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Antinociceptive and anti-inflammatory activities of leaf extracts from Annona tomentosa ***

Journal of Integrative Medicine 2017年第5期15卷 379-387页

作者： Lilian Uchoa Carneiro Ilna Gomes da Silva Mirian Eliza Alves de Souza Wellington da Silva Cortes Mário Geraldo de carvalho Bruno Guimaraes Marinho Postgraduate Program in Physiological Sciences Institute of Biological and Health SciencesFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil Laboratory of Pharmacology Department of Physiological SciencesInstitute of Biological Sciences and HealthFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil Postgraduate Program in Chemistry Department of ChemistryInstitute of Exact SciencesFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil

OBJECTIVE：Annona tomentosa *** is a species not endemic to Brazil that belongs to the phytogeographic areas of the Amazon,Cerrado and *** known as“araticum rasteiro”or“araticum de moita”,*** is edible and tea made from the leaves has been used as an antiinflammatory by native *** is no scientific evidence for these uses of ***,especially those related to the control of pain and *** this reason,in the present study we evaluated the antinociceptive and anti-inflammatory activities of partitions from the methanolic extract of *** leaves（*** leaf methanolic extract（ATFM）in hexane partition：ATFM-H;ATFM in dichloromethane partition：ATFM-D;ATFM in ethyl acetate partition：ATFM-Ac;ATFM in butanol partition：ATFM-B）in ***：The antinociceptive effects of leaf extracts from *** were evaluated by abdominal writhing and tail-flick tests,while the anti-inflammatory effects were evaluated by paw oedema and air-pouch *** locomotor activity was evaluated with the open-field ***,we evaluated the possible action mechanism of ***,using naloxone,nitro-L-arginine methyl ester,glibenclamide,atropine,naltrindole and norbinaltorphimine in tail-flick *** productions of tumor necrosis factorα（TNF-α）and interleukin（IL）-1βwere also ***：The chromatographic fractionation of the partitions of the methanolic extract from the leaves of *** revealed the presence of diterpenes,flavonoids,and steroids *** the analysis of the hexane partition kaurenoic acid was identified as the major ***-H and ATFM-D had a significant antinociceptive effect in acute pain models in *** ATFM-H showed central antinociceptive effect from the involvement of theδopioid receptors,without causing alterations in the locomotor activity of the mice,while ATFM-D was effective in decreasing paw oedema and TNF-α and IL-1β ***：These results demon

关键词： Annona tomentosa cytokines opioid nociception

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Foliar application of rare earth elements on soybean(Glycine max(L)):Effects on biometrics and characterization of phytotoxicity

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Journal of Rare Earths 2020年第10期38卷 1131-1139,I0005页

作者： Eduardo S.Rodrigues Gabriel S.Montanha Joao P.R.Marques Eduardo de Almeida Lauren N.M.Yabuki Amauri A.Menegario Hudson W.Pereira de carvalho Laboratory of Nuclear Instrumentation(LIN) Center for Nuclear Energy in Agriculture(CENA)University of Sao Paulo(USP)PiracicabaSP13416-000Brazil Environmental Studies Center Sao Paulo State University(UNESP)Rio ClaroSP13506-900Brazil

This study aims at investigating the effects of foliar application of aqueous solutions of La3+and Ce3+nitrates on soybean plants(Glycine max).First,we observe that Triton HW 1000 surfactant at 0.01 vol%reduces droplets contact angle and increases their drying *** greenhouse conditions,the foliar treatments do not affect chlorophyll content,plant height,number of leaves,number of pods,number of seeds per pod,and average seed ***,the treatments induce phytotoxicity since foliar injuries appear after the *** X-ray fluorescence spectroscopy combined to scanning electron microscopy shows that the leaf lesions are positively correlated to accumulation of Ce and La on the leaf surface and also promote structural alteration to the epidermal cells.X-ray absorption near edge structure shows that the La and Ce nitrates are partially bio transformed into oxides by the leaves which might explain the harmful effects.

