Cardiovascular NetworkIRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

This article discusses the manuscript recently published in the World Journal of Gastroenterology,which explores the application of deep learning models in decision-making processes via wireless capsule *** artificial intelligence(AI)into gastrointestinal disease diagnosis represents a transformative step toward precision medicine,enhancing real-time accuracy in detecting multi-category lesions at earlier stages,including small bowel lesions and precancerous polyps,ultimately improving patient ***,the use of AI in clinical settings raises ethical considerations that extend beyond technological *** of patient privacy,data security,and potential diagnostic biases require careful *** models must prioritize diverse and representative datasets to mitigate inequities and ensure diagnostic accuracy across ***,balancing AI with clinical expertise is crucial,positioning AI as a supportive tool rather than a replacement for physician *** these ethical challenges will support the responsible deployment of AI,through equitable contribution to patient-centered care.

关键词： Artificial intelligence Endoscopy Ethical implication Gastrointestinal disease Machine learning Omics Precision medicine Wireless capsule endoscopy

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