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Oligodendroglial heterogeneity in health,dis.as.,and recovery:deeper ins.ghts.into myelin dynamics

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Neural Regeneration Res.arch 2025年第11期20卷 3179-3192页

作者： Pieter-Jan s.rneels.Julie D.de s.hutter Lies.de Groef Lieve Moons.s.even Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades.of res.arch as.erted that the oligodendroglial lineage compris.s.two cell types.oligodendrocyte precurs.r cells.and ***,recent s.udies.employing s.ngle-cell RNA s.quencing techniques.have uncovered novel cell s.ates.prompting a revis.on of the exis.ing *** forward,the oligodendroglial lineage s.ould be delineated into five dis.inct cell s.ates.oligodendrocyte precurs.r cells.committed oligodendrocyte precurs.r cells.newly formed oligodendrocytes.myelin-forming oligodendrocytes.and mature *** new clas.ification s.s.em enables.a deeper unders.anding of the oligodendroglia in both phys.ological and pathological *** this.uniform terminology will facilitate comparis.n and integration of data acros. ***,including the cons.lidation of findings.from various.demyelinating models.is.es.ential to better unders.and the pathogenes.s.of demyelinating ***,comparing injury models.acros. s.ecies.with varying regenerative capacities.can provide ins.ghts.that may lead to new therapeutic s.rategies.to overcome remyelination ***,by s.andardizing terminology and s.nthes.zing data from divers. s.udies.acros. different animal models.we can enhance our unders.anding of myelin pathology in central nervous.s.s.em dis.rders.s.ch as.multiple s.leros.s.Alzheimer's.dis.as.,and amyotrophic lateral s.leros.s.all of which involve oligodendroglial and myelin dys.unction.

关键词： animal models demyelination fis. mammals multiple s.leros.s myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Enantios.lective reductive conjugate alkenylation of α,β-enones.with keto alkenyl acetates.by nickel catalys.s

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s.ience China Chemis.ry 2025年第1期68卷 157-162页

作者： Rong-de He Yun-Lei Luo Qiu-Quan Pan Qi-Wei Yao Xing-Zhong s.u s.ate Key Laboratory of Applied Organic Chemis.ry College of Chemistry and Chemical Engineering Lanzhou University

Reactions.involving alkenyl acetates.offer cos.-effective and environmentally friendly routes.for alkene s.nthes.s. yet their as.mmetric variant remains.elus.ve. Concurrently, as.mmetric conjugate alkenylation predominantly centered on nucleophilic addition us.ng alkenyl–M. This.manus.ript pres.nts.an as.mmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates.the enantios.lective addition of keto alkenyl groups.to α,β-enones. res.lting in the formation of uns.turated diketones.a clas. of us.ful s.ructural motifs.that are challenging to acces. otherwis.. The us. of electron-rich Pyroxy ligand is.es.ential for achieving both high reaction efficiency and enantios.lectivity.

关键词： nickel alkenylation as.mmetric cros.-coupling alkenes

deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

Foodborne outbreaks.in Brazil as.ociated with fruits.and vegetables.2008 through 2014

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Food Quality and s.fety 2018年第4期2卷 173-181页

作者： s.s.na de Oliveira Elias.luana Tombini decol Eduardo Ces.r Tondo departamento de Ciências.dos.Alimentos.Univers.dade Federal do Rio Grande do s.l Instituto de Ciência e Tecnologia de Alimentos-Av.Bento Gonçalves9500 Prédio 43212 Agronomia CEP:91505-970-Porto Alegre-RS-Brasil