关键词： Leaf fertilization Rare earth elements Soybean X-ray fluorescence spectroscopy X-ray absorption spectroscopy

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Cerium alleviates drought-induced stress in Phaseolus vulgaris

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Journal of Rare Earths 2020年第3期38卷 324-331页

作者： Olívia Graziela Gelioli Salgado Jéssica Cristina Teodoro Joyce Pereira Alvarenga Cynthia de Oliveira Teotonio Soares de carvalho Débora Domiciano Paulo Eduardo Ribeiro Marchiori luiz Roberto Guimaraes Guilherme department of Soil Science Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil department of Biology Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil

Extreme drought events are expected to be one of the main challenges for tropical agriculture and,consequently,for global food *** this reason,it is urgent to develop strategies to increase water use efficiency,as well as to increase crops’ ability to cope with *** rare earth elements(REEs) are known to alleviate damages in plants under abiotic stresses,we hypothesized that addition of Ce^3+to nutrient solution would promote the growth of common bean,especially under simulated drought *** test this hypothesis,we conducted an experiment evaluating the effect of six Ce^3+concentrations on the development and physiological traits of common bean grown in nutrient solution under normal condition and under induced drought stress,caused by the addition of polyethylene glycol6000 to the nutrient *** results show that Ce^3+alleviates water stress in common bean plants,increasing their survival rate and *** addition,Ce^3+application increases photosynthesis rate,chlorophyll content and water use efficiency under water ***,we observe no significant effect of Ce^3+on plants growing under normal ***,Ce3+seems to be a promising attenuator of drought stress for common bean.

关键词： Water stress Polyethylene glycol Rare earth elements Cerium nitrate Mitigation Common bean

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A Prospective Study of Headache after Carotid Endarterectomy: Incidence and Clinical Characteristics

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Neuroscience & Medicine 2012年第1期3卷 14-17页

作者： lucas Alverne Freitas de Albuquerque Marcos dellaretti Gervásio Teles cardoso de carvalho Wilson Faglioni Júnior Atos Alves de Sousa department of Neurosurgery of Santa Casa de Belo Horizonte Belo Horizonte Minas Gerais Brazil Faculdade de Ciências Medicas de Minais Gerais. Belo Horizonte MG Brazil.

Headache associated with Carotid Endarterectomy (CEA) is a known condition;however, its incidence and etiology are not well defined. In this study, we determined the incidence and evaluated the characteristics of headache following CEA. This prospective study was conducted between January and July 2009, in 32 patients submitted to CEA. 68.7% of patients were male;mean age was 67.3 years-old. Headache incidence was 37.5%, ipsilateral to the CEA in 91% of patients;pressure was the most common pain quality (81.2%) and affected the frontal region alone in 37.5% of headache episodes. All headache episodes were of mild intensity. No correlation (p > 0.05) was found between sexes and no significant value (p > 0.05) was determined between the presence of headache and the mean degree of stenosis in the ipsilateral and contralateral carotid operated. Headache following CEA is a common condition;in most cases it is ipsilateral to the procedure, pressure type, mild and self-limiting.

关键词： Headache Carotid Endarterectomy Stroke Complication

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Usher syndrome:Genetic diagnosis and current therapeutic approaches

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World Journal of Otorhinolaryngology 2024年第1期11卷 1-17页

作者： Beatriz Rocha Cuzzuol Jonathan Santos Apolonio Ronaldo Teixeira da Silva Júnior Lorena Sousa de carvalho luana Kauany de SáSantos luciano Hasimoto Malheiro Marcel Silva luz Mariana Santos Calmon Henrique de Lima Crivellaro Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf *** genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular *** the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset *** type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high ***,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of *** dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with *** date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and *** genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional *** non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating *** drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in ***,CI has proven to be critical in the restoration of *** review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et *** and current treatments of USH WJO https://*** 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and i

关键词： Usher syndromes Hearing loss Retinitis pigmentosa Diagnosis Genetic therapies Cochlear implantation Quality of life

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delayed spontaneous reversibility of left bundle branch block in non-ischemic cardiomyopathy: a case report

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Journal of Geriatric Cardiology 2020年第3期17卷 164-168页

