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Region 2 of 8q24 is associated with the risk of aggressive prostate cancer in Caribbean men of African descent from Guadeloupe （French West Indies）

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Asian Journal of Andrology 2015年第1期17卷 117-119,I0010页

作者： Geraldine Cancel-Tassin Marc Romana Cecile Gaffory Pascal Blanchet Olivier Cussenot luc Multigner CeRePP Pitie-Salpetriere Hospital Paris 75013 France ER2 UPMC Univ Paris 6 Paris 75020 France 3U665 Inserm Pointe a Pitre 97159 Guadeloupe French West Indies Department of Urology Assistance Publique Hopitaux de Paris Tenon Hospital GHU Est Paris 75020 France U1085 - IRSET Inserm Pointe Pitre 97154 Guadeloupe French West Indies Department of Urology CHU Pointe--Pitre/Abymes Pointe Pitre 97159 Guadeloupe French West Indies.

Multiple regions of the genome have been associated with the risk of prostate cancer in Caucasians, particularly including several polymorphisms located at 8q24. Region 2 of 8q24 has been repeatedly found to be associated with the risk of prostate cancer among men of African descent, although one study performed in the Caribbean island of Jamaica did not report this finding. In this study, the single nucleotide polymorphism rs16901979, located in region 2 of 8q24, was genotyped in 498 cases of histologically confirmed prostate cancer and 541 controls from the French Caribbean islands of Guadeloupe, where the population is largely of African descent. The AA genotype and the A allele at rs16901979 were associated with elevated risks of prostate cancer （odds ratios [ORs] = 1.84, 95% confidence interval [95% CI] = 1.26-2.69, P= 0.002 and OR = 1.36, 95% CI = 1.13-1.64, P= 0.001, respectively）. Following stratification of the patients by disease aggressiveness, as defined by the Gleason score, the pooled genotypes AC ＋ AA were associated with a higher risk of a Gleasen score 〉7 at diagnosis （OR = 1.79, 95% CI = 1.17-2.73, P= 0.007）. In summary, the A allele at rs16901979 was associated with the risk of prostate cancer in the Caribbean population of Guadeloupe, confirming its involvement in populations of African descent. Moreover, our study provides the first evidence of an association between this variant and the risk of aggressive prostate cancer.

关键词： African Continental Ancestry Group aggressiveness Caribbean region genetic predisposition to disease prostaticneoplasms

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Bayés syndrome and acute cardioembolic ischemic stroke

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World Journal of Clinical Cases 2017年第3期5卷 93-101页

作者： Adrià Arboix lucía Martí Sebastien Dorison María José Sánchez Division of Cerebrovascular Universitat de Barcelona Department of Neurology Hospita Universitari del Sagrat Cor Medicine School Universidad de los Andes 111711 Bogotá Medical Library Hospital Universitari Sagrat Cor

Bayés syndrome is an under-recognized clinical condition characterized by advanced interatrial ***és syndrome is a subclinical disease that manifests electrocardiographically as a prolonged P wave duration>120 ms with biphasic morphology±in the inferior *** clinical relevance of Bayés syndrome lies in the fact that is a clear arrhythmological syndrome and has a strong association with supraventricular arrhythmias,particularly atypical atrial flutter and atrial ***,Bayés syndrome has been recently identified as a novel risk factor for non-lacunar cardioembolic ischemic stroke and vascular *** interatrial block can be a risk for embolic stroke due to its known sequelae of left atrial dilation,left atrial electromechanical dysfunction or atrial tachyarrhythmia(paroxysmal or persistent atrial fibrillation),conditions predisposing to ***és syndrome may be responsible for some of the unexplained ischemic strokes and shall be considered and investigated as a possible cause for cryptogenetic *** summary,Bayés syndrome is a poorly recognized cardiac rhythm disorder with important cardiologic and neurologic implications.

