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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： nguyen Hoa Binh quang vo luan nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha nguyen Lan Huu Shedrawy Jad L?nnroth Knut nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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Evaluating the yield of systematic screening for tuberculosis among three priority groups in Ho Chi Minh City,Viet Nam

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Infectious Diseases of Poverty 2020年第6期9卷 16-28页

作者： luan nguyen quang vo Andrew James Codlin Rachel Jeanette Forse NgaThuy nguyen Thanh nguyen Vu Giang Truong Le Vinh Van Truong Giang Chau Do Ha Minh Dang Lan Huu nguyen Hoa Binh nguyen Nhung Viet nguyen Jens Levy Knut Lonnroth SBertel Squire Maxine Caws Friends for International TB Relief 68B Nguyen Van Troi8Phu NhuanHo Chi Minh CityViet Nam Interactive Research and Development Ho Chi Minh CityViet Nam Ho Chi Minh City Public Health Association Ho Chi Minh CityViet Nam Pham Ngoc Thach Hospital Ho Chi Minh CityViet Nam National Lung Hospital Ha NoiViet Nam KNCV Tuberculosefonds The HagueThe Netherlands Department of Global Public Health Karolinska InstitutetStockholmSweden Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpoolUK Birat Nepal Medical Trust LazimpatKathmanduNepal

Background: In order to end tuberculosis(TB),it is necessary to expand coverage of TB care services,including systematic screening ***,more evidence is needed for groups among whom systematic screening is only conditionally recommended by the World Health *** study evaluated concurrent screening in multiple target groups using community health workers(CHW).Methods:: In our two-year intervention study lasting from October 2017 to September 2019,CHWs in six districts of Ho Chi Minh City,Viet Nam verbally screened three urban priority groups:(1)household TB contacts;(2)close TB contacts;and(3)residents of urban priority areas without clear documented exposure to TB including hotspots,boarding homes and urban *** persons were referred for further screening with chest radiography and follow-on testing with the Xpert MTB/RIF *** individuals with normal or without radiography results were tested on smear *** described the TB care cascade and characteristics for each priority group,and calculated yield and number needed to ***,we fitted a mixed-effect logistic regression to identify the association of these target groups and secondary patient covariates with TB treatment ***: We verbally screened 321020 people including 24232 household contacts,3182 social and close contacts and 293606 residents of urban priority *** resulted in 1138 persons treated for TB,of whom 85 were household contacts,39 were close contacts and 1014 belonged to urban priority area *** yield of active TB in these groups was 351,1226 and 345 per 100000,respectively,corresponding to numbers needed to screen of 285,82 and *** fitted model showed that close contacts[adjusted odds ratio(aOR)=2.07;95%CI:1.38–3.11;P<0.001]and urban priority area residents(aOR=2.18;95%CI:1.69–2.79;P<0.001)had a greater risk of active TB than household ***: The study detected a large number of un

关键词： Case detection Tuberculosis Active case finding Urban Viet nam

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Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-Truc Chu-Dao Kim-Tuyen Huynh-Dam Dang-Thuc Ngo-Luong quang-luan Le Thanh-Thao vo-nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

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Long-Term Improvement in Precautions for Flood Risk Mitigation:A Case Study in the Low-Lying Area of Central Vietnam

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International Journal of Disaster Risk Science 2021年第2期12卷 250-266页

作者： Cong Dinh nguyen Funiikazu Ubukata quang Tan nguyen Hoang Ha vo Graduate School of Environmental and Life Science Okayama UniversityOkayama 700-8530Japan Faculty of Economics and Development Studies University of EconomicsHue UniversityHue City 49000Vietnam International School Hue UniversityHue City 49000Vietnam

Local actors appear as inseparable components of the integrated flood risk mitigation strategy in *** this fact,this study examined the long-term improvement in precautions taken by commune authorities and households between two major floods in 1999 and 2017 by applying both quantitative and qualitative *** flood-prone villages were selected for a survey;one in a rural area and the other in a suburban area of Thua Thien Hue Province,central *** findings indicate that most villagers doubted the structural works’efficacy and were dissatisfied with the current efforts of local ***’self-preparation thus became the decisive factor in mitigating *** most households have paid greater attention to flood precautions in 2017,others seem to be ***-related barriers were the root causes restraining households in both rural and suburban *** suburban riverine residents were further identified as vulnerable by their limitations in upgrading structural measures,which was ascribed to the inconsistency in the ancient town’s preservation *** multidimensional comparison,in terms of vulnerability,emphasized the importance of space-function links in the suburb and the contradictions of different policy initiatives,such as landscape rehabilitation,disaster prevention,and livelihood maintenance.

