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Oncolytic viruses:A novel treatment strategy for breast cancer

Genes & Diseases 2023年第2期10卷 430-446页

作者： Mohammad Javanbakht Sanaz Tahmasebzadeh luca cegolon Nasrin Gholami Mandana Kashaki Hassan Nikoueinejad Mohamad Mozafari Mahsa Mozaffari Shi Zhao Mostafa Khafaei Morteza Izadi Saeid Fathi Reza Akhavan-Sigari Nephrology and Urology Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Mehrestan Health Network Iranshahr University of Medical SciencesIranshahr ***Iran University of Trieste Department of MedicalSurgical & Health SciencesTrieste 34128Italy University Health Agency Giuliano-Isontina (ASUGI) Public Health DepartmentTriesteItaly Hematology and Oncology Research Center Tabriz University of Medical SciencesTabriz ***Iran Shahid Akbarabadi Clinical Research Development Unit (ShACRDU) Iran University of Medical Sciences (IUMS)Tehran ***Iran Department of General Surgery Urmia University of Medical ScienceUrmia 57147Iran Department of Pediatrics Iran University of Medical SciencesTehran ***Iran JC School of Public Health and Primary Care Chinese University of Hong KongHong Kong Special Administrative Region 999077China Human Genetics Research Center Baqiyatallah University of Medical SciencesTehran 169875931Iran Health Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Razi Vaccine and Serum Research Institute Agriculture ResearchEducation and Extension Organization (AREEO)Karaj 11365-1558Iran Department of Neurosurgery University Medical CenterTuebingen 72076Germany

Breast cancer,an unceasingly occurring neoplasm,is one of the major determinants of mortality in *** ineffective attempts have been pursued using with conventional therapies against breast *** to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using *** constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor *** different DNA-and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus,herpes virus,vaccinia,reovirus,Newcastle Disease virus,measles virus and vesicular stomatitis *** review aims to summarize the viro-therapeutical agents against breast *** Scientific Concepts of Review:In this review paper,we proposed a new strategy to virus's combinatorial treatments using several kinds of transgenes and *** recombinant viruses have provided evidence of treatment efficacy against human breast cancer.

关键词： Adenovirus Breast cancer Herpes virus Measles virus Newcastle disease virus Reovirus Vaccinia Vesicular stomatitis virus Virotherapy

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