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ATM与bRCA1的双杂合性通过影响若干通路增加肿瘤发生风险

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ATM与BRCA1的双杂合性通过影响若干通路增加肿瘤发生风险

bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者：胡文涛苏锋涛 lubomir b.smilenov 周利斌朱佳赟丁楠刘苑辛高清祥 Tom K.Hei Eric J.Hall 周光明中国科学院近代物理研究所 Center for Radiological Research Columbia University Medical Center 兰州大学生命科学学院

＜正＞目的:流行病学统计数据表明杂合性与肿瘤发生相关。ATM和bRCA1都是DNA损伤修复通路中的多功能基因,其单杂合性对于肿瘤易感性的影响已见报道,但双杂合

关键词： ATM bRCA1 杂合性肿瘤发生

来源： cnki会议评论

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Oncology Research 2024年第6期32卷 1031-1036页

作者： CONSTANTINE N.LOGOTHETIS NATHAN P.HORVAT TONY KURIAN CELESTE bELLO JULIO CHAVEZ LEIDY ISENALUMHE bIJAL SHAH lubomir SOKOL HAYDER SAEED JAVIER PINILLA SAMEH GAbALLA Department of Internal Medicine University of South FloridaTampaFL33602USA College of Medicine University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Cancer Center and Research Institute TampaFL33612USA

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone *** bendamustine and rituximab(bR)were derived from trials involving other indolent non-Hodgkin’s *** one trial has evaluated frontline bR prospectively in *** retrospective study reports outcomes among EMZL patients receiving frontline ***-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ *** median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)*** response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not *** estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large b-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to *** is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

关键词： Extranodal marginal zone lymphoma bendamustine Rituximab Front-line therapy

Contributes of Heterozygosity for ATM and/or bRCA1 to Individual Susceptibility to Tumor Initiation

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2007年第1期 104-105页

作者： Zhou Guangming lubomir b. smilenov Su Fengtao Zhou Libin Nie Jing Ronald A. baker Eric J. HalI 不详 Center for Radiological Research the Columbia University New York 10032 USA.

ATM和/或bRCAl基因杂合对肿瘤发生的贡献(英文)

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IMP & HIRFL Annual Report 2007年 104-105页

作者：周光明 lubomir b. smilenov Ronald A. baker Eric J.Hall Center for Radiological Research the Columbia University

Epidemiological data show that heterozygosity resulted from one inactivated allele leading to haploin- sufficiency of proteins involved in DNA damage signaling and repair pathways plays an important role in tumorigene...

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A comparison of soft magnetic composites designed from different ferromagnetic powders and phenolic resins

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Chinese Journal of Chemical Engineering 2015年第4期23卷 736-743页

作者： Magdalena Streckova Radovan bures Maria Faberova lubomir Medvecky Jan Fuzer Peter Kollar Institute of Materials Research Slovak Academy of Sciences Watsonova 47043 53 Kosice Slovak Republic Institute of Physics Faculty of Science P. J. afárik University Park Angelinum 9040 01 Kosice Slovak Republic

Soft magnetic composites （SMCs） were prepared from three different ferromagnetic powder particles： iron powder ASC 100.29, spherical FeSi particles and vitroperm （Fe73CulNb3Si16b7） flakes. Two types of hybrid organic-inorganic phenolic resins modified with either silica nanoparticles or boron were used to design a thin insulating layer perfect- ly covering the ferromagnetic particles. Fourier transform infrared （FTIR） spectrometry confirmed an incorporation of silica or boron into the polymer matrix, which manifested itself through an improved thermal stability of the hybrid resins verified by thermogravimetric-differential scanning calorimetry （TG-DSC） analysis. The core-shell particles prepared from the ferromagnetic powder particles and the modified hybrid resins were further compacted to the cylindrical and toroidal shapes for the mechanical, electrical and magnetic testing. A uniform distribution of the resin between the ferromagnetic particles was evidenced by scanning electron microscope （SEM） analysis, which was also reflected in a rather high value of the electrical resistivity. A low porosity and extraordinary high values of mechanical hardness and flexural strength were found in SMC consisting of the iron powder and phenolic resin modified with boron. The coercive fields of the prepared samples were comparable with the commercial SMCs.

