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Relevant incidental findings at abdominal multi-detector contrast-enhanced computed tomography:A collateral screening?

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World Journal of Radiology 2015年第10期7卷 350-356页

作者： luca maria sconfienza Giovanni Mauri Claudia Muzzupappa Alessandro Poloni Michele Bandirali Anastassia Esseridou Stefania Tritella Francesco Secchi Giovanni Di Leo Francesco Sardanelli Servizio di Radiologia IRCCS Policlinico San Donato Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Scuola di Specia-lizzazione in Radiodiagnostica Università degli Studi di Milano

AIM: To investigate the prevalence of relevant incidental findings(RIFs) detected during routine abdominal contrast-enhanced computed tomography(Ce CT).METHODS: We retrospectively evaluated the reports of a consecutive series of abdominal Ce CT studies performed between January and May 2013. For each report, patients' age and sex, admission as inpatient or outpatient, clinical suspicion as indicated by the requesting physician, availability of a previous abdominal examination, and name of the reporting radiologist were recorded. Based on the clinical suspicion, the presence and features of any RIFs(if needing additional workup) was ***: One thousand forty abdominal Ce CT were performed in 949 patients(528 males, mean age 66 ±14 years). No significant difference was found between inpatients and outpatients age and sex distribution(P > 0.472). RIFs were found in 195/1040(18.8%) Ce CT [inpatients = 108/470(23.0%); outpatients = 87/570(15.2%); P = 0.002]. RIFs were found in 30/440(6.8%) Ce CT with a previous exam and in 165/600(27.5%) without a previous exam(P < 0.001). Radiologists' distribution between inpatients or outpatients was significantly different(P < 0.001). RIFs prevalence increased with aging, except for a peak in 40-49 year group. Most involved organs were kidneys, gallbladder, and ***: A RIF is detected in 1/5 patients undergoing abdominal Ce CT. Risk of overdiagnosis should be taken into account.

关键词： Contrast-enhanced computed tomography Abdomen Inci

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Reporting rotator cuff tears on magnetic resonance arthrography using the Snyder's arthroscopic classification

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World Journal of Radiology 2017年第3期9卷 126-133页

作者： Alberto Aliprandi Carmelo Messina Paolo Arrigoni Michele Bandirali Giovanni Di Leo Stefano Longo Sandro Magnani Chiara Mattiuz Filippo Randelli Silvana Sdao Francesco Sardanelli luca maria sconfienza Pietro Randelli Servizio di Radiologia IRCCS Policlinico San Donato Scuola di Specializzazione in Radiodiagnostica Università degli Studi di Milano Unità Operativa di Ortopedia e Traumatologia Ⅱ IRCCS Policlinico San Donato Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Unità Operativa di Ortopedia e Traumatologia V IRCCS Policlinico San Donato Unità Operativa di Radiologia/Diag-nostica per Immagini con Servizio di Radiologia Interventistica IRCCS Istituto Ortopedico Galeazzi Unità Operativa Complessa I Divisione Istituto Ortopedico Gaetano Pini

AIM To determine diagnostic performance of magnetic resonance arthrography(MRA) in evaluating rotator cuff tears(RCTs) using Snyder's classification for *** One hundred and twenty-six patients(64 males, 62 females; median age 55 years) underwent shoulder MRA and arthroscopy, which represented our reference standard. Surgical arthroscopic reports were reviewed and the reported Snyder's classification was recorded. MRA examinations were evaluated by two independent radiologists(14 and 5 years' experience) using Snyder's classification system, blinded to arthroscopy. Agreement between arthroscopy and MRA on partial-and fullthickness tears was calculated, first regardless of their extent. Then, analysis took into account also the extent of the tear. Interobserver agreement was also calculated the quadratically-weighted Cohen kappa *** On arthroscopy, 71/126 patients(56%) had a fullthickness RCT. The remaining 55/126 patients(44%) had a partial-thickness RCT. Regardless of tear extent, out of 71 patients with arthroscopically-confirmed fullthickness RCTs, 66(93%) were correctly scored by both readers. All 55 patients with arthroscopic diagnosis of partial-thickness RCT were correctly assigned as having a partial-thickness RCT at MRA by both readers. Interobserver reproducibility analysis showed total agreement between the two readers in distinguishing partial-thickness from full-thickness RCTs, regardless of tear extent(k = 1.000). With regard to tear extent, in patients in whom a complete tear was correctly diagnosed, correct tear extent was detected in 61/66 cases(92%); in the remaining 5/66 cases(8%), tear extent was underestimated. Agreement was k = 0.955. Interobserver agreement was total(k = 1.000).CONCLUSION MRA shows high diagnostic accuracy and reproducibility in evaluating RCTs using the Snyder's classification for reporting. Snyder's classification may be adopted for routine reporting of MRA.

