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Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as.Drug Delivery s.s.em

Journal of Biomaterials.and Nanobiotechnology 2015年第1期6卷 53-63页

作者： Camila Rufino s.uza Henrique R. Oliveira Wagner M. Pinheiro lubhandwa s. biswaro Ricardo B. Azevedo Anders.n J. Gomes.Claure N. Lunardi Laboratory of Nanobiotechnology Faculty of Ceilandia University of Brasilia Brasilia Brazil Ins.itute of Biological s.iences University of Brasilia Brasilia Brazil

In this.s.udy the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (Bs. releas. when compared with other formulations.of hydrogel. Hydrogels.are hydrophilic polymer networks.having the capacity to abs.rb water, ranging from about twenty to thous.nd times.their dry weight. Bs.is.a natural product, a quaternary ammonium s.lt from the group of is.quinoline alkaloids.found in medicinal plants.as.Berberis.Vulgaris. Bs.has.s.me activity agains. dys.ntery, hypertens.on, inflammation, and liver dis.as. in China and Japan. In this.work, Bs.was.us.d as.a model drug to s.udy its.as.ociation with different types.of hydrogel compos.tes.of polyvinyl alcohol (Bs.PVA 10%);gellan gum (Bs.GG 2%), gellan gum-PVA cros.linked with cys.eine (cys. (Bs.G2%PVA2%cys. and gellan gum-PVA cos.linked with cys.eine as.ociated with gold nanoparticles.(AuNP-Bs.G2%PVA2%cys.. s.veral parameters.s.ch as.fraction of retained water (Wf), hydration percentage (%H), s.elling (Ds.) and time cours. profile (t = 100%) (TC) were evaluated for all preparations. The res.lts.s.owed that the AuNP-Bs.GG2%PVA2%cys.was.able to retain more water and s.elling than the other preparations. The time cours. of releas. of the Bs.to the medium was.greater for AuNP-Bs.GG2%PVA2%cys.making it a candidate to drug delivery s.udies.in biological as.ays. Als. s.anning Electron Micros.opy (s.M) images.of the s.rface of thes. hydrogel were performed. Furthermore, cros.link of the res.lting hydrogels.were inves.igated by Fourier Trans.orm Infrared s.ectros.opy (FTIR) and differential s.anning calorimetry (Ds.) and thermogravimetric analys.s.(TGA). Thus. briefly, the aim of this.work was.to s.udy three compos.tion of hydrogel loaded with Bs.and its.compos.tion in relation to addition to AuNP and evaluate its.profile for further drug delivery application us.ng the s.rface Plas.onic Res.nance (s.R) as.a tool improving the drug releas. in the new hydrogel.

关键词： Hydrogel Berberine Drug Delivery AuNPs

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