关键词： Central Vietnam Flood risk mitigation Long-term improvement Natural hazards Precautionary measures

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Integrating Machine Learning and Evidential Reasoning for User Profiling and Recommendation

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Journal of Systems Science and Systems Engineering 2023年第4期32卷 393-412页

作者： Toan nguyen Mau quang-Hung Le Duc-Vinh vo Duy Doan Van-Nam Huynh University of Information Technology Ho Chi Minh CityVietnam Vietnam National University Ho Chi Minh CityVietnam Department of Information Technology Quy Nhon UniversityQuy NhonVietnam Ho Chi Minh City University of Banking Ho Chi Minh CityVietnam School of Knowledge Science Japan Advanced Institute of Science and TechnologyIshikawaJapan

User profiles representing users’preferences and interests play an important role in many applications of personalized *** the rapid growth of social platforms,there is a critical need for efficient solutions to learn user profiles from the information they shared on social platforms so as to improve the quality of recommendation *** problem of user profile learning is significantly challenging due to difficulty in handling data from multiple sources,in different formats and often associated with *** this paper,we introduce an integrated approach that combines advanced Machine Learning techniques with evidential reasoning based on Dempster-Shafer theory of evidence for user profiling and *** developed methods for user profile learning and multi-criteria collaborative filtering are demonstrated with experimental results and analysis that show the effectiveness and practicality of the integrated approach.A proposal for extending multi-criteria recommendation systems by incorporating user profiles learned from different sources of data into the recommendation process so as to provide better recommendation capabilities is also highlighted.

关键词： Machine learning Dempster-Shafer theory of evidence user profiles personalized recommendation preferences

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软木塞基碳量子点的水热合成及其生物相融荧光成像应用

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新型炭材料 2022年第3期37卷 595-602页

作者： quang Ngo Khoa Hieu nguyen Ngoc Bao vo Van Quoc Phuoc vo Thi Ngoc Le Xuan Diem Doc Luong quang Tri nguyen Minh Son Le Vu Truong Son Le Van Thanh Ha Che Thi Cam University of Sciences Hue University77 Nguyen HueHueVietnam Faculty of Environmental and Natural Sciences Duy Tan UniversityDa Nang550000Vietnam Institute for Research and Training in Medicine Biology and PharmacyDuy Tan UniversityDa Nang550000Vietnam University of Agriculture and Forestry Hue University102 Phung HungHueVietnam University of Science and Education The University of Da Nang459 Ton Duc ThangLien ChieuDa NangVietnam

以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。... 详细信息

以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。用硫酸奎宁作为参考,碳量子点的量子效率为1.54%。将获得的碳量子点应用在骨髓间充质干细胞的细胞生物成像上,发现用碳量子点处理后,骨髓间充质干细胞分别在320~380 nm、450~490 nm和450~490 nm范围显示绿色、黄色和红色荧光,表明了碳量子点在荧光成像领域具有潜在的应用价值。

关键词：碳点水热合成荧光荧光图像废酒瓶塞

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Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests

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Journal of Forestry Research 2020年第5期31卷 1713-1722页

作者： Tran Van Do Mamoru Yamamoto Osamu Kozan vo Dai Hai Phung Dinh Trung nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai Hung Hoang Van Thang Tran Duc Manh Cao Chi Khiem Vu Tien Lam nguyen quang Hung Tran Hoang Quy Pham quang Tuyen Trinh Ngoc Bon nguyen Thi Thu Phuong Ninh Viet Khuong nguyen Van Tuan Dang Thi Hai Ha Tran Hai Long Dang Van Thuyet Dang Thinh Trieu nguyen Van Thinh Tran Anh Hai Duong quang Trung nguyen Van Bich Dinh Hai Dang Pham Tien Dung nguyen Huy Hoang Le Thi Hanh Phan Minh quang nguyen Thi Thuy Huong Hoang Thanh Son nguyen Thanh Son nguyen Thi Van Anh nguyen Thi Hoai Anh Pham Dinh Sam Hoang Thi Nhung Hoang Van Thanh nguyen Huu Thinh Tran Hong Van Ho Trung Luong Bui Kieu Hung Research Institute for Sustainable Humanosphere Kyoto UniversityUjiKyotoJapan Silviculture Research Institute Vietnamese Academy of Forest SciencesNorth Tu LiemHanoiVietnam Center for Southeast Asian Studies Kyoto UniversityKyotoJapan Vietnamese Academy of Forest Sciences North Tu LiemHanoiVietnam Vietnam Administration of Forestry No.2 Ngoc HaBa DinhHanoiVietnam

Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest *** study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was *** results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of *** area and AGB are positively correlated with trees>30 cm *** areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-*** percent of the areas surveyed had stand densities of 300–600 ***^-1,and 64%had basal areas of 20–40 m^2 ha^-*** is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in *** causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density.

