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石墨烯柔性压阻传感器微织构压缩应变机制

中国表面工程 2024年第1期37卷 169-178页

作者：许静马靖轩王路文连加俤蔡林烜董林玺杭州电子科技大学机械工程学院杭州310018 浙大城市学院信息与电气工程学院杭州310015 中国计量大学机电工程学院杭州310018 杭州电子科技大学电子信息学院杭州310018

为满足智能机器人、电子皮肤等领域对柔性传感器高灵敏度日益增加的需求,通过设计高表面积形貌以制备石墨烯凸台微织构柔性传感器,并对比分析有无微织构传感器的灵敏度;基于结构力学方程与静电方程,建立微织构柔性传感器模型,开展了电... 详细信息

为满足智能机器人、电子皮肤等领域对柔性传感器高灵敏度日益增加的需求,通过设计高表面积形貌以制备石墨烯凸台微织构柔性传感器,并对比分析有无微织构传感器的灵敏度;基于结构力学方程与静电方程,建立微织构柔性传感器模型,开展了电场作用不同基底厚度以及微织构间距下柔性传感器微织构应变的数值模拟,研究柔性压阻传感器微织构压缩应变机制,探寻机械载荷和电载荷的交互作用关系。结果表明,柔性基底的微织构化处理能有效提高柔性压阻传感器的灵敏度。模型总位移的最大值随基底厚度的增加呈非线性增加,微织构应变随着厚度的增加而减小。电场作用下微织构应变受机电耦合压力叠加的影响均大于无电场作用。框状微织构类似于悬臂梁,作用在微织构上的力矩随间距增加而增大,同时刚度减小,微织构的压缩形变增加,应变增大。组合尺寸微织构的应变随着微织构间距的增加而增大,制备多尺寸微结构传感器可使用(150+350)μm的组合尺寸,能够有效增加接触面积提高传感器灵敏度。机械载荷和电载荷的耦合作用,组合尺寸对力矩与刚度的分配有效增加了基底的应变,提高了柔性传感器的灵敏度。

关键词：柔性传感器数值模拟电场超弹性材料接触模型

The Synergism between Methanogens and Methanotrophs and the Nature of their Contributions to the Seasonal Variation of Methane Fluxes in a Wetland:The Case of Dajiuhu Subalpine Peatland

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Advances in Atmospheric Sciences 2022年第8期39卷 1375-1385,I0017-I0023页

作者： luwen wang Jiwen GE Liang FENG Yaoyao LIU Yu LI Jiumei wang Xiang XIAO Zhiqi ZHANG Laboratory of Basin Hydrology and Wetland Eco-Restoration China University of GeosciencesWuhan 430074China Hubei Key Laboratory of Wetland Evolution and Ecological Restoration China University of GeosciencesWuhan 430074China Institution of Ecology and Environmental Sciences China University of GeosciencesWuhan 430074China Shennongjia National Park Administration Bureau Shennongjia Forestry District 442417China

Wetland ecosystems are the most important natural methane(CH_(4))sources,whose fluxes periodically ***(methane producers)and methanotrophs(methane consumers)are considered key factors affecting CH_(4)fluxes in ***,the symbiotic relationship between methanogens and methanotrophs remains *** help close this research gap,we collected and analyzed samples from four soil depths in the Dajiuhu subalpine peatland in January,April,July,and October 2019 and acquired seasonal methane flux data from an eddy covariance(EC)system,and investigated relationships.A phylogenetic molecular ecological networks(pMENs)analysis was used to identify keystone species and the seasonal variations of the co-occurrence patterns of methanogenic and methanotrophic *** results indicate that the seasonal variations of the interactions between methanogenic and methanotrophic communities contributed to CH_(4)emissions in *** keystone species discerned by the network analysis also showed their importance in mediating CH_(4)***(CH_(4))emissions in wetlands were lowest in spring;during this period,the most complex interactions between microbes were observed,with intense competition among methanogens while methanotrophs demonstrated better *** patterns manifested themselves in summer when the highest CH_(4)flux was *** formicica was negatively correlated with CH_(4)fluxes and occupied the largest ecological niches in the spring *** contrast,both Methanocella arvoryzae and Methylocystaceae demonstrated positive correlations with CH_(4)fluxes and were better adapted to the microbial community in the *** addition,soil temperature and nitrogen were regarded as significant environmental factors to CH_(4)*** study was successful in explaining the seasonal patterns and microbial driving mechanisms of CH_(4)emissions in wetlands.

