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Biologic agents for anterior cruciate ligament healing: a systematic review

World Journal of Orthopedics 2016年第9期7卷 592-603页

作者： Berardo Di Matteo Markus Loibl luca andriolo Giuseppe Filardo Johannes Zellner Matthias Koch Peter Angele ⅠOrthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory Rizzoli Orthopaedic Institute Department of Trauma Surgery University Regensburg Medical Centre Sporthopaedicum Regensburg

AIM To systematically review the currently available literature concerning the application of biologic agents such as platelet-rich plasma(PRP) and stem cells to promote anterior cruciate ligament(ACL) *** A systematic review of the literature was performed on the use of biologic agents(i.e., PRP or stem cells) to favor ACL healing during reconstruction or repair. The following inclusion criteria for relevant articles were used: Clinical reports of any level of evidence, written in English language, on the use of PRP or stem cells during ACL reconstruction/repair. Exclusion criteria were articles written in other languages, reviews, or studies analyzing other applications of PRP/stem cells in knee surgery not related to promoting ACL *** The database search identified 394 records that were screened. A total of 23 studies were included in the final analysis: In one paper stem cells were applied for ACL healing, in one paper there was a concomitant application of PRP and stem cells, whereas in the remaining21 papers PRP was used. Based on the ACL injury pattern, two papers investigated biologic agents in ACL partial tears whereas 21 papers in ACL *** at the quality of the available literature, 17 out of 21 studies dealing with ACL reconstruction were randomized controlled trials. Both studies on ACL repair were case *** There is a paucity of clinical trials investigating the role of stem cells in promoting ACL healing both in case of partial and complete tears. The role of PRP is still controversial and the only advantage emerging from the literature is related to a better graft maturation over time, without documenting beneficial effects in terms of clinical outcome, bone-graft integration and prevention of bony tunnel enlargement.

关键词： Platelet-rich plasma Growth factors Stem cells Anterior cruciate ligament reconstruction Anterior cruciate ligament repair Anterior cruciate ligament healing Sports medicine Regenerative medicine

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爱滋病和爱滋病相关症候群:口腔表现和治疗

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国际口腔医学杂志 1987年第5期 287-289页

作者： andriolo MJr 张志平

获得性免疫缺陷综合症(AIDS)是涉及细胞免疫机能障碍的症候群。与此综合症有关的一些疾病具有累及头颈部,包括散在性口腔病损的体征及症状。正如其它系统病有口腔表现一样,牙科医生可以首先发现这些病损。由于爱滋病患者的病损需要活检... 详细信息

获得性免疫缺陷综合症(AIDS)是涉及细胞免疫机能障碍的症候群。与此综合症有关的一些疾病具有累及头颈部,包括散在性口腔病损的体征及症状。正如其它系统病有口腔表现一样,牙科医生可以首先发现这些病损。由于爱滋病患者的病损需要活检、药物或其他治疗。因此对牙科人员来说,熟悉对该综合症的各种表现是很重要的。

关键词：获得性免疫缺陷综合症患者 ARC AIDS 爱滋病口腔表现症候群

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基质辅助自体软骨细胞移植治疗髌股关节软骨损伤——髌骨与滑车损伤修复疗效对比

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中国骨科临床与基础研究杂志 2015年第1期7卷 60-60页

作者： Filardo G Kon E andriolo L 沈洪园章莹

由于自身愈合能力有限，软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高，尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植（matrix-assisted autologous chondrocyte transplantation，MACT）中期随访显示出... 详细信息

由于自身愈合能力有限，软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高，尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植（matrix-assisted autologous chondrocyte transplantation，MACT）中期随访显示出良好疗效，但对于不同患者及不同损伤类型，治疗结果各异。本研究的目的在于对同一手术团队采取同一术式治疗的髌股关节软骨缺损的中期疗效进行前瞻性队列研究，明确髌骨和滑车软骨缺损治疗后是否存在临床愈合结果的差异。

关键词：自体软骨细胞移植膝关节软骨损伤骨损伤修复移植治疗中期疗效基质辅助滑车髌骨

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Overview of angiogenesis and oxidative stress in cancer

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World Journal of Meta-Analysis 2023年第6期11卷 253-265页

作者： Luigi Gaetano andriolo Vittoria Cammisotto Alessandra Spagnoli Danilo Alunni Fegatelli Michele Chicone Gaetano Di Rienzo Vladimiro Dell’Anna Giambattista Lobreglio Giovanni Serio Pasquale Pignatelli Department of General and Specialistic Surgery Paride Stefanini Policlinico Umberto IUniversity of Rome SapienzaRome 06100Italy UnitàOperativa Complessa Chirurgia Toracica Ospedale Vito FazziLecce 73100Italy Department of Clinical Internal Anaesthesiological and Cardiovascular SciencesUniversity of Rome SapienzaRome 06100Italy Department of Public Health and Infectious Diseases University of Rome SapienzaRome 06100Italy Department of Clinical Pathology and Microbiology Ospedale Vito FazziLecce 73100Italy Pathological Anatomy Unit Ospedale Vito FazziLecce 73100Italy

Neoplasms can be considered as a group of aberrant cells that need more vascular supply to fulfill all their ***,they promote angiogenesis through the same neovascularization pathway used *** is a process characterized by a heterogeneous distribution of oxygen caused by the tumor and oxidative stress;the latter being one of the most powerful stimuli of *** a result of altered tumor metabolism due to hypoxia,acidosis *** angiogenic process and oxidative stress can be detected by measuring serum and tissue *** study of the mechanisms underlying angiogenesis and oxidative stress could lead to the identification of new biomarkers,ameliorating the selection of patients with neoplasms and the prediction of their response to possible anti-tumor *** particular,in the treatment of patients with similar clinical tumor phenotypes but different prognoses,the new biomarkers could be ***,they may lead to a better understanding of the mechanisms underlying drug *** studies show that blocking the vascular supply results in antiproliferative activity in vivo in neuroendocrine tumor cells,which require a high vascular supply.

关键词： Neuroendocrine lung tumors Angiogenesis Oxidative stress Neuroendocrine serum markers Neuroendocrine tissue markers Future therapy

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