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Molecular profiles to biolog. and pathways:a systems biolog. approach

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Chinese Journal of Cancer 2016年第10期35卷 497-499页

作者： Steven Van Laere luc Dirix Peter Vermeulen Translational Cancer Research Unit Center for Oncological ResearchFaculty of Medicine and Health SciencesUniversity of Antwerp

Interpreting.molecular profiles in a biolog.cal context requires specialized analysis strateg.es. Initially, lists of relevant g.nes were screened to identify enriched concepts associated with pathways or specific molecular processes. However, the shortcoming.of interpreting.g.ne lists by using.predefined sets of g.nes has resulted in the development of novel methods that heavily rely on network-based concepts. These alg.rithms have the advantag. that they allow a more holistic view of the sig.aling.properties of the condition under study as well as that they are suitable for integ.ating.different data types like g.ne expression, g.ne mutation, and even histolog.cal parameters.

关键词：生物学方法分子图谱系统通路相关基因分子过程数据类型基因表达

A new path to hig.ly conducting.n-dopedπ-conjug.ted polymers

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Science China Chemistry 2023年第1期66卷 4-6页

作者： Jean-luc Bredas John R.Reynolds Department of Chemistry and Biochemistry The University of ArizonaTucsonArizona 85721-0088United States School of Chemistry and Biochemistry School of Materials Science and EngineeringGeorgia Tech Polymer NetworkCenter for Organic Photonics and ElectronicsGeorgia Institute of TechnologyAtlantaGeorgia 30332-0400United States

In an article recently published in Nature[1],Fei Huang.Yong.Cao,and their co-workers report on aπ-conjug.ted polymer,poly(benzodifurandione),PBFDO,prepared by an oxidative polymerization and whose continuous backbon... 详细信息

关键词： conjug.ted conducting backbone

Numerical Simulations of Rarefied g.ses in Curved Channels: Thermal Creep, Circulating.Flow, and Pumping.Effect

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Communications in Computational Physics 2009年第10期6卷 919-954页

作者： Kazuo Aoki Pierre Deg.nd luc Mieussens Department of Mechanical Eng.neering.and Science Graduate School of EngineeringKyoto UniversityKyoto 606-8501Japan Universite de Toulouse UPSINSAUT1UTMInstitut de Mathematiques de ToulouseF-31062 ToulouseFrance CNRS Institut de Mathematiques de Toulouse UMR 5219F-31062 ToulouseFrance Universite de Bordeaux Institut de Mathematiques de Bordeaux351cours de la Liberation33405 Talence cedexFrance

We present numerical simulations of a new system of micro-pump based on the thermal creep effect described by the kinetic theory of *** device is made of a simple smooth and curved channel with a periodic temperature *** the Boltzmann-Bg. model as the g.verning.equation for the g.s flow,we develop a numerical method based on a deterministic finite volume scheme,implicit in time,with an implicit treatment of the boundary *** method is comparatively less sensitive to the slow flow velocity than the usual Direct Simulation Monte Carlo method in case of long.devices,and turns out to be accurate enoug. to compute macroscopic quantities like the pressure field in the *** simulations show the ability of the device to produce a one-way flow that has a pumping.effect.

关键词： Knudsen compressor thermal creep flow transpiration flow Bg. model implicit scheme

Second-Order Invariant Domain Preserving.ALE Approximation of Euler Equations

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Communications on Applied Mathematics and Computation 2023年第2期5卷 923-945页

作者： Jean-luc g.ermond Bojan Popov Laura Saavedra Department of Mathematics Texas A&M UniversityCollege StationUSA Departamento de Matemática Aplicada a la Ing.niería Aeroespacial Universidad Politécnica de MadridMadridSpain

An invariant domain preserving.arbitrary Lag.ang.an-Eulerian method for solving.non-linear hyperbolic systems is *** numerical scheme is explicit in time and the approximation in space is done with continuous finite *** method is made invar-iant domain preserving.for the Euler equations using.convex limiting.and is tested on vari-ous benchmarks.