关键词： CH_(4)fluxes wetland methanogens methanotrophs molecular ecological network

Silicon-based micro direct methanol fuel cell with an N-inputs-N-outputs anode flow pattern

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Chinese Science Bulletin 2011年第8期56卷 826-829页

作者： ZHANG YuFeng wang luwen YUAN ZhenYu wang ShiBo LI JianMin LIU XiaoWei MEMS Center Harbin Institute of Technology Harbin 150001 China Key Laboratory of Micro-Systems and Micro-Structures Manufacturing Ministry of Education Harbin 150001 China

A micro direct methanol fuel cell(μDMFC) is suitable for use in notebook computers,mobile phones,and other digital *** resolve the poor mass-transport efficiency problem in the anode flow channel,this paper presents an N-inputs-N-outputs parallel flow pattern with rectangular convexes to reinforce methanol mass transport and reduce concentration *** simulation results show that the N-inputs-N-outputs parallel flow channels with the rectangle convexes improve the performance.μDMFCs,which have four anode flow patterns,are fabricated using MEMS(microelectromechanical systems) *** experimental results show that the μDMFC with the rectangle convexes has a performance better than previously reported systems,and has a peak power density of 19.96 mW/*** simulation and experimental results are in good agreement.

关键词：直接甲醇燃料电池输入阳极输出微型硅基仿真结果笔记本电脑

Effects of cell cycle on telomerase activity and on hepatitis B virus replication in HepG₂2.2.15 cells

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 543-547页

作者： YanQing Huang luwen wang ShaoNan Yan ZuoJiong Gong Department of Infectious Diseases Renmin Hospital Wuhan University Wuhan 430060 China.

BACKGROUND:It has been shown that telomerase activity and hepatitis B virus (HBV) replication are closely associated with cell cycle. This study aimed to further investigate the effects of cell cycle on telomerase activity and on HBV replication.;METHODS:Human hepatoma cells transfected with HBV DNA (HepG2 2.2.15 cell line) were treated respectively with serum deprivation, all-trans retinoic acid (RA), dimethyl sulfoxide (DMSO), or sodium butyrate. The cell cycle of HepG2 2.2.15 cells was analyzed by flow cytometry. The telomerase activities of the cells were detected by TRAP-PCR-ELISA. HBV DNA in culture medium was assayed by a fluorescent quantitative PCR assay and a semiquantitative dot blot hybridization technique. HBsAg and HBeAg in culture media were quantitatively examined by an ELISA assay.;RESULTS:Treatments with serum deprivation, RA, DMSO, or sodium butyrate inhibited the proliferation of HepG2 2.2.15 cells and led to cell arrest in the G0/G1 phase of cell cycle. The percentage of the G0/G1 phase in the groups of sodium butyrate, DMSO, RA and serum-free was 85.2%, 71.9%, 68.3% and 65.2%, respectively, but in the control group, 43.1% (P<0.01). The activities of telomerase of the cells were also significantly inhibited by 82.8%, 74.6%, 76.1% and 69.4% respectively. In addition, HBV replication of the HepG2 2.2.15 cells remarkably increased as shown by the contents of HBV DNA, HBsAg and HBeAg in the culture media of the cells treated with sodium butyrate, DMSO, RA or serum deprivation (P<0.01). The amounts of HBV DNA in the groups of sodium butyrate, DMSO, RA, serum deprivation and control were 6.7X10(6), 4.8X10(6), 4.4X10(6), 5.1X10(6) and 1.2X10(6) copies/ml, respectively (P<0.01). Telomerase was expressed mainly in the cells in S phase. HBV replication increased in quiescent cells (G0/G1 phase), and decreased in proliferating phase (S phase).;CONCLUSIONS:The current data approve that HBV replication is associated with the cellular proliferative activity.