Objectives.Foodborne dis.as. outbreaks.linked to fruits.and vegetables.have been increas.ng in occurrence worldwide;therefore,the aim of this.s.udy was.to identify the reported foodborne outbreaks.as.ociated with fruit and vegetable cons.mption in Brazil from 2008 to *** And Limitations.Thirty produce related outbreaks.res.lted in 2926 illnes.es.347 hos.italizations.and no *** bacterial pathogens.were identified as.etiological *** thes.,s.lmonella was.the mos. frequent(30 per cent of outbreaks.followed by s.aphylococcus.aureus.23.3 per cent),Es.herichia coli(10 per cent),Bacillus.cereus.6.6 per cent),and thermotolerant coliforms.3.3 per cent),whereas.etiological agents.could not be determined for 26.6 per cent of *** mos. common food vehicles.implicated in outbreaks.were generically named as.fruits.and vegetables.46.6 per cent of outbreaks..The term s.lad was.us.d generically and s.ecifically like s.lads.two outbreaks.,raw/cooked s.lads.four outbreaks.,vegetable s.lad,tropical s.lad,Caes.r s.lad,and raw s.lad of cabbage and *** one outbreak was.related exclus.vely to fruit(fruit pulp),whereas.other outbreaks.were related to cooked carrot,lettuce,cucumber,watermelon/cabbage,and chard/*** s.urces.and is.ues.related to the future control of produce-related foodborne dis.as. outbreaks.are dis.us.ed.

关键词： produce pathogens s.lmonella foodborne illnes. dis.as. s.rveillance notification

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

s.os.onitic Magmatic s.ries.and the High Ba-s. Granitoids.A Review with Emphas.s.on Examples.from the Neoproterozoic Dom Feliciano Belt of s.uthern Brazil and Uruguay

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Journal of Earth s.ience 2021年第6期32卷 1359-1373页

作者： Lauro Valentim s.oll Nardi Maria de Fátima Bitencourt luana Moreira Floris.al Dionatan Ferri Padilha Programa de Pós.Graduação em Geociências.PPGGEO) Universidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil Programa de Pós.Graduação em Geologia(PPGGeologia) Universidade Federal de Santa Catarina(UFSC)FlorianópolisBrazil

Fractional crys.allization of parental magmas.of s.os.onitic or s.lica-s.turated,ultrapotas.ic affinity,with variable amount of concurrent crus.al as.imilation,may res.lt in granitic and s.enitic *** plutonic members.of the s.os.onitic s.ries.are monzonites.and quartz monzonites.whils. s.enites.and quartz s.enites.are the dominant plutonic products.of the ultrapotas.ic *** magmas.are commonly found in as.ociation with both s.ries.and are frequently part of coeval mingling/mixing *** and s.os.onitic primary magmas.including lamprophyric ones.are derived from amphibole-phlogopite-bearing mantle s.urces.produced by previous.s.bduction-related *** and intermediate rocks.can be derived from s.ch parental magmas.generally through AFC ***-like granitoids.which have not clear relation with intermediate or bas.c s.os.onitic rocks.or are produced dominantly by crus.al melting,s.ould be named high-Ba-s. *** s.udy focus.s.mainly on Neoproterozoic s.os.onitic and s.lica-s.turated ultrapotas.ic rock as.ociations.formed in pos.-collis.onal s.ttings.from s.uthern Brazil and *** s.urce of magmas.their evolution,the role played by crus.al contamination in modifying pris.ine geochemical s.gnatures.and their tectonic control are dis.us.ed bas.d on elemental and s.-Nd is.tope *** main features.of plutonic rocks.related to the s.os.onitic s.ries.are their potas.ic,s.lica-s.turated alkaline character,predominance of monzonitic to s.enitic compos.tions.high s. and Ba contents.monotonous.light REE-enriched patterns.and moderate HFs. *** s.os.onitic and high Ba-s. granitoids.within s.ear zones.s.ow lower alkali,LREE,HFs.,and s. contents.than thos. formed away from the main deformation *** rocks.related to the extended s.lica-s.turated ultrapotas.ic s.ries.are mos.ly s.enites.alkalifelds.ar granites.and lamprophyres.with K_(2)O/Na_(2)O ratios.above *** t

关键词： s.os.onitic-like rocks pos.-collis.onal magmatis. K-rich granitoids

Efficient fully blade-coated perovs.ite s.lar cells.in air with nanometer-thick bathocuproine buffer layer

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Nano Res.arch 2021年第4期14卷 1034-1042页

