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Effectiveness of Laser Therapy (AlGaInP) on Cicatrization of Experimental Cutaneous Wound in Rats

International Journal of Clinical Medicine 2014年第9期5卷 525-530页

作者： Renata dos Santos Vasconcelos Renata Prado Vasconcelos luana torres monteiro melo Carolina Araújo Castro Adriana Rolim Campos Ana Paula Vasconcellos Abdon Department of Biotechnology State University of Ceara (UECE) Fortaleza Brazil Department of Health Sciences University of Fortaleza (UNIFOR) Fortaleza Brazil Department of Medical Sciences Federal University of Ceara (UFC) Fortaleza Brazil Department of Physiology State University of Ceara (UECE) Fortaleza Brazil

The use of laser therapy is one of the most effective tools in the prevention and treatment of skin ulcers. It is an effective treatment choice because it potentiates the trophic regenerative, anti inflammatory, and painkiller effects. This study aimed to assess the effectiveness of low level laser therapy in treating induced cutaneous ulcers in rats. An experimental study using 12 female Wistar rats (Rattus novergicus), weighing between 150 and 250 g, from the room of animal husbandry at the Center of Health Sciences of UNIFOR. Rats underwent surgery to induce cutaneous ulcer. Subsequently, the animals were divided into two randomized groups: 1) Control group;and 2) Experimental group. They received nine applications of AlGaInP laser treatment (power of 30 mW) with an intensity of 4 J/cm2, using the scan method, for 15 seconds over the entire ulcer. The cicatrization process was evaluated from the 1st to 19th postoperative (PO) day, but on alternate days. The results showed that animals treated with laser had less area of cutaneous wound than the control group from the 7th until the 17th postoperative day, highlighting the 7th and the 9th PO with a significant reduction in wound area of 28.8% (p = 0.00) and 23,5% (p = 0.01), respectively. Treatment with the AlGaInP laser was effective in the repair of cutaneous wound when compared to the control group—particularly on the 7th postoperative day.

关键词： Laser Therapy Rats Wound Healing Regeneration

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Cannabinoid pharmacology and its therapeutic uses in Alzheimer’s disease

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Neural Regeneration Research 2021年第5期16卷 990-991页

作者： Kadja luana Chagas monteiro Marcone Gomes dos Santos Alcântara Thiago Mendonça de Aquino Edeildo Ferreira da Silva-Júnior Laboratory of Medicinal Chemistry Institute of Pharmaceutical SciencesFederal University of AlagoasMaceióBrazil Chemistry and Biotechnology Institute Federal University of AlagoasMaceióBrazil

Alzheimer’s disease(AD)is a chronic neurodegenerative disease,which is difficult to diagnose in its early *** is associated with aging and consists of a decline in cognitive functions,memory,and other mental *** pathophysiological markers are associated with AD progression and worsening,such as the deposition and intracellular accumulation of senile plaques containing amyloid-β(Aβ)peptides,and tau protein hyperphosphorylation,leading to the formation of neurofibrillary tangles.

关键词： Alzheimer Aβ tau

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Co-expression of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tropical spastic paraparesis development in HTLV-1-infected individuals:A systematic review

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Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 333-340页

作者： Ana Carolina Marinho monteiro Lima Greice Carolina Santos da Silva Fernanda Khouri Barreto Filipe Ferreira de Almeida Rego luana Leandro Gois Luciane Amorim Santos Catholic University of Salvador SalvadorBahiaBrazil Multidisciplinary Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil Postgraduate Program in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/*** review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP *** systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and *** search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject *** screening,six articles were included in this *** studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy *** systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

关键词： HTLV-1 HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXp3 HBZ TAX

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A MPCC-NLP Approach for an Electric Power Market Problem

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Smart Grid and Renewable Energy 2010年第1期1卷 54-61页

作者： Helena Sofia Rodrigues Maria Teresa torres monteiro António Ismael Freitas Vaz Department of Production and Systems University of Minho Portugal School of Business Studies Viana do Castelo Polytechnic Institute Portugal

The electric power market is changing-it has passed from a regulated market, where the government of each country had the control of prices, to a deregulated market economy. Each company competes in order to get more *** and maximize its profits. This market is represented by a Stackelberg game with two firms, leader and follower, and the leader anticipates the reaction of the follower. The problem is formulated as a Mathematical Program with Complementarity Constraints (MPCC). It is shown that the constraint qualifications usually assumed to prove convergence of standard algorithms fail to hold for MPCC. To circumvent this, a reformulation for a nonlinear problem (NLP) is proposed. Numerical tests using the NEOS server platform are presented.