关键词： Bayés syndrome Cardioembolic stroke Electrophysiological processes Cardiovascular risk factors Heart conduction system

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Design support tools to sustain climate change adaptation at the local level： A review and reflection on their suitability

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Frontiers of Architectural Research 2015年第1期4卷 1-11页

作者： Catherine Dubois Genevieve Cloutier Andre Potvin luc Adolphe Fiorent Joerin School of Architecture Laval University I cote de la Fabrique Quebec City G IR 3V6 Canada CRAD Laval University 2325 rue des Bibliotheques Quebec City G1V OA6Canada INSA of Toulouse LMDC 136 avenue de Rangueil 31077 Toulouse Cedex 4 France

For mid-latitude cities, higher summer temperatures due to climate change are a cause for concern because they aggravate the urban heat island phenomenon and reduce thermal comfort inside buildings. By acquiring the appropriate knowledge and skills, architects and urban designers can become key actors in adaptation to climate change. Two workshops bringing together architects and urban designers provided evidence of deficiencies in this area. We hypothesize that a design support tool （DST） focused on the issue of adaptation of mid- latitude cities to rising summer temperatures could help improve knowledge and skills of professionals in the field. The first section presents the results taken from a review and classification of DSTs, which highlight the toots＇ features that are LikeLy to reach this goal Toots of the ＂hybrid＂ category seem most appropriate. To verify this, seven DSTs were selected and tested by fourteen students enrolled in a graduate-level architecture design studio. The second section presents the results from this test, including an analysis of the final projects, a web- based questionnaire and two focus groups. The relevance of hybrid approaches is established, but the results bring into question the capacity of a single DST to meet the individual and multiple needs of professionals.

关键词： Climate chanse adap-tation Mid-Latitude cities Architects Urban designers Design support too[ Architecture designstudio

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高温下自密实混凝土强度和变形性能试验研究

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同济大学学报（自然科学版） 2009年第6期37卷 738-743页

作者：陶津柳献袁勇 luc Taerwe 同济大学地下建筑与工程系上海200092 东南大学土木工程学院南京210096 比利时根特大学Magnel混凝土实验室同济大学岩土及地下工程教育部重点实验室上海200092

进行了不同温度下自密实混凝土、掺加聚丙烯纤维的自密实混凝土、高强混凝土的抗压强度及应力-应变曲线的非持荷试验研究,分析了抗压强度、应力-应变关系随温度的发展变化规律,基于试验结果给出了相应的应力-应变曲线方程,并与普通混凝... 详细信息

进行了不同温度下自密实混凝土、掺加聚丙烯纤维的自密实混凝土、高强混凝土的抗压强度及应力-应变曲线的非持荷试验研究,分析了抗压强度、应力-应变关系随温度的发展变化规律,基于试验结果给出了相应的应力-应变曲线方程,并与普通混凝土、高强、高性能混凝土研究成果进行了对比分析.为高温下自密实混凝土本构模型的建立奠定了基础,也为自密实混凝土结构的设计和分析提供了试验依据.

关键词：自密实混凝土高温抗压强度应力-应变关系

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Analysis of Flow Structure in Microturbine Operating at Low Reynolds Number

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Computers, Materials & Continua 2022年第4期71卷 961-977页

作者： Mohamed Omri Yusuf Al-Turki Ahmed A.Alghamdi Amrid Amnache luc G.Fréchette King Abdulaziz University Deanship of Scientific ResearchJeddahSaudi Arabia King Abdulaziz University Electrical and Computer Engineering DepartmentJeddahSaudi Arabia Universitéde Sherbrooke Interdisciplinary Institute for Technological Innovation(3IT)SherbrookeCanada

In this paper,three-dimensional flows in laminar subsonic cascades at relatively low Reynolds numbers(Re<2500)are presented,based on numerical *** stator and rotor blade designs are those for a MEMS-based Rankine microturbine power-plant-on-a-chip with 109-micron chord *** passage calculations in 3D were done for different Reynolds numbers,tip clearances(from 0 to 20%)and incidences(0◦to 15◦)to determine the impact of aerodynamic conditions on the flow *** conditions are applied to a blade passage for a stationary outer *** 3D blade passage without tip clearance indicates the presence of two large symmetric vortices due to the interaction between hub/casing boundary layers and the *** the tip clearance introduces the tip vortex,which tends to become dominant above a tip clearance of 10%.In addition to providing a description and understanding of the 3D flow in a MEMS microturbine,these results suggest the importance of considering 3D flows in the design of microturbomachinery,even though the geometry is dominantly 2D.

