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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI Maria DI ROSA luca PANDOLFI Michele MARRONI Dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** D1 phase was testified by rare isoclinal *** D2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** D3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the D1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** D2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

PSMA PET/CT in the low-to intermediate-risk prostate cancer:when and why?

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Asian Journal of Andrology 2024年第6期26卷 584-586页

作者： luca Sofia Matteo Bauckneht Department of Health Sciences(DISSAL) University of GenovaGenova 16132Italy Nuclear Medicine IRCCS Ospedale Policlinico San MartinoGenova 16132Italy

Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) represents a significant advancement in the imaging of prostate cancer (PCa), yet its application in low- and intermediate-risk cases continues to be a topic of active discussion. This article delves into the nuanced role of PSMA PET/CT, critically analyzing its strengths and limitations in these specific risk categories. For patients with low-risk PCa, PSMA PET/CT demonstrates limited effectiveness in routine staging due to its minimal tracer uptake in low-grade tumors. However, its ability to differentiate between low- and high-grade tumors suggests a promising role in active surveillance, offering a potential noninvasive method for monitoring disease progression and aiding in treatment decision-making. In the intermediate-risk PCa setting, the high specificity of PSMA PET/CT in nodal staging makes it a valuable asset for precise surgical and radiation therapy planning. The article underscores the necessity for further research to fully realize the potential of PSMA PET/CT in PCa management, particularly in developing more personalized treatment approaches in these clinical scenarios.

关键词： routine intermediate treatment

Building mass to prevent non-alcoholic fatty liver disease?

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 173-176页

作者： Serena Pelusi luca Valenti Department of Pathophysiology and Transplantation Università degli Studi di MilanoMilan Italy Translational Medicine Department of Transfusion Medicine and HematologyFondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico MilanoMilanItaly

While increased adiposity,generally estimated by high body mass index(BMI)is the major risk factor for non-alcoholic fatty liver disease(NAFLD),several studies have now reported an association between low skeletal muscle mass and this condition(1,2).In particular,sarcopenia has been associated with NAFLD in the general population,and with disease severity in patients who underwent liver biopsy(3-5).

关键词： NAFLD liver skeletal

Membrane progesterone receptors(mPRs/PAQRs)in Schwann cells represent a promising target for the promotion of neuroregeneration

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Neural Regeneration Research 2021年第2期16卷 281-282页

作者： luca F.Castelnovo Peter Thomas Valerio Magnaghi Marine Science Institute University of Texas at AustinPort AransasTXUSA Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanItaly

Schwann cells and neuroregeneration:Peripheral nerve injury is a common cause of morbidity,which affects millions of people *** peripheral nervous system,differently from the central nervous system,has an intrinsic ability to regenerate after ***,in most cases the regenerative outcome is not completely satisfactory,in particular for long-gap peripheral nerve injuries in which the microsurgical approach is not *** these cases。

关键词： injuries progesterone cases

Dynamics and self-assembly of bio-functionalized gold nanoparticles in solution： Reactive molecular dynamics simulations

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Nano Research 2018年第4期11卷 1757-1767页

作者： Susanna Monti Giovanni Barcaro luca Sementa Vincenzo Carravetta Hans Agren CNR-ICCOM Institute of Chemistry of Organometallic Compounds Pisa 56124 Italy KTH Royal Institute of Technology School of Biotechnology Division of Theoretical Chemistry and Biology Stockholm S- 10691 Sweden CNR-IPCF Institute of Chemical and Physical Processes Pisa 56124 Italy Institute of Nanotechnology Spectroscopy and Quantum Chemistry Siberian Federal University Svobodny pr. 79 660041 Krasnoyarsk Russia

The self-assembling properties, stability, and dynamics of hybrid nanocarriers （gold nanoparticles （AuNPs） functionalized with cysteine-based peptides） in solution are studied through a series of classical molecular dynamics simulations based on a recently parametrized reactive force field. The results reveal, at the atomic level, all the details regarding the peptide adsorption mechanisms, nanoparticle stabilization, aggregation, and sintering. The data confirm and explain the experimental findings and disclose aspects that cannot be scrutinized by experiments. The biomolecules are both chemisorbed and physisorbed; self-interactions of the adsorbates and formation of stable networks of inter- connected molecules on the AuNP surfaces limit substrate reconstructions, protect the AuNPs from the action of the solvent, and prevent direct interactions of the gold surfaces. The possibility of agglomeration of the functionalized nanoparticles, compared with the sintering of the bare supports in a water solution, is demonstrated through relatively long simulations and fast steered dynamics. The analysis of the trajectories reveals that the AuNPs were well stabilized by the peptides. This prevented particle sintering and kept the particles far apart; however, part of their chains could form interconnections （crosslinks） between neighboring gold vehicles. The excellent agreement of these results with the literature confirm the reliability of the method and its potential application to the modeling of more complex materials relevant to the biomedical sector.