关键词： cell cycle telomerase hepatitis B virus HepG2 2.2.15 replication

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香砂平胃凝胶贴膏制备工艺及质量标准的研究

西北药学杂志 2024年第5期39卷 54-60页

作者：黄思成何雨周云涛赵琼王路文侯安国云南中医药大学中药学院暨云南省南药可持续利用研究重点实验室昆明650500 云南省高校外用给药系统与制剂技术研究重点实验室昆明650500

目的将香砂平胃丸改制为凝胶贴膏,筛选最佳处方与制备工艺,建立其质量标准。方法采用水醇双提法提取挥发油与浸膏;采用正交实验法,以初黏力、持黏力和综合感官为评价指标筛选最佳处方;用薄层色谱法定性鉴别处方中木香、陈皮、甘草、苍... 详细信息

目的将香砂平胃丸改制为凝胶贴膏,筛选最佳处方与制备工艺,建立其质量标准。方法采用水醇双提法提取挥发油与浸膏;采用正交实验法,以初黏力、持黏力和综合感官为评价指标筛选最佳处方;用薄层色谱法定性鉴别处方中木香、陈皮、甘草、苍术;用高效液相色谱法测定指标性成分厚朴酚、和厚朴酚的含量。结果最佳处方为混合浸膏10.0 g、水16.0 g,甘油18.0 g、聚维酮K90 0.2 g、聚丙烯酸钠2.4 g,羧甲基纤维素钠0.6 g、甘羟铝0.5 g、柠檬酸0.5 g、微粉硅胶1.2 g,综合评分高;木香、陈皮、甘草、苍术薄层斑点清晰,分离度好,阴性样品无干扰;建立的厚朴酚与和厚朴酚含量测定方法专属性好,线性范围分别为9.98~149.70μg·mL^(-1)(r=0.9991)、10.10~150.60μg·mL^(-1)(r=0.9999),平均回收率分别为100.03%、102.52%,RSD值分别为1.74%、1.23%。每片中厚朴酚与和厚朴酚的总平均含量为3.8 mg。结论按照优选的处方及制备工艺,该品成型性和黏附性较好,载药量适宜,质量稳定,满足临床及生产的需要。

关键词：香砂平胃凝胶贴膏薄层色谱法高效液相色谱法制备工艺质量标准

Versatile photonic molecule switch in multimode microresonators

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Light(Science & Applications) 2024年第3期13卷 498-509页

作者： Zihan Tao Bitao Shen Wencan Li luwen Xing Haoyu wang Yichen Wu Yuansheng Tao Yan Zhou Yandong He Chao Peng Haowen Shu Xingjun wang State Key Laboratory of Advanced Optical Communications System and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking University100871 BejingChina Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China

Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic ***,the distinct energy levels and interactions in such two-level systems were provided by coupled *** reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric *** highly specific approaches also limit potential ***,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial *** transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications *** particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the *** *** effect.“Switched-off”state allows for perfect low-loss single-mode transition(Qi~10 million)under an ultra-compact bend size(FSR~115 GHz)in a foundry-based silicon *** breaks the stereotyped image of the FSR-Q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic *** demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication.

关键词： switched multimode millimeter

Comparison of two methods for evaluating lower urinary tract symptoms in cervical cancer patients following radical hysterectomy

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Gynecology and Obstetrics Clinical Medicine 2021年第2期1卷 70-74页

作者： Fang An Sha wang Zhiqi wang Lingying Wu Qiubo Lv Aiming Lv Hongwu Wen Jinsong Han Yumei Wu Yunong Gao Qing Liu Sumei wang Hongxia Li luwen wang Yanlong wang Ruifang Wu Huan Li Xiuli Sun Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing100044China Beijing Key Laboratory of Female Pelvic Floor Disorders BeijingChina Female Pelvic Floor Disease Research Center Peking UniversityBeijingChina The Research Center of Female Pelvic Floor Dysfunction and Disease of Peking University People’s Hospital BeijingChina Cancer Hospital Chinese Academy of Medical Sciences BeijingChina Beijing Hospital BeijingChina Peking University First Hospital BeijingChina Peking University Third Hospital BeijingChina Beijing Obstetrics and Gynecology Hospital Capital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Beijing Cancer Hospital&Beijing Institute for Cancer Research BeijingChina Gansu Provincial Maternity and Child-care Hospital GansuChina Beijing Chao-yang Hospital Capital Medical UniversityBeijingChina Beijing Shi Ji Tan Hospital BeijingChina The Third Affiliated Hospital of Zhengzhou University ZhengzhouChina Xiamen Maternal and Child Health Hospital XiamenChina Peking University Shenzhen Hospital ShenzhenChina