关键词： Microturbomachinery turbine vortex internal flows secondary flows

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Gadolinium－Induced Multi－Effect on Properties of IR Transmitting Chalcogenide Glasses

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Chinese Physics Letters 2004年第3期21卷 514-516页

作者：赵东辉夏方聂佳相陈国荣章向华马红丽 ADAMJean-luc SchoolofMaterialsScienceandEngineering EastChinaUniversityofScienceandTechnologyShanghai200237 LaboratoiredesVerresetCéramiques UniversitedeRennesI35042RennescedexFrance

We introduce gadolinium in chalcogenide glasses to exert unexpectedly the multiple magical effects on both optical and thermal mechanical properties of chalcogenide glasses. Notable increases in transition temperature Tg and microhardness Hv were observed due to structural densification and microcrystallization. Calculated molar volume values, differential scanning calorimetry and x-ray diffraction measurements provide supporting evidence. Gadolinium also acts as an oxygen getter by removing or weakening oxygen-related absorption bands, which is associated with the higher negative electrode potential.

关键词： Gadolinium

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Impacts of mixed litter decomposition from Robinia pseudoacacia and other tree species on C loss and nutrient release in the Loess Plateau of China

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Journal of Forestry Research 2016年第3期27卷 525-532页

作者： Xiaoxi Zhang Zengwen Liu Bochao Zhu Yuanhao Bing Nhu Trung luc Liangzhen Du Zhenhua Zhu Northwest A&F University No. 26 Xinong Rd.Yangling 712100 Shaanxi ProvincePeople's Republic of China Department of Agriculture and Rural Development of Lao Cai Lao Cai City 330100 Vietnam

The productivity of Robinia pseudoacacia（R.p.） pure forest usually declines at the late growth stage,and reforming it into mixed forests could be a promising way to resolve this problem. When choosing a suitable tree species that can be mixed with R.p., the interspecific relationship is an important issue. Therefore, we gathered the autumn litter fall from R.p. and 10 other species from the Loess Plateau of China were mixed in dual species litterbags（R.p.＋each other species） and buried them in soil for a 345 days lab decay incubation. We measured the litter mass loss and nutrient contents to determine whether the nutrient release was affected by mixed species litter decomposition. The impacts of mixed litter decomposition on macro-elements release were more obvious than on micro-elements. The litters with similar substrate quality might show variable impacts on nutrients release in mixed decomposition. The C loss and release of nutrient was improved by descending order when R.p. litter was mixed with Hippophae rhamnoides, Ulmus pumila, Populus simonii, Larix principis-rupprechtii and Quercus liaotungensis（Q.l.）. But, except for Q.l., only the other species were recommended as suitable mix-plants for R.p. since promoting a high turnover of the nutrient in the litter compartment and a rapid availability for tree.

关键词： Robinia pseudoacacia Leaf litter Mixeddecomposition Nutrient release

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Petrography of alluvial sands as a past and present environmental indicator:Case of the Loire River(France)

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International Journal of Sediment Research 2013年第3期28卷 285-303页

作者： Jean-Jacques MACAIRE Isabelle GAY-OVEJERO Michel BACCHI Constantin COCIRTA luc PATRYL Stéphane RODRIGUES University Franqois-Rabelais of Tours University Francois-Rabelais of Tours SARL RIVE 4. Commissariat a l'Energie Atomique-CEA DAMDIF

Four sample sets of the Upper and Middle Loire river sands were analyzed in order to study the impact of natural and anthropogenic factors on their petrographic composition in space(on an 800 km stretch) and *** was determined by modal analysis of three sand-size fractions using a polarizing optical microscope and calculated for each sample("standard sand" = Sst).The watershed is composed mainly of endogenic(Massif Central) and sedimentary(southern Parisian Basin) rocks.B-set sands collected in channels for different water flows in 1996 show that Sst compositions vary by only 5%.Present-day sands in the Upper Loire and Middle Loire have very high petrographic immaturity comparing to others worldwide fluvial sands,although bio-climatic conditions favor sand maturation by source-rock weathering in the *** shows the strong impact of the Massif Central on sediment yield due to relief rejuvenation as a consequence of the formation of the Alps during the *** sands stored during the Weichselian and the Holocene in the Middle Loire floodplain,although partly weathered since their deposition,show higher inputs from the endogenic rocks of the Massif Central than present-day *** can be explained by Weichselian periglacial conditions and the development of crop farming since the Neolithic,which favored mechanical erosion,particularly in the Massif Central which is characterized by a cold,humid climate and steep *** upstream-downstream change in the composition of presently deposited sand is low in the diked *** shows however that basalt and some heavy mineral grains are vulnerable to abrasion during transport and indicates a marked sediment yield from ancient sediment stored in the *** is in line with the high incision of the river bed over the last 150 years partly due to dam construction and aggregate mining.

