检索结果-南通市图书馆

Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer＇s disease therapy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第8期12卷 1256-1261页

作者： Asha Hiremathad luca Piemontese Centre for Nano and Material Sciences Jain University Jain Global Campus Kanakapura Ramanagaram Bangalore India Dipartimento di Farmacia-Scienze del Farmaco Universitfl degli Studi di Bari "Aldo Moro" Bari Italy

Nowadays, Alzheimer＇s disease（AD） is widely recognized as a real social problem. In fact, only five drugs are FDA approved for the therapy of this widespread neurodegenerative disease, but with low results so far. Three of them（rivastigmine, donepezil and galantamine） are acetylcholinesterase inhibitors, memantine is a N-methyl-D-aspartate receptor antagonist, whereas the fifth formulation is a combination of donepezil with memantine. The prevention and treatment of AD is the new challenge for pharmaceutical industry, as well as for public institutions, physicians, patients, and their families. The discovery of a new and safe way to cure this neurodegenerative disease is urgent and should not be delayed further. Because of the multiple origin of this pathology, a multi-target strategy is currently strongly pursued by researchers. In this review, we have discussed new structures designed to better the activity on the classical AD targets. We have also examined old and new potential drugs that could prove useful future for the therapy of the pathology by acting on innovative, not usual, and not yet fully explored targets like peroxisome proliferator-activated receptor（PPARs）.

关键词： Alzheimer's disease multi-target strategy peroxisome proliferator-activated receptors heterocycliccompounds neurodegenerative diseases

From the elasticity theory to cosmology and vice versa

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2014年第4期57卷 597-603页

作者： LEVRINO luca TARTAGLIA Angelo Politecnico di Torino Department of Applied Science and Technology Corso Duca degli Abruzzi 2410129 Torino Italy

The paper shows how a generalization of the elasticity theory to four dimensions and to space-time allows for a consistent description of the homogeneous and isotropic universe,including the accelerated *** analogy is manifested by the inclusion in the traditional Lagrangian of general relativity of an additional term accounting for the strain induced in the manifold(*** space-time)by the curvature,be it induced by the presence of a texture defect or by a matter/energy *** additional term is su?cient to account for various observed features of the universe and to give a simple interpretation for the so called dark ***,we show how the same approach can be adopted back in three dimensions to obtain the equilibrium configuration of a given solid subject to strain induced by defects or applied ***,it is shown how concepts coming from the familiar elasticity theory can inspire new approaches to cosmology and in return how methods appropriated to General Relativity can be applied back to classical problems of elastic deformations in three dimensions.

关键词： deformable solids cosmology elastic strain Lagrangian density and tensors

New approaches for prevention and treatment of Alzheimer's disease:a fascinating challenge

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第3期12卷 405-406页

作者： luca Piemontese Dipartimento Farmacia-Scienze del Farmaco UniversitàdegliStudi di Bari"Aldo Moro"BariItaly Centro de Química Estrutural Instituto Superior Técnico-Universidade Técnica de LisboaLisboaPortugal

The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their *** spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.

关键词： PPARs New approaches for prevention and treatment of Alzheimer’s disease:a fascinating challenge

An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2009年第2期18卷 173-184页

作者： luca Fuligno Diego Micheli Carlo Poloni EnginSoft s.p.a. Dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste Dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词： micro gas turbine combustor optimized design

SRAM-Based FPGA Systems for Safety-Critical Applications： A Survey on Design Standards and Proposed Methodologies

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2015年第2期30卷 373-390页

作者： Cinzia Bernardeschi luca Cassano Andrea Domenici Department of Information Engineering University of Pisa Pisa 56122 Italy Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano Milano 20133 Italy

As the ASIC design cost becomes affordable only for very large-scale productions, the FPGA technology is currently becoming the leading technology for those applications that require a small-scale production. FPGAs can be considered as a technology crossing between hardware and software. Only a small-number of standards for the design of safety-critical systems give guidelines and recommendations that take the peculiarities of the FPGA technology into consideration. The main contribution of this paper is an overview of the existing design standards that regulate the design and verification of FPCA-based systems in safety-critical application fields. Moreover, the paper proposes a survey of significant published research proposals and existing industrial guidelines about the topic, and collects and reports about some lessons learned from industrial and research projects involving the use of FPGA devices.