关键词： Aboveground biomass Carbon storage Climatic variables Ecoregion Edaphic variables Oldgrowth forest

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Optical and NH<sub>3</sub>Gas Sensing Properties of Hole-Transport Layers Based on PEDOT: PSS Incorporated with Nano-TiO<sub>2</sub>

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Materials Sciences and Applications 2017年第9期8卷 663-672页

作者： Lam Minh Long Tran quang Trung vo-Van Truong nguyen Nang Dinh University of Engineering and Technology VNU in Hanoi Hanoi Vietnam University of Natural Science VNU in HoChiMinh City Ho Chi Minh City Vietnam Department of Physics Concordia University Montreal Canada

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) incorporated with nanocrystalline TiO2 powder (PEDOT:PSS+nc-TiO2) films were prepared by spin-coating technique. SEM surface morphology, UV-Vis spectra and NH3 gas sensing of were studied. Results showed that the PEDOT:PSS+nc-TiO2 film with a content of 9.0 wt% of TiO2 is most suitable for both the hole transport layer and the NH3 sensing. The responding time of the sensor made from this composite film reached a value as fast as 20 s. The rapid responsiveness to NH3 gas was attributed to the efficient movement of holes as the major charge carriers in PEDOT:PSS+nc-TiO2 composite films. Useful applications in organic electronic devices like light emitting diodes and gas thin film sensors can be envisaged.

关键词： PEDOT:PSS+nc-TiO2 Composite UV-Vis Spectra J-V Characteristic Thermal Sensing Property Hole Transport Layer NH3 Gas Sensing

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The Five Years Surveillance and Trends of Antibiotic Resistance in Some Common Gram Negative Bacteria at the Vietnam Military Hospital

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Advances in Microbiology 2020年第12期10卷 730-741页

作者： Ha Thi Thu Van Hoang Xuan quang vo Thi Bich Thuy nguyen Thai Son Military Hospital 103 Vietnam Military Medical University Hanoi Vietnam Institute of Genome Research Vietnam Academy of Science and Technology Hanoi Vietnam

The study is to identify trends and levels of antibiotic resistance of some common Gram-negative strains over time. The samples were collected from Vietnam Military Hospital 103 between 2014 and 2019. A total of 405 Acinetobacter baumannii., 528 Pseudomonas aeruginosa, 741 Escherichia coli, and 352 Klebsiella pneumoniae strains were identified and antimicrobial susceptibility was by Vitek system and Etest method. The multi-drug resistance (MDR) was major proportion of four common bacteria. In particular, there is a tendency to shift from MDR to Extended drug resistance (XDR) or possibly Pan drug resistant (pPDR). A. baumannii had the highest level of antibiotic resistance, namely, carbapenem (61.5% - 82.5%) and cephalosporin (72.7% - 88.7%). P. aeruginosa resisted most of commonly antibiotics, ranging from 50% to 70%. E. coli had a high resistance with antibiotics like ampicillin (87.2% - 97.6%) and the 3rd generation cephalosporins (up to 79.6%). K. pneumoniae resisted carbapenem from 14.7% to 44.4%, and other antibiotics with the higher rate of 40%. The collected data will be a prerequisite for further studies on mechanisms and factors related to antibiotic resistant bacteria, in order to find out a rational and effective using strategy of antibiotics.

关键词： Gram-Negative Bacteria Antibiotic Resistance Multi-Drug Resistance

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Determination of the Pore Water Velocity Using a Salt Tracer Combined with Self-Potential Measurements

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Journal of Geoscience and Environment Protection 2023年第1期11卷 15-27页

作者： Huong Huynh Thi Thu Son Le Van Hieu Tran Trong Hai Lai Viet quang nguyen Huu luan Phan Thi Department of Tracer Techniques Center for Applications of Nuclear Technique in Industry Dalat Vietnam

The tracer technique is recommended as an effective tool in surveying abnormal seepage through lakes and dams. By injecting a tracer into a known upstream location and monitoring the appearance of the tracer in the downstream leak point, it is possible to determine the direction and the average water velocity of the preferential flow through the dam. The detailed result achieved depends on the number of samples and the sampling locations to analyze tracer concentration over time in the field. This study proposes to use noninvasive self-potential measurements to determine the location and time the salt tracer moves through the seepage zone. The connection between the potential signal according to the propagation of the NaCl salt tracer and the water velocity was demonstrated through an experiment on a sandbox model. Experimental results express a good agreement between the time to reach the maximum value of the potential variation and the salt concentration variation with the time that water comes to monitoring locations. The result indicates an ability to determine the pore water velocity of the seepage zone based on the recording of potential signals produced by a salt tracer movement. The salt tracer test using NaCl combined with self-potential measurements was then applied to survey a leaking earth dam in the Dong Nai river basin (Vietnam).

关键词： Earthen Dams Tracer Technique Leakage Interstitial Velocity

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