关键词： Fluvial sand Sand petrography Sediment source Tectonics impact Human impact Loire river

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自密实混凝土高温爆裂性能影响因素的试验研究

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土木工程学报 2009年第10期42卷 22-26页

作者：陶津柳献袁勇 luc Taerwe 东南大学江苏南京210096 同济大学岩土及地下工程教育部重点实验室上海200092 比利时根特大学Magnel混凝土实验室

对自密实混凝土、掺加聚丙烯纤维的自密实混凝土与高强混凝土进行高温爆裂试验,对不同升温速率、不同聚丙烯纤维掺量、不同应力水平进行综合研究。为了清楚地了解自密实混凝土在高温下爆裂的本质特征,通过环境扫描电镜和汞压力测孔法对... 详细信息

对自密实混凝土、掺加聚丙烯纤维的自密实混凝土与高强混凝土进行高温爆裂试验,对不同升温速率、不同聚丙烯纤维掺量、不同应力水平进行综合研究。为了清楚地了解自密实混凝土在高温下爆裂的本质特征,通过环境扫描电镜和汞压力测孔法对混凝土高温下微观性能进行研究,还进行高温后材料的气渗性能测试。分析初始应力、纤维掺量、不同升温机制等对混凝土爆裂性能的影响,建立自密实混凝土高温爆裂性能与微观组成结构之间的联系,揭示不同影响因素对自密实混凝土高温爆裂性能产生影响的本质原因。试验结果表明初始应力是影响自密实混凝土爆裂的重要因素,且一定掺量的聚丙烯纤维对抑制自密实混凝土高温爆裂具有显著的作用,最后探讨聚丙烯纤维作用机理,提出自密实混凝土高温爆裂抑制措施,对于自密实混凝土的大规模推广和应用具有重要实际意义。

关键词：自密实混凝土高温爆裂聚丙烯纤维

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Influence of anthropic and eco-hydrological factors on the floristic diversity of the herbaceous vegetation around the temporary ponds in Ferlo,northern Senegal

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Journal of Plant Ecology 2022年第1期15卷 26-38页

作者： Ndiabou Faye Aly Diallo Moustapha BassimbéSagna Jean luc Peiry Papa Saliou Sarr Aliou Guisse Département de Biologie Végétale UniversitéCheikh Anta DiopDakarSenegal IRL3189 Environment SantéSociétésCentre National de la Recherche Scientifiques(CNRS)ParisFrance IRL3189 Environnement SantéSociétésUniversitéCheikh Anta DiopDakarSenegal Observatoire international Hommes Milieux-OHMi Tessekere UniversitéCheikh Anta DiopDakarSenegal Observatoire international Hommes Milieux-OHMi Tessekere Centre National de la Recherche Scientifique(CNRS)ParisFrance Departement d’Agroforesterie UniversitéAssane Seck de ZiguinchorZinguinchorSenegal Département de Géographie Universitéde Clermont FerrandClermont-FerrandFrance Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaIbarakiJapan

Temporary ponds play substantial roles in preserving biodiversity in the *** study investigated the influence of anthropic and eco-hydrological factors on the plant diversity around two grazed ponds and one ungrazed pond in Ferlo,northern *** phytoecological transects were established per *** each transect,homogenous herbaceous vegetation units were identified and characterized(herbaceous cover,exposure,soil texture,soil moisture and pH,average height and slope).The herbaceous flora comprised 55 species,41 genera and 22 families across the three *** of the Poaceae,particularly Eragrostis tremula and Enteropogon prieurii,mostly colonized the grazed ponds,while the ungrazed pond favored other families’species such as Achyranthes sp.,Commelina forsskaolii,Corchorus *** Shannon’s diversity index(H′)of Wendu Marodi(ungrazed pond)was slightly higher(4.9 bits)than that of Belel Lougal and Belel Sow(grazed ponds)with 4.8 and 4.5 bits,*** equitability indices were relatively high in the three ponds(0.85,0.83 and 0.78).Eco-ecological factors distinguished four species’groupings:a Tribulus terrestris grouping colonizing the constraining and over-grazed zones,a Digitaria horizontalis grouping,and Chloris barbata grouping found in the transition zones,and an Achyranthes aspera grouping in the wetlands,where woody plants were strongly present and the anthropic action *** study highlighted the importance of maintaining a landscape mosaic of ungrazed or semi-protected ponds and grazed ponds to preserve the herbaceous floristic diversity in the center of Ferlo(Senegal)and the Sahel in general.

关键词： ponds Ferlo grazing herbaceous vegetation transect

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