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Microbiological and chemical hazards of commercial attieke (a fermented cassava product) produced in the south of Côte d’Ivoire

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Food Quality and Safety 2019年第3期3卷 187-190页

作者： Kouamé Kohi Alfred Bouatenin Koffi Maizan Jean Pau Djeni N’dede Théodore Dje Koffi Marcellin Department of Food Sciences and Technology Laboratory of Biotechnology and food MicrobiologyUniversity of Nangui AbrogouaAbidjanCôte d’Ivoire Food Security Research Group Centre Suisse de Recherche ScientifiqueAbidjanCote d’Ivoire

Objectives:Information on the distribution and presence of microbiology and chemical hazard of commercial attieke(a fermented cassava product)produced in the south of Côte d’Ivoire were *** and Methods:Microbiological analyses and chemical were carried out,which included the total viable bacteria,Staphylococcus aureus,Salmonella and Bacillus spores,heavy metal(pb,Cd,Mn,Fe,Cu,and Cr).Results and Conclusions:The results revealed that the viable bacteria counts ranged from in all of *** aureus counts in the samples were comprised between(1.8±0.4)10^(2)(Jacqueville localitie)and(4.3±1.8)10^(3)(Abidjan localitie).While that of Bacillus cereus was ranged from(1.1±0.9)10^(2)(Adzopélocalitie)and(5.1±3.2)10^(2)(Abidjan localitie).Salmonella *** not *** levels of Pb in all samples were between 2.2±0.1 mg/kg(Grand-lahou localitie)and 4.5 mg/kg±0.15(Abidjan localitie)while the Cd levels of the samples varied between 0.02±0.1 mg/kg(Adzopélocalitie)and 0.07±0.1 mg/kg(Divo localitie).The levels of Cr in the samples were comprised between 0.1±0.03 mg/kg(Adzopélocalitie)and 0.95±0.1 mg/kg(Abidjan localitie)while Fe(7.3±1.5 mg/kg)and Cu(1.7±0.2 mg/kg)levels were the highest,respectively in Sikensi and Grand-Lahou *** from Divo localitie contained high amounts of Mn(1.6±0.1 mg/kg).The occurrence of some microbiological and chemical hazard that commercial attieke collected in Cote d’Ivoire may act as a reservoir of pathogenic micro-organisms and heavy metal for human.

关键词： attieke heavy metal microbiogical and chemical hazard

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Assessment of Castor Plant (Ricinus communis L.) Tolerance to Heavy Metal Stress-A Review

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 453-472页

作者： Akwasi Yeboah Jiannong Lu Ting Yang Yuzhen Shi Hanna Amoanimaa-dede Kwadwo Gyapong Agyenim Boateng Xuegui Yin Department of Crop Breeding and Genetics College of Agricultural SciencesGuangdong Ocean UniversityZhanjiang524088China The National Engineering Laboratory for Crop Molecular Breeding MARA Key Laboratory of Soybean Biology(Beijing)Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing100081China

Increased urbanization and industrialization have greatly contributed to the emission of higher amount of heavy metals such as cadmium,nickel,and lead into the *** metals are non-biodegradable and toxic,causing much effects on plants and by extension to animals and humans,which have become a major global *** inherent ability of plants to resist heavy metal toxicity seems to be the most sustainable and cost-effective *** plant is widely studied due to its tolerance to the effects of heavy metal contaminated soils,owing to its large biomass content and high accumulating *** plants to some extent can tolerate elevated levels of heavy metals through several developed mechanisms,such as activation of antioxidant enzymes,exclusion,accumulation of proline,compartmentalization,organic acid exudation,and *** studies have identified some stress-responsive to aid the tolerance of heavy metals in *** caused by heavy metal toxicity affects seedling growth,biomass,photosynthetic pigments,protein level,and nutrient uptake of castor *** response of castor,however,to these stresses differs among cultivars,metal type and concentration,and time of metal *** review aims to summarize the physiological responses and various defense mechanisms of castor to tolerate and eradicate heavy metal toxicity and some stress-responsive genes identified at transcriptional and posttranscriptional levels that confer metal tolerance in this plant.