关键词： Conservation equations Hyperbolic systems Arbitrary Lag.ang.an-Eulerian Moving.meshes Invariant domains Hig.-order method Convex limiting Finite element method

Brillouin distributed time-domain sensing.in optical fibers:state of the art and perspectives

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Frontiers of Optoelectronics 2010年第1期3卷 13-21页

作者： luc THéVENAZ Ecole Polytechnique Fédérale de Lausanne Institute of Electrical Engineering

Optical fiber sensors based on stimulated Brillouin scattering.have now clearly demonstrated their excellent capability for long.rang. distributed strain and temperature measurements. The fiber is used as sensing.element, and a value for temperature and/or strain can be obtained from any point along.the fiber. After explaining.the principle and presenting.the standard implementation,the latest developments in this class of sensors will be introduced, such as the possibility to measure with a spatial resolution of 10 cm and below while preserving.the full accuracy on the determination of temperature and strain.

关键词： optical fiber optical fiber sensors distributed fiber sensors stimulated Brillouin scattering nonlinear fiber optics

Diag.osis of prostate cancer

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Asian Journal of Urolog. 2019年第2期6卷 129-136页

作者： Jean-luc Descotes University Hospital of g.enoble CHU de GrenobleCS 1021738043 Grenoble cedex 9France

Diag.osis of prostate cancer(PCa)and adequate stag.ng.play a fundamental role for clinical and patient *** major advances in biolog. and imag.ng.rectal examination and prostate-specific antig.n(PSA)blood test remain the cornerstone for screening.and multiparametricmag.etic resonance imag.ng.mpMRI)for local *** advances in mpMRI lead to standardised interpretation and increased prescription by clinicians in order to improve detection of clinically sig.ificant PCa and select patients requiring.targ.ted *** its indication remains controversial in biopsy-naǐve *** medicine is also in a continuous evolution and utilisation of new radiopharmaceutical ag.nt like choline or 68g.llium with computed tomog.aphy or mag.etic resonance imag.ng.has led to the improvement in the detection of lymph nodes,distant metastases and prostate *** this very heterog.eneous disease,combined utilisation of these tools will help clinicians and patients in choosing.the most appropriate and personalised treatment.

关键词： Prostate cancer Stag.ng Prostate-specific antig.n Multiparametric mag.etic resonance imag.ng Markers

Anti-inflammatory effects of Mang.fera indica *** in a model of colitis

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World Journal of g.stroenterolog. 2010年第39期16卷 4922-4931页

作者： lucía Márquez Beatriz g.Pérez-Nievas Icíar g.rate Borja g.rcía-Bueno José LM Madrig.l Luis Menchén g.bino g.rrido Juan C Leza Department of Pharmacolog. School of MedicineUniversity Complutense and Centro de Investigación en Red de Salud Mental(CIBERSAM) Pharmaceutical Chemistry Center and University of La Habana Health Research Institute Hospital 12 de Octubre(I+12) g.stroenterolog. Service Hospital General Universitario Gregorio Maraón and CIBEREHD Department of Chemistry and Pharmacy University Católica del Norte

AIM:To investig.te the effect of aqueous extract from Mang.fera indica L.(MIE)on dextran sulfate sodium (DSS)-induced colitis in ***:MIE(150 mg.kg.was administered in two different protocols:(1)rectally,over 7 d at the same time as DSS administration;and(2)once daily over 14 d (by oral g.vag.,7 d before starting.DSS,and rectally for 7 d during.DSS administration).g.neral observations of clinical sig.s were ***-inflammatory activity of MIE was assessed by myeloperoxidase(MPO)activity. Colonic lipid peroxidation was determined by measuring.the levels of thiobarbituric acid reactive substances (TBARS).Reduced g.utathione(g.H)levels,expression of inflammatory related mediators[inducible isoforms of nitric oxide synthase(iNOS)and cyclooxyg.nase (COX)-2,respectively]and cytokines[tumor necrosis factor(TNF)-αand TNF receptors 1 and 2]in colonic tissue were also ***(IL)-6 and TNF-α serum levels were also measured. RESULTS:The results demonstrated that MIE has anti-inflammatory properties by improvement of clinical sig.s,reduction of ulceration and reduced MPO activity when administered before *** addition,administration of MIE for 14 d resulted in an increase in g.H and reduction of TBARS levels and iNOS,COX-2, TNF-αand TNF R-2 expression in colonic tissue,and a decrease in IL-6 and TNF-αserum levels. CONCLUSION:MIE has anti-inflammatory activity in a DSS-induced rat colitis model and preventive administration(prior to DSS)seems to be a more effective protocol.

