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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia Dong Tong-bu lu Di-Chang Zhong School of Chemistry and Chemical engineering Yangzhou University Institute for New energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong luji Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene expression Omnibus (GeO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. enzyme-linked immunosorbent assays (eLISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' uTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-bu lu Huan Pang Xian-He bu Institute for New energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical engineering Yangzhou University School of Materials Science and engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOe Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical engineering and Technology Tiangong University School of Chemistry and Chemical engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.u nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Impacts of CMe Changing Mechanism for Allowing Negative Oil Prices on Prices and Trading Activities in the Crude Oil Futures Market

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Journal of Systems Science & Complexity 2023年第5期36卷 2001-2025页

作者： lu Fengbin bu Hui Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of economics and Management Beihang UniversityBeijing 100191China

This study investigates and compares the effects of the Coronavirus disease 2019(COVID-19)pandemic,the Chicago mercantile exchange(CMe)'s negative price suggestion on prices and trading activities in the crude oil futures market to discuss the cause of negative crude oil futures *** event studies,the empirical results show that the COVID-19 pandemic no longer impacts crude oil futures prices in April,2020 after controlled market risk,while the CMe's negative prices suggestion can explain the crude oil futures price changes around and even after April 8,2020 to some ***,this study uncovers anomalies in prices and trading activities by analyzing returns,trading volu.e,open interest,and illiquidity measures using vector autoregressive(VAR)*** results imply that CMe's allowing negative prices strengthens the price impact on trading volu.e and makes illiquidity risk *** study's results coincide with the following lawsuit evidence of market manipulation.

关键词： event study illiquidity risk market risk negative crude oil futures price price-trading relationship

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： Wen Huang Zeng Lian Kening lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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Study of parametric roll in oblique waves using a three-dimensional hybrid panel method

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Journal of Hydrodynamics 2020年第1期32卷 126-138页

作者： Min Gu Shu-xia bu Jiang lu Jiangsu Key Laboralory of Green Ship Technology China Ship Scientific Research CenterWiuxi 214082.China

A reliable numerical tool for the prediction of the parametric roll is important in the development of the second generation intact stability *** main difficulty of the prediction of the parametric roll comes from the significant coupling of the roll with other motions,especially the heave and pitch *** this paper,the numerical method for determining the parametric roll is studied and the results are benchmarked against the model test ***,a 3 degrees-of-freedom(DOF)time domain hybrid panel method is validated by experimental data in regular oblique waves and irregular head ***,the verified 3D O F method is extended to a fully coupled 6 DOF method with the course ***,taking the C11 containership as the test case,the parametric roll in oblique waves is computed,and the effects of the surge,sway and yaw motions on the parametric roll are evaluated with the developed mathematical *** results show that the effects of the surge and sway motions on the parametric roll is insignificant,while the effects of the yaw motion are more *** results of the roll amplitudes and the standard deviation of the roll angles show that the model based on 3 DOF gives relatively conservative results,and can be directly used for the stability assessment of the parametric roll.

关键词： 6DOF mathematical model irregular oblique waves second generation intact stability in IMO

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Photocatalytic reduction of CO_(2) with H_(2)O into C_(2)H_(6) mediated by dual metalation strategy

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Science China Chemistry 2024年第5期67卷 1381-1383页

作者： Mei Wang Tong-bu lu School of Materials Science and engineering Institute for New Energy Materials&Low Carbon TechnologiesTianjin University of TechnologyTianjin 300384China

Artificial solar-energy-driven CO_(2) reduction into value-added fuels under mild conditions provides a promising strategy to mitigate energy crisis and alleviate environmental issues around the world. Among diverse products of CO_(2) reduction reaction, C_(2+) compounds are more desirable in terms of their high energy density and commercial value [1].Thus far, various photocatalysts have been constructed for CO_(2) reduction.

关键词： reduction desirable value

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical engineering Process of Ministry of education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OeR）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OeR process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OeR. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process inclu.es the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OeR activity. The work provides new insights into complete reconstruction of metal-based complexes during OeR and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

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Covalent Organic Frameworks Based Single-site electrocatalysts for Oxygen Reduction Reaction

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Chemical Research in Chinese universities 2022年第5期38卷 1151-1162页

作者： bu Ran lu Yingying ZHANG Bing State Key Laboratory of Chemical engineering Institute of Pharmaceutical EngineeringCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027P.R.China ZJu-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200P.R.China

Single site catalysts(SSCs)are a new type of heterogeneous catalysts formed by isolated metal atoms supported on kinds of *** have shown great potential for energy conversion and storage in recent years,especially for oxygen reduction reactions(ORR).Typically,SSCs are confined on the substrate by strong chemical interactions,such as coordination ***,the surface chemical environment and porous properties of the supports are crucial to the performance of *** recent years,COFs have become excellent candidates for preparing SSCs as they can precisely assemble monomers into highly ordered crystalline porous materials with a fine structure and definite *** this review,we not only summarize the characteristics and advantages of COFs based SSCs,but also highlight the applications of COFs constructed from different single active sites for ORR in recent ***,challenges in practical application,feasible strategies and perspectives are proposed for the of COFs based SSCs.

关键词： Covalent organic framework Oxygen reduction reaction Single site catalyst energy conversion Carbon-based catalyst

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