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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

Neural Regeneration Research 2025年第2期20卷 343-353页

作者： ana Milena Silva Olaya Fernanda Martins Almeida ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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基于金属有机框架的光催化抗菌材料研究进展

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现代化工 2025年第1期45卷 51-55页

作者：陈翔宇韦文龙刘子儒 Pier-luc Tremblay 张甜武汉理工大学化学化工与生命科学学院湖北武汉430070 武汉理工大学三亚科教创新园海南三亚572024 武汉理工大学材料科学与工程学院湖北武汉430070

对近年来基于金属有机框架的光催化抗菌材料进行了梳理,包括掺杂金属纳米粒子的MOFs材料、异质结MOFs材料、卟啉基MOFs材料以及其他MOFs材料,旨在为相关领域的研究与实践提供参考。

关键词：金属有机框架光催化抗菌优化机理

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Frequency-amplitude behavior in the incipient movement of grains under vibration

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Particuology 2018年第5期16卷 1-9页

作者： Karina A.Valenzuela Aracena Jesica G.Benito luc Oger Irene Ippolito Rodolfo O.Ufiac ana M.Vidales INFAP.CONICET Departamento de FfsieaFacultad de Ciencias Fisico Matemdticas y NaturalesUniversidad Nacional de San LuisEjerdto de los Andes 950D5700HHWSan LuisArgentina Institut de Physique de Rennes UMR UR1-CNRS 6251Universite de Rennes 1263Avenue du General LeclercCampus de BeaulieuCS 7420535042 Rennes CedexFrance Universidad de Buenos Aires Facultad de IngenierfaGrupo de Medios PorososPaseo Colon 8501063Buenos AiresArgentina

The onset of the movement of particles placed on a horizontal rough surface subject to a vertical sinusoidal vibration is investigated through tracking experiments,theoretical analysis,and numerical simulations. The frequency of vibration needed to move particles decays exponentially with the amplitude of the oscillatory *** behavior is explained through a simple mechanism in which a forced damped harmonic oscillator with a spring constant represents all the interactions between the particle and the *** numerical results compare well with experimental data,demonstrating that the forces included in the numerical calculations suitably account for the main particle response,even though the complexity of the surface is not fully taken into *** the way in which frequency varies with amplitude could be relevant to technological applications such as cleaning of material surfaces.

关键词： Vibration Incipient movement Forced oscillator 3D DEM simulation

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ABOUT TWO TYPES OF MICROSTRUCTURES ADAPTED TO HEAT EVACUATION AND ELASTIC STRESS:SNOW FLAKES AND QUASI-CRYSTALS

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Acta Mathematica Scientia 2012年第1期32卷 84-108页

作者： luc Tartar Department of Mathematical Sciences Carnegie Mellon University

I first met Constantine Dafermos in August 1974, at a meeting at Brown University, where I was invited because my former advisor （Jacques-Louis LIONS） could not come, and he had proposed my name. I was happily surprised that Constantine greeted me as if he knew me well, and since for many years now I have considered him as if he was an older brother, I wonder when this feeling started.

关键词： ABOUT TWO TYPES OF MICROSTRUCTURES ADAPTED TO HEAT EVACUATION AND ELASTIC STRESS

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Natural variability of essential oil and antioxidants in the medicinal plant Turnera diffusa

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 114-119页

作者： ana lucía Urbizu-González Octelina Castillo-Ruiz Guillermo Cristian Guadalupe Martínez-Ávila Jorge Ariel Torres-Castillo Universidad Autónoma de Tamaulipas Instituto de Ecología AplicadaDivisión del Golfo 356Col.Libertad87019Ciudad VictoriaTamaulipasMéxico Universidad Autónoma de Tamaulipas Unidad Académica Multidisciplinaria Reynosa AztlánCalle 16 y Lago de Chápala s/n Col.AztlánC.P.88740ReynosaTamaulipasMéxico Universidad Autónoma de Nuevo León Facultad de AgronomíaFrancisco Villa s/n.Col.Ex Hacienda El Canadá66050General EscobedoNuevo LeónMéxico