关键词： Arthroscopy Magnetic resonance imaging Shoulder Arthrography Supraspinatus tendon Rotator cuff tear

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Remarks on Some Trends in Contemporary Philosophy

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Frontiers of Philosophy in China 2018年第2期13卷 174-181页

作者： luca maria Scarantino Intemational University of Language and Media Via Carlo Bo 4 20143 Milan Italy

1A number of observations concerning current trends in philosophy will be addressed in this article insofar as they relate to the upcoming 24^th World Congress of Philosophy （WCP）. As the Secretary General of the International Federation of Philosophical Societies （FISP） and the Chair of the Executive Committee of the Congress, I am pleased to add my own reflections and observations to those of other contributors in this volume, hoping this will reflect the cooperative efforts and friendship that have united us in the course of preparation for this Congress.

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Lower Continental Crusts Involved in the Alpine Orogeny:New Insight from the Santa Lucia Nappe Metasediments(Corsica,France)

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI maria DI ROSA luca PANDOLFI Michele MARRONI Dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** D1 phase was testified by rare isoclinal *** D2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** D3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the D1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** D2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

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Non-celiac gluten sensitivity:Time for sifting the grain

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World Journal of Gastroenterology 2015年第27期21卷 8221-8226页

作者： luca Elli Leda Roncoroni maria Teresa Bardella Center for Prevention and Diagnosis of Celiac Disease Gastroenterology and Endoscopy Unit Department of Pathophysiology and Transplantation Università degli Studi di Milano. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

In the last few years, a new nomenclature has been proposed for the disease induced by the ingestion of gluten, a protein present in wheat, rice, barley and oats. Besides celiac disease and wheat allergy, the most studied forms of gluten-related disorders characterized by an evident immune mechanism(autoimmune in celiac disease and Ig E-mediated in wheat allergy), a new entity has been included, apparently not driven by an aberrant immune response: the non-celiac gluten sensitivity(NCGS). NCGS is characterized by a heterogeneous clinical picture with intestinal and extraintestinal symptoms arising after gluten ingestion and rapidly improving after its withdrawal from the diet. The pathogenesis of NCGS is largely unknown, but a mixture of factors such as the stimulation of the innate immune system, the direct cytotoxic effects of gluten, and probably the synergy with other wheat molecules, are clues for the complicated puzzle. In addition, the diagnostic procedures still remain problematic due to the absence of efficient diagnostic markers; thus, diagnosis is based upon the symptomatic response to a gluten-free diet and the recurrence of symptoms after gluten reintroduction with the possibility of an important involvement of a placebo effect. The temporary withdrawal of gluten seems a reasonable therapy, but the timing of gluten reintroduction and the correct patient management approach are have not yet been determined.

关键词： Celiac disease Gluten Gluten-relateddisorders Gluten sensitivity Non-celiac gluten sensitivity

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Alveolar cleft reconstruction with vomerine bone:two surgical procedures in one step:a case series

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Plastic and Aesthetic Research 2023年第1期10卷 643-655页

作者： luca Autelitano maria Costanza Meazzini Department of Maxillofacial Surgery Cleft Lip and Palate Regional CenterUniversity of MilanSan Paolo Hospital MilanMilan 20142Italy

Aim:Iliac crest(IC)is the most common source of bone for alveolar cleft repair,as it allows for harvesting a large amount of cancellous bone with a high rate of favorable *** drawback is the donor-site *** propose a new technique for alveolar cleft grafting using vomerine bone(VB),which,through bone grafting,reconstructs the alveolus with the VB and simultaneously corrects the nasal septum ***:We performed 18 alveolar reconstructions with VB in patients with a small bony defect and septal deviation,which would benefit from septoplasty.A matched control group with IC bone grafting was *** X-rays were used for vertical assessment of ossification with the Bergland scale and CT scans for the evaluation of the thickness of the grafted area in the VB and IC groups and compared with an independent samples T-test.A paired T-test compared angular measurements of the septal deviation pre-and post-vomerine ***:All grafts healed uneventfully,with no complications at the donor site and respiratory function was *** was no statistically significant difference in ossification height between VB and IC,the alveolar thickness at the occlusal and middle third was higher with *** deviation was reduced ***:Alveolar graft from VB seems to be a viable alternative to IC in patients who present with a mild bony alveolar defect in addition to septal deviation,allowing combined procedures while reducing the morbidity of the donor site.

关键词： Alveolar cleft bone graft vomerine bone septoplasty

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A practical approach to the diagnosis of autoimmune pancreatitis

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World Journal of Gastroenterology 2011年第16期17卷 2076-2079页

作者： luca Frulloni Antonio Amodio Anna maria Katsotourchi Italo Vantini Department of Medicine University of Verona Cattedra di Gastroenterologia Policlinico GB Rossi

Autoimmune pancreatitis is a disease characterized by specific pathological features,different from those of other forms of pancreatitis,that responds dramatically to steroid *** pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging,mimicking pancreatic ***,the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic *** in the presence of a pancreatic mass the probability of tumour is much higher than that of pancreatitis,the physician should be aware that in focal autoimmune pancreatitis the first step before using steroids is to exclude pancreatic *** this review,we briefly analyse the strategies to be followed for a correct diagnosis of autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis Therapy Diagnosis

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Use of oleaginous plants in phytotreatment of grey water and yellow water from source separation of sewage

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Journal of Environmental Sciences 2017年第5期29卷 274-282页