作者： Marcus VH carvalho Priscila C Kroll Vinicius N carvalho department of Cardiothoracic Medicine JundiaíMedical SchoolJundiaíSPBrazil Transplant Hospital E J Zerbini Sao PauloSPBrazil Municipal Hospital Mario Gatti CampinasSao PauloSPBrazil

Left bundle branch block(LBBB)causes a delay in left ventricular contraction with an unsynchronized ventricular *** is an independent determinant of morbi-mortality mainly when associated with cardiomyopathy and left ventricular dysfunction.[1] LBBB due to non-ischemic cardiomyopathy is considered *** irreversibility occurs because LBBB and cardiomyopathy act in a synergic manner in order to maintain both ***,there are a few reports in the literature showing that some patients have had an improvement in cardiac function with normalization of QRS and have experienced a reverse remodelling with pharmacological therapy only.[2–4]

关键词： desynchronization Heart failure Left bundle branch block Reverse remodelling

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Characterization of the Biological Potential of the Essential Oils from Five Species of Medicinal Plants

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American Journal of Plant Sciences 2017年第2期8卷 154-170页

作者： Danubia Aparecida carvalho Selvati Rezende Rafaela Vieira Souza Maisa Lamounier Magalh?es Alex Rodrigues Silva Caetano Marcos Schleiden Sousa carvalho Ellen Cristina de Souza luiz Gustavo de Lima Guimaraes David Lee Nelson luís Roberto Batista Maria das Gra?as cardoso departamento de Química Universidade Federal de LavrasLavrasBrasil departamento de Ciencia dos Alimentos Universidade Federal de LavrasLavrasMGBrasil departamento de Ciência dos Alimentos Universidade Federal de LavrasLavrasMGBrasil departamento de Agricultura Universidade Federal de LavrasLavrasMGBrasil Universidade Federal de Sao Joao del-Rei Sao Joao del-ReiBrasil Universidade Federal do Vale do Jequitinhonha e Mucuri DiamantinaMGBrasil

Essential oils from Mentha piperita, Cymbopogon citratus, Rosmarinus officinalis, Peumus boldus and Foeniculum vulgare were extracted by hydrodistillation, chemically characterized and quantified by GC/MS and GC/FID. The principal componentes in the essential oil of M. piperita (carvone and limonene), C. citratus (geranial, neral and myrcene), R. officinalis (1,8-cineole, camphor and α-pinene), P. boldus (α-terpinyl formate, p-cymene and 1,8-cineole) and F. vulgare (methyl chavicol, limonene and fenchone) were identified. The oils were tested for antioxidant activity employing the DPPH (2,2-diphenyl-1-picryl-hydrazyl) radical-capture method, the oxidation of the β-carotene/linoleic acid system, and the ABTS radical-capture method. The essential oils were not effective. The antioxidant activities of the oils were determined by the hydroxyl method, and the highest activity (62.80%) was observed with the essential oil from M. piperita. Activities of 1.54 and 1.82 μg μg-1, respectively, were observed for the essential oils from C. citratus and P. Boldus using the phosphomolybdenum method. No activity was observed with respect to reducing power. The essential oil from C. citratus was effective in inhibiting the growth of L. monocytogenes (15.63 mg·L-1), S. choleraesuis (15.63 mg·L-1) and E. coli (31.25 mg·L-1), and the essential oil from P. boldus inhibited the growth of S. aureus (62.5 mg·L-1). No essential oil inhibited the growth of P. aeruginosa. A low antioxidant activity and a promising antibacterial activity were observed for these essential oils.