关键词： Composite materialsCore-shell particlesFourier transform infrared (FTIR) spectroscopyPowder metallurgySol-gel method

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The Cytochrome b Polymorphism of Meat Lines Rabbits

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Journal of Life Sciences 2016年第1期10卷 16-20页

作者： Vladimir Parkanyi lubomir Ondruska Dusan Vasicek Research Institute for Animal Production National Agricultural and Food Centre Hlohovecka 2 Luzianky 951 41 Slovak Republic

The cytochrome b mtDNA was analysed from peripheral whole blood samples of meat lines rabbits. The PCR product--692 bp long fragment of Oryctolagus cuniculus_cytochrome b （0CU07566 Genbank, NCb1, USA） was amplified. Synthetically produced oligonucleotides for the detection ofcyt b were designed by own algorithm： ORYCTO-cyt b-FOR 5＇- CTA TCA GCA ATC CCA TAT ATC -3＇ and ORYCTO-cyt b-REV 5＇- CTT CAT TTG AGG ATT TTG TT -3＇. based on AluI-RFLP were described two cytochrome b haplotypes--cyt b 430 and cyt b 306. Haplotype cyt b 430 is 571A （190Threonine-T）＋ 877G （292Alanine-A）. The new haplotype cyt b 306 is presented A571G nucleotide substitution, i.e, 571G （190Alanine-A）＋ 877G （292Alanine-A）.

关键词： Rabbit cytochrome b SNP new haplotype A571G.

Hepatitis b Reactivation with Novel Agents in Non-Hodgkin's Lymphoma and Prevention Strategies

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Journal of Clinical and Translational Hepatology 2016年第2期4卷 143-150页

作者： Oluwatobi O.Ozoya lubomir Sokol Samir Dalia Emergency and Trauma Center Tampa General HospitalTampaFLUSA Department of Hematological Malignancies H.Lee Moffitt Cancer CenterTampaFLUSA Oncology and Hematology Mercy Clinic JoplinJoplinMOUSA

Hepatitis b virus (HbV) infection remains an endemic disease in most parts of the world despite available prophylactic ***-Hodgkin's lymphoma is the most common hematological malignancy,and certain patients undergoing therapy are at increased risk of HbV ***,a monoclonal antibody,is well studied in HbV reactivation,but newer agents have been implicated as ***,we review novel agents suspected in HbV reactivation and effective strategies to prevent HbV *** years of literature were reviewed in order to better understand the reactivation rates of hepatitis b in patients with non-Hodgkin's ***-CD20 antibodies continue to be the main medications that can lead to HbV reactivation,and HbV reactivation rates have decreased with increased *** reactivation is uncommon when using other novel *** and lamivudine remain the agents of choice to prevent HbV reactivation in high risk *** conclusion,the immunosuppressive effect of NHL and its therapy provide a pathway for HbV reactivation,especially in patients treated with anti-CD20 *** many HbV positive patients are often excluded from clinical trials of novel agents in NHL,more aggressive post-market surveillance of new agents,welldesigned best practice advisories,and timely case reports are needed to reduce the incidence of HbV ***,large prospective investigations coupled with well-utilized best practice advisories need to be conducted to understand the impact of more potent novel NHL therapy on HbV reactivation.(C) 2016 The Second Affiliated Hospital of Chongqing Medical *** by XIA & HE Publishing *** rights reserved.

关键词： Hepatitis b virus HbV reactivation Non-Hodgkin's lymphoma Rituximab Anti-CD20 antibody best practice advisories

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基于半监督的网络流量分类识别算法

电子测量与仪器学报 2014年第4期28卷 381-386页

作者：周文刚陈雷霆 lubomir bic 董仕电子科技大学计算机科学与工程学院成都610054 University of California irvineusa92617 东南大学计算机科学与工程学院南京211189

近年来,许多机器学习的方法被广泛应用于网络流量分类识别的问题中,结合有监督学习与无监督学习的特点,提出一种基于半监督学习的流量分类识别方法,该方法改进K均值聚类算法中初始簇中心的选取,通过基于密度因子的相似性函数来满足聚类... 详细信息

近年来,许多机器学习的方法被广泛应用于网络流量分类识别的问题中,结合有监督学习与无监督学习的特点,提出一种基于半监督学习的流量分类识别方法,该方法改进K均值聚类算法中初始簇中心的选取,通过基于密度因子的相似性函数来满足聚类数据的全局一致性要求以获取更适合的初始簇中心,并通过最大似然估计方法标记聚类结果实现与相关应用类型或协议的对应匹配过程,实验结果表明,该算法提升了网络流量分类识别结果的准确性和分类识别效率,能够有效满足流量分类识别的应用需求。

关键词：网络流量半监督学习分类识别聚类中心点

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