Objective:To compare the degree of agreement and consistency of urodynamic studies(UDS)with low urinary tract symptoms(LUTS)questionnaires for evaluating LUTS in cervical cancer patients following radical hysterectomy(RH)and pelvic ***:From January 2012 to March 2015,204 cervical cancer patients who underwent RH in 13 hospitals were evaluated using the Incontinence Questionnaire-Female Lower Urinary Tract Symptoms(ICIQ-FLUTS)and the Overactive Bladder Symptom Score(OABSS).Urodynamic tests were also performed on these patients during the same ***:Study participants’age ranged from 23 to 75 years,with a mean(standard deviation)of 48.0±9.3 *** questionnaires,the prevalence of patients with LUTS symptoms,including storage symptoms,voiding symptoms,stress urinary incontinence(SUI)and overactive bladder(OAB)was 86.3%,77.0%,62.7%,52.9%and 14.7%,*** UDS,the corresponding prevalence was 89.7%,70.1%,66.7%,46.6%and 13.2%,*** diagnostic concordance of questionnaires and UDS for storage symptoms,voiding symptoms,SUI and OAB was 79.9%,66.7%,66.7%,57.4%and 79.9%,*** voiding symptoms,the correlation coefficient was 0.272,which was higher than that of storage symptoms,SUI and OAB.

关键词： Cervical cancer Radical hysterectomy Lower urinary tract symptoms Urodynamics

Trichostatin A inhibits inflammatory response in phorbol myristate acetate-induced macrophages through regulating acetylation of histone and/or non-histone protein

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Trichostatin A inhibits inflammatory response in phorbol myr...

全国第6届中西医结合传染病学术会议

作者： QIAN ZHANG FAN YANG XUN LI luwen wang XIAOGANG CHU HONG ZHANG ZUOJIONG GONG Department of Infectious Diseases Renmin Hospital of Wuhan University Pharmaceutical Department Renmin Hospital of Wuhan University

Histone deacetylase inhibitors(HDACi)are currently used in the routine clinical treatment of *** the anti-tumor activity of HDACi,more attentions are paid to its effects of *** the present study,we analyzed the inhibitory effects of Trichostatin A(TSA),an HDACi,on the release of inflammatory factors in the macrophages differentiated from U-937 *** results showed that low dose of

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非编码RNA与肝衰竭关系的研究进展

中华肝脏病杂志 2019年第5期27卷 397-400页

作者：王瑶王鲁文龚作炯武汉大学人民医院感染科 430060

肝衰竭是常见的危重疾病,临床上无良好的早期诊断指标和治疗方法。研究显示,以微小RNA(miRNA)和长链非编码RNA(lncRNA)为代表的非编码RNA(ncRNA)不仅可以作为肝衰竭的早期诊断指标,也在肝衰竭炎性反应、肝细胞死亡和肝细胞再生过程中发... 详细信息

肝衰竭是常见的危重疾病,临床上无良好的早期诊断指标和治疗方法。研究显示,以微小RNA(miRNA)和长链非编码RNA(lncRNA)为代表的非编码RNA(ncRNA)不仅可以作为肝衰竭的早期诊断指标,也在肝衰竭炎性反应、肝细胞死亡和肝细胞再生过程中发挥着重要的调控作用,同时ncRNA参与的表观遗传调控也参与肝衰竭的发生和发展。现就miRNA和lncRNA与肝衰竭的关系进行综述,以期为肝衰竭的诊断与治疗寻找新的作用靶点。

关键词：肝衰竭微小RNA 非编码RNA