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Effect of antihypertensive therapy on hospitalization and mortality among uncomplicated and high risk hypertensive patients

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Health 2013年第4期5卷 1-8页

作者： luca degli esposti Stefania Saragoni Chiara Veronesi Carlo Cerra Paolo Batacchi Claudia Pagliaro Alessandra Sturani Ezio degli esposti CliCon S.r.l. Health Economics and Outcomes Research Ravenna Italy Department Internal Management Control Local Health Unit of Caserta Caserta Italy Department of Nephrology S. M. delle Croci Hospital Ravenna Italy Information System Local Health Unit of Pavia Pavia Italy

Objective: Evaluate the impact of antihypertensive drugs (AHD) on stroke and acute myocardial infarction (AMI) and death for 3 cohorts of patients: diabetics, high risk, and hypertensive. Methods: This was a retrospective cohort obervational study based on administrative database of 7 Italian Local Health Units. Newly treated patients with AHD were enrolled from 01/01/2004 to 06/30/2007. Drug utilization and incidence of death, stroke and AMI were measured until 12/31/2007. Results: The study enrolled 125,770 patients aged ≥ 18-year-old: 8516 diabetic, 8549 high risk, and 108,705 hypertensive. Diabetic and high risk patients were more frequently male (57.2%, 64.9% VS 46.6%) and older (66.4 ± 11.6, 67.5 ± 13.2 VS 61.6 ± 13.9) than hypertensive patients and were more treated with concomitant therapy. Drugs acting on the renin-angiotensin system were the more fre- quent choice in the three cohorts but with a dif- ferent prevalence (63.9%, 52.9%, 35.9% in dia- betic, hypertensive and high risk patients re- spectively). Adherent patients to AHD > 80% were 44.0% among diabetic patients, 48.4% among high risk, 35.2% among hypertensive. A Cox regression model showed that the risk of the combined outcome was determined by increasing age, male gender, presence of concomitant therapy, low adherence to AHD and first choice of AHD. Conclusions: An integrated analysis of prescription and hospital admission database has the great advantage that it uses routinely available data, it can be done quickly and by few staff, and it is less expensive than planned large scale survey.

关键词： Component Formatting Style Styling Insert

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The effect of chemical structure of carboxylate molecules on hydroxyapatite nanoparticles.A structural and morphological study

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Bioactive Materials 2021年第8期6卷 2360-2371页

作者： Lorenzo degli esposti Alessio Adamiano Dritan Siliqi Cinzia Giannini Michele Iafisco Institute of Science and Technology for Ceramics(ISTEC) National Research Council(CNR)Via Granarolo 6448018FaenzaItaly Institute of Crystallography(IC) National Research Council(CNR)Via Amendola 122/O70126BariItaly

Being the most abundant non-macromolecular organic component of bone,the role of citrate(Cit)in hydroxyapatite(HA)crystallization is of high *** this work we have investigated the influence of hydroxycitrate(CitOH)and glutarate(Glr)on HA crystallization in terms of particle growth,composition,and morphology in comparison to *** and Glr have been selected for this work because they share the same backbone structure of Cit but bear different functional groups in the central *** data has revealed that CitOH strongly inhibits HA crystallization more efficiently than ***-HA nanoparticles are composed of platy,elongated particles similar to those of Cit-HA but they are *** smaller and have a lower crystal *** the other hand,Glr does not inhibit HA crystallization as Cit,but leads to the formation of OCP platelets that convert with maturation time to HA nanorods with larger aspect ratio than *** comparison to Cit-HA samples,Glr-HA nanoparticles have bigger dimensions,and higher structural ***,our data reveal that the central carboxyl group of Cit is involved in the selective binding with HA crystal surface and in regulating HA crystal *** results of this work highlight new possibilities to control the formation of HA for designing advanced bioactive materials and give new insights on the role of the structure of Cit in regulating the HA morphology.

关键词： Hydroxyapatite Nanoparticles Biomineralization Citrate Carboxylates Hydroxycitrate Glutarate

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A combined analysis based on microbial communities and volatile organic compounds as a tool to study soil quality in an urban environment

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Pedosphere 2023年第4期33卷 670-675页

作者： Luisa NERI Fabiano SILLO Elisa ZAMPIERI Erica LUMINI Giovanni MARTURANO Chiara degli esposti Gianniantonio PETRUZZELLI Beniamino GIOLI Alessandro ZALDEI Rita BARALDI Raffaella BALESTRINI National Research Council Institute of BioEconomyVia Piero Gobetti 101Bologna 40129 and Via G.Caproni 8Firenze 50145(Italy) National Research Council Institute for Sustainable Plant ProtectionStrada delle Cacce 73 and Viale Mattioli 25Torino 10135 and 10125(Italy) Department of Biotechnology University of VeronaStrada Le Grazie 15Verona 37134(Italy) National Research Council Institute of Research on Terrestrial Ecosystems(IRET)Via Moruzzi 1Pisa 56124(Italy)

Dear Editor,Soil quality is defined as"the capacity of a soil to function,within ecosystem and land use boundaries,to sustain productivity,maintain environmental quality,and promote plant and animal health"(Doran and Parkin 1994).In this context,soil functionality is fundamental to the biosphere and is highly dependent on the associated *** microorganisms are relevant for terrestrial ecosystem functioning,and understanding the functional changes of the biological community in diverse soils is relevant for monitoring soil quality and developing actions to mitigate soil degradation(Madsen,2008;Delgado-Baquerizo et al.,2021).

关键词： soil volatile maintain

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测量高压设备电流的光纤传感器

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光学技术 1990年第4期16卷 5-7页

作者： G.degli esposti 伍企舜

本文介绍一种传感高压设备电流的测量仪表。这个系统是为瞬态和稳态电流范围1～1000A而设计的。在利用法拉第效应的传感器中,采用了单模低双折射率的光纤,并提出了两种不同结构的传感元件,其中一个用于固定安装;另一个则可在现场使用。... 详细信息

本文介绍一种传感高压设备电流的测量仪表。这个系统是为瞬态和稳态电流范围1～1000A而设计的。在利用法拉第效应的传感器中,采用了单模低双折射率的光纤,并提出了两种不同结构的传感元件,其中一个用于固定安装;另一个则可在现场使用。设计后者的目的是在与线路没有直接接触的条件下来传感电流。这些装置的特点在于它有很好的线性度、灵敏度和绝缘特性。

关键词：光纤传感器高压设备电流测量

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