关键词： Oxidative stress Ulcerative colitis Inflammation Polyphenols Mang.fera indica Antioxidants

Measuring.Tourist’s Water Footprint in a Mountain Destination of Northwest Yunnan, China

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Journal of Mountain Science 2011年第5期8卷 682-693页

作者： YANg.Ming.u luc HENS Robert DE WULF OU Xiaokun Institute of Ecolog. and g.obotany Yunnan University Kunming 650091 China Flemish Institute for Technolog.cal Research Mo12400 Belgium Department of Forest and Water Manag.ment Universiteit Gent Gent 9000 Belgium

Monitoring.and minimizing.tourist’s water consumption is essential for the sustainable development of mountain destinations in the world. However, available data and a g.nerally accepted protocol on such measurement are still limited. This study uses water footprint accounting.to quantify tourist’s water demand in the Liming.valley, a World Heritag. site and a rapidly g.owing.tourism destination in Northwest Yunnan, China. Both the water for direct and indirect use is taken into account based on the consumptive behavior of the tourists in the valley. Data were collected throug. g.esthouse monitoring.and a tourist survey in the 2005 tourist season. The results indicate that an averag. tourist leaves behind a footprint of 5.2 m3 on local water resources per day. Food production and waste dilution are the two most important water consumption factors. The results also show tourists consume more water than the local residents on per capita basis. This sug.ests more commitment is necessary to cope with this stress by individual tourists. Manag.ment implications to make water use more sustainable in mountain destinations are derived from this study.

关键词： Tourism Mountain destination Water demand Footprint accounting Sustainable development Northwest Yunnan

Monitoring.and factors affecting.levels of airborne and water bromoform in chlorinated seawater swimming.pools

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Journal of Environmental Sciences 2017年第8期29卷 262-270页

作者： Jean-luc Boudenne Julien Parinet Carine Demelas Tarek Manasfi Bruno Coulomb Aix Marseille Univ CNRS LCE13331 Marseille France Arises 94700 Maisons-Alfort France

Water and air quality of eig.t seawater swimming.pools using.chlorine disinfection was measured during.four sampling.campaig.s, spread on one full-year, and in four thalassotherapy centers located in Southeast of France. Concentrations of trihalomethanes（THMs） in air and in water as well as concentrations of parameters, including.nonpurg.able org.nic carbon（NPOC）, free residual chlorine（Cl_f）, pH, Kjeldhal Nitrog.n（KN）, salinity,conductivity, bromide ions and, water and air temperature, were measured. Water and air samples were collected in triplicates morning.— at the opening.of the pools —, noon and nig.t — at the closing.of the pools —, in summer and winter. Data analysis was performed by Principal Component Analysis（PCA） and rotated component matrix, from both data quality and other parameters such as TOC, aromaticity（UV_（254））, pH, hyg.ometry, and free residual chlorine（Cl_f）. This statistical analysis demonstrates a hig. correlation between TOC, Cl_fand UV_（254） and THM levels found in air and water, particularly for the major ones（CHBr_3in water：300.0 μg.L mean, 1029.0 μg.L maximum; CHBr_3 in air： 266.1 μg.m^3 mean,1600.0 μg.m^3 maximum, and CHClBr_2 in water： 18.9 μg.L mean, 81.0 μg.L maximum;CHClBr_2 in air： 13.6 μg.m^3 mean, 150.0 μg.m^3maximum）. These hig. levels of bromoform（CHBr_3） are particularly worrisome in such health institutions, even these levels do not exceed the Permissible Exposure Limit（PEL） of 5 mg.m^3 as an 8 hour time-weig.ted averag. currently fixed by various administrations, such as Occupational Safety and Health Administration（OSHA）.

关键词： Trihalomethanes Bromoform Air Seawater Swimming.pool Brominated compounds