关键词： Castor metal stress biomass proline tolerance

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广西合浦大士阁木结构建筑保护与发展研究

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科技创新与生产力 2024年第8期45卷 60-63页

作者：吴佳馨董鼎浩彭德得傅孜瀚邬南宇李达耀北部湾大学东密歇根联合工程学院广西钦州535011

针对大士阁木结构建筑所面临的问题,本文结合国内木结构建筑保护实例,从防腐、防潮等方面提出了一系列保护措施,并指出大士阁木结构建筑的保护对于传承中国古建筑文化有重要意义,为中国古建筑木结构保护应用提供了参考。

关键词：木结构建筑建筑保护大士阁

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甘薯块根花青素生物合成的转录组学和代谢组学分析

甘薯块根花青素生物合成的转录组学和代谢组学分析

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作者： Hanna Amoanimaa-dede 广东海洋大学

学位级别：硕士

花青素属于黄酮类化合物,具有多种生理功能。紫甘薯具有含有丰富的花青素,是低分子量抗氧化剂的来源,对健康有益。因此,随着人们健康意识和食品安全意识的提高,紫肉甘薯作为一种新兴的保健食品备受青睐。因此,了解花青素的生物合成和积... 详细信息

花青素属于黄酮类化合物,具有多种生理功能。紫甘薯具有含有丰富的花青素,是低分子量抗氧化剂的来源,对健康有益。因此,随着人们健康意识和食品安全意识的提高,紫肉甘薯作为一种新兴的保健食品备受青睐。因此,了解花青素的生物合成和积累机制,对于培育更多富含花青素的甘薯品种具有重要意义。本课题结合转录组和代谢组分析,研究了不同薯肉色甘薯的代谢物分布的基因表达模式,探讨了花青素的合成和积累是调控模式。该项研究成果具有潜在的应用价值,因为它提供了花青素生物合成和积累的内部机制,将进一步促进甘薯花青素含量优良品种的分子育种。为了解花青素生物合成和积累的分子机制,对肉色不同的甘薯品种,进行了全转录组和代谢组学分析;利用NCBI-Blastp筛选花青素相关基因,并对其功能进行注释。此外,进行q RT-PCR分析以验证随机选择的10个基因的表达模式。结果表明:广薯87和紫罗兰的转录组测序数据显示,从61335186个高质量的阅读片段中组装出24388个单基因。4469个是差异表达基因（DEGs）,其中2532个上调,1937个下调。在非冗余蛋白质数据库中,共有3602个DEGs（80.6%）被注释有功能。GO分析将DEGs分为细胞成分、生物过程和分子功能等48个GO术语。185-P和185-W转录组测序数据中,共有239415012个高质量的读取被组装到27889个单基因中。共检测到264个差异表达基因（DEGs）,其中100个上调基因和164个下调基因,其中255个（96.6%）在公共数据库中被注释为假定功能。GO分类将DEGs分为36个GO术语,分别属于细胞成分、生物过程和分子功能类别。根据GO分析,生物过程和分子功能类别下的19个术语与两个DEG组（GS87 vs ZLL和185-P vs 185-W）中的花青素生物合成有关。我们的结果表明,黄酮类和苯丙烷类的生物合成途径是花青素生物合成的主要信号途径。除了F3′5′H外,几乎所有与花青素生物合成相关的途径基因包括ANS、DFR、CHS、F3H、CHI、F3H和3GT都被鉴定出来,这是由于该基因在甘薯属植物中丢失所致。NCBI-Blastp序列分析表明,这些基因与其它植物如拟南芥、矮牵牛、水稻和一些甘薯属植物如***,*** and ***。此外,MBW复合物的b HLH和MYB-TFs被鉴定为调节花青素生物合成的主要TFs。值得注意的是,几乎所有与花青素生物合成相关的TF和结构基因都显著上调。此外,还进行了q RT-PCR分析,以验证随机选择的10个基因的表达模式。结果与转录组测序数据一致,证实了测序数据可靠性较高。所有四个花青素相关基因在紫色品种中均显著上调,表明它们在花青素生物合成中的作用。从代谢组中,共鉴定出122种代谢物,其中53种代谢物（6种上调,47种下调）在两个品种（GS87和ZLL）之间表现出差异表达模式。主成分分析和聚类分析表明,不同品种间的代谢特征不同,代谢产物主要富集黄酮和花青素类物质。

