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The interplay of nurse and target plant traits influences magnitude and direction of facilitative interactions under different combinations of stress and disturbance intensities in Andean dry grassland

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Journal of Plant Ecology 2016年第3期9卷 296-310页

作者： Andrea Catorci luca malatesta Jose Luis Velasquez Federico Maria Tardella Horacio Zeballos School of Biosciences and Veterinary Medicine University of Camerinovia Pontoni 5CamerinoMCItaly School of Advanced Studies PhD Course in Environmental Sciences and Public Health University of Camerinovia Lili 55CamerinoMCItaly Centro de Estudios y Promoción del Desarrollo(Desco) Málaga Grenet 678ArequipaPeru Instituto de Ciencias de la Naturaleza Territorio Yenergia RenovablesPontificia Universidad Católica del Perù.Av.Universitaria 1801San Miguel 32LimaPerù

Aims Facilitation is a key process in vegetation dynamics,driving the response to natural and anthropogenic *** harsh-grazed systems,palatable plants mainly survive when nested under unpalatable tussocks and *** magnitude and direction of positive interactions are driven by resource availability,extent of herbivory and type of nurse *** hypothesized that different combinations of disturbance and environmental stress affect community composition in the dry Puna(southern Peruvian Andes)by modifying nurse types and plant interactions in magnitude and specific *** investigated whether different combinations of stress and disturbance influence species richness,type and frequency of occurrence of nurse and beneficiary species and magnitude and patterns of plant interactions;whether nurse species influence these interactions and target species change their interactions under different combinations of stress and disturbance and whether plant functional traits differ in the studied communities and influence the pattern of spatial *** We selected three plant communities subject to different precipitation and management regimes:in each we laid a number of transects proportional to its *** collected include species presence/absence,type of spatial interactions with nurse species and functional *** calculated species richness and rarefaction patterns,described the patterns of plant-plant spatial interactions and investigated the associations between nurse and other species in the three communities using indicator species analysis(ISA).We performed ISA and correlation analysis to investigate whether plant functional traits influenced facilitative *** Findings We found that different combinations of stress and disturbance shaped a complex set of responses,including changes in the nurse species *** composition influenced magnitude and direction of plant interactions under different stress

关键词： dry Puna facilitation functional traits nurse and beneficiary species species-specific interaction stress-gradient hypothesis

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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： Marco Ghibaudi Enrica Boda luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

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Oncology research 2025年第1期33卷 45-55页

作者： Enrico Caliman Sara Fancelli Federico Scolari Adriano Pasqui Clara Manneschi Daniele Lavacchi Francesca Mazzoni Francesca Gensini Valeria Pasini Camilla Eva Comin luca Voltolini Serena Pillozzi Lorenzo Antonuzzo Clinical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Medicine University of Florence Florence 50134 Italy. Department of Health Sciences University of Florence Florence 50134 Italy. Medical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Biomedical Sciences "Mario Serio" University of Florence Florence 50134 Italy. Section of Anatomic Pathology Department of Health Sciences University of Florence Florence 50139 Italy. Section of Surgery Histopathology and Molecular Pathology University of Florence Florence 50139 Italy. Thoracic Surgery Unit Careggi University Hospital Florence 50134 Italy.

Background:Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients' survival.Materials and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes-namely , , and -were performed on patient tumor samples.Results:Overall, elevated expression of genes was observed in SCLC patients compared to healthy controls. Patients with low and expression levels exhibited a better median progression-free survival (mPFS = 7.1 . 4.9 months, = 0.39 for and mPFS = 6.9 . 4.8 months, = 0.093 for ) and overall survival (mOS = 8.7 . 6.0 months, = 0.4 for and mOS = 7.2 . 6.2 months, = 0.13 for ). Genotyping analysis of five SNPs of genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the rs11615 SNP ( = 0.24 for PFS and = 0.14 for OS) and of the rs13181 and rs1799793 SNPs ( = 0.43 and = 0.26 for PFS and = 0.21 and = 0.16 for OS, respectively) compared to patients with homozygous mutant genotypes.Conclusions:The comprehensive analysis of gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： ERCC genes Nucleotide excision repair (NER) pathway Platinum-chemotherapy (CT) Single nucleotide polymorphisms (SNPs) Small cell lung cancer (SCLC)

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Factors that Influence Product Development and their Integration Level in Project Management Approaches

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Journal of Systems Science and Systems Engineering 2023年第4期32卷 462-482页

作者： luca Leib Faculty of Business and Economics Mendel University in BrnoBrnoCzech Republic

Project management literature provides various approaches to organize project ***,several factors influence product development about its efficiency and *** paper analyses the factors that affect product development and evaluates their integration level in project management concerning modern requirements imposed in a volatile,uncertain,complex,and ambiguous(VUCA)*** concludes by identifying undervalued influencing factors worth investigating in future research.