作者： maria Cristina Lavagnolo Mario Malagoli luca Alibardi Francesco Garbo Alberto Pivato Raffaello Cossu Department of Industrial Engineering University of Padova via Lungargine Rovetta 8 35127 Padova Italy DAFNAE University of Padova viale dell'Universita 16 35020 Legnaro Italy

Efficient and economic reuse of waste is one of the pillars of modern environmental engineering. In the field of domestic sewage management,source separation of yellow（urine）,brown（faecal matter）and grey waters aims to recover the organic substances concentrated in brown water,the nutrients（nitrogen and phosphorous）in the urine and to ensure an easier treatment and recycling of grey waters. With the objective of emphasizing the potential of recovery of resources from sewage management,a lab-scale research study was carried out at the University of Padova in order to evaluate the performances of oleaginous plants（suitable for biodiesel production）in the phytotreatment of source separated yellow and grey waters. The plant species used were Brassica napus（rapeseed）,Glycine max（soybean）and Helianthus annuus（sunflower）. Phytotreatment tests were carried out using 20 L pots. Different testing runs were performed at an increasing nitrogen concentration in the feedstock. The results proved that oleaginous species can conveniently be used for the phytotreatment of grey and yellow waters from source separation of domestic sewage,displaying high removal efficiencies of nutrients and organic substances（nitrogen 〉 80%; phosphorous 〉 90%; COD nearly 90%）. No inhibition was registered in the growth of plants irrigated with different mixtures of yellow and grey waters,where the characteristics of the two streams were reciprocally and beneficially integrated.

关键词： Phytotreatment Sewage Source separation Decentralization Grey water Urine Energy crops

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Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy： a preliminary report

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Asian Journal of Andrology 2012年第4期14卷 591-598页

作者： Giorgio Cavallini maria Cristina Magli Andor Crippa Anna Pia Ferraretti luca Gianaroli Medicitalia Andrological Section Outpatient Clinic of Ferrara Ferrara 44100 Italy Laboratory of Assisted Reproduction Societa Italiana di Medicina della Riproduzione (SISMER) Bologna 40138 Italy Operative Unit of Assisted Reproduction Societa Italiana di Medicina della Riproduzione (SISMER) Bologna 40138 Italy

The objective of this study was to investigate whether medical therapy can reduce sperm aneuploidy levels and irfiprove the results of intracytoplasmic sperm injection （ICSI） in patients with severe idiopathic oligoasthenoteratospermia （OAT）. Thirty-three infertile couples requiring ICSI because of severe idiopathic OAT after at least one unsuccessful ICSI cycle were considered. Semen parameters （concentration, motility and morphology）, the percentage of aneuploid sperm and the results of ICSI （the number of oocytes fertilized, embryos transferred, biochemical pregnancies, clinical pregnancies and live births） were compared before and after a 3-month course of treatment with L-carnitine 1 g given twice per day＋acetyI-L-carnitine 500 mg given twice per day＋one 30-mg cinnoxicam tablet every 4 days. Aneuploidy was assessed using fluorescent in situ hybridisation （FISH） performed on chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22. The results showed that 22 of the 33 patients had a reduced frequency of aneuploid sperm and improved sperm morphology after treatment （group 1）, and 11 showed no change （group 2）. The numbers of biochemical pregnancies, clinical pregnancies and live births were significantly higher in group I than in group 2. No significant difference was found between the groups regarding the numbers of oocytes fertilized and embryos transferred. The side effects were negligible. The numbers of ICSI pregnancies and live births in severe idiopathic OAT patients improved with a course of L-carnitine, acetyI-L-carnitine and cinnoxicam.

关键词： acetyI-L-carnitine cinnoxicam ICSl L-carnitine male infertility oligoasthenoteratospermia sperm aneuploidy

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CRISPR/Cas system: An emerging technology in stem cell research

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World Journal of Stem Cells 2019年第11期11卷 937-956页

作者： maria Teresa Valenti Michela Serena luca Dalle Carbonare Donato Zipeto Department of Medicine Section of Internal Medicine DUniversity of VeronaVerona 37134Italy Department of Biochemistry University of OxfordOxford OX13QUUnited Kingdom Department of Neurosciences Biomedicine and Movement SciencesLaboratory of Molecular BiologyVerona 37134Italy

The identification of new and even more precise technologies for modifying and manipulating the genome has been a challenge since the discovery of the DNA double *** ability to modify selectively specific genes provides a powerful tool for characterizing gene functions,performing gene therapy,correcting specific genetic mutations,eradicating diseases,engineering cells and organisms to achieve new and different functions and obtaining transgenic animals as models for studying specific *** regularly interspaced short palindromic repeats(CRISPR)/Cas9 technology has recently revolutionized genome *** application of this new technology to stem cell research allows disease models to be developed to explore new therapeutic *** possibility of translating new systems of molecular knowledge to clinical research is particularly appealing for addressing degenerative *** this review,we describe several applications of CRISPR/Cas9 to stem cells related to degenerative *** addition,we address the challenges and future perspectives regarding the use of CRISPR/Cas9 as an important technology in the medical sciences.

关键词： Gene editing CRISPR/Cas9 Stem cells Degenerative diseases

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