Objective:To evaluate differences in yield and composition of the essential oil and antioxidant contents in *** plants from localities in central region of ***:Samples were collected in Tamaulipas,Mexico in the arid *** oil was obtained through steam distillation and analyzed using *** contents,antioxidant activities using ABTS and ferric reducing antioxidant power(FRAP) methods also were ***:A total of 21 compunds were identified in the essential oils;nevertheless,only Eucalyptol,1,4-Methanocycloocta[d]pyridazine,1,4,4a,5,6,9,10,10a-octahydro-11,11-dimethyl-,(1à,4à,4aà,10aà) y Ethanone,1-(1,3-dimethyl-3-cyclohexen-1-yl) were detected in the three *** contents were registered in the sample from Padrón y Juárez with phenolic content of 33.85 mg GAE/g of dry material and antioxidant activities with ABTS 72.32% and with FRAP 21.33 mg GAE/g of dry *** differences were observed in essential oil,phenolics and antioxidants contents between ***:Results suggest that climatic differences and origin influence the phytochemicals in the medicinal plant ***,and thus,it is worth to consider such effects for industrial and medicinal purposes.

关键词： Essential oil Antioxidants Phytochemicals Chemical variation

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Pathological evolution of hepatitis C virus-“Healthy carriers”

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World Journal of Gastroenterology 2008年第24期14卷 3861-3865页

作者： Rodolphe Sobesky Pascal Lebray Bertrand Nalpas anas Vallet-Pichard Hélène Fontaine Jean-luc Lagneau Stanislas Pol INSERM U785 Centre Hépato-BiliaireHpital Paul Brousse United Hepatologie Hopital CochinUniversite Paris V-Rene Descartes

AIM： To determine factors associated with fibrosis progression in hepatitis C virus （HCV）-infected patients without significant initial pathological lesions. METHODS： Seventy six untreated HCV-infected patients with initially normal liver as defined by a Knodell score ≤ 3, with 2 liver biopsies and detectable HCVRNA were included. Markers of fibrosis progression were assessed. RESULTS： Median duration of infection and time between paired biopsies was 13 （95% CI： 1-28） and 4 （95% CI： 2-16） years respectively. Alaninetransaminase （ALT） activity was normal in 43.4% of cases. 50% demonstrated progression of the necroinflammation and 34% of fibrosis after a median time evolution of 4 years （95% CI： 2-16）. The median difference in the necro-inflammation and fibrosis score between biopsies was low, 1.5 and 0.0 respectively. Univariate analysis showed there was no difference between fibrosis activity or evolution according to genotype or viral load. A higher fibrosis progression （P = 0.03） was observed in patients with body mass index （BMI）〉 25. Fibrosis progression correlated with the time interval between biopsies （P = 0.01）. A significant progression of activity （1.7 vs 0.4, P 〈 0.05） or fibrosis （0.9 vs 0.0, P 〈 0.01） was observed in patients with elevated ALT. There was a significant correlation between activity progression and fibrosis progression（P = 0.003）. Multivariate analysis demonstrated that fibrosis progression was associated with elevated ALT, BMI 〉 25 and the time interval between 2 biopsies. CONCLUSION： There is no fibrosis progression in 66% of patients without significant initial histopathological lesion. Fibrosis progression is associated with elevated ALT and BMI 〉 25.

关键词： Hepatitis C virus Liver fibrosis Liver biopsy Alanine-transaminase Body mass index

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Overlap of reflux and eosinophilic esophagitis in two patients requiring different therapies:A review of the literature

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World Journal of Gastroenterology 2008年第9期14卷 1463-1466页

作者： Javier Molina-Infante lucía Ferrando-Lamana Jose María Mateos-Rodríguez Belén Pérez-Gallardo ana Beatriz Prieto-Bermejo Unit of Gastroenterology Hospital San Pedro de Alcantara Avda. Pablo Naranjo s/n 10003 Caceres Spain Department of Pathology. Hospital San Pedro de Alcantara Avda. Pablo Naranjo s/n 10003 Caceres Spain

Eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD) have overlapping clinical, manometric, endoscopic and histopathologic features. The diagnosis of EE is nowadays based upon the presence of 15 or more eosinophils per high power field (eo/HPF) in esophageal biopsies. We report the cases of two young males suffering from dysphagia and recurrent food impaction with reflux esophagitis and more than 20 eo/HPF in upper-mid esophagus biopsies, both of which became asymptomatic on proton pump inhibitor (PPI) therapy. The first patient also achieved a histologic response, while EE remained in the other patient after effective PPI treatment, as shown by 24-h esophageal pH monitoring. Topical steroid therapy combined with PPI led to complete remission in this latter patient. GERD and EE may be undistinguishable, even by histology, so diagnosis of EE should only be established after a careful correlation of clinical, endoscopic and pathologic data obtained under vigorous acid suppression. These diagnostic difficulties are maximal when both diseases overlap. Limited data are available about this topic, and the interaction between EE and GERD is a matter of debate. In this setting, upper-mid esophagus step biopsies and esophageal pH monitoring of patients on PPI therapy are pivotal to evaluate the role of each disease. A PPI trial is mandatory in patients with a histopathologic diagnosis of EE; in those unresponsive to PPI treatment, EE should be suggested. However, a clinical response to PPI may not rule out quiescent EE, as shown in this report.

关键词： Eosinophils Eosinophilic esophagitis Gastroesophageal reflux Proton pump inhibitors Overlap

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Developing molecular-level models for organic field-effect transistors

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National Science Review 2021年第4期8卷 167-180页

作者： Haoyuan Li Jean-luc Brédas School of Chemistry and Biochemistry and Center for Organic Photonics and Electronics Georgia Institute of Technology Department of Chemistry and Biochemistry University of Arizona

Organic field-effect transistors(OFETs) are not only functional devices but also represent an important tool for measuring the charge-transport properties of organic semiconductors(OSs). Thus, efforts to understand the performance and characteristics of OFET devices are not only useful in helping achieve higher device efficiencies but also critical to ensuring accuracy in the evaluations of OS charge *** studies rely on OFET device models, which connect the measured current characteristics to the properties of the OSs. Developing such OFET models requires good knowledge of the charge-transport processes in OSs. In device active layers, the OS thin films are either amorphous(e.g. in organic light-emitting diodes and organic solar cells) or crystalline(e.g. those optimized for charge transport in OFETs). When the electronic couplings between adjacent OS molecules or polymer chain segments are weak, the charge-transport mechanism is dominated by hopping processes, which is the context in which we frame the discussion in this Review. Factors such as disorder, mobility anisotropy, traps, grain boundaries or film morphology all impact charge transport. To take these features fully into account in an OFET device model requires considering a nano-scale, molecular-level resolution. Here, we discuss the recent development of such molecular-resolution OFET models based on a kinetic Monte Carlo approach relevant to the hopping regime. We also briefly describe the applicability of these models to high-mobility OFETs,where we underline the need to extend them to incorporate aspects related to charge delocalization.

关键词： organic semiconductors charge transport kinetic Monte Carlo simulations mobility measurements gradual channel approximation

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Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility

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Asian Journal of Andrology 2018年第4期20卷 360-365页

作者： Alejandro Oliva luc Multigner Center for Interdisciplinary Studies National University of Rosario Rosario 2000 Argentina University of Rennes Inserm EHESP Irset (Institut de recherche en sante environnement et travail) UMR_S 1085 Rennes F-35000 France

Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis （n = 253）, Grade III varicocele （n = 106）, and both conditions （n = 125） were compared with a control group （n = 168） composed of men without these disorders or any other recognized causes of male infertility. We showed that men who presented isolated chronic epididymitis were more likely to have high percentages of low sperm motility and abnormal sperm morphology as well as a high number of white blood cells. Men with isolated Grade III varicocele had low sperm production and motility and an increased percentage of abnormal sperm morphology. Finally, men who simultaneously presented chronic epididymitis with Grade III varicocele had a low sperm motility and increased percentage of abnormal sperm morphology as well as a high number of white blood cells. Physical examination of the genital organs may identify common disorders, potentially involved as causal factors of patient＇s infertility. These disorders are associated with specific seminal profiles that should help in identifying the best treatment from the available therapeutic options, effectiveness, safety, and allowing as much as possible natural conception.

关键词： couple subfertility epididymitis male factor infertility semen quality varicocele

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