关键词： Communication decision making product development project management team organization VUCA

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DLC coatings for hydraulic applications

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中国有色金属学会会刊：英文版 2009年第4期19卷 810-813页

作者： luca NOBILI luca MAGAGNIN Dip. Chimica Materiali e Ingegneria Chimica ＂G. Natta＂ Politecnico di Milano Via Mancinelli 7-20131 Milano Italy

与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的，由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的，并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被... 详细信息

与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的，由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的，并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被利用扔 hydrogenated DLC 涂层(交流: H ) 在不同底层上。Microindentation 大小证明涂层坚硬在 35 GPa 附近。Tribological 行为被测试与氧化铝在水和水里执行了的 block-on-ring 评估。wear 率在由激光 profilemeter 测量 wear 体积以后被计算。wear 轨道的词法、组合的分析表明那涂层失败可以由磨料发生穿或分层，取决于底层性质。难、光滑的底层给最好的结果，驱散的氧化铝粒子增加 wear 率。

关键词：类金刚石涂层液压元件氧化铝颗粒应用等离子体辅助类金刚石碳固体润滑膜 CVD工艺

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Utilization of irradiance ratios for calculating the effect of reflections from obstructions in building energy simulation

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Building Simulation 2021年第4期14卷 945-967页

作者： Gian luca Brunetti Politecnico di Milano Department of Architecture and Urban Studies(DAStU)via Bonardi 320133MilanoItaly

The ability to take into account reflections from obstructions is of fundamental importance in building energy simulation (BES), because reflections can have a substantial influence on solar gains. In BES tools, this ability is often implemented duplicating functionalities that have already been solved efficiently in lighting simulation tools. This happens because importing those functionalities from a lighting simulation tool (source) into a BES tool (target) is usually a complex operation producing non-portable results. This article demonstrates that this ability can be imported modularly and portably without intervening in the internals of the two tools. This can be obtained by: (1) creating, in the source tool, pairs of models which are analogue-on the one hand-to the original model in the target tool, and-on the other hand-to the model in the target tool hypothetically enriched with some predictive ability only available in the source tool;(2) measuring, at each time step, the ratio between the performances predicted by the source tool as regards the two analogue models;(3) re-scaling, at each time-step, the performance predicted by the target tool on the basis of that ratio. When appropriate analogue models are utilized, this strategy enables distinct simulation tools to work like an integrated computing unit.

关键词： irradiance ratios shading factors analogue models solar reflections insolation factors

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Historic recurrences in medicinal chemistry:nature-inspired structures as a new opportunity for novel multi-target anti-Alzheimer's drugs

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Neural Regeneration Research 2023年第12期18卷 2671-2672页

作者： luca Piemontese Universitàdegli Studi di Bari Aldo Moro Dipartimento di Farmacia-Scienze del Farmacovia E.OrabonaBariItaly

Alzheimer 's disease(AD) is an alarming noncommunicable, multi-factorial, and non-treatable disease. Its underlying neurodegenerative events have not yet been fully explained and its early diagnosis is very difficult. The appearance of the disease is associated with clinical features such as the degeneration of several cholinergic nuclei of the brain.

关键词： Alzheimer drugs diagnosis

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REDUCED BASIS METHOD FOR PARAMETRIZED ELLIPTIC ADVECTION-REACTION PROBLEMS

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Journal of Computational Mathematics 2010年第1期28卷 122-148页

作者： luca Dedè MOX-Modeling■Scientific Computing Dipartimento di Matematica"F.Brioschi"Politecnico di Milano

In this work we consider the Reduced Basis method for the solution of parametrized advection-reaction partial differential equations. For the generation of the basis we adopt a stabilized finite element method and we define the Reduced Basis method in the ＂primal- dual＂ formulation for this stabilized problem. We provide a priori Reduced Basis error estimates and we discuss the effects of the finite element approximation on the Reduced Basis error. We propose an adaptive algorithm, based on the a posteriori Reduced Basis error estimate, for the selection of the sample sets upon which the basis are built; the idea leading this algorithm is the minimization of the computational costs associated with the solution of the Reduced Basis problem. Numerical tests demonstrate the efficiency, in terms of computational costs, of the ＂primal-dual＂ Reduced Basis approach with respect to an ＂only primal＂ one. Parametrized advection-reaction partial differential equations, Reduced Basis method, ＂primal-dual＂ reduced basis approach, Stabilized finite element method, a posteriori error estimation.

关键词： Parametrized advection-reaction partial differential equations Reduced Basis method "primal-dual" reduced basis approach Stabilized finite element method a posteriori error estimation.

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An innovative approach for the treatment of Alzheimer's disease: the role of peroxisome proliferator-activated receptors and their ligands in development of alternative therapeutic interventions

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Neural Regeneration Research 2019年第1期14卷 43-45页

作者： luca Piemontese Dipartimento Farmacia-Scienze del Farmaco Università degli Studi di Bari "Aldo Moro"

Alzheimer＇s disease is a multifactorial pathology, for which no cure is currently available. Nowadays, researchers are moving towards a new hypothesis of the onset of the illness, linking it to a metabolic impairment, q-his innovative approach will lead to the identification of new targets for the preparation of new effective drugs. Peroxisome proliferator-activated receptors and their ligands are the ideal candidates to reach the necessary breakthrough to defeat this complicate disease.

关键词： Alzheimer's disease multifunctional drugs peroxisome proliferator-activated receptors type 3 diabetes innovative therapies type 2 diabetes mellitus metabolism neuroinflammation

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