关键词： nanoparticle ReaxFF functionalization cross-linking biocompatibility

The Effects of a Unilateral Strength and Power Training Intervention on Inter-Limb Asymmetry and Physical Performance in Male Amateur Soccer Players

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Journal of Science in Sport and Exercise 2023年第4期5卷 328-339页

作者： Francesco Bettariga luca Maestroni luca Martorelli Paul Jarvis Anthony Turner Chris Bishop StudioErre Via della Badia1825127 Brescia(BS)Italy School of Medical and Health Sciences Edith Cowan UniversityJoondalupAustralia School of Science and Technology London Sport InstituteMiddlesex UniversityGreenlands LaneLondonUK ReAct Via Madonna della Neve 2424121 BergamoBGItaly

The aims of this study were(a)to investigate the effects of a unilateral training program in reducing inter-limb asymmetry in male soccer players;(b)to explore such effects on measures of physical performance and unilateral inter-limb ***-four soccer players,randomly assigned to a 6-week unilateral strength and power training(UNI)(n=12)or a control group(CON)(n=12),performed single countermovement jump(SLCMJ),single leg broad jump(SLBJ),single leg drop jump(SLDJ),10-m sprint,and 505 change of direction(COD)speed *** jump scores revealed small to large improve-ments in SLCMJ,SLBJ,and SLDJ reactive strength index(RSI)(g=0.46 to 1.66)in the UNI group,whereas negligible changes were found in the CON group(g=−0.31 to 0.33).Asymmetry indexes showed a moderate significant reduction in the SLDJ(RSI)and in the SLDJ stiffness(K)(g=1.00 to 1.11)in the UNI *** between-group comparison indicated a significant change in the SLDJ(RSI)and in the SLDJ(K)(g=1.01 to 1.07)in favour of the UNI ***,a unilateral training program seems to be able to reduce between-limb imbalances and foster improvements in jump performance,without any detrimental effects on linear or COD speed *** the importance of these physical characteristics for soccer,it is suggested that unilateral strength and power training are incorporated into strength training routines for players of all levels.

关键词： Inter-limb asymmetry Training program intervention Between-limb differences Resistance training Plyometrics Football Physical performance

Application of flame-formed carbon nanoparticle films for ethanol sensing Author links open overlay panel

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Particuology 2024年第8期91卷 202-210页

作者： Pegah Darvehi luca Basta Mario Commodo Patrizia Minutolo Andrea D'Anna Istituto di Scienze e Tecnologie per l’Energia e la MobilitàSostenibili Consiglio Nazionale delle RicercheP.le Tecchio 8080125NapoliItaly Dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIP.le Tecchio 8080125NapoliItaly

Carbon nanoparticles(CNPs)have received considerable attention due to their exceptional qualities and *** unique physical and chemical characteristics make them extremely intriguing as materials for numerous high-potential applications,such as electronics and gas *** study focused on producing carbon-based nanomaterial devices by deposition of flame-formed carbon nanoparticles on a suitable substrate and investigating their gas-sensing *** were produced in a fuel-rich laminar premixed ethylene/air flame and the collected CNP film was morphologically and electrically *** electrical conductivity of the film was investigated as a function of ethanol concentration and amount of deposited ***,CNP films exhibited high sensitivity to ambient ethanol gas concentrations,and rapid recovery times at room temperature,and showed a sensitivity increasing with the amount of deposited material and the surface *** findings demonstrate the high potential of combustion-generated CNPs as building materials for low-cost and portable ethanol sensors.

关键词： Flame synthesis Carbon nanoparticles Soot Nanostructured thin film Optical and electrical characterization Atomic force microscopy Sensors

Microstructure and Mechanical Performance of Ti-6Al-4V Lattice Structures Manufactured via Electron Beam Melting(EBM):A Review

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 183-203页

作者： Giuseppe Del Guercio Manuela Galati Abdollah Saboori Paolo Fino luca Iuliano Department of Management and Production Engineering(DIGEP) Politecnico di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly Department of Applied Science and Technology(DISAT) Politecnico di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly Integrated Additive Manufacturing Center(IAM)@Polito Politecnico Di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly

Electron beam melting(EBM) process is an additive manufacturing process largely used to produce complex metallic components made of high-performance materials for aerospace and medical ***,lattice structures made by Ti-6A1-4V have represented a hot topic for the industrial sectors because of having a great potential to combine lower weights and higher performances that can also be tailored by subsequent heat ***,the little knowledge about the mechanical behaviour of the lattice structures is limiting their *** present work aims to provide a comprehensive review of the studies on the mechanical behaviour of the lattice structures made of *** main steps to produce an EBM part were considered as guidelines to review the literature on the lattice performance:(1) design,(2) process and(3) post-heat ***,the correlation between the geometrical features of the lattice structure and their mechanical behaviour is *** addition,the correlation among the mechanical performance of the lattice structures and the process precision,surface roughness and working temperature are also *** investigation on the studies about the properties of heat-treated lattice structure is also conducted.

关键词： Electron beam melting(EBM) Additive manufacturing(AM) Lattice structures Ti–6Al–4V Mechanical properties Heat treatment

Forecasting technical debt evolution in software systems:an empirical study

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Frontiers of Computer Science 2023年第3期17卷 63-75页

作者： Lerina AVERSANO Mario luca BERNARDI Marta CIMITILE Martina IAMMARINO Debora MONTANO Department of Engineering University of SannioBenevento 82100Italy Department of Law and Economics Unitelma Sapienza University of RomeRome 00161Italy

Technical debt is considered detrimental to the long-term success of software development,but despite the numerous studies in the literature,there are still many aspects that need to be investigated for a better understanding of *** particular,the main problems that hinder its complete understanding are the absence of a clear definition and a model for its identification,management,and *** on forecasting technical debt,there is a growing notion that preventing technical debt build-up allows you to identify and address the riskiest debt items for the project before they can permanently compromise ***,despite this high relevance,the forecast of technical debt is still little *** this end,this study aims to evaluate whether the quality metrics of a software system can be useful for the correct prediction of the technical ***,the data related to the quality metrics of 8 different open-source software systems were analyzed and supplied as input to multiple machine learning algorithms to perform the prediction of the technical *** addition,several partitions of the initial dataset were evaluated to assess whether prediction performance could be improved by performing a data *** results obtained show good forecasting performance and the proposed document provides a useful approach to understanding the overall phenomenon of technical debt for practical purposes.

关键词： technical debt empirical study software quality metrics machine learning

Geophysical mapping of Vercelli Seamount： Implications for Miocene evolution of the Tyrrhenian back arc basin

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Geoscience Frontiers 2016年第5期7卷 835-849页

作者： luca Cocchi Giuseppe Masetti Filippo Muccini Cosmo Carmisciano Istituto Nazionale di Geofisica e Vulcanologia Roma 2. Rome Italy Center for Coastal & Ocean Mapping -Joint Hydrographic Center University of New Hampshire Durham NH USA

Since the Tortonian, the geodynamic evolution of the Tyrrhenian Sea has been driven by an eastward roll-back of the entire Apennine subduction system, triggering distinct episodes of back-arc basin formation with spots of oceanic crust. Major structural differences are observed between northern and southern portions of the Tyrrhenian Sea, reflecting two distinct evolution stages of the Ionian slab retreat. In the central portion of the Tyrrhenian Sea, the seafloor morphology is characterized by a set of magmatic intrusions and structural highs associated to an Ee W magnetic lineament along the 41 st geographical parallel. The Vercelli seamount represents one example of structural highs correlated to Miocene magmatic episodes along the 41 st parallel zone. In this study, we discuss the results of new high resolution magnetic data and morphological mapping of the Vercelli seamount acquired during the VER2010 cruise. The seamount represents the relict part of a granitic intrusion emplaced during the Tortonian phase of Tyrrhenian rifting. Tectonic and deep-sea erosive processes have jointly modified the seamount structure that can be observed nowadays. Cumulative gradient analysis highlights an asymmetric morphology of the flanks as a result of erosive action of opposite water mass gyres which modelled the southern portion of the seamount. The joint interpretation of magnetic and bathymetric datasets identifies a high magnetized source laying close to the base of the seamount and located in correspondence to a small basin. This structure has been modelled as a post-Tortonian lava sequence emplaced between structural highs in correspondence of Ne S elongated flat sedimentary *** of new geophysical data highlights the relationship between crustal setting and magnetic evidences of the central Tyrrhenian Sea, providing a new interpretation of the 41 st magnetic lineament.

关键词： Tyrrhenian Sea Seamount Multibeam swath bathymetry Magnetic anomaly Forward modelling