关键词： Electric Power Stackelberg Game Nonlinear Programming Complementarity Constrained Optimization

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Antimicrobial activity of calcium hydroxide and chlorhexidine on intratubular Candida albicans

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International Journal of Oral Science 2013年第1期5卷 32-36页

作者： Ronan Jacques Rezende Delgado Thaís Helena Gasparoto Carla Renata Sipert Claudia Ramos Pinheiro Ivaldo Gomes de Moraes Roberto Brandao Garcia Marco Antnio Hungaro Duarte Clóvis monteiro Bramante Srgio Aparecido torres Gustavo Pompermaier Garlet Ana Paula Campanelli Norberti Bernardineli Department of Biological Sciences Bauru School of DentistryUniversity of Sao Paulo Department of Operative Dentistry Endodontics and Dental MaterialsBauru School of DentistryUniversity of Sao Paulo

This study investigated the efficacy of calcium hydroxide and chlorhexidine gel for the elimination of intratubular Candida albicans (***).Human single-rooted teeth contaminated with *** were treated with calcium hydroxide,2%chlorhexidine gel, calcium hydroxide plus 2%chlorhexidine gel,or saline(0.9%sodium chloride) as a positive *** samples obtained at depths of 0-100 and 100-200μm from the root canal system were analyzed for *** load by counting the number of colony forming units and for the percentage of viable *** using fluorescence ***,the antimicrobial activity of calcium hydroxide and the 2%chlorhexidine gel was evaluated by counting the number of colony forming *** 14 days of intracanal medication,there was a significant decrease in the number of *** colony forming units at a depth of 0-100μm with chlorhexidine treatment either with or without calcium hydroxide compared with the calcium hydroxide only ***,there were no differences in the number of colony forming units at the 100-200μm depth for any of the medications *** viability was also evaluated by vital staining techniques and fluorescence microscopy *** activity against *** significantly increased at both depths in the chlorhexidine groups with and without calcium hydroxide compared with the groups treated with calcium hydroxide *** with only chlorhexidine or chlorhexidine in combination with calcium hydroxide were effective for elimination of ***.

关键词： calcium hydroxide Candida albicans chlorhexidine endodontics

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Superoxide Anion Release by Human Blood Phagocytes Can Increase the Microbicidal Activity Induced by a New Microemulsioned System Containing Cotton Oil

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Advances in Biological Chemistry 2022年第6期12卷 207-227页

作者： luana Cristina da Silva Ramos André Henrique Furtado torres Letícia Damas Leão Dalcin Katleyn Polizeli Galvão Silva luana Gabriela Silva de Freitas Mahmi Fujimori Danny Laura Gomes Fagundes Eduardo Luzia França Adenilda Cristina Honorio França Universidade Federal de Mato Grosso. Barra do Garç as Brazil

The study aimed to develop and characterize a microemulsified system based on cotton oil and verify its effect on superoxide release anion and microbicidal activity by human peripheral blood cells. Microemulsions were formulated using distilled water, degummed cotton oil, Span 80 (SP), Tween 80 (TW), and 1-butanol (BT). The pseudo-ternary diagram delimited ME regions, and the points were pre-selected. The physical-chemical and rheological characterization of the microemulsions was carried out. The ME activity on the interactions between leukocytes and bacteria was analyzed by superoxide release, phagocytosis, and microbicidal activity. The developed formulation was classified as Oil/Water, with an average pH of 5.76, and the viscosity showed resistance to temperature changes. The rheological model of the Power Law classified the microemulsion as a non-Newtonian fluid with pseudoplastic characteristics. The cell viability of cotton oil microemulsion was greater than 90%. There was an increase in the superoxide release by MN phagocytes when treated with cotton oil microemulsion. The cotton oil microemulsion increased phagocytosis and microbicidal activity. The present study suggests that cotton oil is an alternative biomaterial for therapeutic applications, especially in treating infections.