关键词：甘薯花青素转录组代谢组基因表达

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Prevalence of occult HBV infection in haemodialysis patients with chronic HCV

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World Journal of Gastroenterology 2006年第21期12卷 3420-3424页

作者： Vedat Goral Hamza Ozkul Selahattin Tekes dede Sit Ali Kemal Kadiroglu Department of Gastroenterology Dicle University School of Medicine DiyarbakirTurkey Department of Internal Medicine Dicle University School of Medicine DiyarbakirTurkey Department of Molecular Biology Dicle University School of Medicine DiyarbakirTurkey Department of Nephrology Dicle University School of Medicine DiyarbakirTurkey

AIM： To study the prevalence and clinical effects of occult HBV infection in haemodialysis patients with chronic ***： Fifty chronic hemodialysis patients with negative HbsAg, and positive anti-HCV were included in the study. These patients were divided into two groups： HCV-RNA positive and HCV-RNA negative, based on the results of HCV-RNA PCR. HBV-DNA was studied using the PCR method in both ***： None of the 22 HCV-RNA positive patients and 28 HCV-RNA negative patients revealed HBV-DNA in serum by PCR method. The average age was 47.2±17.0 in the HCV-RNA positive group and 39.6±15.6 in the HCV-RNA negative ***： The prevalence of occult HBV infection is not high in haemodialysis patients with chronic HCV in our region. This result of our study has to be evaluated in consideration of the interaction between HBsAg positivity （8%-10%） and frequency of HBV mutants in our region.

关键词： Chronic HCV Haemodialysis Occult HBV infection

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Relationship between antioxidant capacity and oxidative stress in children with acute hepatitis A

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World Journal of Gastroenterology 2006年第38期12卷 6212-6215页

作者： Mustafa Cemek Semiha dede Fahri Bayiro■lu Hseyin aksen Fatma Cemek Nihat Mert Department of Chemistry (Biochemistry Division) Faculty of Science Afyon Kocatepe University Afyon Turkey Department of Biochemistry Faculty of Veterinary Medicine Yznc Y1l University Van Turkey Department of Physiology Faculty of Veterinary Medicine Yznc Y1l University Van Turkey Department of Pediatrics Faculty of Medicine Yznc Y1l University Van Turkey

AIM： To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde （MDA, an indicator of oxidative stress） and nonenzymic antioxidants in children with acute hepatitis A. METHODS： Whole blood MDA and reduced glutathione （GSH）, serum β-carotene, retinol, vitamin E and vitamin C levels were studied in 19 （10 females, 9 males） children with acute hepatitis A and in 29 （β females, 16 males） healthy control subjects. RESULTS： There was a statistically significant difference between patients and controls for all parameters （P 〈 0.05）. Lipid peroxidation marker MDA was significantly elevated （P 〈 0.001）, while antioxidants β-carotene, retinol and GSH were significantly decreased （all P 〈 0.001） in patients compared to healthy subjects. In addition, o-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls （P 〈 0.05, P 〈 0.01, respectively）. CONCLUSION： Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A.