关键词： Natural Products Antioxidant Antibacterial Activity

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Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress

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World Journal of Gastroenterology 2017年第28期23卷 5146-5157页

作者： Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira Centro de Pesquisas Aggeu Magalhaes Fundacao Oswaldo Cruz Immunopathogenesis Section Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaMDUSA and Laboratório de Doencas Parasitárias e infecciosasFaculdade de MedicinaUniversidade Federal de Minas Gerais departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de Pernambuco departamento de Biofísica e Radiobiologia Universidade Federal de Pernambuco Centro Acadêmico de Vitória Universidade Federal de Pernambuco departamento de Medicina Tropical Universidade Federal de Pernambuco

To evaluate the therapeutic effects of bone marrow-derived CD11b+CD14+ monocytes in a murine model of chronic liver *** liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry, biochemical assessment, immunohistochemistry and enzyme-linked immunosorbent ***11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-6 and IL-1β, in addition to pro-fibrotic factors, such as IL-13, transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased, while IL-10 and matrix metalloproteinase-9 increased in the monocyte-treated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and *** therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation, as well as increasing anti-fibrogenic factors.

关键词： Monocytes Bone marrow mononuclear cells Cell therapy Macrophages Glutathione Liver fibrosis

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Organomineral Phosphorus Fertilization in the Production of Corn,Soybean and Bean Cultivated in Succession

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American Journal of Plant Sciences 2017年第10期8卷 2407-2421页

作者： denize carvalho Martins Alvaro Vilela de Resende Joao Carlos cardoso Galvao Eduardo de Paula Simao José Paulo Da Costa Ferreira Gabriela de Oliveira Almeida department of Plant Science Federal University of VicosaVicosaBrazil Embrapa Maize and Sorghum Sete LagoasBrazil Federal University of Sao Joao del Rei Sete LagoasBrazil

The use of organic waste in agriculture has been used aiming at greater productivity, decrease in the cost of production and sustainable use of resources. The present study aimed at evaluating the effect of phosphate fertilization with the maintenance of organomineral fertilizers, combining poultry manure and soluble or reactive phosphate, in the production of grains in corn culture and the residual effect for subsequent crops of beans and soybeans. The experiment was conducted in Sete Lagoas, MG, in 2015, using three fertilizers with sources of different phosphorus sources (triple super phosphate—STP, organomineral with STP and organomineral with Bayovar phosphate) applied at the doses of 65, 130, 195 and 260 kg·ha¯1 of P2O5 total, and compared to the control without phosphate fertilization. We evaluated the contents of foliar P, P accumulation in the grains, yields of corn grains, beans and soy, accumulated productivity and export of accumulated P of the three cultures. The three cultures assessed presented higher productivity when compared to the average of the factorial treatments that received phosphate fertilization relative to the control. Organomineral fertilizers increased grain production, obtaining average productivity equal to or greater than those obtained with the exclusive use of STP.

关键词： Reactive Phosphate Poultry Manure New Fertilizers

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Turning Industrial Waste into a Valuable Bioproduct:Starch from Mango Kernel derivative to Oil Industry Mango Starch derivative in Oil Industry

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Journal of Renewable Materials 2019年第2期7卷 139-152页

作者： Nívia do Nascimento Marques Caroline Suzy do Nascimento Garcia Liszt Yeltsin Coutinho Madruga Marcos Antônio Villetti Men de SáMoreira de Souza Filho Edson Noriyuki Ito Rosangela de carvalho Balaban Instituto de Química Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil departamento de Física Universidade Federal de Santa Maria-UFSMSanta Maria97105900Brazil Embrapa Agroindústria Tropical Fortaleza60511-110Brazil departamento de Engenharia de Materiais Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil

After industrial mango processing,tons of residues such as peels and kernels are discarded as ***,almost 60% of the mango kernel is due to starch on a dry weight ***,starch from mango(Manguifera Indica L.)kernel was applied to obtain a starch fatty ester with vinyl laurate,in DMSO,under basic ***,1H and 13C NMR confirmed that a starch ester with a degree of modification of 2.6 was *** showed that the modified starch has higher thermal stability than its precursors and higher than a vinyl laurate/starch physical *** data showed that granular shape and smooth surface on mango starch changed after chemical modification to a continuous and shapeless *** industrial reject derivative behaved as an efficient alternative environmentally friendly fluid loss controller in oil drilling fluids,even in conditions of high temperatures and high pressures(HTHP)drilling.

关键词： Mango Starch oil drilling fluid transesterification vinyl laurate

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