关键词： Cotton Oil Microemulsion Phagocytosis Infection Human Phagocytes

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Electrochemical Evaluation of Aminoguanidine Hydrazone Derivative with Potential Anticancer Activity:Studies of Glassy Carbon/CNT and Gold Electrodes Both Modified with PAMAM

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Journal of Biomaterials and Nanobiotechnology 2020年第1期11卷 33-48页

作者： Marilya Palmeira Galdino da Silva Ygor Mendes de Oliveira Anna Caroline Lima Candido Joao Xavier de Araujo-Junior Erica Erlanny da Silva Rodrigues Kadja luana Chagas monteiro Thiago Mendonca de Aquino Fabiane Caxico de Abreu Institute of Chemistry and Biotechnology Federal University of AlagoasMaceioALBrazil Institute of Pharmaceutical Sciences Federal University of AlagoasMaceioALBrazil

Aminoguanidine hydrazones (AGHs) are a class of compounds that have interesting pharmacological activities. They are derived from the same chemical group as aminoguanidine, so it has mixed properties (receptor and donor) in the formation of hydrogen bonds. Its anticancer agent properties were recently highlighted, but the molecules of this class have solubility in aqueous solutions that can be considered low. The identification of this class, by a simple, sensitive and low-cost technique, such as electrochemistry, which also allows the evaluation of its solubilization process through agents such as PAMAM dendrimer is the main objective of the work described here. The electrochemical response of the LQM10 (AGH derivative) was evaluated, as well as its behavior in different electrochemical sensors. Electrochemical experiments were performed in buffered (phosphate at pH 7.02 and acetate at 4.5). LQM10 has a reversible oxidation peak with a potential of +0.22 V. It was efficiently detected in different electrodes tested (glass carbon/CNT, glass carbon/CNT/PAMAM), which proves the viability of the electrodes for various analyses and has the determination of the apparent constant association, indicating its interaction with the analysis that is higher in the presence of the PAMAM encapsulating agent. This was corroborated by the results for the modified gold electrode with MUA and PAMAM. The sum of the results shows the possibility of electrochemically evaluating the Aminoguanidine hydrazone derivative, the viability of electrodes employed and the greater solubilization of LQM10 in the presence of the PAMAM dendrimer.

关键词： Drug Delivery Aminoguanidine Hydrazone Modified Electrode PAMAM

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MLEA： A Solution for Users of Android in UTPVirtual

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Computer Technology and Application 2011年第5期2卷 406-412页

作者： Gisela torres de Clunie Sergio Crespo Coelho da Silva Pinto Aris Linet Castillo Lucas monteiro Braz Tasia Serrao Norman Rangel Jeanette Riley Olinda de Barraza Kexy Rodriguez Computer Systems Engineering Department Technological University of Panama Panama 0819 Panama Computer Science Research and Graduate Program in Applied Computing University of the Sinos Valley （UNISINOS） RS 93022-000 Brazil CIDITIC Technological University of Panama Panama 0819 Panama

This paper describes a design of an educational platform for a mobile learning architecture, which is a state of the an topic in distance education. The product will allow users to interact in an efficient, flexible, and transparent fashion with a web-based education environment, in this case Module Object-Oriented Dynamic Learning Environment （Moodle）, using Android mobile devices. In order to provide a strong and lasting architecture, the Service Oriented Architecture （SOA） methodology is used given that it allows easy software re-utilization as well as integration of heterogeneous services. The architecture is based on web services implemented with Representational State Transfer （REST）, as it has been demonstrated to be lighter and less consuming than other protocols, for devices with limited resources such as mobile devices. Web services provide the communication means between the server side and the client side of the architecture, whereas agents are used to deliver the services itself. The authors propose the development of an environment that facilitates the integration of various educational resources to support m-learning. An important aspect of the proposal is the offering of a tool to provide customized alerts for students and teachers, enabling them to remain updated about activities taking place in the courses.

关键词： Distance learning virtual education m-learning service oriented architecture (SOA) mobile learning mobile computing interoperability representational state transfer (REST).

