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Neural Regeneration Research 2017年第8期12卷 1256-1261页

作者： Asha Hiremathad luca Piemontese Centre for Nano and Material Sciences Jain University Jain Global Campus Kanakapura Ramanagaram Bangalore India Dipartimento di Farmacia-Scienze del Farmaco Universitfl degli Studi di Bari "Aldo Moro" Bari Italy

Nowadays, Alzheimer＇s disease（AD） is widely recognized as a real social problem. In fact, only five drugs are FDA approved for the therapy of this widespread neurodegenerative disease, but with low results so far. Three of them（rivastigmine, donepezil and galantamine） are acetylcholinesterase inhibitors, memantine is a N-methyl-D-aspartate receptor antagonist, whereas the fifth formulation is a combination of donepezil with memantine. The prevention and treatment of AD is the new challenge for pharmaceutical industry, as well as for public institutions, physicians, patients, and their families. The discovery of a new and safe way to cure this neurodegenerative disease is urgent and should not be delayed further. Because of the multiple origin of this pathology, a multi-target strategy is currently strongly pursued by researchers. In this review, we have discussed new structures designed to better the activity on the classical AD targets. We have also examined old and new potential drugs that could prove useful future for the therapy of the pathology by acting on innovative, not usual, and not yet fully explored targets like peroxisome proliferator-activated receptor（PPARs）.

关键词： Alzheimer's disease multi-target strategy peroxisome proliferator-activated receptors heterocycliccompounds neurodegenerative diseases

From the elasticity theory to cosmology and vice versa

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Science China(Physics,Mechanics & Astronomy) 2014年第4期57卷 597-603页

作者： LEVRINO luca TARTAGLIA Angelo Politecnico di Torino Department of Applied Science and Technology Corso Duca degli Abruzzi 2410129 Torino Italy

The paper shows how a generalization of the elasticity theory to four dimensions and to space-time allows for a consistent description of the homogeneous and isotropic universe,including the accelerated *** analogy is manifested by the inclusion in the traditional Lagrangian of general relativity of an additional term accounting for the strain induced in the manifold(*** space-time)by the curvature,be it induced by the presence of a texture defect or by a matter/energy *** additional term is su?cient to account for various observed features of the universe and to give a simple interpretation for the so called dark ***,we show how the same approach can be adopted back in three dimensions to obtain the equilibrium configuration of a given solid subject to strain induced by defects or applied ***,it is shown how concepts coming from the familiar elasticity theory can inspire new approaches to cosmology and in return how methods appropriated to General Relativity can be applied back to classical problems of elastic deformations in three dimensions.

关键词： deformable solids cosmology elastic strain Lagrangian density and tensors

New approaches for prevention and treatment of Alzheimer's disease:a fascinating challenge

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Neural Regeneration Research 2017年第3期12卷 405-406页

作者： luca Piemontese Dipartimento Farmacia-Scienze del Farmaco UniversitàdegliStudi di Bari"Aldo Moro"BariItaly Centro de Química Estrutural Instituto Superior Técnico-Universidade Técnica de LisboaLisboaPortugal

The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their *** spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.

关键词： PPARs New approaches for prevention and treatment of Alzheimer’s disease:a fascinating challenge

An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

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Journal of Thermal Science 2009年第2期18卷 173-184页

作者： luca Fuligno Diego Micheli Carlo Poloni EnginSoft s.p.a. Dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste Dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词： micro gas turbine combustor optimized design

SRAM-Based FPGA Systems for Safety-Critical Applications： A Survey on Design Standards and Proposed Methodologies

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Journal of Computer Science & Technology 2015年第2期30卷 373-390页

作者： Cinzia Bernardeschi luca Cassano Andrea Domenici Department of Information Engineering University of Pisa Pisa 56122 Italy Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano Milano 20133 Italy

As the ASIC design cost becomes affordable only for very large-scale productions, the FPGA technology is currently becoming the leading technology for those applications that require a small-scale production. FPGAs can be considered as a technology crossing between hardware and software. Only a small-number of standards for the design of safety-critical systems give guidelines and recommendations that take the peculiarities of the FPGA technology into consideration. The main contribution of this paper is an overview of the existing design standards that regulate the design and verification of FPCA-based systems in safety-critical application fields. moreover, the paper proposes a survey of significant published research proposals and existing industrial guidelines about the topic, and collects and reports about some lessons learned from industrial and research projects involving the use of FPGA devices.

关键词： design verification electronic design safety-critical system SRAM-based FPGA

Photoluminescence monitoring of oxide formation and surface state passivation on InAs quantum dots exposed to water vapor

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Nano Research 2016年第10期9卷 3018-3026页

作者： Giovanna Trevisi luca Seravalli Paola Frigeri CNR-IMEM Institute Parco Area delle Scienze 37a 43124 Parma Italy

The room-temperature light emission of uncapped III-V semiconductor quantum dots is used to investigate the properties and evolution of the surface under exposure to a humid environment. Enhanced photoluminescence intensity resulting from exposure to polar molecules has already been reported; here we demonstrate that the external environment also has a relevant effect on the emission energy of quantum dots. Experimental results are interpreted on the basis of a model of the quantum system that takes into account the formation of oxide on pristine III-V surfaces and the presence of surface states. As a result of our study, we can clearly distinguish the effect of surface oxidation from that of surface state passivation on the emission of InAs surface quantum dots. This work sheds new light on the properties of semiconductor surface quantum dots as building blocks of novel and highly efficient sensing devices based on optical transduction.

关键词： epitaxial quantum dots surface states oxide photoluminescence quantum modeling optical nanosensor

Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 74-80页

作者： Adriana Handra-luca Departments of Pathology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique GHU Avicenne 125 rue Stalingrad Bobigny 93000 France

BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.

关键词： blood group type blood group antigen immunohistochemistry CA19-9 prognosis invasive carcinoma pancreas intraductal papillary mucinous neoplasm

Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky Jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.Eid Hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

Searching for alternatives to brain regeneration

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Neural Regeneration Research 2021年第11期16卷 2198-2200页

作者： Chiara La Rosa luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly Department of Veterinary Sciences University of TurinGrugliascoItaly

Brain regeneration from an evolutionary perspective:Brain regeneration(the full restoration of tissue after loss from injury or disease)is the most sought after goal for researchers working in developmental *** also appears to be the most challenging to achieve when considering the mammalian *** remarkable regenerative capacities can be present in the central nervous systems of many non-mammalian vertebrates(e.g.,fish,amphibians),these kinds of processes appear to be dramatically reduced in mammals(Bonfanti,2011).

关键词： regeneration sought injury

Intra-cycle depolarization of ultraintense laser pulses focused by off-axis parabolic mirrors

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High Power Laser Science and Engineering 2018年第2期6卷 141-148页

作者： luca Labate Gianluca Vantaggiato Leonida A.Gizzi Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche Istituto Nazionale di Fisica Nucleare Sezione di Pisa

A study of the structure of the electric and magnetic fields of ultraintense laser pulses focused by an off-axis parabolic mirror is reported. At first, a theoretical model is laid out, whose final equations integration allows the space and time structure of the fields to be retrieved. The model is then employed to investigate the field patterns at different times within the optical cycle, for off-axis parabola parameters normally employed in the context of ultraintense laser–plasma interaction experiments. The results show that nontrivial, complex electromagnetic field patterns are observed at the time at which the electric and magnetic fields are supposed to vanish. The importance of this effect is then studied for different laser polarizations, f numbers and off-axis angles.

关键词： laser-driven particle acceleration laser focusing off-axis parabolic mirrors ultrashort laser pulses