关键词： Antioxidant Oxidative stress Hepatitis A Child

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Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance

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World Journal of Gastroenterology 2010年第37期16卷 4691-4696页

作者： Lee Guan Lim Myat Oo Aung Bee Leng Seet Cindy Tan Yock Young Dan Yin Mei Lee dede Selamat Sutedja Mark Fernandes Guan Huei Lee Evelyn Koay Seng Gee Lim Department of Gastroenterology and Hepatology National University Health System Yong Yoo Lin School of Medicine National University of Singapore Department of Medicine National University Health System Yong Yoo Lin School of Medicine National University of Singapore Molecular Diagnostic Centre National University Health System Yong Yoo Lin School of Medicine National University of Singapore Investigative Medicine Unit National University Health System Yong Yoo Lin School of Medicine National University of Singapore

AIM: To investigate the accuracy of serum alanine aminotransferase (ALT) in diagnosing lamivudine resistance and factors that contributed to abnormal serum ***: This was a retrospective study of chronic hepatitis B patients on lamivudine therapy who were followed for 3-mo with liver function tests and hepatitis B virus (HBV) DNA measurement. Lamivudine resistance was defined as HBV DNA ≥ 1 log from nadir on at least 2 occasions, confirmed by genotyping. Serum ALT levels in patients with lamivudine resistance were compared to serum ALT levels in those without lamivudine resistance. RESULTS: There were 111 patients with and 117 without lamivudine resistance. The area under the receiver operating characteristic of serum ALT to diagnose lamivudine resistance was 0.645 ± 0.037. Serum ALT > 42.5 U/L gave the best diagnostic accuracy with sensitivity = 61%, specificity = 60%, positive predictive value = 60%, negative predictive value = 61%, positive likelihood ratio = 1.53 and negative likelihood ratio = 0.65 for predicting lamivudine resistance, missing 39% of resistant patients. Using other serum ALT cutoffs, diagnostic accuracy was lower. By multivariate analysis, baseline abnormal serum ALT was associated with abnormal ALT during resistance (OR = 5.98, P = 0.003), and males were associated with serum ALT flares during resistance (OR = 8.9, P = 0.016). CONCLUSION: Serum ALT is inadequate for diagnosing lamivudine resistance and has implications where viral resistance testing is suboptimal and for reimbursement of rescue therapy.

关键词： Antiviral therapy Chronic hepatitis B Sensitivity Specificity YMDD mutants

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Merging GIS and Machine Learning Techniques: A Paper Review

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Journal of Geoscience and Environment Protection 2022年第9期10卷 61-83页

作者： Chikodinaka Vanessa Ekeanyanwu Inioluwa Feranmi Obisakin Precious Aduwenye Nathaniel dede-Bamfo Department of Geography and Environmental Studies Texas State University San Marcos TX USA Ingram School of Engineering Texas State University San Marcos TX USA

GIS (Geographic Information Systems) data showcase locations of earth observations or features, their associated attributes and spatial relationships that exist between such observations. Analysis of GIS data varies widely and may include some modeling and predictions which are usually computing-intensive and complicated, especially, when large datasets are involved. With advancement in computing technologies, techniques such as Machine learning (ML) are being suggested as a potential game changer in the analysis of GIS data because of their comparative speed, accuracy, automation, and repeatability. Perhaps, the greatest benefit of using both GIS and ML is the ability to transfer results from one database to another. GIS and ML tools have been used extensively in medicine, urban development, and environmental modeling such as landslide susceptibility prediction (LSP). There is also the problem of data loss during conversion between GIS systems in medicine, while in geotechnical areas such as erosion and flood prediction, lack of data and variability in soil has limited the use of GIS and ML techniques. This paper gives an overview of the current ML methods that have been incorporated into the spatial analysis of data obtained from GIS tools for LSP, health, and urban development. The use of Supervised Machine Learning (SML) algorithms such as decision trees, SVM, KNN, and perceptron including Unsupervised Machine Learning algorithms such as k-means, elbow algorithms, and hierarchal algorithm have been discussed. Their benefits, as well as their shortcomings as studied by several researchers have been elucidated in this review. Finally, this review also discusses future optimization techniques.