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Antimicrobial and Antioxidant Activity of Anacardium occidentale L. Flowers in Comparison to Bark and Leaves Extracts

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Journal of Biosciences and Medicines 2016年第4期4卷 87-99页

作者： Rubenice Amaral da Silva Silvana Amado Liberio Flavia M. M. do Amaral Flavia Raquel Fernandes do Nascimento Luce Maria Brandão torres Valério monteiro Neto Rosane Nassar Meireles Guerra Laboratory of Immunophysiology Universidade Federal do Maranhao Campus do Bacanga Sao Luis Brazil Instituto Botanico de Sao Paulo Sao Paulo Brazil Departament of Pathology Universidade Federal do Maranhao Sao Luis Brazil Universidade Ceuma Sao Luís Brazil

Anacardium occidentale L., Anacardiaceae, is frequently used to treat infections. We evaluated the antimicrobial and antioxidant activity of extracts obtained from aerial parts of the plant in comparison with the extract prepared with the flowers. Ethanol extracts of the leaves (EEL), stem bark (EEB), and flowers (EEF) were prepared separately. The antimicrobial activity was evaluated by agar diffusion and broth dilution methods. The minimum bactericidal and fungicidal concentrations were determined against: Streptococcus mutans, Lactobacillus acidophilus, Staphylococcus aureus, MRSA, Enterococcus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Helicobacter pylori, Salmonella choleraesuis, Candida albicans, and Candida tropicalis. The antioxidant activity of the extracts was evaluated based on their scavenger capacity of 2,2-diphenyl-1-picrylhydrazyle. The phytochemical profile was analyzed by colorimetric methods and by HPLC with UV detection. All extracts exhibited antioxidant and antimicrobial activity. Although, the EEF was the most effective since it inhibited the growth of all 14 microorganisms tested. Anacardic and galic acids were identified in all extracts as well phenolic compounds, triterpenes, flavones and xanthones. In conclusion, the extracts obtained from the aerial parts of A. occidentale, mainly the extract of flowers that was the most effective, are rich in bioactive metabolites that exert a potent antioxidant and antimicrobial effect. Taken together, the results indicate an important biotechnological potential of A. occidentale as a source of compounds with broad-spectrum antimicrobial and of antioxidant activity to be used in the food and cosmetics industry.

关键词： Anacardium occidentale Antimicrobial Agents Flowers Cashew Caju Antioxidant

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Modified Caffeine Release System and Its Immunomodulatory Effects on Breast Tumor Cells and Blood Phagocytes

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Advances in Biological Chemistry 2023年第1期13卷 25-41页

作者： Tatiane Araújo Soares André Henrique Furtado torres Letícia Damas Leão Dalcin Luis Carlos Oliveira Gonçalves Anibal monteiro de Magalhães Neto Adenilda Cristina Honorio-França Elton Brito Ribeiro Eduardo Luzía França Postgraduate Program in Imunology and Parasitology Federal University of Mato Grosso Barra do Gar&#231as Brazil Department of Biotechnology Biotechnology in Regenerative Medicine and Medicinal Chemistry University of Araraquara (UNIARA) Araraquara Brazil Department of Biotechnology S&#227o Paulo State University (Unesp) Institute of Chemistry Araraquara Brazil Postgraduate Program in Materials Science Federal University of Mato Grosso Barra do Gar&#231as Brazil

Caffeine is an alkaloid present in a wide variety of plants. Currently the most consumed psychostimulant worldwide, its consumption is associated with several health benefits, including modulation of the innate and adaptive immune response, reduction of oxidative cellular stress, and decreased incidence of some cancers, including breast cancer. Breast cancer is the most common cause of cancer among women and the second leading cause of cancer death in women worldwide. The interaction between biomaterials and drugs has enabled a great advance in science for developing controlled drug delivery systems and has been used to treat numerous pathologies. This work aimed to evaluate the immunomodulatory effects of caffeine associated or not with polyethylene glycol adsorbed in microemulsion (MLP) on MCF-7 cells, phagocytic cells (MN), and coculture. For biological assays, ATCC (American Type Culture Collection, USA) cell lines of breast adenocarcinoma (MCF-7) and phagocytes (MN) obtained from voluntary donors were used. The cells (MN and MCF-7) and coculture were treated with caffeine and MLP and incubated for rheological characterization analyses: flow curve and viscosity, oxidative stress: superoxide anion assay (), and activity of the enzyme superoxide dismutase (Cu-Zn-SOD). Caffeine and MLP increased viscosity and blood and MCF-7 cells and affected the immunomodulation of oxidative stress metabolism of MN and MCF-7 cells treated with caffeine and associated caffeine to the MLP. These data suggest that caffeine is associated or not with MLP-induced immunomodulatory effects on MN phagocytes and MCF-7 cells, demonstrating the antitumor activity via oxidative stress and can be a complementary alternative for treating breast cancer.

关键词： Breast Cancer Microemulsion Polyethyleneglycol Caffeine Oxidative Stress

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