关键词： design verification electronic design safety-critical system SRAM-based FPGA

Photoluminescence monitoring of oxide formation and surface state passivation on InAs quantum dots exposed to water vapor

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2016年第10期9卷 3018-3026页

作者： Giovanna Trevisi luca Seravalli Paola Frigeri CNR-IMEM Institute Parco Area delle Scienze 37a 43124 Parma Italy

The room-temperature light emission of uncapped III-V semiconductor quantum dots is used to investigate the properties and evolution of the surface under exposure to a humid environment. Enhanced photoluminescence intensity resulting from exposure to polar molecules has already been reported; here we demonstrate that the external environment also has a relevant effect on the emission energy of quantum dots. Experimental results are interpreted on the basis of a model of the quantum system that takes into account the formation of oxide on pristine III-V surfaces and the presence of surface states. As a result of our study, we can clearly distinguish the effect of surface oxidation from that of surface state passivation on the emission of InAs surface quantum dots. This work sheds new light on the properties of semiconductor surface quantum dots as building blocks of novel and highly efficient sensing devices based on optical transduction.

关键词： epitaxial quantum dots surface states oxide photoluminescence quantum modeling optical nanosensor

Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 74-80页

作者： Adriana Handra-luca Departments of Pathology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique GHU Avicenne 125 rue Stalingrad Bobigny 93000 France

BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.

关键词： blood group type blood group antigen immunohistochemistry CA19-9 prognosis invasive carcinoma pancreas intraductal papillary mucinous neoplasm

Open avenues for carotenoid biofortification of plant tissues

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2023年第1期4卷 228-237页

作者： luca Morelli Manuel Rodriguez-Concepcion Institute for Plant Molecular and Cell Biology(IBMCP) CSIC-Universitat Polite`cnica de Vale`ncia46022 ValenciaSpain Department of Biology&CESAM&ECOMARE Universidade de Aveiro3810-193 AveiroPortugal

Plant carotenoids are plastidial isoprenoids that function as photoprotectants,pigments,and precursors of apocarotenoids such as the hormones abscisic acid and *** do not produce carotenoids but need to obtain them from their diet as precursors of retinoids,including vitamin *** also provide numerous other health *** attempts to improve the carotenoid profile of different crops have been carried out by manipulating carotenoid biosynthesis,degradation,and/or ***,we will focus on open questions and emerging subjects related to the use of biotechnology for carotenoid *** impressive achievements,new efforts should be directed to extend the use of genome-editing technologies to overcome regulatory constraints and improve consumer acceptance of the carotenoid-enriched *** challenge is to prevent off-target effects like those resulting from altered hormone levels and metabolic *** on biofortification of green tissues should also look for new ways to deal with the negative impact that altered carotenoid contents may have on *** a carotenoid-enriched product has been obtained,additional effort should be devoted to confirming that carotenoid intake from the engineered food is also *** involves ensuring post-harvest stability and assessing bioaccessibility of the biofortified product to confirm that release of carotenoids from the food matrix has not been negatively *** addressing these challenges will ensure new milestones in carotenoid biotechnology and biofortification.

关键词： biofortification biotechnology carotenoids plastidial isoprenoids vitamin A

Searching for alternatives to brain regeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第11期16卷 2198-2200页

作者： Chiara La Rosa luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly Department of Veterinary Sciences University of TurinGrugliascoItaly

Brain regeneration from an evolutionary perspective:Brain regeneration(the full restoration of tissue after loss from injury or disease)is the most sought after goal for researchers working in developmental *** also appears to be the most challenging to achieve when considering the mammalian *** remarkable regenerative capacities can be present in the central nervous systems of many non-mammalian vertebrates(e.g.,fish,amphibians),these kinds of processes appear to be dramatically reduced in mammals(Bonfanti,2011).

关键词： regeneration sought injury