关键词： GIS Machine Learning Landslide Susceptibility Random Forest Urban Development Flood Prediction Health GeoAI

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Complications of endoscopic retrograde cholangiography in the post-MRCP era: A tertiary center experience

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World Journal of Gastroenterology 2005年第33期11卷 5209-5212页

作者： Tze-Zen Ong Jen-Lock Khor dede-Sutedja Selamat Khay-Guan Yeoh Khek-Yu Ho Department of Gastroenterology and Hepatology National University Hospital Singapore

AZM： To evaluate our experience in endoscopic retrograde cholangio-pancreatography （ERCP） in terms of fulfilling the ASGE guidelines in indications, positive findings, and complications in the post-magnetic resonance cholangiopancreatography （MRCP） era. METHODS： Between November 2001 and February 2003, consecutive ERCP cases were prospectively evaluated with regard to the indications, findings, cannulation techniques, devices used during the procedure, sedation given, duration of procedure, and complications. These data were entered in a database for subsequent processing and analysis. RESULTS： Of 336 cases, 21.4% were diagnostic and 78.6% therapeutic ERCR The indications for ERCP fulfilled the ASGE guidelines in 323 cases （96.1%）. Suspected bile duct stone was the most frequent indication （26.8%）, and this was followed by cholangitis （24.4%）, dilated common bile duct （14.9%）, and cholestatic jaundice （23.4%）. Cannulation success rate was 94%. Biliary sphincterotomy was performed in 175 （52.1%） patients. Repeated ERCP was performed on 31.5% of the patients. Overall, the complication rate was 9.8% with 0.3% being procedurerelated mortality. The complications were pancreatitis （5.4%）, bleeding （0.8%）, cholangitis （2.4%） and others （1.5%）. No significant difference was observed between the complication rate and the type of ERCP performed. CONCLUSION： Our study showed that post-ERCP complication rate was comparable with the other large prospective studies and there was no difference in the complication between the diagnostic and therapeutic ERCP.

关键词： Endoscopic retrograde cholangiopancreatogram Complication Pancreatitis

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Outcome of lamivudine-resistant hepatitis B virus is generally benign except in cirrhotics

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World Journal of Gastroenterology 2005年第28期11卷 4344-4350页

作者： Yock-Young Dan Chun-Tao Wai Yin-Mei Lee dede Selamat Sutedja Bee-Leng Seer Seng-Gee Lim Division of Gastroenterology National University Hospital Singapore

AIM： We set to determine factors that determine clinical severity after the development of resistance.METHODS： Thirty-five Asian patients with genotypic lamivudine resistance were analyzed in three groups： 13/35 （37%） were non-cirrhotics with normal pre-treatment ALT （Group IA）, 12/35 （34%） were non-cirrhotics with elevated pre-treatment ALT （Group IB）, and 10/35 （29%） were cirrhotics （Group II）. Patients were followed for a median of 98 wk （range 26-220） after the emergence of genotypic resistance.RESULTS： Group IA patients tended to retain normal ALT. Group IB patients showed initial improvement of ALT with lamivudine but 9/12 patients （75%） developed abnormal ALT subsequently. On follow-up however, this persisted in only 33%. Group II patients also showed improvement while on treatment, but they deteriorated with the emergence of resistance with 30% death from decompensated liver disease. Pretreatment ALT levels and CPT score （in the cirrhotic group） were predictive of clinical resistance and correlated with peak ALT levels and CPT score.CONCLUSION： The phenotype of lamivudine-resistant HBV correlated with the pretreatment phenotype. The clinical course was generally benign in non-cirrhotics. However, cirrhotics had a high risk of progression and death （30%） with the development of lamivudine resistance.

关键词： Lamivudine resistance YMDD mutants Hepatitis B treatment Nucleoside analog

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