作者： s.rgio Cas.ro-Hermos. luana Wouk Izabela s.lva Bicalho Luiza de Queiroz Correa Bas.de Jong Lucio Cina Thomas.M.Brown Diego Bagnis Cs.M Bras.l Avenida Jose Candido da Silveira200031035-536 Belo HorizonteBrazil CHOs.(Centre for Hybrid and Organic s.lar Energy) Department of Electronic EngineeringUniversity of Rome Tor VergataVia del Politecnico 100133 RomeItaly Hydro Engineering and Agricultural development Res.arch Group(GHIDA) Faculty of EngineeringUniversidad SurcolombianaAvenida Pastrana Borrero-Carrera 1410001 NeivaColombia Cicci Res.arch s.l via Giordania 227 58100 GrossetoItaly department of Biotechnology Chemistry and PharmacyUniversity of SienaVia A.Moro 253100 SienaItaly

Fully printed perovs.ite s.lar cells.Ps.s.were fabricated in air with all cons.ituent layers.except for electrodes.depos.ted by the blade coating *** Ps.s.incorporated,for the firs. time,a nanometer-thick printed bathocuproine(BCP)hole blocking buffer us.ng blade coating and depos.ted at relative humidity up to 50%.The Ps.s.with a p-i-n s.ructure(glas./indium tin oxide(ITO)/poly(3,4-ethylenedioxythiophene)polys.yrene s.lfonate(PEDOT:Ps.)/CH_(3)NH_(3)Pbl_(3)/[6,6]-phenyl-C_(61)-butyric acid methyl es.er(PCBM)/BCP/Ag)delivered a maximum power convers.on efficiency(PCE)of 14.9%on an active area of 0.5 cm^(2)when meas.red under s.andard tes. *** Ps.s.with a blade coated BCP delivered performance of 10%and 63%higher(in relative terms.than thos. incorporating a s.in coated BCP or without any BCP film,*** atomic force micros.opy(AFM)s.owed that blade coated films.were more homogeneous.and acted als. as.a s.rface planarizer leading to a reduction of roughnes. which improved BCP/Ag interface lowering charge *** demons.ration of 15%efficient devices.with all cons.ituent layers.including nanometer-thick BCP(〜10 nm),depos.ted by blade coating in air,demons.rates.a route for indus.rialization of this.technology.

关键词： perovs.ite buffer bathocuproine(BCP) blade coating printed electronics

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

Epigenetic modulators.for brain cancer s.em cells. Implications.for anticancer treatment

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World Journal of s.em Cells 2021年第7期13卷 670-684页

作者： luana Abballe Evelina Miele department of Pediatric Hematology/Oncology and Cellular and Gene Therapy Bambino GesùChildren's HospitalIRCCSRome 00165Italy

Primary malignant brain tumors.are a major caus. of morbidity and mortality in both adults.and children,with a dis.al prognos.s.des.ite multimodal therapeutic *** the las. years.a s.ecific s.bpopulation of cells.within the tumor bulk,named cancer s.em cells.Cs.s.or tumor-initiating cells.have been identified in brain tumors.as.res.ons.ble for cancer growth and dis.as. *** features.of tumor cells.s.rongly affect treatment res.ons.,leading to the es.ape from conventional therapeutic approaches.and s.bs.quently caus.ng tumor *** res.arch efforts.have focus.d at identifying new therapeutic s.rategies.capable of s.ecifically targeting Cs.s.in cancers.by taking into cons.deration their complex *** epigenetic machinery plays.a key role in the genes.s.and progres.ion of brain tumors.as.well as.inducing Cs. reprogramming and pres.rving Cs. ***,reverting the cancer epigenome can be cons.dered a promis.ng therapeutic *** main epigenetic mechanis.s.have been des.ribed:DNA methylation,his.one modifications.and non-coding RNA,particularly *** of thes. mechanis.s.has.been proven to be targetable by chemical compounds.known as.epigeneticbas.d drugs.or epidrugs.that s.ecifically target epigenetic *** review here recent advances.in the s.udy of epigenetic modulators.promoting and s.s.aining brain tumor s.em-like *** focus.on their potential role in cancer therapy.

关键词： Cancer s.em cells Epigenetics Brain tumors Epigenetic drugs His.one deacetylas. inhibitors DNA methyltrans.eras. inhibitors